JP2009263394A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009263394A5 JP2009263394A5 JP2009160619A JP2009160619A JP2009263394A5 JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5 JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- phenyl
- heterocycle
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33619101P | 2001-10-22 | 2001-10-22 | |
| US41072602P | 2002-09-13 | 2002-09-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Division JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009263394A JP2009263394A (ja) | 2009-11-12 |
| JP2009263394A5 true JP2009263394A5 (enExample) | 2011-07-21 |
Family
ID=26990085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Expired - Lifetime JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
| JP2009160619A Pending JP2009263394A (ja) | 2001-10-22 | 2009-07-07 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538137A Expired - Lifetime JP4623962B2 (ja) | 2001-10-22 | 2002-10-19 | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7129225B2 (enExample) |
| EP (1) | EP1444204A4 (enExample) |
| JP (2) | JP4623962B2 (enExample) |
| CA (1) | CA2464214C (enExample) |
| MX (1) | MXPA04003758A (enExample) |
| WO (1) | WO2003035621A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60045474D1 (de) * | 1999-01-13 | 2011-02-17 | Univ New York State Res Found | Neues verfahren zum erschaffen von proteinkinase-inhibitoren |
| US7005445B2 (en) * | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| CA2464214C (en) * | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| GB2403474B (en) * | 2002-04-18 | 2006-10-11 | Inst Med Molecular Design Inc | Amide derivatives |
| ATE482938T1 (de) | 2002-08-09 | 2010-10-15 | Merck Sharp & Dohme | Tyrosinkinaseinhibitoren |
| AU2003257170B2 (en) * | 2002-08-09 | 2008-12-11 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US20060148829A1 (en) * | 2002-12-17 | 2006-07-06 | Laurent Meijer | Means for inducing differentiation of supernumerary hair cells and deiters' cells in the developing organ of corti |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| EP1643991B1 (en) * | 2003-07-11 | 2014-03-12 | Merck Patent GmbH | Benzimidazole carboxamides as raf kinase inhibitors |
| US20050089936A1 (en) * | 2003-10-23 | 2005-04-28 | Jianping Cai | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides |
| EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| WO2005114197A2 (en) * | 2004-04-15 | 2005-12-01 | Albert Einstein College Of Medicine Of Yeshiva University | Activity-based probes for protein tyrosine phosphatases |
| WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006053274A2 (en) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006055435A1 (en) * | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
| GB0425919D0 (en) * | 2004-11-25 | 2004-12-29 | Prosidion Ltd | Indole-2-carboxylic acid amides |
| KR20070100277A (ko) * | 2004-12-06 | 2007-10-10 | 아벤티스 파마 소시에떼아노님 | 치환된 인돌, 그를 함유하는 조성물, 그의 제조 방법 및그의 용도 |
| FR2878849B1 (fr) | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| CA2587664A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
| EP2308839B1 (en) * | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| FR2884821B1 (fr) * | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation |
| MY148644A (en) | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
| JP2009521427A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | 胃食道逆流症及び過敏性腸症候群の治療のためのピラゾール |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| DE602007008742D1 (de) | 2006-09-15 | 2010-10-07 | Pfizer | Substituierte pyridylmethylbicyclocarboxyamidverbindungen |
| EP2222631B1 (en) | 2006-10-23 | 2011-08-17 | Pfizer Inc. | Substituted phenylmethyl bicyclocarboxyamide compounds |
