JP2006516622A5 - - Google Patents

Download PDF

Info

Publication number
JP2006516622A5
JP2006516622A5 JP2006502975A JP2006502975A JP2006516622A5 JP 2006516622 A5 JP2006516622 A5 JP 2006516622A5 JP 2006502975 A JP2006502975 A JP 2006502975A JP 2006502975 A JP2006502975 A JP 2006502975A JP 2006516622 A5 JP2006516622 A5 JP 2006516622A5
Authority
JP
Japan
Prior art keywords
group
groups
alkyl
optionally substituted
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006502975A
Other languages
English (en)
Japanese (ja)
Other versions
JP4560035B2 (ja
JP2006516622A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/001927 external-priority patent/WO2004069158A2/en
Publication of JP2006516622A publication Critical patent/JP2006516622A/ja
Publication of JP2006516622A5 publication Critical patent/JP2006516622A5/ja
Application granted granted Critical
Publication of JP4560035B2 publication Critical patent/JP4560035B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006502975A 2003-01-27 2004-01-23 置換ピラゾール、このような化合物を含有する組成物及び使用方法 Expired - Fee Related JP4560035B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44282803P 2003-01-27 2003-01-27
PCT/US2004/001927 WO2004069158A2 (en) 2003-01-27 2004-01-23 Substituted pyrazoles, compositions containing such compounds and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010027448A Division JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Publications (3)

Publication Number Publication Date
JP2006516622A JP2006516622A (ja) 2006-07-06
JP2006516622A5 true JP2006516622A5 (enExample) 2007-11-01
JP4560035B2 JP4560035B2 (ja) 2010-10-13

Family

ID=32850762

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006502975A Expired - Fee Related JP4560035B2 (ja) 2003-01-27 2004-01-23 置換ピラゾール、このような化合物を含有する組成物及び使用方法
JP2010027448A Expired - Fee Related JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010027448A Expired - Fee Related JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Country Status (8)

