JP2016503403A5 - - Google Patents
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- Publication number
- JP2016503403A5 JP2016503403A5 JP2015540765A JP2015540765A JP2016503403A5 JP 2016503403 A5 JP2016503403 A5 JP 2016503403A5 JP 2015540765 A JP2015540765 A JP 2015540765A JP 2015540765 A JP2015540765 A JP 2015540765A JP 2016503403 A5 JP2016503403 A5 JP 2016503403A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acceptable salt
- pharmaceutically acceptable
- compound
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 8
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 0 O=C(*c1ccc(*c2ccccc2)cc1)C1=CN=C*1 Chemical compound O=C(*c1ccc(*c2ccccc2)cc1)C1=CN=C*1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722152P | 2012-11-03 | 2012-11-03 | |
| US61/722,152 | 2012-11-03 | ||
| PCT/US2013/067674 WO2014070979A1 (en) | 2012-11-03 | 2013-10-31 | Inhibitors of cytomegalovirus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503403A JP2016503403A (ja) | 2016-02-04 |
| JP2016503403A5 true JP2016503403A5 (enExample) | 2016-12-15 |
| JP6372666B2 JP6372666B2 (ja) | 2018-08-15 |
Family
ID=49620281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540765A Active JP6372666B2 (ja) | 2012-11-03 | 2013-10-31 | サイトメガロウイルスの阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9334249B2 (enExample) |
| EP (1) | EP2914592B1 (enExample) |
| JP (1) | JP6372666B2 (enExample) |
| WO (1) | WO2014070979A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL311677B2 (en) | 2014-01-13 | 2025-06-01 | Aurigene Oncology Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
| CN120267671A (zh) | 2017-03-31 | 2025-07-08 | 奥锐金肿瘤有限公司 | 用于治疗血液病的化合物和组合物 |
| EP4410377A3 (en) | 2017-10-31 | 2024-11-13 | Curis, Inc. | Compounds and compositions for treating hematological disorders |
| US11072610B2 (en) | 2018-09-12 | 2021-07-27 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| CN114667285B (zh) | 2019-09-26 | 2025-08-08 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| CN111763201A (zh) * | 2020-03-03 | 2020-10-13 | 中国药科大学 | 苯并噻唑类化合物及医药用途 |
| CN113831301B (zh) * | 2020-06-08 | 2023-06-06 | 沈阳药科大学 | 苯并噻唑类衍生物及其用途 |
| EP4188365A4 (en) * | 2020-07-31 | 2024-11-06 | Emory University | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) MODULATORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| CA3214747A1 (en) | 2021-04-08 | 2022-10-13 | Reinhard Von Roemeling | Combination therapies for the treatment of cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| CN1367785A (zh) * | 1998-12-09 | 2002-09-04 | 美国家庭用品有限公司 | 含取代的苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂 |
| ID30158A (id) * | 1998-12-09 | 2001-11-08 | American Home Prod | Thiourea yang mengandung heterosiklik karboksamida, pencegah-pencegah virus-virus herpes yang mengandung gugus fenilenadiamina |
| EP1137632B1 (en) | 1998-12-09 | 2004-07-28 | Wyeth | Thiourea inhibitors of herpes viruses |
| BR0209054A (pt) * | 2001-04-19 | 2004-04-20 | Bayer Ag | Arilsulfonamidas como agentes antivirais |
| JP2005536533A (ja) | 2002-08-08 | 2005-12-02 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換ベンゾイミダゾール化合物 |
| EP1957461B1 (en) | 2005-11-14 | 2016-11-02 | Genentech, Inc. | Bisamide inhibitors of hedgehog signaling |
| JP5296688B2 (ja) * | 2006-09-11 | 2013-09-25 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 殺虫化合物 |
| WO2009011850A2 (en) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| US20110294853A1 (en) | 2008-09-12 | 2011-12-01 | Benjamin Pelcman | Bis Aromatic Compounds for Use in the Treatment of Inflammation |
| EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| TW201103904A (en) | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
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2013
- 2013-10-31 EP EP13792795.0A patent/EP2914592B1/en active Active
- 2013-10-31 US US14/440,087 patent/US9334249B2/en active Active
- 2013-10-31 JP JP2015540765A patent/JP6372666B2/ja active Active
- 2013-10-31 WO PCT/US2013/067674 patent/WO2014070979A1/en not_active Ceased