JP6482466B2 - サイトメガロウイルスの阻害剤 - Google Patents
サイトメガロウイルスの阻害剤 Download PDFInfo
- Publication number
- JP6482466B2 JP6482466B2 JP2015540764A JP2015540764A JP6482466B2 JP 6482466 B2 JP6482466 B2 JP 6482466B2 JP 2015540764 A JP2015540764 A JP 2015540764A JP 2015540764 A JP2015540764 A JP 2015540764A JP 6482466 B2 JP6482466 B2 JP 6482466B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- ring
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 O*C1=CN=C*1 Chemical compound O*C1=CN=C*1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722151P | 2012-11-03 | 2012-11-03 | |
| US61/722,151 | 2012-11-03 | ||
| PCT/US2013/067673 WO2014070978A1 (en) | 2012-11-03 | 2013-10-31 | Inhibitors of cytomegalovirus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536947A JP2015536947A (ja) | 2015-12-24 |
| JP2015536947A5 JP2015536947A5 (enExample) | 2016-12-15 |
| JP6482466B2 true JP6482466B2 (ja) | 2019-03-13 |
Family
ID=49620280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540764A Active JP6482466B2 (ja) | 2012-11-03 | 2013-10-31 | サイトメガロウイルスの阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9284310B2 (enExample) |
| EP (1) | EP2914591B1 (enExample) |
| JP (1) | JP6482466B2 (enExample) |
| WO (1) | WO2014070978A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| KR102467347B1 (ko) | 2016-04-15 | 2022-11-14 | 바이엘 애니멀 헬스 게엠베하 | 피라졸로피리미딘 유도체 |
| CN111448194A (zh) * | 2017-12-04 | 2020-07-24 | 拜耳作物科学股份公司 | 3-氨基-[1，2，4]-三唑衍生物及其用于防治不希望的植物生长的用途 |
| CN108003062B (zh) * | 2017-12-25 | 2020-08-11 | 常州吉恩药业有限公司 | 一种单boc保护双氨基化合物的合成方法 |
| AU2019339777B2 (en) | 2018-09-12 | 2022-09-01 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| AR118243A1 (es) | 2019-03-07 | 2021-09-22 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| AR119140A1 (es) | 2019-06-13 | 2021-11-24 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| JP7573289B2 (ja) * | 2019-06-25 | 2024-10-25 | マイクロバイオティックス， インク． | フィロシクロビルによる眼感染症を治療または予防するための組成物および方法 |
| WO2021033141A1 (en) | 2019-08-20 | 2021-02-25 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| US11667613B2 (en) | 2019-09-26 | 2023-06-06 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
| AR121344A1 (es) | 2020-02-18 | 2022-05-11 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes para el control de plagas |
| TWI904906B (zh) | 2020-08-24 | 2025-11-11 | 美商達薩瑪治療公司 | Sarm1之抑制劑 |
| WO2022208370A1 (en) | 2021-03-31 | 2022-10-06 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| PY2513474A (es) | 2024-02-23 | 2025-10-10 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y usos de los mismos |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2353900A (en) | 1998-12-09 | 2000-06-26 | Wyeth | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
| CN1348446A (zh) | 1998-12-09 | 2002-05-08 | 美国家庭用品有限公司 | 含苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂 |
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| CZ20011957A3 (cs) * | 1998-12-09 | 2001-10-17 | American Home Products Corporation | Thiomočoviny jako inhibitory herpes virů |
| DE50204780D1 (de) | 2001-04-19 | 2005-12-08 | Bayer Healthcare Ag | Arylsulfonamide als antivirale mittel |
| EP2172460A1 (en) | 2002-11-01 | 2010-04-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| SE0203654D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
| WO2004071426A2 (en) | 2003-02-11 | 2004-08-26 | Kemia Inc. | Compounds for the treatment of viral infection |
| US20090196912A1 (en) | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| MX2007015679A (es) | 2005-06-30 | 2008-02-21 | Amgen Inc | Inhibidores de quinasa bis-aril y su uso en el tratamiento de inflamacion, angiogenesis y cancer. |
| US20090069288A1 (en) | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| WO2010029300A1 (en) | 2008-09-12 | 2010-03-18 | Biolipox Ab | Bis aromatic compounds for use in the treatment of inflammation |
| EP2177521A1 (en) | 2008-10-14 | 2010-04-21 | Almirall, S.A. | New 2-Amidothiadiazole Derivatives |
| WO2010077582A1 (en) | 2008-12-16 | 2010-07-08 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of alzheimer's disease |
| JP2013530199A (ja) | 2010-07-06 | 2013-07-25 | ノバルティス アーゲー | キナーゼ阻害剤として有用な環状エーテル化合物 |
-
2013
- 2013-10-31 JP JP2015540764A patent/JP6482466B2/ja active Active
- 2013-10-31 WO PCT/US2013/067673 patent/WO2014070978A1/en not_active Ceased
- 2013-10-31 EP EP13792794.3A patent/EP2914591B1/en active Active
- 2013-10-31 US US14/440,086 patent/US9284310B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014070978A1 (en) | 2014-05-08 |
| US20150315180A1 (en) | 2015-11-05 |
| US9284310B2 (en) | 2016-03-15 |
| JP2015536947A (ja) | 2015-12-24 |
| EP2914591A1 (en) | 2015-09-09 |
| EP2914591B1 (en) | 2017-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
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