JP2012503008A5 - - Google Patents
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- Publication number
- JP2012503008A5 JP2012503008A5 JP2011527977A JP2011527977A JP2012503008A5 JP 2012503008 A5 JP2012503008 A5 JP 2012503008A5 JP 2011527977 A JP2011527977 A JP 2011527977A JP 2011527977 A JP2011527977 A JP 2011527977A JP 2012503008 A5 JP2012503008 A5 JP 2012503008A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydroxy
- substituted
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 hydroxy, phenyl Chemical group 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001408 amides Chemical group 0.000 claims 3
- 150000001412 amines Chemical group 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 210000001320 hippocampus Anatomy 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 210000001176 projection neuron Anatomy 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9808808P | 2008-09-18 | 2008-09-18 | |
| US61/098,088 | 2008-09-18 | ||
| PCT/US2009/057401 WO2010033757A1 (en) | 2008-09-18 | 2009-09-18 | Nmda receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503008A JP2012503008A (ja) | 2012-02-02 |
| JP2012503008A5 true JP2012503008A5 (enExample) | 2012-11-08 |
| JP5702288B2 JP5702288B2 (ja) | 2015-04-15 |
Family
ID=42039880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527977A Expired - Fee Related JP5702288B2 (ja) | 2008-09-18 | 2009-09-18 | Ｎｍｄａレセプターモジュレータ及びその用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US20110306586A1 (enExample) |
| EP (1) | EP2331571B1 (enExample) |
| JP (1) | JP5702288B2 (enExample) |
| KR (1) | KR101769999B1 (enExample) |
| CN (1) | CN102186883B (enExample) |
| AU (1) | AU2009293164B2 (enExample) |
| BR (1) | BRPI0918868B8 (enExample) |
| CA (1) | CA2740628C (enExample) |
| ES (1) | ES2553968T3 (enExample) |
| IL (1) | IL211802A (enExample) |
| MX (1) | MX2011003015A (enExample) |
| RU (1) | RU2515615C2 (enExample) |
| WO (1) | WO2010033757A1 (enExample) |
Families Citing this family (32)
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| JP2008188285A (ja) * | 2007-02-06 | 2008-08-21 | Bridgestone Corp | バックパッド及び車両用シート |
| CA2740628C (en) | 2008-09-18 | 2018-05-01 | Naurex, Inc. | Nmda receptor modulators and uses thereof |
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| US9101612B2 (en) | 2010-02-11 | 2015-08-11 | Northwestern University | Secondary structure stabilized NMDA receptor modulators and uses thereof |
| KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| KR20200043534A (ko) * | 2011-04-27 | 2020-04-27 | 노오쓰웨스턴 유니버시티 | 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 |
| EP3514158B1 (en) * | 2013-01-29 | 2022-10-12 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| EA031905B1 (ru) | 2013-01-29 | 2019-03-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
| CA2898774C (en) * | 2013-01-29 | 2021-07-13 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| US9708335B2 (en) * | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| CA2899010A1 (en) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
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| CN104546809B (zh) * | 2015-01-13 | 2018-08-24 | 西安力邦制药有限公司 | 3,3’,5,5’-四异丙基-4,4’-二联苯酚在预防及治疗缺血性脑卒中中的应用 |
| US10583171B2 (en) | 2015-11-30 | 2020-03-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | NMDAR antagonists for the treatment of diseases associated with angiogenesis |
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| JP7032378B2 (ja) | 2016-08-01 | 2022-03-08 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| EP3490974B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda receptor modulators and uses thereof |
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| CN112218866A (zh) * | 2018-01-31 | 2021-01-12 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
| WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| AU2019215058A1 (en) | 2018-01-31 | 2020-09-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| MX2022000069A (es) * | 2019-06-24 | 2022-05-24 | Naurex Inc | Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidroxi-1-oxobutan-2-il )-1-oxo 2,5-diazaspiro[3.4]octano-5-carboxilato de terc-butilo y métodos para prepararlas. |
| CN114269338B (zh) * | 2019-06-24 | 2025-02-18 | 诺雷克斯股份有限公司 | 生产二氮杂螺内酰胺化合物的方法和中间体 |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| US9708335B2 (en) | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| EP3514158B1 (en) | 2013-01-29 | 2022-10-12 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| CA2898774C (en) | 2013-01-29 | 2021-07-13 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| CA2899010A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| MX378566B (es) | 2016-05-19 | 2025-03-11 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos. |
| JP7032378B2 (ja) | 2016-08-01 | 2022-03-08 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| EP3490974B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda receptor modulators and uses thereof |
| KR102462288B1 (ko) | 2016-08-01 | 2022-11-01 | 앱티닉스 인크. | 스피로-락탐 및 비스-스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
| JP2019527233A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
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2009
- 2009-09-18 CA CA2740628A patent/CA2740628C/en active Active
- 2009-09-18 CN CN200980141061.7A patent/CN102186883B/zh not_active Expired - Fee Related
- 2009-09-18 BR BRPI0918868A patent/BRPI0918868B8/pt not_active IP Right Cessation
- 2009-09-18 ES ES09815233.3T patent/ES2553968T3/es active Active
- 2009-09-18 AU AU2009293164A patent/AU2009293164B2/en not_active Ceased
- 2009-09-18 WO PCT/US2009/057401 patent/WO2010033757A1/en not_active Ceased
- 2009-09-18 KR KR1020117008824A patent/KR101769999B1/ko not_active Expired - Fee Related
- 2009-09-18 EP EP09815233.3A patent/EP2331571B1/en active Active
- 2009-09-18 JP JP2011527977A patent/JP5702288B2/ja not_active Expired - Fee Related
- 2009-09-18 MX MX2011003015A patent/MX2011003015A/es active IP Right Grant
- 2009-09-18 RU RU2011114982/04A patent/RU2515615C2/ru active
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2011
- 2011-03-17 IL IL211802A patent/IL211802A/en active IP Right Grant
- 2011-03-18 US US13/051,237 patent/US20110306586A1/en not_active Abandoned
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2013
- 2013-10-10 US US14/050,641 patent/US9512133B2/en not_active Expired - Fee Related
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2014
- 2014-12-23 US US14/580,803 patent/US9802946B2/en not_active Expired - Fee Related
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2017
- 2017-10-17 US US15/785,603 patent/US10906913B2/en not_active Expired - Fee Related
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2020
- 2020-12-04 US US17/111,657 patent/US20210332061A1/en not_active Abandoned
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