WO2014036502A8 - Tetracycline compounds - Google Patents
Tetracycline compounds Download PDFInfo
- Publication number
- WO2014036502A8 WO2014036502A8 PCT/US2013/057690 US2013057690W WO2014036502A8 WO 2014036502 A8 WO2014036502 A8 WO 2014036502A8 US 2013057690 W US2013057690 W US 2013057690W WO 2014036502 A8 WO2014036502 A8 WO 2014036502A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- structural formula
- tetracycline compounds
- pharmaceutically acceptable
- acceptable salt
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
Priority Applications (30)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201331346T SI2890673T1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
EA201590475A EA031523B1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
MEP-2019-48A ME03329B (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
RS20190195A RS58572B1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
BR112015004523-5A BR112015004523B1 (en) | 2012-08-31 | 2013-08-30 | TETRACYCLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES |
NZ705849A NZ705849A (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
PL13762660T PL2890673T3 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
EP18192684.1A EP3461809A1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
MX2015002657A MX364400B (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds. |
EP13762660.2A EP2890673B1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
KR1020217026972A KR102375238B1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
LTEP13762660.2T LT2890673T (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
SG11201501516YA SG11201501516YA (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
ES13762660T ES2712476T3 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
CN201380056726.0A CN104768922B (en) | 2012-08-31 | 2013-08-30 | Tetracycline compound |
AU2013308504A AU2013308504B2 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
US14/424,765 US9573895B2 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
KR1020157008309A KR102295673B1 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
CA2883238A CA2883238C (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
JP2015530126A JP6301335B2 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compound |
DK13762660.2T DK2890673T3 (en) | 2012-08-31 | 2013-08-30 | tetracycline |
IL237437A IL237437B (en) | 2012-08-31 | 2015-02-26 | Tetracycline compounds |
HK15112755.3A HK1211917A1 (en) | 2012-08-31 | 2015-12-28 | Tetracycline compounds |
AU2016247054A AU2016247054B2 (en) | 2012-08-31 | 2016-10-18 | Tetracycline compounds |
US15/400,674 US10315992B2 (en) | 2012-08-31 | 2017-01-06 | Tetracyline compounds |
AU2017200857A AU2017200857B2 (en) | 2012-08-31 | 2017-02-08 | Tetracycline compounds |
HRP20190268TT HRP20190268T1 (en) | 2012-08-31 | 2019-02-11 | Tetracycline compounds |
CY20191100197T CY1122744T1 (en) | 2012-08-31 | 2019-02-14 | TETRACYCLINE COMPOUNDS |
US16/393,725 US10913712B2 (en) | 2012-08-31 | 2019-04-24 | Tetracycline compounds |
IL266719A IL266719A (en) | 2012-08-31 | 2019-05-19 | Tetracycline compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261695947P | 2012-08-31 | 2012-08-31 | |
US61/695,947 | 2012-08-31 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/400,674 Continuation US10315992B2 (en) | 2012-08-31 | 2017-01-06 | Tetracyline compounds |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/424,765 A-371-Of-International US9573895B2 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
US15/400,674 Continuation US10315992B2 (en) | 2012-08-31 | 2017-01-06 | Tetracyline compounds |
US16/393,725 Continuation US10913712B2 (en) | 2012-08-31 | 2019-04-24 | Tetracycline compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2014036502A2 WO2014036502A2 (en) | 2014-03-06 |
WO2014036502A3 WO2014036502A3 (en) | 2014-04-24 |
WO2014036502A8 true WO2014036502A8 (en) | 2014-07-31 |
Family
ID=49170898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/057690 WO2014036502A2 (en) | 2012-08-31 | 2013-08-30 | Tetracycline compounds |
Country Status (27)
Country | Link |
---|---|
US (3) | US9573895B2 (en) |
EP (2) | EP2890673B1 (en) |
JP (2) | JP6301335B2 (en) |
KR (2) | KR102295673B1 (en) |
CN (3) | CN108329312B (en) |
AU (3) | AU2013308504B2 (en) |
BR (1) | BR112015004523B1 (en) |
CA (1) | CA2883238C (en) |
CY (1) | CY1122744T1 (en) |
DK (1) | DK2890673T3 (en) |
EA (2) | EA031523B1 (en) |
ES (1) | ES2712476T3 (en) |
HK (1) | HK1211917A1 (en) |
HR (1) | HRP20190268T1 (en) |
HU (1) | HUE042600T2 (en) |
IL (2) | IL237437B (en) |
LT (1) | LT2890673T (en) |
ME (1) | ME03329B (en) |
MX (1) | MX364400B (en) |
NZ (3) | NZ705849A (en) |
PL (1) | PL2890673T3 (en) |
PT (1) | PT2890673T (en) |
RS (1) | RS58572B1 (en) |
SG (2) | SG11201501516YA (en) |
SI (1) | SI2890673T1 (en) |
TR (1) | TR201902057T4 (en) |
WO (1) | WO2014036502A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2682387T3 (en) | 2008-08-08 | 2016-01-04 | Tetraphase Pharmaceuticals Inc | C7-fluoro-substituted tetracycline compounds |
