|
CN102985557B
(zh)
|
2009-03-13 |
2018-06-15 |
安吉奥斯医药品有限公司 |
用于细胞增殖相关病症的方法和组合物
|
|
JP5756457B2
(ja)
|
2009-04-06 |
2015-07-29 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
ピルビン酸キナーゼm2調節剤、治療組成物および関連する使用方法
|
|
DK2448581T3
(en)
|
2009-06-29 |
2017-03-13 |
Agios Pharmaceuticals Inc |
Therapeutic compositions and methods for their applications
|
|
PE20120693A1
(es)
|
2009-06-29 |
2012-07-04 |
Agios Pharmaceuticals Inc |
Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
|
|
EP2525790B1
(en)
|
2009-10-21 |
2020-05-27 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
WO2011050210A1
(en)
|
2009-10-21 |
2011-04-28 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
US9221792B2
(en)
|
2010-12-17 |
2015-12-29 |
Agios Pharmaceuticals, Inc |
N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
|
|
WO2012088314A1
(en)
|
2010-12-21 |
2012-06-28 |
Agios Pharmaceuticals, Inc. |
Bicyclic pkm2 activators
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
PT3406251T
(pt)
|
2011-05-03 |
2024-01-24 |
Agios Pharmaceuticals Inc |
Ativadores da piruvato-cinase para utilização em terapia
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN102827170A
(zh)
*
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
MX342326B
(es)
|
2011-09-27 |
2016-09-26 |
Novartis Ag |
3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
|
|
SMT201800334T1
(it)
|
2012-01-06 |
2018-09-13 |
Agios Pharmaceuticals Inc |
Composti terapeuticamente attivi e loro metodi di utilizzo
|
|
US9474779B2
(en)
|
2012-01-19 |
2016-10-25 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their methods of use
|
|
UY34632A
(es)
|
2012-02-24 |
2013-05-31 |
Novartis Ag |
Compuestos de oxazolidin- 2- ona y usos de los mismos
|
|
WO2014062511A1
(en)
|
2012-10-15 |
2014-04-24 |
Agios Pharmaceuticals, Inc. |
Therapeutic compounds and compositions
|
|
US9296733B2
(en)
|
2012-11-12 |
2016-03-29 |
Novartis Ag |
Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
|
|
CA2903979A1
(en)
*
|
2013-03-14 |
2014-09-18 |
Novartis Ag |
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
|
|
US20160113911A1
(en)
|
2013-06-06 |
2016-04-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
|
WO2015003355A2
(en)
*
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
WO2015003360A2
(en)
|
2013-07-11 |
2015-01-15 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
CN105593215B
(zh)
|
2013-07-11 |
2019-01-15 |
安吉奥斯医药品有限公司 |
用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物
|
|
MX375030B
(es)
|
2013-07-11 |
2025-03-06 |
Agios Pharmaceuticals Inc |
Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer.
|
|
WO2015010297A1
(en)
|
2013-07-25 |
2015-01-29 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds and their methods of use
|
|
LT3077395T
(lt)
|
2013-12-05 |
2018-02-12 |
Pfizer Inc. |
Pirolo[2,3-d]pirimidinilo, pirolo[2,3-b]pirazinilo ir pirolo[2,3-d]piridinilo akrilamidai
|
|
CN105980365B
(zh)
|
2014-02-11 |
2019-06-21 |
拜耳医药股份公司 |
作为mIDH1抑制剂的苯并咪唑-2-胺
|
|
PE20170143A1
(es)
|
2014-02-11 |
2017-03-19 |
Bayer Pharma AG |
Benzimidazol-2-aminas como inhibidores de midh1
|
|
PH12021551647A1
(en)
|
2014-03-14 |
2022-06-06 |
Agios Pharmaceuticals Inc |
Pharmaceutical compositions of therapeutically active compounds
|
|
ES2913282T3
(es)
*
|
2014-05-09 |
2022-06-01 |
Shanghai Syncores Tech Inc Ltd |
Producto intermedio de vortioxetina y procedimiento de síntesis del mismo
|
|
CA2961807A1
(en)
*
|
2014-09-19 |
2016-03-24 |
Forma Therapeutics, Inc. |
Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
|
|
WO2016044781A1
(en)
|
2014-09-19 |
2016-03-24 |
Forma Therapeutics, Inc. |
Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
|
|
WO2016044787A1
(en)
*
|
2014-09-19 |
2016-03-24 |
Forma Therapeutics, Inc. |
Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
|
|
HUE062424T2
(hu)
*
|
2014-09-19 |
2023-11-28 |
Forma Therapeutics Inc |
Piridin-2(1H)-on kinolinon származékok mint mutáns izocitrát dehidrogenáz inhibitorok
|
|
ES2905564T3
(es)
|
2014-12-22 |
2022-04-11 |
Us Health |
Inhibidores mutantes de IDH1 útiles para tratar el cáncer
|
|
US9624175B2
(en)
*
|
2015-04-21 |
2017-04-18 |
Forma Therapeutics, Inc. |
Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
|
|
US10407419B2
(en)
|
2015-04-21 |
2019-09-10 |
Forma Therapeutics, Inc. |
Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors
|
|
MX384883B
(es)
|
2015-06-11 |
2025-03-14 |
Agios Pharmaceuticals Inc |
Métodos para usar activadores de piruvato cinasa.
