JP2009263394A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009263394A5 JP2009263394A5 JP2009160619A JP2009160619A JP2009263394A5 JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5 JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- phenyl
- heterocycle
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33619101P | 2001-10-22 | 2001-10-22 | |
| US41072602P | 2002-09-13 | 2002-09-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Division JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009263394A JP2009263394A (ja) | 2009-11-12 |
| JP2009263394A5 true JP2009263394A5 (enExample) | 2011-07-21 |
Family
ID=26990085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Expired - Lifetime JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
| JP2009160619A Pending JP2009263394A (ja) | 2001-10-22 | 2009-07-07 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Expired - Lifetime JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7129225B2 (enExample) |
| EP (1) | EP1444204A4 (enExample) |
| JP (2) | JP4623962B2 (enExample) |
| CA (1) | CA2464214C (enExample) |
| MX (1) | MXPA04003758A (enExample) |
| WO (1) | WO2003035621A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0007532A (pt) * | 1999-01-13 | 2001-11-20 | Univ New York State Res Found | Métodos para identificar inibidores de proteìnaquinase, para testar compostos para umacapacidade de inibir a atividade de proteìnaquinase e para inibir uma proteìna quinase, inibidorde proteìna tirosina quinase não peptìdica, e,método de tratar uma condição responsiva a uminibidor de proteìna quinase em um paciente |
| US7005445B2 (en) * | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| CA2464214C (en) * | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| WO2003086377A1 (en) | 2002-04-18 | 2003-10-23 | Institute Of Medicinal Molecular Design. Inc. | Amide derivatives |
| AU2003261415C1 (en) | 2002-08-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| EP1534268A4 (en) * | 2002-08-09 | 2006-11-02 | Merck & Co Inc | TYROSINE KINASE INHIBITORS |
| ATE409484T1 (de) * | 2002-12-17 | 2008-10-15 | Centre Nat Rech Scient | Verwendung von purinderivaten zur induktion der differenzierung überzähliger haarzellen und deiter-zellen im entwickelnden corti-organ zur behandlung von taubheit |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| WO2005004863A1 (en) * | 2003-07-11 | 2005-01-20 | Merck Patent Gmbh | Benzimidazole carboxamides as raf kinase inhibitors |
| US20050089936A1 (en) * | 2003-10-23 | 2005-04-28 | Jianping Cai | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides |
| EP1532980A1 (en) | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| US7736911B2 (en) | 2004-04-15 | 2010-06-15 | Albert Einstein College Of Medicine Of Yeshiva University | Activity-based probes for protein tyrosine phosphatases |
| WO2006053274A2 (en) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006055463A2 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| US7223786B2 (en) * | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
| WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| GB0425919D0 (en) * | 2004-11-25 | 2004-12-29 | Prosidion Ltd | Indole-2-carboxylic acid amides |
| MX2007006764A (es) * | 2004-12-06 | 2007-08-15 | Aventis Pharma Sa | Indoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion. |
| FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| WO2006066879A2 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
| EP2308839B1 (en) * | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| FR2884821B1 (fr) * | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation |
| MY148644A (en) | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
| EP1966150A4 (en) * | 2005-12-23 | 2011-07-20 | Astrazeneca Ab | PYRAZOLE FOR THE TREATMENT OF GERD AND IBS |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| JP2010503657A (ja) | 2006-09-15 | 2010-02-04 | ファイザー株式会社 | 置換ピリジルメチルビシクロカルボキサミド化合物 |
