JP2006509015A5 - - Google Patents
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- Publication number
- JP2006509015A5 JP2006509015A5 JP2004557589A JP2004557589A JP2006509015A5 JP 2006509015 A5 JP2006509015 A5 JP 2006509015A5 JP 2004557589 A JP2004557589 A JP 2004557589A JP 2004557589 A JP2004557589 A JP 2004557589A JP 2006509015 A5 JP2006509015 A5 JP 2006509015A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- alkyl
- optionally substituted
- halo
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(CC1)CCC1(CN1Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)CN(c2ccc(*)cc2)C1=O Chemical compound CC(CC1)CCC1(CN1Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)CN(c2ccc(*)cc2)C1=O 0.000 description 37
- AFXVJUFSVHBGFA-UHFFFAOYSA-N CC(C(CNC(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)=O)=O)=O Chemical compound CC(C(CNC(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)=O)=O)=O AFXVJUFSVHBGFA-UHFFFAOYSA-N 0.000 description 1
- VEZFHBRVVUVDEY-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O VEZFHBRVVUVDEY-UHFFFAOYSA-N 0.000 description 1
- XXNUNAVTFOXUGX-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(OC)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CCN1c(cc2)ccc2OC(F)(F)F)N(Cc(cc2)ccc2C(NCC(C(OC)=O)O)=O)C1=O XXNUNAVTFOXUGX-UHFFFAOYSA-N 0.000 description 1
- SAOQLSXJSDSLDQ-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1C(CI)c(cc2)ccc2Br)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1C(CI)c(cc2)ccc2Br)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O SAOQLSXJSDSLDQ-UHFFFAOYSA-N 0.000 description 1
- CFKYQBKCUXSYSF-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O CFKYQBKCUXSYSF-UHFFFAOYSA-N 0.000 description 1
- WSOWRQHROVAZER-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2F)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O WSOWRQHROVAZER-UHFFFAOYSA-N 0.000 description 1
- ZJGCRKSGKMYEPI-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2S(C)C(O)=O)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cc2)ccc2S(C)C(O)=O)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O ZJGCRKSGKMYEPI-UHFFFAOYSA-N 0.000 description 1
- LJUHOCLOILBHQI-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(ccc(F)c2)c2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(ccc(F)c2)c2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O LJUHOCLOILBHQI-UHFFFAOYSA-N 0.000 description 1
- UBZKWBYUYMXLFH-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c(cccc2)c2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c(cccc2)c2Cl)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O UBZKWBYUYMXLFH-UHFFFAOYSA-N 0.000 description 1
- HASGNSGSQSLVJJ-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c2cc(Cl)cc(Cl)c2)N(CC2C=CC(C(NCC(C(O)=O)O)=O)=CC2)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c2cc(Cl)cc(Cl)c2)N(CC2C=CC(C(NCC(C(O)=O)O)=O)=CC2)C1=O HASGNSGSQSLVJJ-UHFFFAOYSA-N 0.000 description 1
- AFLDSFRTXXHWIX-UHFFFAOYSA-N CC(C)(C)C(CC1)CCC1(CN1c2cccc(Cl)c2)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O Chemical compound CC(C)(C)C(CC1)CCC1(CN1c2cccc(Cl)c2)N(Cc(cc2)ccc2C(NCC(C(O)=O)O)=O)C1=O AFLDSFRTXXHWIX-UHFFFAOYSA-N 0.000 description 1
- VKWGTVXXZWQDDH-UHFFFAOYSA-N CC(C)(C1)C1(CC1)CCC1(CN1c2cc(C(F)(F)F)cc(C(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)(C1)C1(CC1)CCC1(CN1c2cc(C(F)(F)F)cc(C(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O VKWGTVXXZWQDDH-UHFFFAOYSA-N 0.000 description 1
