HRP20180176T1 - Spojevi korisni u sintezi spojeva benzamida - Google Patents
Spojevi korisni u sintezi spojeva benzamida Download PDFInfo
- Publication number
- HRP20180176T1 HRP20180176T1 HRP20180176TT HRP20180176T HRP20180176T1 HR P20180176 T1 HRP20180176 T1 HR P20180176T1 HR P20180176T T HRP20180176T T HR P20180176TT HR P20180176 T HRP20180176 T HR P20180176T HR P20180176 T1 HRP20180176 T1 HR P20180176T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound according
- compounds
- cclh2
- ccl2h
- cfh2
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 21
- 150000003936 benzamides Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 101100495923 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr2 gene Proteins 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- ZBZJXHCVGLJWFG-UHFFFAOYSA-N trichloromethyl(.) Chemical compound Cl[C](Cl)Cl ZBZJXHCVGLJWFG-UHFFFAOYSA-N 0.000 claims 8
- ROWMQJJMCWDJDT-UHFFFAOYSA-N tribromomethane Chemical compound Br[C](Br)Br ROWMQJJMCWDJDT-UHFFFAOYSA-N 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- MMLLIZJCTNVTMW-UHFFFAOYSA-N 2-amino-4,6-dimethoxybenzonitrile Chemical compound COC1=CC(N)=C(C#N)C(OC)=C1 MMLLIZJCTNVTMW-UHFFFAOYSA-N 0.000 claims 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (15)
1. Spoj Formule I:
[image]
Formula I
gdje:
R1 se bira između Br i CN;
R2 je odabran između H i Br;
R3 je odabran između H i
[image]
gdje:
R se bira između H, CH3, CF3, CF2H, CFH2, CCl3, CCl2H, CClH2, CBr3, CBr2H i
CBrH2; i
X se bira između O i S;
pod uvjetom da:
kada R1 je CN, tada R2 je H; i
kada R1 je Br, tada R3 je
[image]
i
pri čemu ako R1 je Br i R2 je H, tada R3 je
[image]
gdje se R bira između CF3, CF2H, CFH2, CCl3, CCl2H, CClH2, CBr3, CBr2H i CBrH2; i
X se bira između O i S.
2. Spoj sukladno patentnom zahtjevu 1, gdje:
R1 je Br;
R2 je H;
R3 je
[image]
gdje
R se bira između CF3, CF2H, CFH2, CCl3, CCl2H, CClH2, CBr3, CBr2H i CBrH2; i
X se bira između O i S.
3. Spoj sukladno patentnom zahtjevu 1, gdje:
R1 je Br;
R2 je Br;
R3 je
[image]
gdje
R se bira između H, CH3, CF3, CF2H, CFH2, CCl3, CCl2H, CClH2, CBr3, CBr2H i
CBrH2; i
X se bira između O i S.
4. Spoj sukladno patentnom zahtjevu 1, gdje:
R1 je CN;
R2 je H;
R3 je
[image]
gdje
R se bira između H, CH3, CF3, CF2H, CFH2, CCl3, CCl2H, CClH2, CBr3, CBr2H i
CBrH2; i
X se bira između O i S.
5. Spoj sukladno patentnom zahtjevu 1, naznačeno time, da je spoj odabrano između:
2-bromo-3,5-dimetoksitrifluoroacetanilida,
2, 4-dibromo-3,5-dimetoksitrifluoroacetanilida,
2-cijano-3,5-dimetoksitrifluoroacetanilida, i
2-amino-4,6-dimetoksibenzonitrila.