|
|
JP2018525413A
(ja)
*
|
2015-08-24 |
2018-09-06 |
ザ メソディスト ホスピタル |
ユーイングファミリー腫瘍を治療する組成物及び方法
|
|
MD3362066T2
(ro)
|
2015-10-15 |
2022-08-31 |
Les Laboratoires Servier Sas |
Terapie combinată pentru tratamentul tumorilor maligne
|
|
HUE067449T2
(hu)
|
2015-10-15 |
2024-10-28 |
Servier Lab |
Ivozidenib, citarabin és daunorubicin vagy idarubicin kombinációs terápa akut mielogén leukémia kezelésére
|
|
MX2018008169A
(es)
*
|
2015-12-30 |
2019-02-20 |
Agios Pharmaceuticals Inc |
Tratamiento de tumores que incorpora isocitrato deshidrogenasa mutante.
|
|
WO2017153952A1
(en)
*
|
2016-03-10 |
2017-09-14 |
Glaxosmithkline Intellectual Property Development Limited |
5-sulfamoyl-2-hydroxybenzamide derivatives
|
|
EP3444237B1
(en)
|
2016-03-22 |
2020-10-28 |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
Iridinesulfonamide compound and use method thereof
|
|
US20180369206A1
(en)
|
2017-04-24 |
2018-12-27 |
Aurigene Discovery Technologies Limited |
Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
|
|
CA3060390A1
(en)
*
|
2017-04-24 |
2018-11-01 |
Aurigene Discovery Technologies Limited |
Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
|
|
CN109897044A
(zh)
*
|
2017-12-07 |
2019-06-18 |
北京大学 |
抗神经病理性疼痛化合物及其制备方法
|
|
CA3091792A1
(en)
|
2018-02-20 |
2019-08-29 |
Agios Pharmaceuticals, Inc. |
Methods of use for trisubstituted benzotriazole derivatives
|
|
US11013734B2
(en)
|
2018-05-16 |
2021-05-25 |
Forma Therapeutics, Inc. |
Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation
|
|
US11013733B2
(en)
|
2018-05-16 |
2021-05-25 |
Forma Therapeutics, Inc. |
Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
|
|
WO2019222551A1
(en)
|
2018-05-16 |
2019-11-21 |
Forma Therapeutics, Inc. |
Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
|
|
US11311527B2
(en)
|
2018-05-16 |
2022-04-26 |
Forma Therapeutics, Inc. |
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
|
|
SMT202300073T1
(it)
|
2018-05-16 |
2023-05-12 |
Forma Therapeutics Inc |
Inibizione di idh-1 mutante
|
|
CN108822082B
(zh)
*
|
2018-06-06 |
2020-11-03 |
青岛科技大学 |
一种含氟吡啶哌嗪酰胺类化合物及其应用
|
|
US10980788B2
(en)
|
2018-06-08 |
2021-04-20 |
Agios Pharmaceuticals, Inc. |
Therapy for treating malignancies
|
|
CN116768806B
(zh)
*
|
2022-03-11 |
2026-01-02 |
中国农业大学 |
取代的1,2,3-三唑类化合物及其制备方法和在防治植物病害中的用途
|
|
CN114685399A
(zh)
*
|
2022-04-26 |
2022-07-01 |
河北广祥制药有限公司 |
一种乌拉地尔中间体1-(2-甲氧基苯基)哌嗪及其盐的制备方法
|
|
CN116425653A
(zh)
*
|
2023-03-22 |
2023-07-14 |
烟台盛凯伦化学科技有限公司 |
一种n,n’-二(对乙氧基苯基)-1,4-苯二甲亚胺的制备方法
|
|
WO2024238709A2
(en)
*
|
2023-05-18 |
2024-11-21 |
Concarlo Therapeutics, Inc. |
Small molecule inhibitors of p27
|
|
WO2026088050A1
(en)
*
|
2024-10-23 |
2026-04-30 |
Fondazione Per L'istituto Oncologico Di Ricerca (Ior) |
Small molecule inhibitor of foxa1 and foxa2 for the treatment of foxa1/foxa2-dependent cancers or other diseases
|