JP2014508752A5 - - Google Patents

Download PDF

Info

Publication number
JP2014508752A5
JP2014508752A5 JP2013553913A JP2013553913A JP2014508752A5 JP 2014508752 A5 JP2014508752 A5 JP 2014508752A5 JP 2013553913 A JP2013553913 A JP 2013553913A JP 2013553913 A JP2013553913 A JP 2013553913A JP 2014508752 A5 JP2014508752 A5 JP 2014508752A5
Authority
JP
Japan
Prior art keywords
prevention
salt
treatment
cancer
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013553913A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014508752A (ja
Filing date
Publication date
Priority claimed from DE102011080405A external-priority patent/DE102011080405A1/de
Application filed filed Critical
Priority claimed from PCT/EP2012/052520 external-priority patent/WO2012110518A1/de
Publication of JP2014508752A publication Critical patent/JP2014508752A/ja
Publication of JP2014508752A5 publication Critical patent/JP2014508752A5/ja
Pending legal-status Critical Current

Links

JP2013553913A 2011-02-17 2012-02-14 治療用の置換３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デカ−３−エン−２−オン Pending JP2014508752A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161443852P 2011-02-17 2011-02-17
EP11154805 2011-02-17
US61/443,852 2011-02-17
EP11154805.3 2011-02-17
DE102011080405A DE102011080405A1 (de) 2011-08-04 2011-08-04 Substituierte 3-(Biphenyl-3-yl)-8,8-difluor-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one zur Therapie
DE102011080405.6 2011-08-04
PCT/EP2012/052520 WO2012110518A1 (de) 2011-02-17 2012-02-14 Substituierte 3-(biphenyl-3-yl)-8,8-difluor-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one zur therapie

Publications (2)

Publication Number Publication Date
JP2014508752A JP2014508752A (ja) 2014-04-10
JP2014508752A5 true JP2014508752A5 (enExample) 2015-04-02

Family

ID=46671961

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013553914A Active JP5905908B2 (ja) 2011-02-17 2012-02-14 治療のための置換された３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デク−３−エン−２−オン類およびハロゲン−置換されたスピロ環状ケトエノール類
JP2013553913A Pending JP2014508752A (ja) 2011-02-17 2012-02-14 治療用の置換３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デカ−３−エン−２−オン

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2013553914A Active JP5905908B2 (ja) 2011-02-17 2012-02-14 治療のための置換された３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デク−３−エン−２−オン類およびハロゲン−置換されたスピロ環状ケトエノール類

Country Status (7)

Country Link
US (2) US8946124B2 (enExample)
EP (2) EP2675788A1 (enExample)
JP (2) JP5905908B2 (enExample)
CN (2) CN103492367B (enExample)
BR (1) BR112013021021A2 (enExample)
CA (1) CA2827398A1 (enExample)
WO (2) WO2012110519A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3059225A4 (en) 2013-10-17 2017-09-06 Shionogi & Co., Ltd. Novel alkylene derivative
WO2016022520A1 (en) * 2014-08-05 2016-02-11 Kyung-An Han Composition and methods for modulation of the octopamine receptor and its homologs
TW202140422A (zh) 2014-10-06 2021-11-01 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
CN106674323B (zh) * 2015-11-05 2019-10-22 苏州博创园生物医药科技有限公司 具有acc1蛋白调控作用的五环三萜类化合物及其用途
DK3402775T5 (da) 2016-01-15 2021-09-27 Bayer Cropscience Ag Fremgangsmåde til fremstilling af 2-(4-chlor-2,6-dimethylphenyl)ethanol
EP3436446B1 (en) 2016-03-31 2023-06-07 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
KR102466169B1 (ko) 2016-08-04 2022-11-14 바이엘 크롭사이언스 악티엔게젤샤프트 스피로케탈-치환된 사이클릭 케토에놀의 제조 방법
JOP20190042B1 (ar) 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
HRP20201946T1 (hr) 2016-12-09 2021-01-22 Vertex Pharmaceuticals Incorporated Modulator regulatora transmembranske provodljivosti cistične fibroze, farmaceutski sastavi, postupci liječenja, i postupak za dobivanje modulatora
CN108721304B (zh) * 2017-04-17 2020-10-16 北京大学 用于治疗肿瘤的药物组合物及其用途
MA54105A (fr) 2017-06-08 2021-09-15 Vertex Pharma Méthodes de traitement de la fibrose kystique
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
WO2019028228A1 (en) 2017-08-02 2019-02-07 Vertex Pharmaceuticals Incorporated PROCESSES FOR THE PREPARATION OF PYRROLIDINE COMPOUNDS
US10743535B2 (en) 2017-08-18 2020-08-18 H&K Solutions Llc Insecticide for flight-capable pests
WO2019079760A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
AU2018380426B2 (en) 2017-12-08 2023-05-18 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
IL277679B2 (en) * 2018-04-13 2024-06-01 Bayer Ag Solid formulation of insecticidal mixtures
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
KR20210061336A (ko) 2018-07-27 2021-05-27 아페르타 바이오사이언시스 엘엘씨 모낭충으로 유발된 안구 및 안면 증상의 치료를 위한 스피노신 제제
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN118164897B (zh) * 2024-03-11 2024-11-15 南开大学 一种螺环特胺酸类化合物及其制备方法和应用
CN119842724B (zh) * 2025-03-24 2025-07-15 浙江农林大学 台湾乳白蚁Or-43884基因及其在防治白蚁中的应用

