JP2008528447A5 - - Google Patents
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- Publication number
- JP2008528447A5 JP2008528447A5 JP2007549577A JP2007549577A JP2008528447A5 JP 2008528447 A5 JP2008528447 A5 JP 2008528447A5 JP 2007549577 A JP2007549577 A JP 2007549577A JP 2007549577 A JP2007549577 A JP 2007549577A JP 2008528447 A5 JP2008528447 A5 JP 2008528447A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- alkyl
- independently selected
- substituted
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 claims 184
- 125000000217 alkyl group Chemical group 0.000 claims 143
- 125000005842 heteroatom Chemical group 0.000 claims 132
- 125000001072 heteroaryl group Chemical group 0.000 claims 94
- 239000000203 mixture Substances 0.000 claims 91
- 125000000623 heterocyclic group Chemical group 0.000 claims 88
- 125000000753 cycloalkyl group Chemical group 0.000 claims 73
- 125000001188 haloalkyl group Chemical group 0.000 claims 68
- 125000003118 aryl group Chemical group 0.000 claims 55
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- -1 4,5-dihydro - oxazolyl Chemical group 0.000 claims 21
- 125000000842 isoxazolyl group Chemical group 0.000 claims 21
- 125000002971 oxazolyl group Chemical group 0.000 claims 21
- 125000004076 pyridyl group Chemical group 0.000 claims 21
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 21
- 125000003831 tetrazolyl group Chemical group 0.000 claims 21
- 125000003710 aryl alkyl group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000002619 bicyclic group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 8
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 125000000335 thiazolyl group Chemical group 0.000 claims 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 150000004820 halides Chemical class 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 235000010603 pastilles Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 1
- 0 CC(C=C(CN(*)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N(*)*)=N)=C Chemical compound CC(C=C(CN(*)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N(*)*)=N)=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64079804P | 2004-12-31 | 2004-12-31 | |
| US60/640,798 | 2004-12-31 | ||
| PCT/US2005/047203 WO2006073973A2 (en) | 2004-12-31 | 2005-12-28 | Novel benzylamine derivatives as cetp inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528447A JP2008528447A (ja) | 2008-07-31 |
| JP2008528447A5 true JP2008528447A5 (enExample) | 2012-02-23 |
| JP5096927B2 JP5096927B2 (ja) | 2012-12-12 |
Family
ID=36648035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549577A Expired - Fee Related JP5096927B2 (ja) | 2004-12-31 | 2005-12-28 | Cetpインヒビターとしての新規ベンジルアミン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9040558B2 (enExample) |
| EP (1) | EP1848430B1 (enExample) |
| JP (1) | JP5096927B2 (enExample) |
| KR (1) | KR101238525B1 (enExample) |
| CN (2) | CN101443006B (enExample) |
| CA (1) | CA2605214C (enExample) |
| DK (1) | DK1848430T3 (enExample) |
| ES (2) | ES2644450T3 (enExample) |
| MX (1) | MX2007007919A (enExample) |
| WO (1) | WO2006073973A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007007919A (es) | 2004-12-31 | 2008-01-22 | Reddy Us Therapeutics Inc | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| EP1981342B1 (en) * | 2005-12-28 | 2016-11-30 | Dr. Reddy's Laboratories Ltd. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
| EP1968941A1 (en) * | 2005-12-29 | 2008-09-17 | Novartis AG | Pyridinyl amine derivatives as inhibitors of cholesteryl ester transfer protein (cetp) |
| UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
| PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
| US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| EP2024356A1 (en) | 2006-05-10 | 2009-02-18 | Novartis AG | Bicyclic derivatives as cetp inhibitors |
| GB0609268D0 (en) * | 2006-05-10 | 2006-06-21 | Novartis Ag | Organic compounds |
| CA2650515A1 (en) * | 2006-05-11 | 2007-11-22 | Novartis Ag | Benzylamine derivatives as cetp inhibitors |
| AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| US7750019B2 (en) | 2006-08-11 | 2010-07-06 | Kowa Company, Ltd. | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same |
| BRPI0718399A2 (pt) * | 2006-11-15 | 2014-03-11 | Novartis Ag | Derivados heterocíclicos como inibidores de cetp |
| US20100076021A1 (en) * | 2006-11-15 | 2010-03-25 | Hidetomo Imase | Organic Compounds |
| US20080221161A1 (en) * | 2007-02-09 | 2008-09-11 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| US7790737B2 (en) | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
| US8759383B2 (en) | 2007-03-16 | 2014-06-24 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
| US7659271B2 (en) | 2007-04-13 | 2010-02-09 | Kowa Company, Ltd. | Pyrimidine compound having dibenzylamine structure and medicament comprising the same |
| WO2008137105A1 (en) * | 2007-05-07 | 2008-11-13 | Merck & Co., Inc. | Method of treatment using fused aromatic compounds having anti-diabetic activity |
| JP4846769B2 (ja) * | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| ES2598358T3 (es) | 2009-02-13 | 2017-01-27 | Ucb Pharma, S.A. | Derivados de quinolina como inhibidores de PI3K quinasa |
| JP2013503135A (ja) | 2009-08-26 | 2013-01-31 | サノフイ | 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用 |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013024358A2 (en) * | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
| KR101803866B1 (ko) * | 2011-09-27 | 2017-12-04 | 닥터 레디스 레보러터리즈 리미티드 | 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체 |
| JPWO2013080999A1 (ja) | 2011-11-29 | 2015-04-27 | 興和株式会社 | NPC1L1及び/又はLIPGmRNAの発現抑制剤並びに肥満症の予防及び/又は治療剤 |
| WO2014017569A1 (ja) * | 2012-07-26 | 2014-01-30 | 興和株式会社 | 血中ldlを低下させるための医薬 |
| US20170071930A1 (en) * | 2012-11-19 | 2017-03-16 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| WO2014128564A2 (en) * | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ldlコレステロールを低下させる医薬 |
| US10214502B2 (en) * | 2016-10-04 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Method of inhibiting apolipoprotein-E expression while increasing expression of at least one of LDL-receptor protein or AbcA1 protein comprising administering a small compound |
| CN108329330B (zh) * | 2017-01-20 | 2021-05-04 | 复旦大学 | 2-苄氧苯基噁唑并吡啶类化合物及其药物用途 |
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-
2005
- 2005-12-28 MX MX2007007919A patent/MX2007007919A/es active IP Right Grant
- 2005-12-28 JP JP2007549577A patent/JP5096927B2/ja not_active Expired - Fee Related
- 2005-12-28 WO PCT/US2005/047203 patent/WO2006073973A2/en not_active Ceased
- 2005-12-28 DK DK05855717.4T patent/DK1848430T3/da active
- 2005-12-28 US US11/320,120 patent/US9040558B2/en not_active Expired - Fee Related
- 2005-12-28 KR KR1020077017632A patent/KR101238525B1/ko not_active Expired - Fee Related
- 2005-12-28 ES ES05855717.4T patent/ES2644450T3/es active Active
- 2005-12-28 CA CA2605214A patent/CA2605214C/en not_active Expired - Fee Related
- 2005-12-28 EP EP05855717.4A patent/EP1848430B1/en not_active Not-in-force
- 2005-12-28 CN CN200580048913XA patent/CN101443006B/zh not_active Expired - Fee Related
- 2005-12-28 CN CN201210404509.3A patent/CN103102303B/zh not_active Expired - Fee Related
-
2006
- 2006-06-29 ES ES06774300.5T patent/ES2615340T3/es active Active
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2015
- 2015-04-15 US US14/687,467 patent/US9782407B2/en not_active Expired - Fee Related
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