| CA2669915C (en) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| JP2010512800A (ja) * | 2006-12-18 | 2010-04-30 | アンブルックス，インコーポレイテッド | 非天然のアミノ酸およびポリペプチドを含んでいる組成物、これらが関連する方法、ならびにこれらの利用 |
| EP2146740A4 (en) | 2007-04-13 | 2010-05-26 | Agency Science Tech & Res | METHOD FOR CONTROLLING TUMORIGENESIS AND DIAGNOSIS OF THE RISK |
| CN101808995A (zh) | 2007-07-27 | 2010-08-18 | 百时美施贵宝公司 | 新颖的葡糖激酶激活剂及其使用方法 |
| HRP20120837T1 (hr) | 2007-08-31 | 2012-11-30 | Astellas Pharma Inc. | Derivati piperidina |
| EP2242491B1 (en) | 2008-02-19 | 2012-07-11 | DSM IP Assets B.V. | Novel use of 3,3'-diindolylmethane |
| EP2306975A4 (en) | 2008-07-21 | 2012-10-31 | Otonomy Inc | COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE |
| GEP20135793B (en) | 2008-09-11 | 2013-03-25 | Pfizer | Heteroaryls amide derivatives and their use as glucokinase activators |
| DK2406253T3 (da) | 2009-03-11 | 2013-08-12 | Pfizer | Benzofuranylderivater anvendt som glucokinase-inhibitorer |
| JP6223452B2 (ja) | 2012-09-07 | 2017-11-01 | ノバルティス アーゲー | インドールカルボキサミド誘導体およびその使用 |
| CN103044311B (zh) * | 2012-12-26 | 2015-04-22 | 山东大学 | 一种多取代吲哚类化合物及其制备方法和应用 |
| CA2944198C (en) | 2013-04-26 | 2021-11-16 | Indiana University Research & Technology Corporation | Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2) |
| RS60878B1 (sr) * | 2014-04-04 | 2020-11-30 | Iomet Pharma Ltd | Derivati indola za upotrebu u medicini |
| CN104876851A (zh) * | 2015-05-15 | 2015-09-02 | 南京大学 | 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用 |
| PL3884939T3 (pl) | 2016-03-09 | 2024-02-26 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| EP4234552A3 (en) * | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| EP3746437B1 (en) | 2018-01-31 | 2024-08-21 | HepaRegeniX GmbH | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| EP3810139A1 (en) | 2018-06-21 | 2021-04-28 | HepaRegeniX GmbH | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2019303986B2 (en) | 2018-07-16 | 2024-02-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| JP7639008B2 (ja) | 2020-01-15 | 2025-03-04 | ヘパリジェニックス ゲーエムベーハー | 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤 |
| US20230183810A1 (en) * | 2020-05-04 | 2023-06-15 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
| US20240350492A1 (en) | 2020-07-10 | 2024-10-24 | Ting Therapeutics Llc | Methods for the Prevention and Treatment of Hearing Loss |
| WO2024109642A1 (zh) * | 2023-07-28 | 2024-05-30 | 常州大学 | 一种苯并氮杂环类化合物作为β2-肾上腺素受体别构调节剂的应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01132579A (ja) | 1987-11-19 | 1989-05-25 | Ss Pharmaceut Co Ltd | インドール誘導体 |
| GB8827189D0 (en) | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
| JPH07110852B2 (ja) * | 1989-12-28 | 1995-11-29 | ジ・アップジョン・カンパニー | 二芳香族置換抗ａｉｄｓ化合物 |
| US5552534A (en) | 1991-08-22 | 1996-09-03 | The Trustees Of The University Of Pennsylvania | Non-Peptide peptidomimetics |
| DE4307883A1 (en) * | 1992-03-12 | 1993-09-23 | Westarp Martin Egon Dr Med | Use of anti-retroviral substances - to treat motor-neuronal diseases |
| US5705585A (en) | 1993-06-30 | 1998-01-06 | Arqule, Inc. | Aminimide-containing molecules and materials as molecular recognition agents |
| SK283413B6 (sk) | 1992-08-06 | 2003-07-01 | Warner-Lambert Company | 2-Tioindoly, 2-indolíntióny a polysulfidy, ich selénové analógy a farmaceutické prostriedky na ich báze |
| US6011175A (en) | 1993-05-18 | 2000-01-04 | University Of Pittsburgh | Inhibition of farnesyltransferase |
| US5532167A (en) | 1994-01-07 | 1996-07-02 | Beth Israel Hospital | Substrate specificity of protein kinases |
| US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| FR2733995B1 (fr) | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