- ZOKNATNTTBBZQZ-UHFFFAOYSA-N CC(C)C(CC1)CCC1(CCC1c2ccc(C(C3C)OC3=O)cc2)N(Cc(cc2)ccc2C(Nc2nnn[nH]2)=O)C1=O Chemical compound CC(C)C(CC1)CCC1(CCC1c2ccc(C(C3C)OC3=O)cc2)N(Cc(cc2)ccc2C(Nc2nnn[nH]2)=O)C1=O ZOKNATNTTBBZQZ-UHFFFAOYSA-N 0.000 description 1
- DZHWUPOXGAAJPF-UHFFFAOYSA-N CC(C)C(CC1)CCC1(CN1c2cccc(OC(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1O Chemical compound CC(C)C(CC1)CCC1(CN1c2cccc(OC(F)(F)F)c2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1O DZHWUPOXGAAJPF-UHFFFAOYSA-N 0.000 description 1
- MNOJIEJTKWCCEG-UHFFFAOYSA-N CC(C)C(CCC(CC1)(CCC1C(C)(C(C)C)C=C)N1Cc(cc2)ccc2C(NC2=NCNC2C)=O)C1=O Chemical compound CC(C)C(CCC(CC1)(CCC1C(C)(C(C)C)C=C)N1Cc(cc2)ccc2C(NC2=NCNC2C)=O)C1=O MNOJIEJTKWCCEG-UHFFFAOYSA-N 0.000 description 1
- QWDDJEUDPPBDNL-UHFFFAOYSA-N CC(C)C(CCC1)CC1C(CN1c(cc2F)ccc2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)C(CCC1)CC1C(CN1c(cc2F)ccc2F)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O QWDDJEUDPPBDNL-UHFFFAOYSA-N 0.000 description 1
- LCEUJJGHQCVSDF-UHFFFAOYSA-N CC(C)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CC(C)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O LCEUJJGHQCVSDF-UHFFFAOYSA-N 0.000 description 1
- VZZJXALBAVRQLJ-UHFFFAOYSA-N CC(CC=C)(C(CC1)CCC1(CN1c2ccccc2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O)C=C Chemical compound CC(CC=C)(C(CC1)CCC1(CN1c2ccccc2)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O)C=C VZZJXALBAVRQLJ-UHFFFAOYSA-N 0.000 description 1
- BEBMPKNEZXAXHT-UHFFFAOYSA-N CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)CC(Cc(cc1)ccc1C(Nc1nnn[nH]1)=O)=C1)C1=O Chemical compound CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)CC(Cc(cc1)ccc1C(Nc1nnn[nH]1)=O)=C1)C1=O BEBMPKNEZXAXHT-UHFFFAOYSA-N 0.000 description 1
- MVJIHYHAKQEZJL-UHFFFAOYSA-N CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCc2nnn[nH]2)=O)C1=O Chemical compound CC(c(cc1)ccc1Br)N(CC(CC1)(CCC1C(C)(C)C)N1Cc(cc2)ccc2C(NCc2nnn[nH]2)=O)C1=O MVJIHYHAKQEZJL-UHFFFAOYSA-N 0.000 description 1
- AMPICRWPLIJTSR-UHFFFAOYSA-N CCC(C)(C)C(CC1)CCC1(CN1Cc2cc(F)ccc2)N(Cc(cc2)ccc2C(NC2=NN=NCC2=C)=O)C1=O Chemical compound CCC(C)(C)C(CC1)CCC1(CN1Cc2cc(F)ccc2)N(Cc(cc2)ccc2C(NC2=NN=NCC2=C)=O)C1=O AMPICRWPLIJTSR-UHFFFAOYSA-N 0.000 description 1
- FVWXVNGQVMGYQL-UHFFFAOYSA-N CCC(C)(C)C(CC1)CCC1(CN1c(cc(cc2)Cl)c2Cl)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O Chemical compound CCC(C)(C)C(CC1)CCC1(CN1c(cc(cc2)Cl)c2Cl)N(Cc(cc2)ccc2C(NCCC(O)=O)=O)C1=O FVWXVNGQVMGYQL-UHFFFAOYSA-N 0.000 description 1
- NYIOLAWHSMOPIS-UHFFFAOYSA-N O=C(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)Nc1n[n]c[nH]1 Chemical compound O=C(c1ccc(CN(C2(CN3c(cc4)ccc4OC(F)(F)F)CCN(Cc4ccccc4)CC2)C3=O)cc1)Nc1n[n]c[nH]1 NYIOLAWHSMOPIS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43079902P | 2002-12-04 | 2002-12-04 | |
| PCT/US2003/038590 WO2004050039A2 (en) | 2002-12-04 | 2003-11-26 | Spirocyclic ureas, compositions containing such compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509015A JP2006509015A (ja) | 2006-03-16 |
| JP2006509015A5 true JP2006509015A5 (enExample) | 2006-08-03 |
Family
ID=32469534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004557589A Withdrawn JP2006509015A (ja) | 2002-12-04 | 2003-11-26 | スピロ環尿素、そのような化合物を含有する組成物、及び使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060116366A1 (enExample) |
| EP (1) | EP1569915A4 (enExample) |
| JP (1) | JP2006509015A (enExample) |
| AU (1) | AU2003298889A1 (enExample) |
| CA (1) | CA2508581A1 (enExample) |
| WO (1) | WO2004050039A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7572922B2 (en) | 2003-01-27 | 2009-08-11 | Merck & Co., Inc. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| SI1756064T1 (sl) * | 2004-06-04 | 2008-12-31 | Merck & Co Inc | Derivati pirazola, sestavki vsebujoäśi takĺ ne sestavine in postopki uporabe |
