CA2738650C - Fused diimidazodiazepine compounds and methods of use and manufacture thereof - Google Patents

Fused diimidazodiazepine compounds and methods of use and manufacture thereof Download PDF

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Publication number
CA2738650C
CA2738650C CA2738650A CA2738650A CA2738650C CA 2738650 C CA2738650 C CA 2738650C CA 2738650 A CA2738650 A CA 2738650A CA 2738650 A CA2738650 A CA 2738650A CA 2738650 C CA2738650 C CA 2738650C
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CA
Canada
Prior art keywords
illustrative embodiments
groups
compound
certain illustrative
benzyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2738650A
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English (en)
French (fr)
Other versions
CA2738650A1 (en
Inventor
Ramachandra S. Hosmane
Venu Raman
Raj Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CA2738650A1 publication Critical patent/CA2738650A1/en
Application granted granted Critical
Publication of CA2738650C publication Critical patent/CA2738650C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2738650A 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof Active CA2738650C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9932408P 2008-09-23 2008-09-23
US61/099,324 2008-09-23
PCT/US2009/005273 WO2010039187A2 (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Publications (2)

Publication Number Publication Date
CA2738650A1 CA2738650A1 (en) 2010-04-08
CA2738650C true CA2738650C (en) 2017-07-04

Family

ID=42074054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2738650A Active CA2738650C (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Country Status (6)

Country Link
US (1) US8518901B2 (enExample)
EP (1) EP2350086B1 (enExample)
JP (1) JP5802872B2 (enExample)
AU (1) AU2009300357B2 (enExample)
CA (1) CA2738650C (enExample)
WO (1) WO2010039187A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
JP2014511396A (ja) * 2011-03-09 2014-05-15 ザ・ジョンズ・ホプキンス・ユニバーシティ 除去的放射線治療に使用される組成物およびその使用方法
KR20150046787A (ko) * 2012-09-04 2015-04-30 고쿠리츠다이가쿠호진 니이가타 다이가쿠 암 줄기세포에서 발현하는 분자를 타깃으로 하는 암 진단 및 치료 방법
WO2015200779A2 (en) * 2014-06-26 2015-12-30 The Johns Hopkins University Methods of prevention and treatment of viral disease by use of ddx3 inhibitors
AU2020345000A1 (en) * 2019-09-13 2022-03-31 Origenis Gmbh 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
RS65045B1 (sr) * 2019-09-13 2024-02-29 Origenis Gmbh Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti
US20230077636A1 (en) * 2021-08-31 2023-03-16 Natsar Pharmaceuticals, Inc. Intravenous formulations of rk-33

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
TW201311B (enExample) * 1991-06-17 1993-03-01 Hoffmann La Roche
EP1968581A4 (en) * 2005-12-16 2009-05-27 Genentech Inc TETRACYCLIC KINASE INHIBITORS

Also Published As

Publication number Publication date
AU2009300357A1 (en) 2010-04-08
JP5802872B2 (ja) 2015-11-04
WO2010039187A2 (en) 2010-04-08
EP2350086A2 (en) 2011-08-03
US8518901B2 (en) 2013-08-27
US20110275588A1 (en) 2011-11-10
CA2738650A1 (en) 2010-04-08
EP2350086B1 (en) 2021-04-21
WO2010039187A3 (en) 2010-06-17
EP2350086A4 (en) 2012-06-27
JP2012503653A (ja) 2012-02-09
AU2009300357B2 (en) 2014-07-03

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Effective date: 20140923