JP2009263394A5 - - Google Patents

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Publication number
JP2009263394A5
JP2009263394A5 JP2009160619A JP2009160619A JP2009263394A5 JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5 JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009160619 A JP2009160619 A JP 2009160619A JP 2009263394 A5 JP2009263394 A5 JP 2009263394A5
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JP
Japan
Prior art keywords
compound according
compound
phenyl
heterocycle
aryl
Prior art date
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Pending
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JP2009160619A
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JP2009263394A (ja
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Publication of JP2009263394A publication Critical patent/JP2009263394A/ja
Publication of JP2009263394A5 publication Critical patent/JP2009263394A5/ja
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Claims (12)

  1. 下記式を有する化合物：
    Figure 2009263394
    （式中、
    Ｘはハロゲンであり；
    Ｒ１、Ｒ２、Ｒ３およびＲ４は、同じかまたは異なってもよく、Ｈ、ハロゲン、アリール、ヘテロアリール、ビアリール、ヘテロビアリール、ヘテロ環式化合物、および分岐、環式、もしくは非分岐型のアルキルからなる群より選択され；
    Ｒ５およびＲ６は共に、非置換のヘテロ環またはフェニル基を置換基に有するヘテロ環を形成し、該Ｒ ５ およびＲ ６ により形成されたヘテロ環は、下記
    Figure 2009263394
    から選ばれ、Ｒがフェニルである；
    Ｒ１からＲ４は置換されているかまたは置換されていない）。
  2. Ｘがフッ素である、請求項１に記載の化合物。
  3. Ｒ４がＨである、請求項１または２に記載の化合物。
  4. Ｒ４がアリールである、請求項１または２に記載の化合物。
  5. Ｒ４がフェニルである、請求項４に記載の化合物。
  6. Ｒ１、Ｒ２、Ｒ３およびＲ４がそれぞれＨである、請求項１または２に記載の化合物。
  7. Ｒ２、Ｒ３およびＲ４がそれぞれＨである、請求項１または２に記載の化合物。
  8. Ｒ１がＨである、請求項１または２に記載の化合物。
  9. 下記から選ばれる化合物：
    Figure 2009263394
    。
  10. 請求項１〜９のいずれかに記載の化合物を含有する、癌、乾癬、関節硬化症、糖尿病、肥満または免疫系活性調節のための治療剤。
  11. 請求項１〜９のいずれかに記載の化合物を含有する、聴覚損失の防御または治療剤。
  12. 請求項１〜９のいずれかに記載の化合物および薬学的に許容される賦形剤を含む、薬学的組成物。
JP2009160619A 2001-10-22 2009-07-07 タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 Pending JP2009263394A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33619101P 2001-10-22 2001-10-22
US41072602P 2002-09-13 2002-09-13

Related Parent Applications (1)

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JP2003538137A Division JP4623962B2 (ja) 2001-10-22 2002-10-19 タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法

Publications (2)

Publication Number Publication Date
JP2009263394A JP2009263394A (ja) 2009-11-12
JP2009263394A5 true JP2009263394A5 (ja) 2011-07-21

Family

ID=26990085

Family Applications (2)

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JP2003538137A Expired - Lifetime JP4623962B2 (ja) 2001-10-22 2002-10-19 タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法
JP2009160619A Pending JP2009263394A (ja) 2001-10-22 2009-07-07 タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法

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JP2003538137A Expired - Lifetime JP4623962B2 (ja) 2001-10-22 2002-10-19 タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法

Country Status (6)

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US (2) US7129225B2 (ja)
EP (1) EP1444204A4 (ja)
JP (2) JP4623962B2 (ja)
CA (1) CA2464214C (ja)
MX (1) MXPA04003758A (ja)
WO (1) WO2003035621A1 (ja)

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