HK1121162A1 - Oxazole compound and pharmaceutical composition - Google Patents
Oxazole compound and pharmaceutical compositionInfo
- Publication number
- HK1121162A1 HK1121162A1 HK09101124.8A HK09101124A HK1121162A1 HK 1121162 A1 HK1121162 A1 HK 1121162A1 HK 09101124 A HK09101124 A HK 09101124A HK 1121162 A1 HK1121162 A1 HK 1121162A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pharmaceutical composition
- oxazole compound
- oxazole
- compound
- pharmaceutical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005330590 | 2005-11-15 | ||
PCT/JP2006/323066 WO2007058338A2 (en) | 2005-11-15 | 2006-11-14 | Oxazole compound and pharmaceutical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1121162A1 true HK1121162A1 (en) | 2009-04-17 |
Family
ID=37879936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09101124.8A HK1121162A1 (en) | 2005-11-15 | 2009-02-06 | Oxazole compound and pharmaceutical composition |
Country Status (23)
Country | Link |
---|---|
US (7) | USRE46792E1 (xx) |
EP (1) | EP1954684B1 (xx) |
JP (1) | JP5305914B2 (xx) |
KR (1) | KR101439557B1 (xx) |
CN (1) | CN101309912B (xx) |
AR (3) | AR057891A1 (xx) |
AU (1) | AU2006316079B2 (xx) |
BR (1) | BRPI0618589B8 (xx) |
CA (1) | CA2627541C (xx) |
CY (1) | CY1115302T1 (xx) |
DK (1) | DK1954684T3 (xx) |
ES (1) | ES2483992T3 (xx) |
HK (1) | HK1121162A1 (xx) |
IL (1) | IL191008A (xx) |
MY (1) | MY153720A (xx) |
NO (1) | NO341440B1 (xx) |
PL (1) | PL1954684T3 (xx) |
PT (1) | PT1954684E (xx) |
RU (1) | RU2418793C2 (xx) |
SI (1) | SI1954684T1 (xx) |
TW (1) | TWI330639B (xx) |
WO (1) | WO2007058338A2 (xx) |
ZA (1) | ZA200803758B (xx) |
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JP4986927B2 (ja) * | 2007-05-14 | 2012-07-25 | 大塚製薬株式会社 | 医薬 |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
PT2959900T (pt) * | 2008-06-16 | 2017-06-22 | Univ Tennessee Res Found | Composto para tratamento do cancro |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
GB2465890A (en) * | 2008-12-05 | 2010-06-09 | Scynexis Inc | 2-Arylazole derivatives as antiprotozoal agents |
MX2012010115A (es) | 2010-03-01 | 2013-02-26 | Gtx Inc | Compuestos para el tratamiento de cancer. |
US8513230B2 (en) * | 2010-03-05 | 2013-08-20 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
ES2742195T3 (es) | 2010-03-12 | 2020-02-13 | Omeros Corp | Inhibidores de PDE10 y composiciones y métodos relacionados |
US9303000B2 (en) | 2011-01-17 | 2016-04-05 | Karyopharm Therapeutics Inc. | Olefin containing nuclear transport modulators and uses thereof |
PL3333164T3 (pl) | 2011-07-29 | 2023-12-18 | Karyopharm Therapeutics Inc. | Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania |
EA201490406A1 (ru) | 2011-07-29 | 2014-07-30 | Кариофарм Терапевтикс, Инк. | Модуляторы ядерного транспорта и их применение |
US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
WO2013072938A2 (en) * | 2011-11-09 | 2013-05-23 | Mylan Laboratories Ltd | An improved process for the preparation of roflumilast |
EP3404027B1 (en) | 2012-05-09 | 2020-03-04 | Biogen MA Inc. | Nuclear transport modulators and uses thereof |
BR112015004023A2 (pt) * | 2012-08-30 | 2017-07-04 | Otsuka Pharma Co Ltd | composto, e, método para produzir um composto |
WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
CN110183422B (zh) | 2013-06-21 | 2023-07-14 | 卡尔约药物治疗公司 | 核转运调节剂及其用途 |
CN105085428B (zh) * | 2014-04-25 | 2019-03-22 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
DK3180331T3 (da) | 2014-08-15 | 2022-09-12 | Karyopharm Therapeutics Inc | Polymorfer af selinexor |
TWI689497B (zh) * | 2014-09-04 | 2020-04-01 | 南北兄弟藥業投資有限公司 | 芳雜環類衍生物及其在藥物中的應用 |
CN107530313A (zh) | 2015-04-24 | 2018-01-02 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
CN106188027B (zh) * | 2015-09-02 | 2020-10-20 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物中的应用 |
CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
TWI726027B (zh) | 2015-12-28 | 2021-05-01 | 日商大塚製藥股份有限公司 | 軟膏 |
