JP2007518822A5 - - Google Patents
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- Publication number
- JP2007518822A5 JP2007518822A5 JP2006551391A JP2006551391A JP2007518822A5 JP 2007518822 A5 JP2007518822 A5 JP 2007518822A5 JP 2006551391 A JP2006551391 A JP 2006551391A JP 2006551391 A JP2006551391 A JP 2006551391A JP 2007518822 A5 JP2007518822 A5 JP 2007518822A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- group
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53898004P | 2004-01-23 | 2004-01-23 | |
| PCT/US2005/002270 WO2005070930A2 (en) | 2004-01-23 | 2005-01-24 | Tetrahydrocarboline compounds as anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007518822A JP2007518822A (ja) | 2007-07-12 |
| JP2007518822A5 true JP2007518822A5 (enExample) | 2008-01-31 |
Family
ID=34807249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551391A Pending JP2007518822A (ja) | 2004-01-23 | 2005-01-24 | 抗癌剤としてのテトラヒドロカルボリン化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7855295B2 (enExample) |
| EP (1) | EP1706404A2 (enExample) |
| JP (1) | JP2007518822A (enExample) |
| CN (1) | CN1910183A (enExample) |
| AU (1) | AU2005206570A1 (enExample) |
| BR (1) | BRPI0506977A (enExample) |
| CA (1) | CA2554150A1 (enExample) |
| MX (1) | MXPA06008211A (enExample) |
| WO (1) | WO2005070930A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4671123B2 (ja) * | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| PL1737461T3 (pl) | 2004-03-15 | 2013-05-31 | Ptc Therapeutics Inc | Pochodne karbolinowe użyteczne w hamowaniu angiogenezy |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| DK1829874T3 (da) | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co | Tricyklisk forbindelse og anvendelse deraf |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| EP2214485B1 (en) * | 2007-09-25 | 2016-07-20 | Minerva Biotechnologies Corp. | Methods for treatment of cancer |
| US11202775B2 (en) | 2007-09-25 | 2021-12-21 | Minerva Biotechnologies Corporation | Methods for treatment of cancer |
| EP2050747A1 (en) * | 2007-10-12 | 2009-04-22 | BioAlliance Pharma | Dimers of harmol or of its derivatives and uses thereof |
| EP2476680B1 (en) | 2008-01-11 | 2014-08-27 | Albany Molecular Research, Inc. | (1-Azinone)-Substituted Pyridoindoles |
| CN101591348B (zh) * | 2008-05-30 | 2011-07-27 | 首都医科大学 | 四氢咔啉酰氨基酸苄酯及其制备方法和应用 |
| CN101597289B (zh) * | 2008-06-02 | 2011-09-21 | 首都医科大学 | 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用 |
| EP2434891B9 (en) | 2009-05-27 | 2021-05-05 | PTC Therapeutics, Inc. | Methods for treating cancer and non-neoplastic conditions |
| SG176260A1 (en) | 2009-05-27 | 2012-01-30 | Ptc Therapeutics Inc | Processes for the preparation of substituted tetrahydro beta-carbolines |
| WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
| US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| US9073925B2 (en) * | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8618299B2 (en) * | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| JP2012532144A (ja) * | 2009-07-01 | 2012-12-13 | アルバニー モレキュラー リサーチ， インコーポレイテッド | アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用 |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| US9006246B2 (en) | 2010-07-06 | 2015-04-14 | Ono Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
| TW201309698A (zh) | 2011-03-18 | 2013-03-01 | Ono Pharmaceutical Co | 四氫咔啉衍生物 |
