CN1910183A - 四氢咔啉化合物作为抗癌药 - Google Patents

四氢咔啉化合物作为抗癌药 Download PDF

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Publication number
CN1910183A
CN1910183A CNA2005800030203A CN200580003020A CN1910183A CN 1910183 A CN1910183 A CN 1910183A CN A2005800030203 A CNA2005800030203 A CN A2005800030203A CN 200580003020 A CN200580003020 A CN 200580003020A CN 1910183 A CN1910183 A CN 1910183A
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China
Prior art keywords
substituted
compound
hydrogen
unsubstituted
alkyl
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CNA2005800030203A
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English (en)
Chinese (zh)
Inventor
王为波
Z·-J·倪
P·巴杉蒂
S·佩奇
夏奕
N·布拉默尔
M·特罗托
E·加赞
K·威曼
D·蒂伯
程捷恺
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NOVARTIS VACCINES and DIAGNOSTIC Inc
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Chiron Corp
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Publication of CN1910183A publication Critical patent/CN1910183A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA2005800030203A 2004-01-23 2005-01-24 四氢咔啉化合物作为抗癌药 Pending CN1910183A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53898004P 2004-01-23 2004-01-23
US60/538,980 2004-01-23

Publications (1)

Publication Number Publication Date
CN1910183A true CN1910183A (zh) 2007-02-07

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CNA2005800030203A Pending CN1910183A (zh) 2004-01-23 2005-01-24 四氢咔啉化合物作为抗癌药

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US (1) US7855295B2 (enExample)
EP (1) EP1706404A2 (enExample)
JP (1) JP2007518822A (enExample)
CN (1) CN1910183A (enExample)
AU (1) AU2005206570A1 (enExample)
BR (1) BRPI0506977A (enExample)
CA (1) CA2554150A1 (enExample)
MX (1) MXPA06008211A (enExample)
WO (1) WO2005070930A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
CN103087062A (zh) * 2013-01-19 2013-05-08 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN106967063A (zh) * 2017-03-21 2017-07-21 浙江大学 1‑三氟甲基‑1,2,3,4‑四氢‑β‑咔啉衍生物及其制备方法
CN110791389A (zh) * 2019-09-30 2020-02-14 义乌欧风汽车用品有限公司 一种环保型除胶剂及其制备方法和应用
CN113527289A (zh) * 2015-09-23 2021-10-22 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法

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JP4671123B2 (ja) * 2003-06-23 2011-04-13 小野薬品工業株式会社 新規三環性複素環化合物
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
PL1737461T3 (pl) 2004-03-15 2013-05-31 Ptc Therapeutics Inc Pochodne karbolinowe użyteczne w hamowaniu angiogenezy
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
DK1829874T3 (da) 2004-12-22 2014-05-12 Ono Pharmaceutical Co Tricyklisk forbindelse og anvendelse deraf
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
EP2214485B1 (en) * 2007-09-25 2016-07-20 Minerva Biotechnologies Corp. Methods for treatment of cancer
US11202775B2 (en) 2007-09-25 2021-12-21 Minerva Biotechnologies Corporation Methods for treatment of cancer
EP2050747A1 (en) * 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
EP2476680B1 (en) 2008-01-11 2014-08-27 Albany Molecular Research, Inc. (1-Azinone)-Substituted Pyridoindoles
EP2434891B9 (en) 2009-05-27 2021-05-05 PTC Therapeutics, Inc. Methods for treating cancer and non-neoplastic conditions
SG176260A1 (en) 2009-05-27 2012-01-30 Ptc Therapeutics Inc Processes for the preparation of substituted tetrahydro beta-carbolines
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja) * 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
US9006246B2 (en) 2010-07-06 2015-04-14 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
TW201309698A (zh) 2011-03-18 2013-03-01 Ono Pharmaceutical Co 四氫咔啉衍生物
JP6248048B2 (ja) * 2012-01-09 2017-12-13 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
PE20160874A1 (es) 2013-05-28 2016-09-04 Astrazeneca Ab Compuestos quimicos
JP2019001715A (ja) * 2015-10-30 2019-01-10 協和発酵キリン株式会社 三環性化合物
CA3011391C (en) * 2015-11-12 2021-02-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
US11458126B2 (en) 2017-08-01 2022-10-04 Ptc Therapeutics, Inc. DHODH inhibitor for use in treating hematologic cancers
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
JP2025501285A (ja) * 2021-12-31 2025-01-17 ピーティーシー セラピューティクス， インコーポレイテッド カルボリン化合物及びその使用
WO2024099898A1 (en) * 2022-11-07 2024-05-16 Merck Patent Gmbh Substituted bi-and tricyclic hset inhibitors

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EP0300541B1 (en) 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
JPH03287586A (ja) 1990-04-02 1991-12-18 Taisho Pharmaceut Co Ltd テトラヒドロ―β―カルボリン誘導体
JP3287586B2 (ja) 1991-07-09 2002-06-04 キヤノン株式会社 カラー画像処理方法、及びカラー画像処理装置
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5622960A (en) 1992-04-14 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JP2000508302A (ja) * 1996-04-04 2000-07-04 エフ．ホフマン―ラ ロッシュ エイジー 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
FR2796644B1 (fr) 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6720331B2 (en) * 2001-04-03 2004-04-13 National Sun Yat-Sen University 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents
EP1438310B1 (en) * 2001-10-19 2006-12-20 TransTech Pharma Inc. Beta-carbolin derivatives as ptp-inhibitors

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101591348B (zh) * 2008-05-30 2011-07-27 首都医科大学 四氢咔啉酰氨基酸苄酯及其制备方法和应用
CN101597289B (zh) * 2008-06-02 2011-09-21 首都医科大学 2-色氨酰-β-四氢咔啉-3-甲酰基氨基酸苄酯及其制备方法和应用
CN103087062A (zh) * 2013-01-19 2013-05-08 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN103087062B (zh) * 2013-01-19 2015-06-03 安徽师范大学 N-磺酰基取代-β-四氢咔啉衍生物的制备方法
CN113527289A (zh) * 2015-09-23 2021-10-22 米纳瓦生物技术公司 筛选分化干细胞的试剂的方法
CN106967063A (zh) * 2017-03-21 2017-07-21 浙江大学 1‑三氟甲基‑1,2,3,4‑四氢‑β‑咔啉衍生物及其制备方法
CN106967063B (zh) * 2017-03-21 2019-01-11 浙江大学 1-三氟甲基-1,2,3,4-四氢-β-咔啉衍生物及其制备方法
CN110791389A (zh) * 2019-09-30 2020-02-14 义乌欧风汽车用品有限公司 一种环保型除胶剂及其制备方法和应用
CN110791389B (zh) * 2019-09-30 2021-06-01 义乌欧风汽车用品有限公司 一种除胶剂及其制备方法和应用

Also Published As

Publication number Publication date
BRPI0506977A (pt) 2007-07-03
AU2005206570A1 (en) 2005-08-04
WO2005070930A3 (en) 2006-01-19
US7855295B2 (en) 2010-12-21
WO2005070930A2 (en) 2005-08-04
EP1706404A2 (en) 2006-10-04
CA2554150A1 (en) 2005-08-04
MXPA06008211A (es) 2006-08-31
US20050215580A1 (en) 2005-09-29
JP2007518822A (ja) 2007-07-12

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Owner name: NOVARTIS VACCINES & DIAGNOSTIC

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Effective date: 20080530

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