CA2761241C (en) | 2009-05-08 | 2018-02-27 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
EP3275861A1 (en) | 2009-08-28 | 2018-01-31 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
KR102295673B1 (en) | 2012-08-31 | 2021-08-27 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Tetracycline compounds |
MX2019002453A (en) * | 2016-08-30 | 2020-02-17 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds and methods of treatment. |
CN110582486B (en) | 2016-10-19 | 2024-01-12 | 四相制药公司 | Crystalline forms of Ai Rewei tetracyclines |
EP3829545A1 (en) | 2018-07-27 | 2021-06-09 | Sandoz Ag | Process for preparing rapidly or very rapidly dissolving tablets comprising freely soluble api |
CN113444070A (en) * | 2021-07-28 | 2021-09-28 | 深圳市真味生物科技有限公司 | Preparation method for synthesizing chiral nicotine from chiral tert-butyl sulfinamide |
CN115448849B (en) * | 2022-11-10 | 2023-02-03 | 苏州富士莱医药股份有限公司 | Preparation method of 2-benzyloxy-3-dibenzylamino-5-fluoro-6-methylbenzoic acid phenyl ester |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE639292A (en) | ||||
GB935384A (en) | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
US3338963A (en) | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
GB1034933A (en) * | 1962-10-29 | 1966-07-06 | American Cyanamid Co | 4-demethylamino-4-substituted amino 6-demethyl tetracyclines |
US3364123A (en) * | 1963-05-06 | 1968-01-16 | Squibb & Sons Inc | Production of 4n-demethyl-4n-ethyl tetracyclines |
USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
GB1065715A (en) * | 1964-04-16 | 1967-04-19 | Pfizer & Co C | Tetracycline derivatives |
US3247226A (en) * | 1964-07-06 | 1966-04-19 | American Cyanamid Co | 4-dimethylamino and 4-hydroxytetracycloxides |
US3394178A (en) * | 1965-01-26 | 1968-07-23 | Merck & Co Inc | Nu-ethyloxytetracycline |
GB1077598A (en) | 1965-05-12 | 1967-08-02 | Pfizer & Co C | Preparation of n-demethyl tetracyclines |
US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
US3433709A (en) | 1965-12-07 | 1969-03-18 | American Cyanamid Co | Biological transformation of alpha-6-deoxytetracyclines to tetracyclines |
US3849493A (en) * | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
US3824285A (en) * | 1967-09-13 | 1974-07-16 | Pfizer | 4-oxo-4-dedimethylaminotetracycline-4,6-hemiketals |
US3947517A (en) | 1969-06-12 | 1976-03-30 | Research Corporation | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines |
DE2437487A1 (en) | 1974-08-03 | 1976-02-19 | Merck Patent Gmbh | 7-METHOXY-6-THIA-TETRACYCLINE AND THE METHOD FOR MANUFACTURING IT |
DE2442829A1 (en) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | TETRACYCLIC COMPOUNDS AND PROCEDURES FOR THEIR PRODUCTION |
YU290176A (en) * | 1976-11-26 | 1982-05-31 | Pliva Zagreb | Process for preparing 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracycline |
USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
JP3016587B2 (en) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | Combination of non-steroidal anti-inflammatory drug and tetracycline |
US5770588A (en) | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
ATE211128T1 (en) | 1991-10-04 | 2002-01-15 | American Cyanamid Co | 7-SUBSTITUTED-9-SUBSTITUTED AMINO-6-DEMETHYL-6-DEOXY-TETRACYCLINE |
US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
US5420272A (en) | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5442059A (en) | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5284963A (en) | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
JPH06256280A (en) | 1992-11-17 | 1994-09-13 | Univ New York State | Tetracycline containing non-antibacterial chemically modified tetracycline inhibiting excess collagen crosslinking bonding in diabetes |
US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5371076A (en) | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
AU1279095A (en) | 1994-02-17 | 1995-09-04 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5843925A (en) | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5574026A (en) | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
US5827840A (en) | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
US5773430A (en) | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
CA2318580A1 (en) | 1998-01-23 | 1999-07-29 | Mark L. Nelson | Pharmaceutically active compounds and methods of use thereof |
US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
US6914057B1 (en) | 1998-09-28 | 2005-07-05 | The Research Foundation Of State University Of New York | Inhibitor of cataract formation |
EP1124558A4 (en) | 1998-09-28 | 2004-10-27 | Res Foundation Ofstate Univers | A novel inhibitor of cataract formation |
US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
WO2001098260A1 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
CZ303702B6 (en) | 2000-07-07 | 2013-03-20 | Trustees Of Tufts College | Minocycline compounds |
US6624168B2 (en) | 2000-07-07 | 2003-09-23 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