| JP6248048B2 (ja) * | 2012-01-09 | 2017-12-13 | エックス−アールエックス，インコーポレーテッド | キナーゼ阻害活性を有するトリプトリン誘導体及びその使用 |
| CN103087062B (zh) * | 2013-01-19 | 2015-06-03 | 安徽师范大学 | N-磺酰基取代-β-四氢咔啉衍生物的制备方法 |
| PE20160874A1 (es) | 2013-05-28 | 2016-09-04 | Astrazeneca Ab | Compuestos quimicos |
| US11931347B2 (en) * | 2015-09-23 | 2024-03-19 | Minerva Biotechnologies Corporation | Method of screening for agents for differentiating stem cells |
| JP2019001715A (ja) * | 2015-10-30 | 2019-01-10 | 協和発酵キリン株式会社 | 三環性化合物 |
| CA3011391C (en) * | 2015-11-12 | 2021-02-09 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Acrylic acid derivative, preparation method and use in medicine thereof |
| CN106967063B (zh) * | 2017-03-21 | 2019-01-11 | 浙江大学 | 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法 |
| US11458126B2 (en) | 2017-08-01 | 2022-10-04 | Ptc Therapeutics, Inc. | DHODH inhibitor for use in treating hematologic cancers |
| EP3860996A4 (en) | 2018-10-02 | 2022-08-31 | Northwestern University | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) |
| CN110791389B (zh) * | 2019-09-30 | 2021-06-01 | 义乌欧风汽车用品有限公司 | 一种除胶剂及其制备方法和应用 |
| JP2025501285A (ja) * | 2021-12-31 | 2025-01-17 | ピーティーシー セラピューティクス， インコーポレイテッド | カルボリン化合物及びその使用 |
| WO2024099898A1 (en) * | 2022-11-07 | 2024-05-16 | Merck Patent Gmbh | Substituted bi-and tricyclic hset inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300541B1 (en) | 1987-07-20 | 1996-03-27 | Duphar International Research B.V | 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives |
| EP0357122A3 (en) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties |
| JPH03287586A (ja) | 1990-04-02 | 1991-12-18 | Taisho Pharmaceut Co Ltd | テトラヒドロ―β―カルボリン誘導体 |
| JP3287586B2 (ja) | 1991-07-09 | 2002-06-04 | キヤノン株式会社 | カラー画像処理方法、及びカラー画像処理装置 |
| US5206377A (en) * | 1991-12-05 | 1993-04-27 | Whitby Research, Inc. | Compounds useful as antiproliferative agents |
| US5622960A (en) | 1992-04-14 | 1997-04-22 | The United States Of America As Represented By The Department Of Health And Human Services | Topoisomerase II inhibitors and therapeutic uses therefor |
| JP2000508302A (ja) * | 1996-04-04 | 2000-07-04 | エフ．ホフマン―ラ ロッシュ エイジー | 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用 |
| FR2796644B1 (fr) | 1999-07-23 | 2001-09-07 | Adir | Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| US6720331B2 (en) * | 2001-04-03 | 2004-04-13 | National Sun Yat-Sen University | 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents |
| EP1438310B1 (en) * | 2001-10-19 | 2006-12-20 | TransTech Pharma Inc. | Beta-carbolin derivatives as ptp-inhibitors |
-
2005
- 2005-01-24 MX MXPA06008211A patent/MXPA06008211A/es unknown
- 2005-01-24 CN CNA2005800030203A patent/CN1910183A/zh active Pending
- 2005-01-24 WO PCT/US2005/002270 patent/WO2005070930A2/en not_active Ceased
- 2005-01-24 EP EP05711958A patent/EP1706404A2/en not_active Withdrawn
- 2005-01-24 AU AU2005206570A patent/AU2005206570A1/en not_active Abandoned
- 2005-01-24 CA CA002554150A patent/CA2554150A1/en not_active Abandoned
- 2005-01-24 JP JP2006551391A patent/JP2007518822A/ja active Pending
- 2005-01-24 BR BRPI0506977-7A patent/BRPI0506977A/pt not_active IP Right Cessation
- 2005-01-24 US US11/042,474 patent/US7855295B2/en not_active Expired - Fee Related
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