JP2005527593A5 - - Google Patents
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- Publication number
- JP2005527593A5 JP2005527593A5 JP2003586132A JP2003586132A JP2005527593A5 JP 2005527593 A5 JP2005527593 A5 JP 2005527593A5 JP 2003586132 A JP2003586132 A JP 2003586132A JP 2003586132 A JP2003586132 A JP 2003586132A JP 2005527593 A5 JP2005527593 A5 JP 2005527593A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chloro
- trifluoromethylbenzamide
- phenyl
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011282 treatment Methods 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- -1 1-ethylpiperidin-2-yl Chemical group 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 206010000117 Abnormal behaviour Diseases 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000002877 Epileptic Syndromes Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000003556 anti-epileptic effect Effects 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000009329 sexual behaviour Effects 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0204916A FR2838739B1 (fr) | 2002-04-19 | 2002-04-19 | Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique |
| PCT/FR2003/001232 WO2003089411A1 (fr) | 2002-04-19 | 2003-04-17 | Derives de n-[phenyl(piperidin-2-yl)methyl] benzamide, leur preparation et leur application en therapeutique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005527593A JP2005527593A (ja) | 2005-09-15 |
| JP2005527593A5 true JP2005527593A5 (enExample) | 2006-06-08 |
| JP4597532B2 JP4597532B2 (ja) | 2010-12-15 |
Family
ID=28686193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586132A Expired - Fee Related JP4597532B2 (ja) | 2002-04-19 | 2003-04-17 | Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体類、それらの製造方法および治療におけるそれらの使用 |
Country Status (35)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861070B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
| US7202269B2 (en) | 2003-10-30 | 2007-04-10 | Janssen Pharmaceutica N.V. | GlyT2 modulators |
| WO2005092442A2 (en) * | 2004-03-22 | 2005-10-06 | Apkarian Vania A | Method and compositions for treatment of chronic neuropathic pain |
| CN101189228A (zh) * | 2005-04-08 | 2008-05-28 | 辉瑞产品有限公司 | 用作i型甘氨酸转运抑制剂的二环[3.1.0]杂芳酰胺 |
| JP2009179562A (ja) * | 2006-08-11 | 2009-08-13 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害剤 |
| FR2917735B1 (fr) * | 2007-06-21 | 2009-09-04 | Sanofi Aventis Sa | Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique |
| WO2009013535A1 (en) * | 2007-07-23 | 2009-01-29 | Astrazeneca Ab | 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor |
| EP2178842A2 (en) | 2007-08-22 | 2010-04-28 | Abbott GmbH & Co. KG | 4-benzylaminoquinolines, pharmaceutical compositions containing them and their use |
| EP2527328A1 (en) | 2008-04-01 | 2012-11-28 | Abbott GmbH & Co. KG | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| AR075182A1 (es) * | 2009-01-28 | 2011-03-16 | Astrazeneca Ab | Compuestos 2-aza-biciclo (2.2.2) octano y sus usos |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| TW201038569A (en) | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| JP5618047B2 (ja) * | 2010-01-29 | 2014-11-05 | 国立大学法人千葉大学 | ポジトロン断層撮影法およびポジトロン放出化合物 |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| PE20140868A1 (es) | 2011-06-24 | 2014-07-18 | Amgen Inc | Antagonistas trpm8 y su uso en tratamientos |
| CA2839703A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| CN103889968A (zh) | 2011-08-05 | 2014-06-25 | 艾伯维德国有限责任两合公司 | 氨基苯并二氢吡喃、氨基苯并二氢噻喃及氨基-1,2,3,4-四氢喹啉衍生物，包含这些化合物的药用组合物，及其在治疗中的用途 |
| MX2014006004A (es) | 2011-11-18 | 2015-04-16 | Abbvie Deutschland | Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia. |
| FR2983197B1 (fr) * | 2011-11-29 | 2014-07-25 | Assist Publ Hopitaux De Paris | Utilisation de phacetoperane pour traiter un trouble deficit de l'attention hyperactivite |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| AU2014336154A1 (en) | 2013-10-17 | 2016-04-28 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2016537323A (ja) | 2013-10-17 | 2016-12-01 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノクロマン誘導体、アミノチオクロマン誘導体およびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用 |