EP1301466A2 (en) | 2000-07-07 | 2003-04-16 | Trustees Of Tufts College | 7-substituted tetracycline compounds |
EA201000388A1 (en) | 2001-03-13 | 2010-10-29 | Пэрэтек Фамэсьютикэлс, Инк. | SUBSTITUTED TETRACYCLINE COMPOUNDS (OPTIONS), PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF TETRACYCLINE-SENSITIVE CONDITION OF THE SUBJECT |
CA2440757A1 (en) | 2001-03-14 | 2002-09-19 | Michael Draper | Substituted tetracycline compounds as synergistic antifungal agents |
EP1379255A2 (en) | 2001-03-14 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
JP2004529927A (en) | 2001-04-24 | 2004-09-30 | パラテック ファーマシューティカルズ, インク. | Substituted tetracycline compounds for the treatment of malaria |
US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US20060194773A1 (en) | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
EP2329828A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of ischaemia |
WO2003057169A2 (en) | 2002-01-08 | 2003-07-17 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
EP2316450A1 (en) | 2002-03-08 | 2011-05-04 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
AU2003218243B2 (en) | 2002-03-21 | 2010-04-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
KR101089429B1 (en) | 2002-07-12 | 2011-12-07 | 파라테크 파마슈티컬스, 인크. | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS |
AU2003287217B2 (en) | 2002-10-24 | 2010-03-04 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate RNA |
EP2277504A1 (en) | 2002-10-24 | 2011-01-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
WO2005009943A2 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
WO2005082860A1 (en) | 2004-02-27 | 2005-09-09 | National Research Council Of Canada | Tetracyclines and their use as calpain inhibitors |
PL1753713T3 (en) | 2004-05-21 | 2017-02-28 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
EP2305637A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
CA2585418A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
AU2006210406C1 (en) | 2005-02-04 | 2013-03-07 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
CN101119964A (en) | 2005-02-15 | 2008-02-06 | 惠氏公司 | 9-substituted tetracyclines |
US20070093455A1 (en) | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
EP2298324A1 (en) | 2006-01-24 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
AU2007235279B2 (en) * | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
EP2537934A3 (en) | 2006-05-15 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
EP2076133B1 (en) | 2006-10-11 | 2012-12-12 | President and Fellows of Harvard College | Synthesis of enone intermediate |
WO2008079339A2 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
TWI334106B (en) | 2006-12-27 | 2010-12-01 | Icp Electronics Inc | Apparatus for converting gray scale and method for the same |
US7935687B2 (en) | 2007-04-12 | 2011-05-03 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
DK2176216T3 (en) | 2007-07-06 | 2012-07-30 | Paratek Pharm Innc | Methods for synthesizing 9-substituted minocycline |
WO2009073056A1 (en) | 2007-09-07 | 2009-06-11 | Dr. Reddy's Laboratories Ltd. | Novel tetracycline derivatives as antibacterial agents |
US20100022483A1 (en) | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
US8338477B2 (en) * | 2008-07-11 | 2012-12-25 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
DK2682387T3 (en) | 2008-08-08 | 2016-01-04 | Tetraphase Pharmaceuticals Inc | C7-fluoro-substituted tetracycline compounds |
EP2424834B1 (en) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthesis of tetracyclines and intermediates thereof |
CA2761241C (en) * | 2009-05-08 | 2018-02-27 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
EP2427190B1 (en) | 2009-05-08 | 2013-09-18 | Tetraphase Pharmaceuticals, Inc. | 8-aza tetracycline compounds |
US20120115819A1 (en) | 2009-05-13 | 2012-05-10 | Clark Roger B | Pentacycline Compounds |
EP3275861A1 (en) | 2009-08-28 | 2018-01-31 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
CA2790240A1 (en) | 2010-03-10 | 2011-09-15 | University Health Network | Use of tigecycline for treatment of cancer |
WO2011123536A1 (en) | 2010-03-31 | 2011-10-06 | Tetraphase Pharmaceuticals, Inc. | Polycyclic tetracycline compounds |
AR082633A1 (en) * | 2010-08-12 | 2012-12-19 | Tetraphase Pharmaceuticals Inc | TETRACICLINE ANALOGS |
WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
KR102295673B1 (en) | 2012-08-31 | 2021-08-27 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Tetracycline compounds |
MA40836A (en) | 2014-10-23 | 2017-08-29 | Tetraphase Pharmaceuticals Inc | SEMI-SYNTHESIS PROCEDURES |
CN108495844B (en) | 2016-01-22 | 2022-12-02 | 桑多斯股份公司 | Crystalline Erlenmex dihydrochloride |
MX2019002453A (en) | 2016-08-30 | 2020-02-17 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds and methods of treatment. |
CN110582486B (en) | 2016-10-19 | 2024-01-12 | 四相制药公司 | Crystalline forms of Ai Rewei tetracyclines |
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