CA2554150A1 - Tetrahydrocarboline compounds as anticancer agents - Google Patents

Tetrahydrocarboline compounds as anticancer agents Download PDF

Info

Publication number
CA2554150A1
CA2554150A1 CA002554150A CA2554150A CA2554150A1 CA 2554150 A1 CA2554150 A1 CA 2554150A1 CA 002554150 A CA002554150 A CA 002554150A CA 2554150 A CA2554150 A CA 2554150A CA 2554150 A1 CA2554150 A1 CA 2554150A1
Authority
CA
Canada
Prior art keywords
substituted
beta
tetrahydro
carbolin
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002554150A
Other languages
English (en)
French (fr)
Inventor
Weibo Wang
Zhi-Jie Ni
Paul Barsanti
Sabina Pecchi
Yi Xia
Nathan Brammeier
Megan Treutle
Elisa Jazan
Kelly Wayman
David Dibble
Jie-Kai Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2554150A1 publication Critical patent/CA2554150A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002554150A 2004-01-23 2005-01-24 Tetrahydrocarboline compounds as anticancer agents Abandoned CA2554150A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53898004P 2004-01-23 2004-01-23
US60/538,980 2004-01-23
PCT/US2005/002270 WO2005070930A2 (en) 2004-01-23 2005-01-24 Tetrahydrocarboline compounds as anticancer agents

Publications (1)

Publication Number Publication Date
CA2554150A1 true CA2554150A1 (en) 2005-08-04

Family

ID=34807249

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002554150A Abandoned CA2554150A1 (en) 2004-01-23 2005-01-24 Tetrahydrocarboline compounds as anticancer agents

Country Status (9)

Country Link
US (1) US7855295B2 (enExample)
EP (1) EP1706404A2 (enExample)
JP (1) JP2007518822A (enExample)
CN (1) CN1910183A (enExample)
AU (1) AU2005206570A1 (enExample)
BR (1) BRPI0506977A (enExample)
CA (1) CA2554150A1 (enExample)
MX (1) MXPA06008211A (enExample)
WO (1) WO2005070930A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4671123B2 (ja) * 2003-06-23 2011-04-13 小野薬品工業株式会社 新規三環性複素環化合物
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
PL1737461T3 (pl) 2004-03-15 2013-05-31 Ptc Therapeutics Inc Pochodne karbolinowe użyteczne w hamowaniu angiogenezy
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
DK1829874T3 (da) 2004-12-22 2014-05-12 Ono Pharmaceutical Co Tricyklisk forbindelse og anvendelse deraf
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
EP2214485B1 (en) * 2007-09-25 2016-07-20 Minerva Biotechnologies Corp. Methods for treatment of cancer
US11202775B2 (en) 2007-09-25 2021-12-21 Minerva Biotechnologies Corporation Methods for treatment of cancer
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
EP2476680B1 (en) 2008-01-11 2014-08-27 Albany Molecular Research, Inc. (1-Azinone)-Substituted Pyridoindoles
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
EP2434891B9 (en) 2009-05-27 2021-05-05 PTC Therapeutics, Inc. Methods for treating cancer and non-neoplastic conditions
SG176260A1 (en) 2009-05-27 2012-01-30 Ptc Therapeutics Inc Processes for the preparation of substituted tetrahydro beta-carbolines
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja) * 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
US9006246B2 (en) 2010-07-06 2015-04-14 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
TW201309698A (zh) 2011-03-18 2013-03-01 Ono Pharmaceutical Co 四氫咔啉衍生物
JP6248048B2 (ja) * 2012-01-09 2017-12-13 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
CN103087062B (zh) * 2013-01-19 2015-06-03 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
PE20160874A1 (es) 2013-05-28 2016-09-04 Astrazeneca Ab Compuestos quimicos
US11931347B2 (en) * 2015-09-23 2024-03-19 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells
JP2019001715A (ja) * 2015-10-30 2019-01-10 協和発酵キリン株式会社 三環性化合物
CA3011391C (en) * 2015-11-12 2021-02-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
CN106967063B (zh) * 2017-03-21 2019-01-11 浙江大学 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
CN110791389B (zh) * 2019-09-30 2021-06-01 义乌欧风汽车用品有限公司 一种除胶剂及其制备方法和应用
JP2025501285A (ja) * 2021-12-31 2025-01-17 ピーティーシー セラピューティクス， インコーポレイテッド カルボリン化合物及びその使用
WO2024099898A1 (en) * 2022-11-07 2024-05-16 Merck Patent Gmbh Substituted bi-and tricyclic hset inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300541B1 (en) 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
JPH03287586A (ja) 1990-04-02 1991-12-18 Taisho Pharmaceut Co Ltd テトラヒドロ―β―カルボリン誘導体
JP3287586B2 (ja) 1991-07-09 2002-06-04 キヤノン株式会社 カラー画像処理方法、及びカラー画像処理装置
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5622960A (en) 1992-04-14 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
FR2796644B1 (fr) 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6720331B2 (en) * 2001-04-03 2004-04-13 National Sun Yat-Sen University 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents
EP1438310B1 (en) * 2001-10-19 2006-12-20 TransTech Pharma Inc. Beta-carbolin derivatives as ptp-inhibitors

Also Published As

Publication number Publication date
BRPI0506977A (pt) 2007-07-03
AU2005206570A1 (en) 2005-08-04
WO2005070930A3 (en) 2006-01-19
US7855295B2 (en) 2010-12-21
WO2005070930A2 (en) 2005-08-04
EP1706404A2 (en) 2006-10-04
MXPA06008211A (es) 2006-08-31
US20050215580A1 (en) 2005-09-29
CN1910183A (zh) 2007-02-07
JP2007518822A (ja) 2007-07-12

Similar Documents

Publication Publication Date Title
CA2554150A1 (en) Tetrahydrocarboline compounds as anticancer agents
EP1636225B1 (en) Pyridino 1,2-a pyrimidin-4-one compounds as anticancer agents
US7345046B2 (en) Heteroaryl-fused pyrimidinyl compounds as anticancer agents
EP1689724B1 (en) Quinazolinone compounds as anticancer agents
JP2007500237A5 (enExample)
JP2007512368A5 (enExample)
KR20060135035A (ko) 유사분열 키네신 억제제
MXPA06005844A (en) Quinazolinone compounds as anticancer agents

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued