HRP20161103T1 - Kemijski spojevi - Google Patents
Kemijski spojevi Download PDFInfo
- Publication number
- HRP20161103T1 HRP20161103T1 HRP20161103TT HRP20161103T HRP20161103T1 HR P20161103 T1 HRP20161103 T1 HR P20161103T1 HR P20161103T T HRP20161103T T HR P20161103TT HR P20161103 T HRP20161103 T HR P20161103T HR P20161103 T1 HRP20161103 T1 HR P20161103T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- compound according
- salt
- intended
- metabolic disorder
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 22
- 150000003839 salts Chemical class 0.000 claims 8
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Claims (20)
1. Spoj Formule I
[image]
,
naznačen time što je R1 H, Cl, Br, N(CH3)2 ili metoksi;
R2 je H ili OH;
svaki R3 je neovisno C1-6alkil;
X je CH2, C(O) ili CH=CH;
Q je C0-6alkil;
R4 je NR5R5; gdje je jedan R5 H, a drugi je CH2CO2H, CH2SO3H, CH2CH2SO3H ili CH(R7)C0-1alkilCO2H;
R7 je C0-6alkilCO2H, C0-6alkilOH, C0-6alkilSO3H ili C0-6alkilPO3H2.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je R1 metoksi.
3. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što R2 je H.
4. Spoj u skladu s patentnim zahtjevima 1-3, naznačen time što je X CH2.
5. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je X C(O).
6. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je Q C0-2alkil.
7. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je Q C0 alkil (tj. odsutan je).
8. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je svaki R3 neovisno C2-4 alkil.
9. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je svaki R3 neovisno etil ili n-butil.
10. Spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je R7 C0-1alkilCO2H ili C0-2alkilSO3H.
11. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je
[image]
.
12. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je
[image]
.
13. Spoj u skladu s patentnim zahtjevom 12, naznačen time što je navedeni spoj kristalni.
14. Farmaceutski prihvatljiva sol, naznačena time što je sol spoja u skladu s bilo kojim od prethodnih patentnih zahtjeva.
15. Farmaceutski pripravak, naznačen time što sadrži spoj ili sol u skladu s patentnim zahtjevima 1-14.
16. Farmaceutski pripravak u skladu s patentnim zahtjevom 15, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju metaboličkog poremećaja kod čovjeka.
17. Spoj ili sol u skladu s bilo kojim od patentnim zahtjevima 1-14, naznačeni time što su namijenjeni upotrebi u liječenju ili sprječavanju metaboličkog poremećaja kod čovjeka.
18. Upotreba spoja ili soli, kao prilikom upotrebe u skladu s patentnim zahtjevom 17, naznačena time što je navedeni metabolički poremećaj dijabetes melitus (tip I i tip II) ili pretilost.
19. Spoj ili sol u skladu s bilo kojim od patentnim zahtjevima 1-14, naznačeni time što su namijenjeni upotrebi u terapiji.
20. Upotreba spoja ili soli u skladu s bilo kojim od patentnim zahtjevima 1-14, naznačena time što su spoj ili sol namijenjeni proizvodnji medikamenta za liječenje ili sprječavanje metaboličkog poremećaja kod čovjeka.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32821210P | 2010-04-27 | 2010-04-27 | |
| US32922510P | 2010-04-29 | 2010-04-29 | |
| PCT/US2011/034024 WO2011137135A1 (en) | 2010-04-27 | 2011-04-27 | Chemical compounds |
| EP11775513.2A EP2563122B1 (en) | 2010-04-27 | 2011-04-27 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161103T1 true HRP20161103T1 (hr) | 2016-11-04 |
Family
ID=44861895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161103TT HRP20161103T1 (hr) | 2010-04-27 | 2016-08-29 | Kemijski spojevi |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US9040518B2 (hr) |
| EP (1) | EP2563122B1 (hr) |
| JP (1) | JP5702853B2 (hr) |
| KR (1) | KR101769079B1 (hr) |
| CN (1) | CN102858159B (hr) |
| AR (1) | AR081337A1 (hr) |
| AU (1) | AU2011245393B2 (hr) |
| BR (1) | BR112012026767B1 (hr) |
| CA (1) | CA2795543C (hr) |
| CL (1) | CL2012003009A1 (hr) |
| CO (1) | CO6612267A2 (hr) |
| CR (1) | CR20120557A (hr) |
| CY (1) | CY1118187T1 (hr) |
| DK (1) | DK2563122T3 (hr) |
| DO (1) | DOP2012000263A (hr) |
| EA (1) | EA021753B1 (hr) |
| ES (1) | ES2588743T3 (hr) |
| HK (1) | HK1175650A1 (hr) |
| HR (1) | HRP20161103T1 (hr) |