Family Cites Families (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2842476A (en) 1953-04-23 1958-07-08 Mclaughlin Gormley King Co Insecticidal compositions
US4272417A (en) 1979-05-22 1981-06-09 Cargill, Incorporated Stable protective seed coating
US4245432A (en) 1979-07-25 1981-01-20 Eastman Kodak Company Seed coatings
DE3008186A1 (de) 1980-03-04 1981-10-15 Hoechst Ag, 6000 Frankfurt Synergistische kombinationen von phosphinothricin
US4362682A (en) 1980-08-21 1982-12-07 Badische Corporation Chip-free staple fiber process
MA19709A1 (fr) 1982-02-17 1983-10-01 Ciba Geigy Ag Application de derives de quinoleine a la protection des plantes cultivees .
EP0094349B1 (de) 1982-05-07 1994-04-06 Ciba-Geigy Ag Verwendung von Chinolinderivaten zum Schützen von Kulturpflanzen
EP0106258A3 (de) 1982-10-09 1985-05-15 Heinz Dipl.-Ing. Hölter Verfahren zur kontinuierlichen Nutzung von Abfall, vorzugsweise Müll und Klärschlamm
WO1984002919A1 (en) 1983-01-17 1984-08-02 Monsanto Co Plasmids for transforming plant cells
BR8404834A (pt) 1983-09-26 1985-08-13 Agrigenetics Res Ass Metodo para modificar geneticamente uma celula vegetal
JPS6087254A (ja) 1983-10-19 1985-05-16 Japan Carlit Co Ltd:The 新規尿素化合物及びそれを含有する除草剤
DE3525205A1 (de) 1984-09-11 1986-03-20 Hoechst Ag, 6230 Frankfurt Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
EP0191736B1 (de) 1985-02-14 1991-07-17 Ciba-Geigy Ag Verwendung von Chinolinderivaten zum Schützen von Kulturpflanzen
DE3686633T2 (de) 1985-10-25 1993-04-15 David Matthew Bisaro Pflanzenvektoren.
EP0242236B2 (en) 1986-03-11 1996-08-21 Plant Genetic Systems N.V. Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering
EP0305398B1 (en) 1986-05-01 1991-09-25 Honeywell Inc. Multiple integrated circuit interconnection arrangement
JPS638302A (ja) 1986-06-27 1988-01-14 Kao Corp 殺生剤用効力増強剤
JPH0618761B2 (ja) 1986-07-14 1994-03-16 花王株式会社 粒状農薬の製造方法
US5013659A (en) 1987-07-27 1991-05-07 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
IL83348A (en) 1986-08-26 1995-12-08 Du Pont Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
US4925868A (en) 1986-08-29 1990-05-15 Takeda Chemical Industries, Ltd. 4-Hydroxy-3-pyrrolin-2-ones and treatment of circulatory disorders therewith
DE3633840A1 (de) 1986-10-04 1988-04-14 Hoechst Ag Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener
DE3775527D1 (de) 1986-10-22 1992-02-06 Ciba Geigy Ag 1,5-diphenylpyrazol-3-carbonsaeurederivate zum schuetzen von kulturpflanzen.
US4808430A (en) 1987-02-27 1989-02-28 Yazaki Corporation Method of applying gel coating to plant seeds
DE3733017A1 (de) 1987-09-30 1989-04-13 Bayer Ag Stilbensynthase-gen
US5689046A (en) 1987-09-30 1997-11-18 Bayer Aktiengesellschaft Stilbene synthase gene
DE3808896A1 (de) 1988-03-17 1989-09-28 Hoechst Ag Pflanzenschuetzende mittel auf basis von pyrazolcarbonsaeurederivaten
GB8810120D0 (en) 1988-04-28 1988-06-02 Plant Genetic Systems Nv Transgenic nuclear male sterile plants
DE3817192A1 (de) 1988-05-20 1989-11-30 Hoechst Ag 1,2,4-triazolderivate enthaltende pflanzenschuetzende mittel sowie neue derivate des 1,2,4-triazols