| EP2222631B1 (en) | 2006-10-23 | 2011-08-17 | Pfizer Inc. | Substituted phenylmethyl bicyclocarboxyamide compounds |
| EP2091944B1 (en) | 2006-11-17 | 2011-05-18 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| KR20090100407A (ko) * | 2006-12-18 | 2009-09-23 | 암브룩스, 인코포레이티드 | 비천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비천연 아미노산 및 폴리펩티드의 용도 |
| WO2008127199A1 (en) | 2007-04-13 | 2008-10-23 | Agency For Science, Technology And Research | Methods of controlling tumorigenesis and diagnosing the risk thereof |
| EP2173717B9 (en) | 2007-07-27 | 2013-06-26 | Bristol-Myers Squibb Company | Novel glucokinase activators and methods of using same |
| US8513422B2 (en) | 2007-08-31 | 2013-08-20 | Astellas Pharma Inc. | Piperidine derivative |
| US8420677B2 (en) | 2008-02-19 | 2013-04-16 | Dsm Ip Assets B.V. | Use of 3,3′-diindolylmethane |
| CA2731769C (en) | 2008-07-21 | 2013-09-10 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
| MX2011002613A (es) | 2008-09-11 | 2011-05-23 | Pfizer | Derivados de heteroarilamida y su uso como activadores de glucoquinasa. |
| HRP20130661T1 (en) | 2009-03-11 | 2013-08-31 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
| CN104603106B (zh) | 2012-09-07 | 2017-05-10 | 诺华股份有限公司 | 吲哚甲酰胺衍生物及其用途 |
| CN103044311B (zh) * | 2012-12-26 | 2015-04-22 | 山东大学 | 一种多取代吲哚类化合物及其制备方法和应用 |
| EP2988741B1 (en) | 2013-04-26 | 2019-11-27 | Indiana University Research&Technology Corporation | Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2) |
| HRP20201621T1 (hr) * | 2014-04-04 | 2021-03-05 | Iomet Pharma Ltd. | Derivati indola za uporabu u medicini |
| CN104876851A (zh) * | 2015-05-15 | 2015-09-02 | 南京大学 | 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用 |
| PL3426244T3 (pl) * | 2016-03-09 | 2023-09-25 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| HUE055197T2 (hu) | 2016-03-09 | 2021-11-29 | Raze Therapeutics Inc | 3-Foszfoglicerát-dehidrogenáz inhibitorok és alkalmazásuk |
| ES3000465T3 (en) | 2018-01-31 | 2025-02-28 | Heparegenix Gmbh | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| WO2019243315A1 (en) | 2018-06-21 | 2019-12-26 | Heparegenix Gmbh | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| JP7365393B2 (ja) | 2018-07-16 | 2023-10-19 | ヘパリジェニックス ゲーエムベーハー | 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤 |
| CA3164361A1 (en) | 2020-01-15 | 2021-07-22 | Heparegenix Gmbh | 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases |
| US20230183810A1 (en) * | 2020-05-04 | 2023-06-15 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
| WO2022020114A2 (en) | 2020-07-10 | 2022-01-27 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| WO2024109642A1 (zh) * | 2023-07-28 | 2024-05-30 | 常州大学 | 一种苯并氮杂环类化合物作为β2-肾上腺素受体别构调节剂的应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01132579A (ja) * | 1987-11-19 | 1989-05-25 | Ss Pharmaceut Co Ltd | インドール誘導体 |
| GB8827189D0 (en) | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
| CA2071529C (en) * | 1989-12-28 | 2001-03-20 | Donna Lee Romero | Diaromatic substituted anti-aids compounds |
| US5552534A (en) | 1991-08-22 | 1996-09-03 | The Trustees Of The University Of Pennsylvania | Non-Peptide peptidomimetics |
| DE4307883A1 (en) * | 1992-03-12 | 1993-09-23 | Westarp Martin Egon Dr Med | Use of anti-retroviral substances - to treat motor-neuronal diseases |
| US5705585A (en) | 1993-06-30 | 1998-01-06 | Arqule, Inc. | Aminimide-containing molecules and materials as molecular recognition agents |
| JPH08503450A (ja) | 1992-08-06 | 1996-04-16 | ワーナー−ランバート・コンパニー | 蛋白チロシンキナーゼを阻害し、かつ抗腫瘍特性を有する２−チオインドール（セレノインドール）および関連ジスルフィド（セレニド） |
| US6011175A (en) | 1993-05-18 | 2000-01-04 | University Of Pittsburgh | Inhibition of farnesyltransferase |
| US5532167A (en) | 1994-01-07 | 1996-07-02 | Beth Israel Hospital | Substrate specificity of protein kinases |
| US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| FR2733995B1 (fr) * | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
