JP2011006480A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011006480A5 JP2011006480A5 JP2010228356A JP2010228356A JP2011006480A5 JP 2011006480 A5 JP2011006480 A5 JP 2011006480A5 JP 2010228356 A JP2010228356 A JP 2010228356A JP 2010228356 A JP2010228356 A JP 2010228356A JP 2011006480 A5 JP2011006480 A5 JP 2011006480A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- cancer
- lower alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000003463 hyperproliferative effect Effects 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005277 alkyl imino group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- ICCBZGUDUOMNOF-UHFFFAOYSA-N azidoamine Chemical compound NN=[N+]=[N-] ICCBZGUDUOMNOF-UHFFFAOYSA-N 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- -1 hydroxy, hydroxy Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42535202P | 2002-11-07 | 2002-11-07 | |
| US60/425,352 | 2002-11-07 | ||
| US47374303P | 2003-05-27 | 2003-05-27 | |
| US60/473,743 | 2003-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507102A Division JP4641941B2 (ja) | 2002-11-07 | 2003-11-07 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013147528A Division JP2013213054A (ja) | 2002-11-07 | 2013-07-16 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011006480A JP2011006480A (ja) | 2011-01-13 |
| JP2011006480A5 true JP2011006480A5 (enExample) | 2011-11-17 |
| JP5679757B2 JP5679757B2 (ja) | 2015-03-04 |
Family
ID=32314587
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507102A Expired - Fee Related JP4641941B2 (ja) | 2002-11-07 | 2003-11-07 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
| JP2010228356A Expired - Fee Related JP5679757B2 (ja) | 2002-11-07 | 2010-10-08 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
| JP2013147528A Pending JP2013213054A (ja) | 2002-11-07 | 2013-07-16 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507102A Expired - Fee Related JP4641941B2 (ja) | 2002-11-07 | 2003-11-07 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013147528A Pending JP2013213054A (ja) | 2002-11-07 | 2013-07-16 | トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040152708A1 (enExample) |
| EP (3) | EP2135867B1 (enExample) |
| JP (3) | JP4641941B2 (enExample) |
| KR (2) | KR100996996B1 (enExample) |
| AT (1) | ATE452888T1 (enExample) |
| AU (1) | AU2003291337B2 (enExample) |
| CA (1) | CA2505368C (enExample) |
| CY (1) | CY1110295T1 (enExample) |
| DE (1) | DE60330703D1 (enExample) |
| DK (1) | DK1562941T3 (enExample) |
| ES (2) | ES2436296T3 (enExample) |
| PT (1) | PT1562941E (enExample) |
| SI (1) | SI1562941T1 (enExample) |
| WO (1) | WO2004043954A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7384964B2 (en) * | 2002-08-23 | 2008-06-10 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| EP2186811A1 (en) | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP2135867B1 (en) * | 2002-11-07 | 2013-09-25 | Kosan Biosciences Incorporated | Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same |
| CN1330648C (zh) * | 2002-11-07 | 2007-08-08 | 科桑生物科学公司 | 反式－9,10－脱氢埃坡霉素c和d,其类似物以及制备这些化合物的方法 |
| US20050002983A1 (en) * | 2003-03-28 | 2005-01-06 | Johnson Robert G. | Devices, methods, and compositions to prevent restenosis |
| KR20060122819A (ko) * | 2003-10-09 | 2006-11-30 | 코산 바이오사이언시즈, 인코포레이티드 | 치료학적 제형 |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| BRPI0720306A2 (pt) | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CA2678941C (en) | 2007-02-23 | 2018-11-27 | Aileron Therapeutics, Inc. | Triazole macrocycle systems |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| WO2008141234A2 (en) * | 2007-05-11 | 2008-11-20 | Kosan Biosciences Incorporated | Methods of making epothilones |
| US8030503B2 (en) | 2007-05-11 | 2011-10-04 | Kosan Biosciences Incorporated | Process for the preparation of epothilones |
| BRPI1006139A2 (pt) | 2009-01-14 | 2017-05-30 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
| WO2011038049A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| KR20180058866A (ko) | 2010-08-13 | 2018-06-01 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| BR112014009418A2 (pt) | 2011-10-18 | 2017-04-18 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
| WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
| CA2776178A1 (en) * | 2012-04-05 | 2013-10-05 | Hydro-Quebec | Ionic compounds |
| MX2015005244A (es) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos. |