US4985063A (en) 1988-08-20 1991-01-15 Bayer Aktiengesellschaft 3-aryl-pyrrolidine-2,4-diones
ATE84302T1 (de) 1988-10-20 1993-01-15 Ciba Geigy Ag Sulfamoylphenylharnstoffe.
US5215570A (en) 1988-10-20 1993-06-01 Ciba-Geigy Corporation Sulfamoylphenylureas
DE58907411D1 (de) 1989-01-07 1994-05-11 Bayer Ag 3-Aryl-pyrrolidin-2,4-dion-Derivate.
WO1990008324A1 (en) 1989-01-17 1990-07-26 The Johns Hopkins University Cancer related haptoglobin (hpr)
US5759837A (en) 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
DE3929087A1 (de) 1989-09-01 1991-03-07 Bayer Ag 3-aryl-pyrrolidin-2,4-dion-derivate
DE4014420A1 (de) 1989-09-23 1991-04-04 Bayer Ag 5h-furan-2-on-derivate
DE3939010A1 (de) 1989-11-25 1991-05-29 Hoechst Ag Isoxazoline, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschuetzende mittel
US5700758A (en) 1989-11-30 1997-12-23 Hoechst Aktiengesellschaft Pyrazolines for protecting crop plants against herbicides
DE3939503A1 (de) 1989-11-30 1991-06-06 Hoechst Ag Neue pyrazoline zum schutz von kulturpflanzen gegenueber herbiziden
DE4032090A1 (de) 1990-02-13 1991-08-14 Bayer Ag Polycyclische 3-aryl-pyrrolidin-2,4-dion-derivate
DE4004496A1 (de) 1990-02-14 1991-08-22 Bayer Ag 3-aryl-pyrrolidin-2,4-dion-derivate
WO1991013972A1 (en) 1990-03-16 1991-09-19 Calgene, Inc. Plant desaturases - compositions and uses
JPH0747523B2 (ja) 1990-04-16 1995-05-24 花王株式会社 殺生剤効力増強剤
DE4107394A1 (de) 1990-05-10 1991-11-14 Bayer Ag 1-h-3-aryl-pyrrolidin-2,4-dion-derivate
JP3325022B2 (ja) 1990-06-18 2002-09-17 モンサント カンパニー 植物中の増加された澱粉含量
AU655197B2 (en) 1990-06-25 1994-12-08 Monsanto Technology Llc Glyphosate tolerant plants
DE4107396A1 (de) 1990-06-29 1992-01-02 Bayer Ag Stilbensynthase-gene aus weinrebe
WO1992000964A1 (fr) 1990-07-05 1992-01-23 Nippon Soda Co., Ltd. Derive d'amine
SE467358B (sv) 1990-12-21 1992-07-06 Amylogene Hb Genteknisk foeraendring av potatis foer bildning av staerkelse av amylopektintyp
DE59108636D1 (de) 1990-12-21 1997-04-30 Hoechst Schering Agrevo Gmbh Neue 5-Chlorchinolin-8-oxyalkancarbonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Antidots von Herbiziden
US5811374A (en) 1991-02-07 1998-09-22 Bayer Aktiengesellschaft 3-aryl-pyrrolidine-2,4-dione derivatives
DE4104782B4 (de) 1991-02-13 2006-05-11 Bayer Cropscience Gmbh Neue Plasmide, enthaltend DNA-Sequenzen, die Veränderungen der Karbohydratkonzentration und Karbohydratzusammensetzung in Pflanzen hervorrufen, sowie Pflanzen und Pflanzenzellen enthaltend dieses Plasmide
US5352674A (en) 1991-03-25 1994-10-04 Valent U.S.A. Chemically stable granules containing insecticidal phosphoroamidothioates
DE4121365A1 (de) 1991-06-28 1993-01-14 Bayer Ag Substituierte 1-h-3-aryl-pyrrolidin-2,4-dion-derivate
DE4216814A1 (de) * 1991-07-16 1993-01-21 Bayer Ag 3-aryl-4-hydroxy-(delta)(pfeil hoch)3(pfeil hoch)-dihydrofuranon- und 3-aryl-4-hydroxy-(delta)(pfeil hoch)3(pfeil hoch)-dihydrothiophenon-derivate
US5462912A (en) 1991-10-09 1995-10-31 Kao Corporation Agricultural chemical composition enhancer comprising quaternary di(polyoxyalkylene) ammonium alkyl sulfates
GB9210393D0 (en) 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
TW259690B (enExample) 1992-08-01 1995-10-11 Hoechst Ag