| US9550754B2 (en) | 2014-09-11 | 2017-01-24 | AbbVie Deutschland GmbH & Co. KG | 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US20170143681A1 (en) | 2015-11-02 | 2017-05-25 | Apkarian Technologies Llc | Methods and compositions for treating pain |
| FR3045044B1 (fr) * | 2015-12-11 | 2019-04-19 | Liphatech | Composition et appat rodonticide comprenant du flocoumafene, procede de lutte contre des rongeurs cibles nuisibles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254569A (en) * | 1991-01-14 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | (Amidomethyl)nitrogen heterocyclic analgesics |
| JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| US5524569A (en) * | 1995-03-20 | 1996-06-11 | Rich; William A. | Anchor cover |
| WO1999045011A1 (en) * | 1998-03-06 | 1999-09-10 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
| CA2406652A1 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
-
2002
- 2002-04-19 FR FR0204916A patent/FR2838739B1/fr not_active Expired - Fee Related
-
2003
- 2003-04-15 AR ARP030101310A patent/AR039413A1/es unknown
- 2003-04-17 DE DE60313602T patent/DE60313602T2/de not_active Expired - Lifetime
- 2003-04-17 EP EP03740634A patent/EP1499589B1/fr not_active Expired - Lifetime
- 2003-04-17 PT PT03740634T patent/PT1499589E/pt unknown
- 2003-04-17 WO PCT/FR2003/001232 patent/WO2003089411A1/fr not_active Ceased
- 2003-04-17 PL PL03373195A patent/PL373195A1/xx not_active IP Right Cessation
- 2003-04-17 IL IL16440003A patent/IL164400A0/xx unknown
- 2003-04-17 AU AU2003262420A patent/AU2003262420B2/en not_active Ceased
- 2003-04-17 UA UA20041008110A patent/UA78025C2/uk unknown
- 2003-04-17 NZ NZ536015A patent/NZ536015A/en not_active IP Right Cessation
- 2003-04-17 DK DK03740634T patent/DK1499589T3/da active
- 2003-04-17 HR HR20040977A patent/HRP20040977B1/xx not_active IP Right Cessation
- 2003-04-17 EA EA200401172A patent/EA007225B1/ru not_active IP Right Cessation
- 2003-04-17 US US10/511,886 patent/US7326722B2/en not_active Expired - Fee Related
- 2003-04-17 ES ES03740634T patent/ES2286444T3/es not_active Expired - Lifetime
- 2003-04-17 BR BR0309397-2A patent/BR0309397A/pt not_active IP Right Cessation
- 2003-04-17 RS YU91404A patent/RS51888B/sr unknown
- 2003-04-17 SI SI200330893T patent/SI1499589T1/sl unknown
- 2003-04-17 AT AT03740634T patent/ATE361279T1/de active
- 2003-04-17 CN CNB038140063A patent/CN100482646C/zh not_active Expired - Fee Related
- 2003-04-17 KR KR1020087018794A patent/KR101019313B1/ko not_active Expired - Fee Related
- 2003-04-17 CA CA002481461A patent/CA2481461C/en not_active Expired - Fee Related
- 2003-04-17 ME MEP-256/08A patent/MEP25608A/xx unknown
- 2003-04-17 MX MXPA04010326A patent/MXPA04010326A/es active IP Right Grant
- 2003-04-17 JP JP2003586132A patent/JP4597532B2/ja not_active Expired - Fee Related
- 2003-04-17 KR KR10-2004-7016718A patent/KR20040103973A/ko not_active Ceased
- 2003-04-18 TW TW092109074A patent/TWI306402B/zh not_active IP Right Cessation
-
2004
- 2004-09-30 IS IS7479A patent/IS2540B/is unknown
- 2004-10-04 IL IL164400A patent/IL164400A/en not_active IP Right Cessation
- 2004-10-07 MA MA27892A patent/MA27192A1/fr unknown
- 2004-10-08 ZA ZA200408154A patent/ZA200408154B/en unknown
- 2004-10-14 CO CO04103284A patent/CO5631432A2/es not_active Application Discontinuation
- 2004-10-15 NO NO20044388A patent/NO329065B1/no not_active IP Right Cessation
- 2004-10-18 EC EC2004005369A patent/ECSP045369A/es unknown
- 2004-10-18 TN TNP2004000208A patent/TNSN04208A1/fr unknown
-
2007
- 2007-04-03 US US11/695,912 patent/US20070197601A1/en not_active Abandoned
- 2007-07-24 CY CY20071100988T patent/CY1108025T1/el unknown
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