6. Spoj sukladno patentnom zahtjevu 2, naznačeno time, da je X kisik.
7. Spoj sukladno patentnom zahtjevu 3, naznačeno time, da je X kisik.
8. Spoj sukladno patentnom zahtjevu 4, naznačeno time, da je X kisik.
9. Spoj sukladno patentnom zahtjevu 2, naznačeno time, da je R odabran od CF3, CF2H, CFH2, CCl3, CCl2H, i CClH2.
10. Spoj sukladno patentnom zahtjevu 3, naznačeno time da je R odabran od CF3, CF2H, CFH2, CCl3, CCl2H, i CClH2.
11. Spoj sukladno patentnom zahtjevu 4, naznačeno time, da je R odabran od CF3, CF2H, CFH2, CCl3, CCl2H, i CClH2.
12. Spoj sukladno patentnom zahtjevu 5, naznačeno time, da je spoj 2-bromo-3,5-dimetoksitrifluoroacetanilid.
13. Spoj sukladno patentnom zahtjevu 5, naznačeno time, da je spoj 2,4-dibromo-3,5-dimetoksitrifluoroacetanilid.
14. Spoj sukladno patentnom zahtjevu 5, naznačeno time, da je spoj 2-cijano-3,5-dimetoksitrifluoroacetanilid.
15. Spoj sukladno patentnom zahtjevu 5, naznačeno time, da je spoj 2-amino-4,6-dimetoksibenzonitril.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713711P | 2012-10-15 | 2012-10-15 | |
| PCT/IB2013/003031 WO2014060852A2 (en) | 2012-10-15 | 2013-10-09 | Compounds useful in the synthesis of benzamide compounds |
| EP13846466.4A EP2906531B1 (en) | 2012-10-15 | 2013-10-09 | Compounds useful in the synthesis of benzamide compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180176T1 true HRP20180176T1 (hr) | 2018-03-09 |
Family
ID=50475926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180176TT HRP20180176T1 (hr) | 2012-10-15 | 2018-01-30 | Spojevi korisni u sintezi spojeva benzamida |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8884046B2 (hr) |
| EP (1) | EP2906531B1 (hr) |
| JP (2) | JP6307087B2 (hr) |
| KR (1) | KR101532570B1 (hr) |
| CN (1) | CN104884427B (hr) |
| AU (1) | AU2013333575B2 (hr) |
| BR (1) | BR112015008389B1 (hr) |
| CA (1) | CA2888378C (hr) |
| CY (1) | CY1119862T1 (hr) |
| DK (1) | DK2906531T3 (hr) |
| ES (1) | ES2658221T3 (hr) |
| HK (1) | HK1207623A1 (hr) |
| HR (1) | HRP20180176T1 (hr) |
| HU (1) | HUE036421T2 (hr) |
| IL (2) | IL238186A (hr) |
| LT (1) | LT2906531T (hr) |
| MX (1) | MX338885B (hr) |
| NO (1) | NO2992016T3 (hr) |
| NZ (1) | NZ707276A (hr) |
| PL (1) | PL2906531T3 (hr) |
| PT (1) | PT2906531T (hr) |
| RS (1) | RS56846B1 (hr) |
| RU (1) | RU2593752C1 (hr) |
| SA (1) | SA515360284B1 (hr) |
| SI (1) | SI2906531T1 (hr) |
| WO (1) | WO2014060852A2 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
| BRPI1009315B8 (pt) | 2009-03-18 | 2021-05-25 | Resverlogix Corp | composto anti-flamatórios e suas composições farmacêuticas |
| TR201818390T4 (tr) | 2009-04-22 | 2019-01-21 | Resverlogix Corp | Yeni̇ anti̇-i̇nflamatuvar ajanlar |
| PL2773354T3 (pl) | 2011-11-01 | 2019-12-31 | Resverlogix Corp. | Doustna formulacja o natychmiastowym uwalnianiu dla podstawowych chinazolinów |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0118752D0 (en) * | 2001-08-01 | 2001-09-26 | Pfizer Ltd | Process for the production of quinazolines |
| GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| US20040033480A1 (en) | 2002-08-15 | 2004-02-19 | Wong Norman C.W. | Use of resveratrol to regulate expression of apolipoprotein A1 |
| US20050080024A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
| US20050080021A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders |
| CA2541590A1 (en) | 2003-10-10 | 2005-04-21 | Resverlogix Corp. | Treatment of diseases associated with the egr-1 enhancer element |
| GB0512324D0 (en) * | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| EP1838296B1 (en) | 2004-10-20 | 2012-08-08 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| EP2314295B1 (en) | 2005-07-29 | 2015-01-28 | Resverlogix, Inc | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| US8053440B2 (en) * | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| MX2009013781A (es) * | 2007-06-21 | 2010-02-01 | Irm Llc | Inhibidores de cinasa de proteina y metodos para el uso de los mismos. |
| PT2346837E (pt) | 2008-06-26 | 2015-04-02 | Resverlogix Corp | Métodos de preparação de derivados de quinazolinona |
| ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
| BRPI1009315B8 (pt) | 2009-03-18 | 2021-05-25 | Resverlogix Corp | composto anti-flamatórios e suas composições farmacêuticas |
| TR201818390T4 (tr) | 2009-04-22 | 2019-01-21 | Resverlogix Corp | Yeni̇ anti̇-i̇nflamatuvar ajanlar |