DE4236400A1 (de) 1992-10-28 1994-05-05 Bayer Ag N-Phenylacetaminonitrile
AU666040B2 (en) 1992-10-28 1996-01-25 Bayer Aktiengesellschaft Substituted 1-H-3-aryl-pyrrolidine-2,4-dione derivatives
MY111077A (en) 1992-11-13 1999-08-30 Kao Corp Agricultural chemical composition
DE4306259A1 (de) 1993-03-01 1994-09-08 Bayer Ag Dialkyl-1-H-3-(2,4-dimethylphenyl)-pyrrolidin-2,4-dione, ihre Herstellung und ihre Verwendung
DE4306257A1 (de) 1993-03-01 1994-09-08 Bayer Ag Substituierte 1-H-3-Phenyl-5-cycloalkylpyrrolidin-2,4-dione, ihre Herstellung und ihre Verwendung
BR9407006A (pt) 1993-07-05 1996-08-06 Bayer Ag Heterociclos aril cetoenólicos substituidos
DE4331448A1 (de) 1993-09-16 1995-03-23 Hoechst Schering Agrevo Gmbh Substituierte Isoxazoline, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung als Safener
ES2127859T3 (es) 1993-09-17 1999-05-01 Bayer Ag Derivados de la 3-aril-4-hidroxi-3-dihidrofuranona.
BR9406470A (pt) 1993-12-28 1996-01-23 Kao Corp Composição e processo para aperfeiçoar produtos quimicos aplicáveis na agricultura e composição quimica aplicável na agricultura
DE4401542A1 (de) 1994-01-20 1995-07-27 Hoechst Schering Agrevo Gmbh Synergistische Kombinationen von Ammoniumsalzen
DE4425617A1 (de) 1994-01-28 1995-08-03 Bayer Ag 1-H-3-Aryl-pyrrolidin-2,4-dion-Derivate
DE4431730A1 (de) 1994-02-09 1995-08-10 Bayer Ag Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
CA2187015A1 (en) 1994-04-05 1995-10-12 Reiner Fischer Alkoxy-alkyl-substituted 1-h-3-aryl-pyrrolidine-2,4-diones used as herbicides and pesticides
DE4416303A1 (de) 1994-05-09 1995-11-16 Bayer Ag Schaumarmes Netzmittel und seine Verwendung
MX9704646A (es) 1994-12-23 1997-09-30 Bayer Ag Derivados del acido 3-aril-tetronico, su obtencion y su empleo como agentes pesticidas.
ES2224156T3 (es) 1995-02-13 2005-03-01 Bayer Cropscience Ag 1,2-cetoenoles heterociclicos 2-fenil- substituidos como herbicidas y pesticidas.
EP0821729B1 (en) 1995-04-20 2006-10-18 Basf Aktiengesellschaft Structure-based designed herbicide resistant products
JP4153033B2 (ja) 1995-05-09 2008-09-17 バイエル アクチェンゲゼルシャフト 有害生物防除剤及び除草剤として有用なアルキルジハロゲン化フェニル置換ケトエノール
US6110872A (en) 1995-06-28 2000-08-29 Bayer Aktiengesellschaft 2,4,5-trisubstituted phenylketo-enols for use as pesticides and herbicides
US5994274A (en) 1995-06-30 1999-11-30 Bayer Aktiengesellschaft Dialkyl phenyl halide-substituted keto-enols for use as herbicides and pesticides
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
CN1631879A (zh) 1996-04-02 2005-06-29 拜尔公司 取代的苯基酮烯醇杀虫剂及除草剂
JP4306799B2 (ja) 1996-05-10 2009-08-05 バイエル アクチェンゲゼルシャフト 新規な置換ピリジルケトエノール
DE19621522A1 (de) 1996-05-29 1997-12-04 Hoechst Schering Agrevo Gmbh Neue N-Acylsulfonamide, neue Mischungen aus Herbiziden und Antidots und deren Verwendung
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
PL201168B1 (pl) 1996-08-05 2009-03-31 Bayer Ag Podstawione fenyloketoenole, sposób wytwarzania tych związków, związki pośrednie, pestycydy i zastosowanie związków
DE19632126A1 (de) 1996-08-09 1998-02-12 Bayer Ag Phenylsubstituierte cyclische Ketoenole
AR009811A1 (es) 1996-09-26 2000-05-03 Novartis Ag Compuestos herbicidas, proceso para su produccion, proceso para la produccion de intermediarios, compuestos intermediarios para su exclusivo usoen dicho proceso, composicion que tiene actividad herbicida selectiva y proceso para el control selectivo de malas hierbas y gramineas en cultivos de planta
DE19651686A1 (de) 1996-12-12 1998-06-18 Bayer Ag Neue substituierte Phenylketoenole
DE19652961A1 (de) 1996-12-19 1998-06-25 Hoechst Schering Agrevo Gmbh Neue 2-Fluoracrylsäurederivate, neue Mischungen aus Herbiziden und Antidots und deren Verwendung
GB9703054D0 (en) 1997-02-14 1997-04-02 Ici Plc Agrochemical surfactant compositions
US6071856A (en) 1997-03-04 2000-06-06 Zeneca Limited Herbicidal compositions for acetochlor in rice
DE19727410A1 (de) 1997-06-27 1999-01-07 Hoechst Schering Agrevo Gmbh 3-(5-Tetrazolylcarbonyl)-2-chinolone und diese enthaltende nutzpflanzenschützende Mittel
DE19742492A1 (de) 1997-09-26 1999-04-01 Bayer Ag Spirocyclische Phenylketoenole
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
DE19749720A1 (de) 1997-11-11 1999-05-12 Bayer Ag Neue substituierte Phenylketoenole
DE19808261A1 (de) 1998-02-27 1999-10-28 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
DE19813354A1 (de) 1998-03-26 1999-09-30 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
DE19818732A1 (de) 1998-04-27 1999-10-28 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
JP2000053670A (ja) 1998-08-10 2000-02-22 Ube Ind Ltd アルコキシメチルフラノン誘導体及び有害生物防除剤
US6503904B2 (en) 1998-11-16 2003-01-07 Syngenta Crop Protection, Inc. Pesticidal composition for seed treatment
DE19857963A1 (de) 1998-12-16 2000-06-21 Bayer Ag Agrochemische Formulierungen
EP1210333B1 (de) 1999-09-07 2004-11-17 Syngenta Participations AG p-Tolyl-Heterocyclen als Herbizide
DE19946625A1 (de) 1999-09-29 2001-04-05 Bayer Ag Trifluormethylsubstituierte spirocyclische Ketoenole
DE10016544A1 (de) 2000-04-03 2001-10-11 Bayer Ag C2-phenylsubstituierte Ketoenole
JP2002205984A (ja) 2000-05-11 2002-07-23 Sankyo Co Ltd Ｎ−置換スピロジヒドロピロール誘導体
DE10032587A1 (de) 2000-07-05 2002-01-17 Bayer Ag 4-Alkoxy-cyclohexan-1-amino-carbonsäureester und Verfahren zu ihrer Herstellung
US6660690B2 (en) 2000-10-06 2003-12-09 Monsanto Technology, L.L.C. Seed treatment with combinations of insecticides
AR031027A1 (es) 2000-10-23 2003-09-03 Syngenta Participations Ag Composiciones agroquimicas
US20020134012A1 (en) 2001-03-21 2002-09-26 Monsanto Technology, L.L.C. Method of controlling the release of agricultural active ingredients from treated plant seeds
WO2002096882A1 (en) 2001-05-31 2002-12-05 Nihon Nohyaku Co., Ltd. Substituted anilide derivatives, intermediates thereof, agricultural and horticultural chemicals, and their usage
DE10139465A1 (de) 2001-08-10 2003-02-20 Bayer Cropscience Ag Selektive Herbizide auf Basis von substituierten, cayclischen Ketoenolen und Safenern
DE10201239A1 (de) 2002-01-15 2003-07-24 Bayer Cropscience Ag Fungizide biphenylsubstituierte cyclische Ketoenole
EP1468000A1 (en) 2002-01-22 2004-10-20 Syngenta Participations AG Phenyl substituted heterocyclic compounds useful as herbicides
