JP6482466B2 - サイトメガロウイルスの阻害剤 - Google Patents
サイトメガロウイルスの阻害剤 Download PDFInfo
- Publication number
- JP6482466B2 JP6482466B2 JP2015540764A JP2015540764A JP6482466B2 JP 6482466 B2 JP6482466 B2 JP 6482466B2 JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015540764 A JP2015540764 A JP 2015540764A JP 6482466 B2 JP6482466 B2 JP 6482466B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- ring
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 O*C1=CN=C*1 Chemical compound O*C1=CN=C*1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722151P | 2012-11-03 | 2012-11-03 | |
| US61/722,151 | 2012-11-03 | ||
| PCT/US2013/067673 WO2014070978A1 (en) | 2012-11-03 | 2013-10-31 | Inhibitors of cytomegalovirus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536947A JP2015536947A (ja) | 2015-12-24 |
| JP2015536947A5 JP2015536947A5 (enExample) | 2016-12-15 |
| JP6482466B2 true JP6482466B2 (ja) | 2019-03-13 |
Family
ID=49620280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540764A Active JP6482466B2 (ja) | 2012-11-03 | 2013-10-31 | サイトメガロウイルスの阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9284310B2 (enExample) |
| EP (1) | EP2914591B1 (enExample) |
| JP (1) | JP6482466B2 (enExample) |
| WO (1) | WO2014070978A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| ES2953467T3 (es) | 2016-04-15 | 2023-11-13 | Elanco Animal Health Gmbh | Derivados de pirazolopirimidina |
| CN111448194A (zh) * | 2017-12-04 | 2020-07-24 | 拜耳作物科学股份公司 | 3-氨基-[1，2，4]-三唑衍生物及其用于防治不希望的植物生长的用途 |
| CN108003062B (zh) * | 2017-12-25 | 2020-08-11 | 常州吉恩药业有限公司 | 一种单boc保护双氨基化合物的合成方法 |
| US11072610B2 (en) | 2018-09-12 | 2021-07-27 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| AR118243A1 (es) | 2019-03-07 | 2021-09-22 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| AR119140A1 (es) | 2019-06-13 | 2021-11-24 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| MX2022000232A (es) * | 2019-06-25 | 2022-04-25 | Microbiotix Inc | Composiciones y metodos para tratar o evitar infecciones oculares con filociclovir. |
| WO2021033141A1 (en) | 2019-08-20 | 2021-02-25 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| CN114667285B (zh) | 2019-09-26 | 2025-08-08 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| AR121344A1 (es) | 2020-02-18 | 2022-05-11 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes para el control de plagas |
| TW202334117A (zh) | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
| TW202304919A (zh) | 2021-03-31 | 2023-02-01 | 印度商皮埃企業有限公司 | 稠合雜環化合物及其作為害蟲控制劑之用途 |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| WO2025177310A1 (en) | 2024-02-23 | 2025-08-28 | Pi Industries Ltd. | Fused heterocyclic compounds and its uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1137632B1 (en) * | 1998-12-09 | 2004-07-28 | Wyeth | Thiourea inhibitors of herpes viruses |
| US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| CN1367785A (zh) | 1998-12-09 | 2002-09-04 | 美国家庭用品有限公司 | 含取代的苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂 |
| ID30158A (id) | 1998-12-09 | 2001-11-08 | American Home Prod | Thiourea yang mengandung heterosiklik karboksamida, pencegah-pencegah virus-virus herpes yang mengandung gugus fenilenadiamina |
| BR0209054A (pt) * | 2001-04-19 | 2004-04-20 | Bayer Ag | Arilsulfonamidas como agentes antivirais |
| EP1562911B1 (en) | 2002-11-01 | 2010-01-06 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| SE0203654D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
| US20040248850A1 (en) | 2003-02-11 | 2004-12-09 | Kemia, Inc. | Compounds for the treatment of HIV infection |
| US20090196912A1 (en) | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| EP1896461A2 (en) | 2005-06-30 | 2008-03-12 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| US20110294853A1 (en) | 2008-09-12 | 2011-12-01 | Benjamin Pelcman | Bis Aromatic Compounds for Use in the Treatment of Inflammation |
| EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| WO2010077582A1 (en) | 2008-12-16 | 2010-07-08 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of alzheimer's disease |
| WO2012004217A1 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
-
2013
- 2013-10-31 US US14/440,086 patent/US9284310B2/en active Active
- 2013-10-31 JP JP2015540764A patent/JP6482466B2/ja active Active
- 2013-10-31 WO PCT/US2013/067673 patent/WO2014070978A1/en not_active Ceased
- 2013-10-31 EP EP13792794.3A patent/EP2914591B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015536947A (ja) | 2015-12-24 |
| US20150315180A1 (en) | 2015-11-05 |
| US9284310B2 (en) | 2016-03-15 |
| EP2914591A1 (en) | 2015-09-09 |
| WO2014070978A1 (en) | 2014-05-08 |
| EP2914591B1 (en) | 2017-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2914591B1 (en) | Inhibitors of cytomegalovirus | |
| AU2021237841B2 (en) | Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors | |
| JP7150903B2 (ja) | Ｂ型肝炎ウイルスコアタンパク質モジュレーター | |
| JP6372666B2 (ja) | サイトメガロウイルスの阻害剤 | |
| US11267825B2 (en) | Highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis B virus (HBV) | |
| JP2023513077A (ja) | 化合物およびその使用 | |
| AU2017226004A1 (en) | Inhibitors of WDR5 protein-protein binding | |
| AU2015373996A1 (en) | Derivatives and methods of treating hepatitis B infections | |
| US20220081444A1 (en) | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| CN111655692B (zh) | 含氮杂环酰胺化合物及其医药用途 | |
| TW202026296A (zh) | 抗病毒性吡啶并吡二酮化合物 | |
| WO2011143772A1 (en) | Inhibitors of hiv replication | |
| US20220363686A1 (en) | Novel 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| EP3512845A1 (en) | Hepatitis b core protein modulators | |
| JP2020525453A (ja) | ジヒドロピリミジン化合物、及び医薬におけるその使用 | |
| WO2012103113A1 (en) | Pyrazine and imidazolidine derivatives and their uses to treat hepatitis c | |
| JP2021529188A (ja) | ジヒドロピリミジン誘導体及びｈｂｖ感染又はｈｂｖ誘導性疾患の治療におけるその使用 | |
| EP3801525A1 (en) | Inhibitors of prolyl-trna-synthetase | |
| US20220227785A1 (en) | Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv) | |
| US20180111954A1 (en) | Process for making phosphoramidate protected nucleoside compounds | |
| US20170275327A1 (en) | Substituted phosphoramidate compounds and uses thereof | |
| RU2830596C1 (ru) | Биарильные производные в качестве ингибиторов белок-белкового взаимодействия yap/taz-tead | |
| WO2025085347A1 (en) | Il4i1 inhibitors and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161026 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20161026 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20171012 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171023 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180122 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180627 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180927 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190110 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190212 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6482466 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |