JP2015536947A5 - - Google Patents
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- Publication number
- JP2015536947A5 JP2015536947A5 JP2015540764A JP2015540764A JP2015536947A5 JP 2015536947 A5 JP2015536947 A5 JP 2015536947A5 JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015536947 A5 JP2015536947 A5 JP 2015536947A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acceptable salt
- pharmaceutically acceptable
- compound according
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 14
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 11
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 7
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003852 triazoles Chemical class 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722151P | 2012-11-03 | 2012-11-03 | |
| US61/722,151 | 2012-11-03 | ||
| PCT/US2013/067673 WO2014070978A1 (en) | 2012-11-03 | 2013-10-31 | Inhibitors of cytomegalovirus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536947A JP2015536947A (ja) | 2015-12-24 |
| JP2015536947A5 true JP2015536947A5 (enExample) | 2016-12-15 |
| JP6482466B2 JP6482466B2 (ja) | 2019-03-13 |
Family
ID=49620280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540764A Active JP6482466B2 (ja) | 2012-11-03 | 2013-10-31 | サイトメガロウイルスの阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9284310B2 (enExample) |
| EP (1) | EP2914591B1 (enExample) |
| JP (1) | JP6482466B2 (enExample) |
| WO (1) | WO2014070978A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| ES2953467T3 (es) | 2016-04-15 | 2023-11-13 | Elanco Animal Health Gmbh | Derivados de pirazolopirimidina |
| JP2021505652A (ja) * | 2017-12-04 | 2021-02-18 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ３−アミノ−［１，２，４］−トリアゾール誘導体および望ましくない植物成長を制御するためのその使用 |
| CN108003062B (zh) * | 2017-12-25 | 2020-08-11 | 常州吉恩药业有限公司 | 一种单boc保护双氨基化合物的合成方法 |
| WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| AR118243A1 (es) | 2019-03-07 | 2021-09-22 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| AR119140A1 (es) | 2019-06-13 | 2021-11-24 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| JP7573289B2 (ja) * | 2019-06-25 | 2024-10-25 | マイクロバイオティックス， インク． | フィロシクロビルによる眼感染症を治療または予防するための組成物および方法 |
| WO2021033141A1 (en) | 2019-08-20 | 2021-02-25 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| TW202535873A (zh) | 2019-09-26 | 2025-09-16 | 瑞士商諾華公司 | 抗病毒吡唑并吡啶酮化合物 |
| AR121344A1 (es) | 2020-02-18 | 2022-05-11 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes para el control de plagas |
| TW202334117A (zh) | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
| WO2022208370A1 (en) | 2021-03-31 | 2022-10-06 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| WO2025177310A1 (en) | 2024-02-23 | 2025-08-28 | Pi Industries Ltd. | Fused heterocyclic compounds and its uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| KR20010086091A (ko) * | 1998-12-09 | 2001-09-07 | 이곤 이 버그 | 치환된 페닐렌디아민 그룹을 함유하는 허프스 바이러스의헤테로사이클릭 카복사미드-함유 티오우레아 억제제 |
| JP2002531554A (ja) * | 1998-12-09 | 2002-09-24 | ワイス | フェニレンジアミン群を含む、複素環式カルボキサミド含有の、ヘルペスウイルスのチオ尿素インヒビター |
| AU1934500A (en) * | 1998-12-09 | 2000-06-26 | Wyeth | Thiourea inhibitors of herpes viruses |
| HUP0303813A3 (en) | 2001-04-19 | 2005-05-30 | Bayer Ag | Arylsulfonamides as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing them |
| CA2506772A1 (en) | 2002-11-01 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| SE0203654D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
| EP1594512A4 (en) | 2003-02-11 | 2007-07-11 | Kemia Inc | COMPOUNDS FOR THE TREATMENT OF VIRUS INFECTIONS |
| US20090196912A1 (en) | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| EP1896461A2 (en) | 2005-06-30 | 2008-03-12 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
| US20090069288A1 (en) * | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| WO2010029300A1 (en) | 2008-09-12 | 2010-03-18 | Biolipox Ab | Bis aromatic compounds for use in the treatment of inflammation |
| EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| EP2379075A4 (en) | 2008-12-16 | 2012-05-30 | Merck Sharp & Dohme | TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE |
| US20130109682A1 (en) | 2010-07-06 | 2013-05-02 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
-
2013
- 2013-10-31 US US14/440,086 patent/US9284310B2/en active Active
- 2013-10-31 EP EP13792794.3A patent/EP2914591B1/en active Active
- 2013-10-31 WO PCT/US2013/067673 patent/WO2014070978A1/en not_active Ceased
- 2013-10-31 JP JP2015540764A patent/JP6482466B2/ja active Active