Country Link
US (2) US7572922B2 (enExample)
EP (1) EP1590336B1 (enExample)
JP (2) JP4560035B2 (enExample)
AT (1) ATE490244T1 (enExample)
AU (2) AU2004210127B2 (enExample)
CA (1) CA2513102C (enExample)
DE (1) DE602004030318D1 (enExample)
WO (1) WO2004069158A2 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572922B2 (en) 2003-01-27 2009-08-11 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
CA2520804A1 (en) 2003-04-03 2004-10-28 Merck & Co., Inc. Biaryl substituted pyrazoles as sodium channel blockers
CN1964947A (zh) 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
JP2008505905A (ja) 2004-07-07 2008-02-28 メルク エンド カムパニー インコーポレーテッド ピラゾールアミド誘導体、こうした化合物を含有する組成物および使用方法
CA2574147A1 (en) * 2004-07-22 2006-02-09 Linda Brockunier Substituted pyrazoles, compositions containing such compounds and methods of use
JP2008524246A (ja) 2004-12-16 2008-07-10 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CN101146762A (zh) 2005-03-21 2008-03-19 默克公司 取代的芳基和杂芳基衍生物
WO2006122319A2 (en) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007002563A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
WO2007015999A2 (en) * 2005-07-26 2007-02-08 Merck & Co., Inc. Process for synthesizing a substituted pyrazole
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
AR056574A1 (es) * 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
EP2001472A2 (en) 2006-03-23 2008-12-17 Merck and Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP2402317B1 (en) 2006-03-31 2013-07-03 Novartis AG DGAT inhibitor
JP2009537525A (ja) 2006-05-16 2009-10-29 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、このような化合物を含む組成物及び使用方法
WO2008073825A1 (en) * 2006-12-08 2008-06-19 Exelixis, Inc. Lxr and fxr modulators
JPWO2008093639A1 (ja) 2007-01-29 2010-05-20 武田薬品工業株式会社 ピラゾール化合物
WO2008098244A1 (en) 2007-02-09 2008-08-14 Metabasis Therapeutics, Inc. Novel antagonists of the glucagon receptor
WO2009015897A1 (en) 2007-08-02 2009-02-05 Recordati Ireland Limited Novel heterocyclic compounds as mglu5 antagonists
US8232413B2 (en) * 2007-09-12 2012-07-31 Merck Sharp & Dohme Corp. Process for the production of a crystalline glucagon receptor antagonist compound
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
EP2210876B1 (en) 2007-11-01 2015-05-20 Takeda Pharmaceutical Company Limited Heterocyclic compound as glucagon antagonist
NZ586190A (en) 2007-12-26 2013-05-31 Elster Electricity Llc A utility meter network wherein meters can transmit electrical and other readings to a collector by using other meters as repeaters
BRPI0912245A2 (pt) * 2008-03-05 2019-09-24 Takeda Pharmaceuticals Co composto, prodroga, medicamento, métodos de suprimir produção de açúcar em um mamífero e para a profilaxia ou o tratamento de diabetes em um mamífero, e, uso do composto
CA2724294A1 (en) 2008-05-16 2009-11-19 Schering Corporation Glucagon receptor antagonists, compositions, and methods for their use
JPWO2010007943A1 (ja) * 2008-07-17 2012-01-05 旭化成ファーマ株式会社 含窒素複素環化合物
CN104803891B (zh) 2008-08-13 2017-10-20 症变治疗公司 胰高血糖素拮抗剂
US8436015B2 (en) * 2008-09-15 2013-05-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
AR073412A1 (es) * 2008-10-03 2010-11-03 Schering Corp Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende.
EP2344467A1 (en) * 2008-10-10 2011-07-20 Lonza Ltd. Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans
WO2010093535A1 (en) 2009-02-12 2010-08-19 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8318667B2 (en) 2009-02-25 2012-11-27 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8470773B2 (en) 2009-06-12 2013-06-25 Merck Sharp & Dohme Corp. Thiophenes as glucagon receptor antagonists, compositions, and methods for their use
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
WO2011143057A1 (en) 2010-05-11 2011-11-17 Merck Sharp & Dohme Corp. Novel prolylcarboxypeptidase inhibitors
WO2012003405A1 (en) * 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
NZ609955A (en) 2010-11-09 2015-05-29 Ironwood Pharmaceuticals Inc Sgc stimulators
MX2013006768A (es) 2010-12-23 2013-07-22 Pfizer Moduladores de receptor de glucagon.
ES2597972T3 (es) 2011-02-08 2017-01-24 Pfizer Inc Modulador del receptor de glucagón
RU2013157388A (ru) 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
CN104066731B (zh) * 2011-12-27 2016-06-15 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
EP3065736B1 (en) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
JP2017519000A (ja) 2014-06-12 2017-07-13 リガンド・ファーマシューティカルズ・インコーポレイテッド グルカゴンアンタゴニスト
TW201811752A (zh) * 2016-09-06 2018-04-01 比利時商健生藥品公司 用作升糖素受體拮抗劑之吲唑衍生物
TWI757332B (zh) * 2016-09-06 2022-03-11 比利時商健生藥品公司 使用作為升糖素受體拮抗劑之吲唑衍生物
JP2021513564A (ja) 2018-02-13 2021-05-27 リガンド・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体拮抗薬
WO2023122780A2 (en) * 2021-12-23 2023-06-29 The Katholieke Universiteit Leuven 2-pyrazole anilines and related analogs for inhibiting yap/taz-tead
WO2025034531A1 (en) * 2023-08-04 2025-02-13 The University Of Vermont And State Agricultural College Small molecule allosteric modulator to pac1 receptor and uses thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9303993D0 (en) 1993-02-26 1993-04-14 Fujisawa Pharmaceutical Co New heterocyclic derivatives
BE1009189A3 (fr) * 1995-03-14 1996-12-03 Solvay Procede pour la fabrication d'un corps creux.
WO1997016442A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US5776954A (en) 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
WO1998022108A1 (en) 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles and methods of use
WO1998021957A1 (en) 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
AU730295B2 (en) 1996-11-20 2001-03-01 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
EP0945438B1 (en) 1996-12-12 2003-03-05 Banyu Pharmaceutical Co., Ltd. Pyrazole derivatives
ID23687A (id) 1997-04-18 2000-05-11 Searle & Co Metode penggunaan penghambat siklooksigenase-2 dalam pencegahan penyakit kardiovaskuler
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6420427B1 (en) 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
DE69839278T2 (de) 1997-12-19 2008-09-11 Amgen Inc., Thousand Oaks Substituierte pyridin- und pyridazinderivate und ihre pharmazeutische verwendung
CA2344300A1 (en) 1998-09-17 2000-03-23 Jeffrey A. Robl Method for treating atherosclerosis employing an ap2 inhibitor and combination
BR0010651A (pt) 1999-05-17 2002-03-19 Novo Nordisk As Composto, uso de um composto, composição farmacêutica, e, método para o tratamento e/ou prevenção de distúrbios ou de doenças mediadas por uma ação antagonìstica de glucagon
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
CA2381532A1 (en) * 1999-08-10 2001-02-15 Akihiko Yanagi Herbicidal tetrazolinone derivatives
ES2225252T3 (es) * 1999-11-10 2005-03-16 Takeda Chemical Industries, Ltd. Compuestos n-heterociclicos de 5 miembros con actividad hipoglucemica e hipolipidemica.
WO2002000612A1 (en) 2000-06-23 2002-01-03 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
JP2004513076A (ja) 2000-07-25 2004-04-30 メルク エンド カムパニー インコーポレーテッド 糖尿病治療で有用なn−置換インドール類
US20030203946A1 (en) 2000-11-17 2003-10-30 Carsten Behrens Glucagon antagonists/inverse agonists
AU2002223501A1 (en) 2000-11-17 2002-05-27 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
ITMI20010733A1 (it) 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
EP1463715A1 (en) 2001-12-03 2004-10-06 Novo Nordisk A/S Novel glucagon antagonists
US6881746B2 (en) 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
US6762318B2 (en) 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
AU2002351730A1 (en) 2001-12-19 2003-06-30 Novo Nordisk A/S Glucagon receptor antagonists/inverse agonists
AU2002347022A1 (en) 2001-12-20 2003-07-09 Novo Nordisk A/S Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten
BR0307409A (pt) 2002-02-01 2004-12-28 Dainippon Pharmaceutical Co Compostos de hidrazida de ácido 2-furanocarboxìlico, composições farmacêuticas contendo os mesmos e uso dos mesmos para preparação de um agente preventivo ou terapêutico
JP2006500325A (ja) 2002-06-27 2006-01-05 ノボ ノルディスク アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
JP4890761B2 (ja) 2002-07-19 2012-03-07 バクスター・インターナショナル・インコーポレイテッド 腹膜透析を実施するためのシステムおよび方法
EP1400243A1 (en) 2002-09-19 2004-03-24 Tanabe Seiyaku Co., Ltd. Calcium-activated K channel activator
CA2508581A1 (en) 2002-12-04 2004-06-17 Merck & Co., Inc. Spirocyclic ureas, compositions containing such compounds and methods of use
US7572922B2 (en) 2003-01-27 2009-08-11 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
DE10317108A1 (de) 2003-04-14 2004-11-11 Mutzbauer, Till S., Dr. Dr.med. Transdermal applizierbares Beruhigungs- und Sedierungsmittel
WO2004092146A2 (en) 2003-04-14 2004-10-28 The Institutes For Pharmaceutical Discovery, Llc N- (((((1,3-thiazol-2-yl) amino) carbonyl) phenyl) sulfonyl) phenylalanine derivatives and related compounds for the treatment of diabetes
CN1784226A (zh) 2003-05-09 2006-06-07 麦克公司 苯并咪唑化合物、含有苯并咪唑化合物的组合物以及使用方法
CN1964947A (zh) 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
CA2574147A1 (en) * 2004-07-22 2006-02-09 Linda Brockunier Substituted pyrazoles, compositions containing such compounds and methods of use
AR056574A1 (es) 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso

Similar Documents

Publication Publication Date Title
CA2513102A1 (en) Substituted pyrazoles, compositions containing such compounds and methods of use
TWI354666B (en) Heterocyclic aspartyl protease inhibitors
JP2006509015A5 (enExample)
CA2557538A1 (en) Benzimidazole derivative and use as an angiotensin ii receptor antagonist
KR940701383A (ko) 질소 함유 헤테로사이클릭 화합물의 플루오로알콕시벤질아미노 유도체
JP2013528602A5 (enExample)
JP2008513498A5 (enExample)
RU2011105422A (ru) Дейтерированные бензилбензольные производные и способы применения
JP2008526724A5 (enExample)
AR065276A1 (es) Herbicidas de n-oxidos de piridina sustituidos
RU2009126745A (ru) Производные сульфонилфенил-2н-{1,2,4}оксадиазол-5-она, способы их получения и их применение в качестве фармацевтических средств
PE20071009A1 (es) Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3
JP2002535323A5 (enExample)
JP2009528271A5 (enExample)
JP2009535358A5 (enExample)
JP2008513516A5 (enExample)
JP2009521483A5 (enExample)
JP2011520969A5 (enExample)
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
JP2011511840A5 (enExample)
AR056155A1 (es) Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
JP2009533410A5 (enExample)
TW202334116A (zh) 一種取代的苯丙酸衍生物及其用途
EP1325921A3 (en) Oxo or oxy-pyridine compounds as 5-HT4 receptor modulators
DE602004030004D1 (de) Verbindungen zur behandlung von stoffwechselstörungen