| GB201007286D0 (en) * | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| DE102010048800A1 (de) * | 2010-10-20 | 2012-05-10 | Merck Patent Gmbh | Chinoxalinderivate |
| PL2773354T3 (pl) | 2011-11-01 | 2019-12-31 | Resverlogix Corp. | Doustna formulacja o natychmiastowym uwalnianiu dla podstawowych chinazolinów |
| CA2886973C (en) * | 2012-10-15 | 2017-08-15 | Albemarle Corporation | Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds |
| TWI641936B (zh) * | 2012-11-13 | 2018-11-21 | 美商慧盛材料美國責任有限公司 | 漿料供應及／或化學品摻合物供應設備、方法、使用方法及製造方法 |
-
2013
- 2013-10-09 NZ NZ707276A patent/NZ707276A/en unknown
- 2013-10-09 WO PCT/IB2013/003031 patent/WO2014060852A2/en active Application Filing
- 2013-10-09 LT LTEP13846466.4T patent/LT2906531T/lt unknown
- 2013-10-09 CA CA2888378A patent/CA2888378C/en active Active
- 2013-10-09 KR KR1020157012499A patent/KR101532570B1/ko active IP Right Grant
- 2013-10-09 BR BR112015008389-7A patent/BR112015008389B1/pt active IP Right Grant
- 2013-10-09 HU HUE13846466A patent/HUE036421T2/hu unknown
- 2013-10-09 PL PL13846466T patent/PL2906531T3/pl unknown
- 2013-10-09 AU AU2013333575A patent/AU2013333575B2/en active Active
- 2013-10-09 JP JP2015536239A patent/JP6307087B2/ja active Active
- 2013-10-09 MX MX2015004764A patent/MX338885B/es active IP Right Grant
- 2013-10-09 DK DK13846466.4T patent/DK2906531T3/en active
- 2013-10-09 RS RS20180117A patent/RS56846B1/sr unknown
- 2013-10-09 ES ES13846466.4T patent/ES2658221T3/es active Active
- 2013-10-09 US US14/050,076 patent/US8884046B2/en active Active
- 2013-10-09 RU RU2015113484/04A patent/RU2593752C1/ru active
- 2013-10-09 PT PT138464664T patent/PT2906531T/pt unknown
- 2013-10-09 EP EP13846466.4A patent/EP2906531B1/en active Active
- 2013-10-09 CN CN201380053651.0A patent/CN104884427B/zh active Active
- 2013-10-09 SI SI201330930T patent/SI2906531T1/en unknown
-
2014
- 2014-04-30 NO NO14724662A patent/NO2992016T3/no unknown
-
2015
- 2015-04-12 IL IL238186A patent/IL238186A/en active IP Right Grant
- 2015-04-14 SA SA515360284A patent/SA515360284B1/ar unknown
- 2015-08-20 HK HK15108083.4A patent/HK1207623A1/xx unknown
-
2016
- 2016-02-10 IL IL244099A patent/IL244099A0/en unknown
-
2017
- 2017-02-28 JP JP2017036605A patent/JP2017088632A/ja not_active Withdrawn
-
2018
- 2018-01-30 HR HRP20180176TT patent/HRP20180176T1/hr unknown
- 2018-01-30 CY CY20181100109T patent/CY1119862T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20180176T1 (hr) | Spojevi korisni u sintezi spojeva benzamida | |
| HRP20161103T1 (hr) | Kemijski spojevi | |
| HRP20171175T1 (hr) | Novi triciklički spojevi | |
| RS53301B (en) | TIOACETATE COMPOUNDS, COMPOSITIONS AND USE PROCEDURES | |
| RS54873B1 (sr) | Policiklična-karbamoilpiridonska jedinjenja i njihova farmaceutska upotreba | |
| RS53688B1 (en) | 1,2,5-OXADIAZOLES AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | |
| RS54485B1 (en) | C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS | |
| HRP20160001T1 (hr) | Postupak za pripravu fenil supstituiranih n-metoksi-[1-metil-2-feniletil]amida 3-difluorometil-1-metil-1h-pirazol-4-karboksilne kiseline | |
| WO2011123536A8 (en) | Polycyclic tetracycline compounds | |
| EA201492255A1 (ru) | Феноксиэтилпиперидиновые соединения | |
| WO2014054058A8 (en) | Novel compounds, their synthesis and their uses | |
| WO2014036502A8 (en) | Tetracycline compounds | |
| RS52171B (en) | NALMEFEN DI-ESTER PRODUCTS | |
| RS53940B1 (en) | HETEROARYL UNITS AS LIGANDS OF 5-HT4 RECEPTORS | |
| WO2010129057A3 (en) | Tetracycline compounds | |
| WO2011025982A3 (en) | Tetracycline compounds | |
| ME01144B (me) | 3-aminociklopentankarboksamidi kao modulatori hemokin receptora | |
| AR073008A1 (es) | Compuestos de 2- aminopirimidina como potentes inhibidores de hsp-90 | |
| MX363685B (es) | Una sintesis telescopica de sal de 5-amino-4-nitro-1-alquil-1h-pir azol. | |
| RS54001B1 (en) | SUBSTITUTED [(5H-Pyrrolo [2,1-C] [1,4] BENZODIAZEPIN-11-IL-) PIPERAZIN-1-IL] -2,2-DIMETHYLPROPANOIC ACID COMPOUNDS HT 2A | |
| CR20130029A (es) | Compuestos de tiofeno 2,3,5-trisustituidos y usos de los mismos | |
| TH96530B (th) | สูตรผสม | |
| EA201300177A1 (ru) | Составы | |
| UA96477U (xx) | ЗАСТОСУВАННЯ ЦИС-ТЕТРАГАЛОГЕНОДИ-μ-АДАМАНТИЛКАРБОКСИЛАТИ ДИРЕНІЮ (ІІІ), ЯК СПОЛУК, ЩО ПРОЯВЛЯЮТЬ ГЕПАТОПРОТЕКТОРНУ ТА ГЕПАТОМОДУЛЮЮЧУ АКТИВНІСТЬ | |
| RS54314B1 (en) | (S) -2-AMINO-3-CYCLOHEXYLPROPANIC ACID DERIVATIVES, THEIR PRODUCTION AND USE |