| DE602005017895D1 (de) * | 2004-07-07 | 2010-01-07 | Merck & Co Inc | Pyrazolamid-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren |
| AU2005269792B9 (en) | 2004-07-22 | 2008-11-27 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| CA2615656A1 (en) | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP2009502923A (ja) | 2005-07-26 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | 置換ピラゾールを合成するための方法 |
| TW200745031A (en) | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
| WO2007111864A2 (en) | 2006-03-23 | 2007-10-04 | Merck & Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| CA2650619A1 (en) | 2006-05-16 | 2007-11-29 | Merck And Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| US8293759B2 (en) | 2006-10-30 | 2012-10-23 | Merck, Sharp & Dohme, Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| MX2009008534A (es) | 2007-02-09 | 2009-11-23 | Metabasis Therapeutics Inc | Antagonistas novedosos del receptor de glucagon. |
| EP2799428B1 (en) | 2008-08-13 | 2016-11-16 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
| WO2011119559A1 (en) * | 2010-03-25 | 2011-09-29 | Schering Corporation | Novel spiro imidazolones as glucagon receptor antagonists, compositions, and methods for their use |
| JP2013523642A (ja) * | 2010-03-26 | 2013-06-17 | メルク・シャープ・エンド・ドーム・コーポレイション | グルカゴン受容体拮抗薬としての新規なスピロイミダゾロン誘導体、組成物およびそれらの使用方法 |
| JP2014040374A (ja) * | 2010-12-15 | 2014-03-06 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害物質 |
| AU2011346670B2 (en) | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
| PH12013501557A1 (en) | 2011-02-08 | 2019-06-03 | Pfizer | Glucagon receptor modulator |
| RU2013157388A (ru) | 2011-07-22 | 2015-08-27 | Пфайзер Инк. | Хинолинильные модуляторы глюкагонового рецептора |
| US8742111B1 (en) * | 2013-02-21 | 2014-06-03 | The United States Of America As Represented By The Secretary Of The Army | Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics |
| EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| JP7155102B2 (ja) * | 2016-07-07 | 2022-10-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
| WO2018015235A1 (en) * | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| JP2021513564A (ja) | 2018-02-13 | 2021-05-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体拮抗薬 |
| WO2021078132A1 (en) * | 2019-10-21 | 2021-04-29 | Sironax Ltd | Inhibitors of mtor-mediated induction of autophagy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
| FR2677984B1 (fr) * | 1991-06-21 | 1994-02-25 | Elf Sanofi | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
| DE4201709A1 (de) * | 1992-01-23 | 1993-07-29 | Bayer Ag | (alpha)-aryl-(alpha)-hydroxy-ss-imidazolinyl-propionsaeureamide |
| KR19990012061A (ko) * | 1997-07-26 | 1999-02-25 | 성재갑 | 파네실 전이효소 저해제로 유용한 하이덴토인 유도체 |
| US6384061B1 (en) * | 1997-07-26 | 2002-05-07 | Lg Chemical Ltd. | Hydantoin compounds and methods related thereto |
-
2003
- 2003-11-26 JP JP2004557589A patent/JP2006509015A/ja not_active Withdrawn
- 2003-11-26 AU AU2003298889A patent/AU2003298889A1/en not_active Abandoned
- 2003-11-26 WO PCT/US2003/038590 patent/WO2004050039A2/en not_active Ceased
- 2003-11-26 CA CA002508581A patent/CA2508581A1/en not_active Abandoned
- 2003-11-26 US US10/537,187 patent/US20060116366A1/en not_active Abandoned
- 2003-11-26 EP EP03796648A patent/EP1569915A4/en not_active Withdrawn
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