| HU (1) | HUE029480T2 (hr) |
| IL (1) | IL222365A (hr) |
| JO (1) | JO3131B1 (hr) |
| LT (1) | LT2563122T (hr) |
| MA (1) | MA34235B1 (hr) |
| ME (1) | ME02490B (hr) |
| MX (1) | MX2012012527A (hr) |
| MY (1) | MY162933A (hr) |
| NZ (1) | NZ602754A (hr) |
| PE (1) | PE20130384A1 (hr) |
| PL (1) | PL2563122T3 (hr) |
| PT (1) | PT2563122T (hr) |
| RS (1) | RS55079B1 (hr) |
| SG (1) | SG184812A1 (hr) |
| SI (1) | SI2563122T1 (hr) |
| SM (1) | SMT201600293B (hr) |
| UA (1) | UA110338C2 (hr) |
| UY (1) | UY33353A (hr) |
| WO (1) | WO2011137135A1 (hr) |
| ZA (1) | ZA201207858B (hr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3400944T3 (pl) | 2010-11-08 | 2020-11-16 | Albireo Ab | Inhibitory ibat w leczeniu chorób wątroby |
| BR112014004544A2 (pt) * | 2011-08-31 | 2017-04-04 | Mallinckrodt Llc | modificação com peg de nanopartículas com h-fosfonatos |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| AU2014261111B2 (en) | 2013-05-02 | 2017-03-16 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
| US10709755B2 (en) | 2014-06-25 | 2020-07-14 | Elobix Ab | Solid formulation and method for preventing or reducing coloration thereof |
| CA2956833C (en) * | 2014-08-05 | 2022-08-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Synthesis of benzothiazepines |
| KR101674806B1 (ko) * | 2014-10-20 | 2016-11-10 | 씨제이헬스케어 주식회사 | 신규한 아미노알킬벤조티아제핀 유도체 및 이의 용도 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| CN107873023B (zh) | 2015-02-02 | 2021-07-23 | 福马治疗股份有限公司 | 作为hdac抑制剂的3-烷基-4-酰氨基-双环[4，5，0]异羟肟酸 |
| TW201636329A (zh) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | 作為ｈｄａｃ抑制劑之雙環［４，６，０］異羥肟酸 |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| EP3475266B1 (en) * | 2016-06-27 | 2023-09-06 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Synthetic methods |
| WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| PE20210136A1 (es) | 2018-06-20 | 2021-01-21 | Albireo Ab | Formulacion farmaceutica de odevixibat |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| WO2020161216A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| SI3921028T1 (sl) | 2019-02-06 | 2023-02-28 | Albireo Ab | Benzotiadiazepinske spojine in njihova uporaba kot modulatorji žolčnih kislin |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CA3129735A1 (en) * | 2019-02-12 | 2020-08-20 | Mirum Pharmaceuticals, Inc. | Methods for increasing growth in pediatric subjects having cholestatic liver disease |
| EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| EP4069359B1 (en) * | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AR120682A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
| TW202134222A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
| WO2021110886A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202134223A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| EP4069360B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN114761080A (zh) * | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| CN116157389A (zh) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2022084212A1 (en) | 2020-10-20 | 2022-04-28 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods for treating cholestatic pruritus |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| WO2022117778A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN116964041A (zh) | 2020-12-23 | 2023-10-27 | 葛兰素史克知识产权第二有限公司 | Linerixibat的形式 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2023203248A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US2370015A (en) | 1933-07-24 | 1945-02-20 | Merck & Co Inc | Derivatives of tertiary amino aliphatic acids |
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| US7169908B2 (en) | 2003-01-09 | 2007-01-30 | Genentech, Inc. | Purification of polypeptides |
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| CN102316872B (zh) * | 2008-11-26 | 2016-12-21 | 萨蒂奥根制药公司 | 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 |
-
2011
- 2011-04-25 JO JOP/2011/0139A patent/JO3131B1/ar active
- 2011-04-26 UY UY0001033353A patent/UY33353A/es not_active Application Discontinuation
- 2011-04-26 AR ARP110101432A patent/AR081337A1/es active IP Right Grant
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