JP2015536947A5 - - Google Patents
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- Publication number
- JP2015536947A5 JP2015536947A5 JP2015540764A JP2015540764A JP2015536947A5 JP 2015536947 A5 JP2015536947 A5 JP 2015536947A5 JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015536947 A5 JP2015536947 A5 JP 2015536947A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acceptable salt
- pharmaceutically acceptable
- compound according
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 14
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 11
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 7
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003852 triazoles Chemical class 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722151P | 2012-11-03 | 2012-11-03 | |
| US61/722,151 | 2012-11-03 | ||
| PCT/US2013/067673 WO2014070978A1 (en) | 2012-11-03 | 2013-10-31 | Inhibitors of cytomegalovirus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536947A JP2015536947A (ja) | 2015-12-24 |
| JP2015536947A5 true JP2015536947A5 (enExample) | 2016-12-15 |
| JP6482466B2 JP6482466B2 (ja) | 2019-03-13 |
Family
ID=49620280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540764A Active JP6482466B2 (ja) | 2012-11-03 | 2013-10-31 | サイトメガロウイルスの阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9284310B2 (enExample) |
| EP (1) | EP2914591B1 (enExample) |
| JP (1) | JP6482466B2 (enExample) |
| WO (1) | WO2014070978A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| PL3442974T3 (pl) | 2016-04-15 | 2023-12-04 | Elanco Animal Health Gmbh | Pochodne pirazolopirymidyny |
| EP3720853A1 (de) * | 2017-12-04 | 2020-10-14 | Bayer CropScience Aktiengesellschaft | 3-amino-[1,2,4]-triazolderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums |
| CN108003062B (zh) * | 2017-12-25 | 2020-08-11 | 常州吉恩药业有限公司 | 一种单boc保护双氨基化合物的合成方法 |
| CN112996789B (zh) | 2018-09-12 | 2025-11-11 | 诺华股份有限公司 | 抗病毒吡啶并吡嗪二酮化合物 |
| AR118243A1 (es) | 2019-03-07 | 2021-09-22 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| AR119140A1 (es) | 2019-06-13 | 2021-11-24 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| CA3145062C (en) * | 2019-06-25 | 2024-07-02 | Microbiotix, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OR PREVENTION OF EYE INFECTIONS WITH FILOCICLOVIR |
| WO2021033141A1 (en) | 2019-08-20 | 2021-02-25 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| EP4034537A1 (en) | 2019-09-26 | 2022-08-03 | Novartis AG | Antiviral pyrazolopyridinone compounds |
| AR121344A1 (es) | 2020-02-18 | 2022-05-11 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes para el control de plagas |
| TW202334117A (zh) | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
| TW202304919A (zh) | 2021-03-31 | 2023-02-01 | 印度商皮埃企業有限公司 | 稠合雜環化合物及其作為害蟲控制劑之用途 |
| PE20251179A1 (es) | 2022-04-22 | 2025-04-23 | Vertex Pharma | Compuestos de heteroarilo para el tratamiento del dolor |
| WO2025177310A1 (en) | 2024-02-23 | 2025-08-28 | Pi Industries Ltd. | Fused heterocyclic compounds and its uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332725A (zh) | 1998-12-09 | 2002-01-23 | 美国家庭用品有限公司 | 疱疹病毒的硫脲抑制剂 |
| TR200101664T2 (tr) * | 1998-12-09 | 2002-03-21 | American Home Products Corporation | Fenilendiamin grubu ieren herpesviruslarìn heteroksiklik karboksamid ieren tiore inhibitrleri |
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| EA200100639A1 (ru) * | 1998-12-09 | 2002-06-27 | Американ Хоум Продактс Корпорейшн | Производные тиомочевины, содержащие гетероциклический карбоксамид и защитную группу фенилэтиленамина, в качестве ингибиторов вирусов герпеса |
| EP1383749B1 (de) * | 2001-04-19 | 2005-11-02 | Bayer HealthCare AG | Arylsulfonamide als antivirale mittel |
| JP2006512314A (ja) | 2002-11-01 | 2006-04-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｊａｋインヒビターおよび他のプロテインキナーゼインヒビターとしての組成物の使用 |
| SE0203654D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
| US20040248850A1 (en) | 2003-02-11 | 2004-12-09 | Kemia, Inc. | Compounds for the treatment of HIV infection |
| US20090196912A1 (en) | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| JP2009500347A (ja) | 2005-06-30 | 2009-01-08 | アムジエン・インコーポレーテツド | ビスアリールキナーゼ阻害剤及びこれらの炎症、血管新生及び癌の治療における使用 |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| US20110294853A1 (en) | 2008-09-12 | 2011-12-01 | Benjamin Pelcman | Bis Aromatic Compounds for Use in the Treatment of Inflammation |
| EP2177521A1 (en) * | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| EP2379075A4 (en) | 2008-12-16 | 2012-05-30 | Merck Sharp & Dohme | TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE |
| US20130109682A1 (en) | 2010-07-06 | 2013-05-02 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
-
2013
- 2013-10-31 US US14/440,086 patent/US9284310B2/en active Active
- 2013-10-31 WO PCT/US2013/067673 patent/WO2014070978A1/en not_active Ceased
- 2013-10-31 EP EP13792794.3A patent/EP2914591B1/en active Active
- 2013-10-31 JP JP2015540764A patent/JP6482466B2/ja active Active
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