| AU2015320549A1 (en) | 2014-09-24 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69329073T2 (de) | 1992-03-23 | 2001-01-18 | Georgetown University, Washington | In liposomen verkapseltes taxol und verwendungsverfahren |
| AU6833994A (en) | 1993-05-17 | 1994-12-12 | Liposome Company, Inc., The | Incorporation of taxol into liposomes and gels |
| US5415869A (en) | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| EP0932399B1 (en) | 1996-03-12 | 2006-01-04 | PG-TXL Company, L.P. | Water soluble paclitaxel prodrugs |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| PT1052974E (pt) | 1998-02-05 | 2009-08-07 | Novartis Ag | Formulação farmacêutica contendo epotilona |
| US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
| DE19907480A1 (de) * | 1999-02-11 | 2000-08-17 | Schering Ag | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| DE19954229A1 (de) * | 1999-11-04 | 2001-05-10 | Schering Ag | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| US6156373A (en) | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
| JP2003500368A (ja) | 1999-05-24 | 2003-01-07 | ソーナス ファーマシューティカルス，インコーポレイテッド | 溶解度が不十分な薬剤のためのエマルジョンビヒクル |
| GB9918429D0 (en) | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
| KR100832145B1 (ko) | 2000-04-28 | 2008-05-27 | 코산 바이오사이언시즈, 인코포레이티드 | 폴리케타이드의 제조방법 |
| AU2001266583A1 (en) * | 2000-05-26 | 2001-12-11 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| US6906188B2 (en) * | 2001-04-30 | 2005-06-14 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Method for synthesizing epothilones and epothilone analogs |
| WO2003022844A2 (en) * | 2001-09-06 | 2003-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones intermediates thereto and analogues thereof |
| EP2186811A1 (en) * | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) * | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP2135867B1 (en) * | 2002-11-07 | 2013-09-25 | Kosan Biosciences Incorporated | Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same |
-
2003
- 2003-11-07 EP EP09012671.5A patent/EP2135867B1/en not_active Expired - Lifetime
- 2003-11-07 KR KR1020107000780A patent/KR100996996B1/ko not_active Expired - Fee Related
- 2003-11-07 AT AT03768730T patent/ATE452888T1/de active
- 2003-11-07 AU AU2003291337A patent/AU2003291337B2/en not_active Ceased
- 2003-11-07 SI SI200331732T patent/SI1562941T1/sl unknown
- 2003-11-07 EP EP09012860A patent/EP2135868A1/en not_active Withdrawn
- 2003-11-07 WO PCT/US2003/035411 patent/WO2004043954A2/en not_active Ceased
- 2003-11-07 CA CA2505368A patent/CA2505368C/en not_active Expired - Fee Related
- 2003-11-07 DE DE60330703T patent/DE60330703D1/de not_active Expired - Lifetime
- 2003-11-07 DK DK03768730.8T patent/DK1562941T3/da active
- 2003-11-07 ES ES09012671T patent/ES2436296T3/es not_active Expired - Lifetime
- 2003-11-07 PT PT03768730T patent/PT1562941E/pt unknown
- 2003-11-07 KR KR1020057008039A patent/KR100966667B1/ko not_active Expired - Fee Related
- 2003-11-07 US US10/703,404 patent/US20040152708A1/en not_active Abandoned
- 2003-11-07 EP EP03768730A patent/EP1562941B1/en not_active Expired - Lifetime
- 2003-11-07 JP JP2005507102A patent/JP4641941B2/ja not_active Expired - Fee Related
- 2003-11-07 ES ES03768730T patent/ES2336911T3/es not_active Expired - Lifetime
-
2008
- 2008-07-11 US US12/172,174 patent/US20090186927A1/en not_active Abandoned
-
2010
- 2010-03-19 CY CY20101100250T patent/CY1110295T1/el unknown
- 2010-10-08 JP JP2010228356A patent/JP5679757B2/ja not_active Expired - Fee Related
-
2013
- 2013-07-16 JP JP2013147528A patent/JP2013213054A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011006480A5 (enExample) | ||
| KR102279999B1 (ko) | 선택적 에스트로겐 수용체 분해제로서의 벤조티오펜 유도체 및 그의 조성물 | |
| JP2013513613A5 (enExample) | ||
| JP2017537949A5 (enExample) | ||
| JP2011526924A5 (enExample) | ||
| JP2011520906A5 (enExample) | ||
| JP2013532652A5 (enExample) | ||
| JP2012506872A5 (enExample) | ||
| JP2010523522A5 (enExample) | ||
| JP2011507896A5 (enExample) | ||
| JP2014518266A5 (enExample) | ||
| JP2016040288A5 (enExample) | ||
| JP2013542261A5 (enExample) | ||
| JP2009507909A5 (enExample) | ||
| JP2010518094A5 (enExample) | ||
| JP2014500235A5 (enExample) | ||
| EP1857457A3 (en) | Benzimidazole derivative and its use as AII receptor antagonist | |
| JP2011509949A5 (enExample) | ||
| JP2014505107A5 (enExample) | ||
| JP2010077141A5 (enExample) | ||
| JP2008535902A5 (enExample) | ||
| JP2006524660A5 (enExample) | ||
| JP2012512863A5 (enExample) | ||
| JP2015512943A5 (enExample) | ||
| JP2013544860A5 (enExample) |