CN106279138B (zh) * | 2015-12-29 | 2019-03-01 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物中的应用 |
US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
MA43529A (fr) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics Inc | Modulateurs de transport nucléaire et leurs utilisations |
WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
BR112020019377A2 (pt) | 2018-04-04 | 2021-01-05 | Otsuka Pharmaceutical Co., Ltd. | Cristal de composto oxazol |
CN116194451A (zh) * | 2020-11-27 | 2023-05-30 | 瑞石生物医药有限公司 | 芳基或杂芳基取代五元芳杂环化合物及其用途 |
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JP2004203871A (ja) | 2002-12-13 | 2004-07-22 | Yamanouchi Pharmaceut Co Ltd | 医薬組成物 |
TW200505913A (en) | 2003-03-28 | 2005-02-16 | Hoffmann La Roche | Novel oxazole derivatives, their manufacture and use as pharmaceutical agents |
KR101242310B1 (ko) | 2004-05-17 | 2013-03-12 | 오츠카 세이야쿠 가부시키가이샤 | 티아졸 화합물 및 그의 용도 |
ATE432926T1 (de) | 2004-07-26 | 2009-06-15 | Lilly Co Eli | Oxazolderivate als histamin-h3-rezeptor- wirkstoffe, deren herstellung und therapeutische verwendung |
DE102004051277A1 (de) * | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
CA2602336A1 (en) * | 2005-03-31 | 2006-10-05 | Ucb Pharma S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
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2006
- 2006-11-14 US US15/623,249 patent/USRE46792E1/en active Active
- 2006-11-14 WO PCT/JP2006/323066 patent/WO2007058338A2/en active Application Filing
- 2006-11-14 CN CN200680042484XA patent/CN101309912B/zh active Active
- 2006-11-14 PT PT68234673T patent/PT1954684E/pt unknown
- 2006-11-14 RU RU2008123839/04A patent/RU2418793C2/ru active
- 2006-11-14 KR KR1020087014483A patent/KR101439557B1/ko active IP Right Grant
- 2006-11-14 AR ARP060104973A patent/AR057891A1/es active IP Right Grant
- 2006-11-14 PL PL06823467T patent/PL1954684T3/pl unknown
- 2006-11-14 SI SI200631792T patent/SI1954684T1/sl unknown
- 2006-11-14 ES ES06823467.3T patent/ES2483992T3/es active Active
- 2006-11-14 EP EP06823467.3A patent/EP1954684B1/en active Active
- 2006-11-14 MY MYPI20081379A patent/MY153720A/en unknown
- 2006-11-14 TW TW095142068A patent/TWI330639B/zh active
- 2006-11-14 AU AU2006316079A patent/AU2006316079B2/en active Active
- 2006-11-14 BR BRPI0618589A patent/BRPI0618589B8/pt active IP Right Grant
- 2006-11-14 ZA ZA200803758A patent/ZA200803758B/xx unknown
- 2006-11-14 DK DK06823467.3T patent/DK1954684T3/da active
- 2006-11-14 CA CA2627541A patent/CA2627541C/en active Active
- 2006-11-14 JP JP2008539670A patent/JP5305914B2/ja active Active
- 2006-11-14 US US12/090,951 patent/US8637559B2/en not_active Ceased
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2008
- 2008-04-23 NO NO20081930A patent/NO341440B1/no unknown
- 2008-04-27 IL IL191008A patent/IL191008A/en active IP Right Grant
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2009
- 2009-02-06 HK HK09101124.8A patent/HK1121162A1/xx unknown
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2013
- 2013-12-12 US US14/104,871 patent/US20140100226A1/en not_active Abandoned
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2014
- 2014-07-01 CY CY20141100485T patent/CY1115302T1/el unknown
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2017
- 2017-04-11 US US15/485,203 patent/US20170216260A1/en not_active Abandoned
- 2017-07-10 AR ARP170101904A patent/AR109006A2/es unknown
- 2017-07-10 AR ARP170101905A patent/AR109007A2/es unknown
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2018
- 2018-11-01 US US16/178,517 patent/US20190070151A1/en not_active Abandoned
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2019
- 2019-11-12 US US16/681,360 patent/US20200078340A1/en not_active Abandoned
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2022
- 2022-02-24 US US17/679,659 patent/US20220265613A1/en not_active Abandoned
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