| FI974437L (fi) | 1995-06-06 | 1997-12-05 | Pfizer | Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina |
| DK0832065T3 (da) | 1995-06-06 | 2001-11-19 | Pfizer | Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer |
| US5648378A (en) | 1995-06-07 | 1997-07-15 | Research Corporation Technologies, Inc. | 2-iminochromene derivatives as inhibitors of protein tyrosine kinase |
| WO1997011692A2 (en) | 1995-09-11 | 1997-04-03 | Osteoarthritis Sciences, Inc. | Protein tyrosine kinase inhibitors for treating osteoarthritis |
| JP2001506230A (ja) * | 1996-08-09 | 2001-05-15 | スミスクライン・ビーチャム・コーポレイション | 新規ピペラジン含有化合物 |
| US5952322A (en) * | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| AU6229698A (en) * | 1997-02-21 | 1998-09-09 | Takeda Chemical Industries Ltd. | Fused ring compounds, process for producing the same and use thereof |
| US6420338B1 (en) | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6573289B1 (en) * | 1998-04-23 | 2003-06-03 | Takeda Chemical Industries, Ltd. | Naphthalene derivatives, their production and use |
| AU9297998A (en) * | 1998-05-15 | 1999-12-06 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
| CA2345295C (en) * | 1998-09-25 | 2009-12-15 | Cephalon, Inc. | Use of fused pyrrolocarbazoles in preventing/treating damage to sensory hair cells and cochlear neurons |
| US7070936B1 (en) * | 1999-01-13 | 2006-07-04 | The Research Foundation Of State University Of New York | Method for designing protein kinase inhibitors |
| BR0007532A (pt) | 1999-01-13 | 2001-11-20 | Univ New York State Res Found | Métodos para identificar inibidores de proteìnaquinase, para testar compostos para umacapacidade de inibir a atividade de proteìnaquinase e para inibir uma proteìna quinase, inibidorde proteìna tirosina quinase não peptìdica, e,método de tratar uma condição responsiva a uminibidor de proteìna quinase em um paciente |
| EP1212296B9 (en) * | 1999-08-27 | 2006-05-10 | Sugen, Inc. | Phosphate mimics and methods of treatment using phosphatase inhibitors |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| AU2868601A (en) * | 2000-01-27 | 2001-08-07 | Ribotargets Ltd | Biaryl compounds, their preparation and their use in therapy |
| ATE369359T1 (de) * | 2000-02-15 | 2007-08-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
| KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| DK1686130T3 (da) * | 2000-06-26 | 2009-04-06 | Pfizer Prod Inc | Pyrrolo-[2,3-d]-pyrimidinforbindelser som immunsuppressive midler |
| ATE321052T1 (de) * | 2000-07-07 | 2006-04-15 | Novo Nordisk As | Modulatoren von protein tyrosin phosphatasen (ptpasen) |
| EP1373204B1 (en) * | 2001-03-09 | 2016-10-26 | Janssen Pharmaceuticals, Inc. | Heterocyclic compounds |
| KR100429841B1 (ko) | 2001-07-19 | 2004-05-04 | 삼성전자주식회사 | Ｇｒｉｎ 렌즈를 구비하는 광 기록헤드 |
| US7005445B2 (en) * | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| CA2464214C (en) | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| JP3975272B2 (ja) | 2002-02-21 | 2007-09-12 | 独立行政法人産業技術総合研究所 | 超微細流体ジェット装置 |
| CA2484209C (en) | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| JP4539538B2 (ja) * | 2005-11-17 | 2010-09-08 | トヨタ自動車株式会社 | エネルギ回収装置 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
-
2002
- 2002-10-19 CA CA2464214A patent/CA2464214C/en not_active Expired - Fee Related
- 2002-10-19 EP EP02773833A patent/EP1444204A4/en not_active Withdrawn
- 2002-10-19 JP JP2003538137A patent/JP4623962B2/ja not_active Expired - Lifetime
- 2002-10-19 MX MXPA04003758A patent/MXPA04003758A/es active IP Right Grant
- 2002-10-19 WO PCT/US2002/033660 patent/WO2003035621A1/en not_active Ceased
- 2002-10-19 US US10/277,220 patent/US7129225B2/en not_active Expired - Lifetime
-
2006
- 2006-03-31 US US11/395,937 patent/US7427608B2/en not_active Expired - Lifetime
-
2009
- 2009-07-07 JP JP2009160619A patent/JP2009263394A/ja active Pending