| CA2342471C (en) * | 1995-06-06 | 2002-10-29 | Judith L. Treadway | Heterocyclecarbonylmethyl amine intermediates |
| EP0832066B1 (en) | 1995-06-06 | 2001-09-12 | Pfizer Inc. | Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors |
| US5648378A (en) | 1995-06-07 | 1997-07-15 | Research Corporation Technologies, Inc. | 2-iminochromene derivatives as inhibitors of protein tyrosine kinase |
| DE69634900T2 (de) | 1995-09-11 | 2006-05-18 | Osteoarthritis Sciences, Inc., Cambridge | Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis |
| JP2001506230A (ja) * | 1996-08-09 | 2001-05-15 | スミスクライン・ビーチャム・コーポレイション | 新規ピペラジン含有化合物 |
| US5952322A (en) | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
| JP2001505585A (ja) * | 1996-12-16 | 2001-04-24 | 藤沢薬品工業株式会社 | 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途 |
| WO1998037070A1 (en) * | 1997-02-21 | 1998-08-27 | Takeda Chemical Industries, Ltd. | Fused ring compounds, process for producing the same and use thereof |
| US6420338B1 (en) | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| CA2328973A1 (en) * | 1998-04-23 | 1999-10-28 | Akio Ojida | Naphthalene derivatives, their production and use |
| AU9297998A (en) * | 1998-05-15 | 1999-12-06 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
| CA2345295C (en) * | 1998-09-25 | 2009-12-15 | Cephalon, Inc. | Use of fused pyrrolocarbazoles in preventing/treating damage to sensory hair cells and cochlear neurons |
| DE60045474D1 (de) | 1999-01-13 | 2011-02-17 | Univ New York State Res Found | Neues verfahren zum erschaffen von proteinkinase-inhibitoren |
| US7070936B1 (en) | 1999-01-13 | 2006-07-04 | The Research Foundation Of State University Of New York | Method for designing protein kinase inhibitors |
| ATE309207T1 (de) * | 1999-08-27 | 2005-11-15 | Sugen Inc | Phosphat-mimetika sowie behandlungsmethoden unter verwendung von phosphatase-inhibitoren |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| AU2868601A (en) * | 2000-01-27 | 2001-08-07 | Ribotargets Ltd | Biaryl compounds, their preparation and their use in therapy |
| DE122008000002I1 (de) * | 2000-02-15 | 2008-04-17 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
| KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| PL359563A1 (pl) * | 2000-06-26 | 2004-08-23 | Pfizer Products Inc. | Związki pirolo [2,3-d] pirymidynowe jako środki immunosupresyjne |
| JP2004502775A (ja) * | 2000-07-07 | 2004-01-29 | ノボ ノルディスク アクティーゼルスカブ | 非ヌクレオシド逆転写阻害剤抗レトロウイルス療法をモニターするための手段および方法 |
| US6803362B2 (en) * | 2001-03-09 | 2004-10-12 | Ortho-Mcneil Pharmaceutical Inc. | Heterocyclic compounds |
| KR100429841B1 (ko) | 2001-07-19 | 2004-05-04 | 삼성전자주식회사 | Ｇｒｉｎ 렌즈를 구비하는 광 기록헤드 |
| US7005445B2 (en) * | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| CA2464214C (en) | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| JP3975272B2 (ja) | 2002-02-21 | 2007-09-12 | 独立行政法人産業技術総合研究所 | 超微細流体ジェット装置 |
| JP4901102B2 (ja) | 2002-05-03 | 2012-03-21 | エクセリクシス， インク． | プロテインキナーゼモジュレーターおよびその使用方法 |
| JP4539538B2 (ja) * | 2005-11-17 | 2010-09-08 | トヨタ自動車株式会社 | エネルギ回収装置 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
-
2002
- 2002-10-19 CA CA2464214A patent/CA2464214C/en not_active Expired - Fee Related
- 2002-10-19 MX MXPA04003758A patent/MXPA04003758A/es active IP Right Grant
- 2002-10-19 US US10/277,220 patent/US7129225B2/en not_active Expired - Lifetime
- 2002-10-19 JP JP2003538137A patent/JP4623962B2/ja not_active Expired - Lifetime
- 2002-10-19 EP EP02773833A patent/EP1444204A4/en not_active Withdrawn
- 2002-10-19 WO PCT/US2002/033660 patent/WO2003035621A1/en not_active Ceased
-
2006
- 2006-03-31 US US11/395,937 patent/US7427608B2/en not_active Expired - Lifetime
-
2009
- 2009-07-07 JP JP2009160619A patent/JP2009263394A/ja active Pending