US6645914B1 (en) 2002-05-01 2003-11-11 Ndsu-Research Foundation Surfactant-ammonium sulfate adjuvant composition for enhancing efficacy of herbicides
WO2003101197A1 (en) 2002-05-31 2003-12-11 Cjb Industries, Inc. Adjuvant for pesticides
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
DE10231333A1 (de) 2002-07-11 2004-01-22 Bayer Cropscience Ag Cis-Alkoxysubstituierte spirocyclische 1-H-Pyrrolidin-2,4-dion-Derivate
DE10239479A1 (de) 2002-08-28 2004-03-04 Bayer Cropscience Ag Substituierte spirocyclische Ketoenole
US6984662B2 (en) 2003-11-03 2006-01-10 The Hartz Mountain Corporation High concentration topical insecticide containing insect growth regulator
US7132448B2 (en) 2002-09-12 2006-11-07 The Hartz Mountain Corporation High concentration topical insecticide containing insect growth regulator
DE10301804A1 (de) 2003-01-20 2004-07-29 Bayer Cropscience Ag 2,4-Dihalogen-6-(C2-C3-alkyl)-phenyl substituierte Tetramsäure-Derivate
DE10311300A1 (de) 2003-03-14 2004-09-23 Bayer Cropscience Ag 2,4,6-Phenylsubstituierte cyclische Ketoenole
UA90844C2 (ru) 2003-03-26 2010-06-10 Байер Кропсайенс Аг Применение гидроксиароматических соединений в качестве сафенеров, способ защиты культурных или полезных растений от фитотоксичного побочного влияния агрохимикатов и средство для защиты растений
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
DE10326386A1 (de) 2003-06-12 2004-12-30 Bayer Cropscience Ag N-Heterocyclyl-phenylsubstituierte cyclische Ketoenole
DE10335725A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Safener auf Basis aromatisch-aliphatischer Carbonsäuredarivate
DE10335726A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Verwendung von Hydroxyaromaten als Safener
UA79404C2 (en) 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
DE10351647A1 (de) 2003-11-05 2005-06-09 Bayer Cropscience Ag 2-Halogen-6-alkyl-phenyl substituierte Tetramsäure-Derivate
DE10351646A1 (de) 2003-11-05 2005-06-09 Bayer Cropscience Ag 2-Halogen-6-alkyl-phenyl substituierte spirocyclische Tetramsäure-Derivate
DE10354628A1 (de) 2003-11-22 2005-06-16 Bayer Cropscience Ag 2-Ethyl-4,6-dimethyl-phenyl-substituierte Tetramsäure-Derivate
DE10354629A1 (de) 2003-11-22 2005-06-30 Bayer Cropscience Ag 2-Ethyl-4,6-dimethyl-phenyl substituierte spirocyclische Tetramsäure-Derivate
GB0329744D0 (en) 2003-12-23 2004-01-28 Koninkl Philips Electronics Nv A beverage maker incorporating multiple beverage collection chambers
DE102004001433A1 (de) 2004-01-09 2005-08-18 Bayer Cropscience Ag cis-Alkoxyspiro-substituierte Tetramsäure-Derivate
DE602005025601D1 (de) 2004-02-18 2011-02-10 Ishihara Sangyo Kaisha Anthranilamide, verfahren zu deren herstellung und diese enthaltende schädlingsbekämpfungsmittel
US7388027B2 (en) 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
SI1731512T1 (sl) 2004-03-05 2015-01-30 Nissan Chemical Industries, Ltd. Z izoksazolinom substituirana benzamidna spojina in sredstvo za uravnavanje škodljivih organizmov
DE102004014620A1 (de) 2004-03-25 2005-10-06 Bayer Cropscience Ag 2,4,6-phenylsubstituierte cyclische Ketoenole
DE102004023332A1 (de) 2004-05-12 2006-01-19 Bayer Cropscience Gmbh Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung
DE102004030753A1 (de) 2004-06-25 2006-01-19 Bayer Cropscience Ag 3'-Alkoxy spirocyclische Tetram- und Tretronsäuren
DE102004041529A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Gmbh Herbizid-Kombinationen mit speziellen Ketoenolen
DE102004044827A1 (de) 2004-09-16 2006-03-23 Bayer Cropscience Ag Jod-phenylsubstituierte cyclische Ketoenole
US7872036B2 (en) 2004-10-20 2011-01-18 Kumiai Chemical Industry Co., Ltd. 3-triazolylphenyl sulfide derivative and insecticide, miticide and nematicide containing it as an active ingredient
TWI360539B (en) * 2004-10-28 2012-03-21 Shionogi & Co 3-carbamoyl-2-pyridone derivatives
DE102004053192A1 (de) 2004-11-04 2006-05-11 Bayer Cropscience Ag 2-Alkoxy-6-alkyl-phenyl substituierte spirocyclische Tetramsäure-Derivate
DE102004053191A1 (de) 2004-11-04 2006-05-11 Bayer Cropscience Ag 2,6-Diethyl-4-methyl-phenyl substituierte Tetramsäure-Derivate
ATE469124T1 (de) 2004-11-26 2010-06-15 Basf Se Neue 2-cyano-3- (halogen)alkoxybenzolsulfonamidverbindungen zur bekämpfung tierischer schädlinge
DE102005008021A1 (de) 2005-02-22 2006-08-24 Bayer Cropscience Ag Spiroketal-substituierte cyclische Ketoenole
MX2007010840A (es) 2005-03-24 2007-10-16 Basf Ag Compuestos de 2-cianobencenosulfonamida para el tratamiento de semillas.
CA2612187C (en) * 2005-06-23 2013-05-07 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
JPWO2007023719A1 (ja) 2005-08-22 2009-02-26 クミアイ化学工業株式会社 薬害軽減剤及び薬害が軽減された除草剤組成物
US20070061917A1 (en) 2005-08-24 2007-03-15 Pioneer Hi-Bred International, Inc. Methods and compositions for the expression of a polynucleotide of interest
JPWO2007023764A1 (ja) 2005-08-26 2009-02-26 クミアイ化学工業株式会社 薬害軽減剤及び薬害が軽減された除草剤組成物
BRPI0615657B8 (pt) 2005-08-31 2019-12-24 Monsanto Technology Llc polinucleotídeo recombinante, proteína e composição inseticidas, cassete de expressão e vetor, bem como métodos para controlar infestação por insetos lepidópteros em planta e para proteger colheita em campo de infestação por insetos lepidópteros
KR101006362B1 (ko) 2005-10-06 2011-01-10 닛뽕소다 가부시키가이샤 고리형 아민 화합물 및 유해 생물 방제제
PE20070707A1 (es) 2005-10-06 2007-08-20 Novartis Ag Compuestos de tetrahidro-pirrolizinona como inhibidores de lfa-1
DE102005051325A1 (de) 2005-10-27 2007-05-03 Bayer Cropscience Ag Alkoxyalkyl spirocyclische Tetram- und Tetronsäuren
PE20070847A1 (es) 2005-11-21 2007-09-21 Basf Ag Compuestos derivados de 3-amino-1,2-bencisotiazol como insecticidas
DE102005059471A1 (de) * 2005-12-13 2007-07-12 Bayer Cropscience Ag Herbizide Zusammensetzungen mit verbesserter Wirkung
DE102005059469A1 (de) 2005-12-13 2007-06-14 Bayer Cropscience Ag Insektizide Zusammensetzungen mit verbesserter Wirkung
DE102005059891A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag 3'-Alkoxy-spirocyclopentyl substituierte Tetram- und Tetronsäuren
DE102005059892A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag Alkylthio-spirocyclische Tetramsäuren
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
DE102006007882A1 (de) 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
WO2007101369A1 (fr) 2006-03-09 2007-09-13 East China University Of Science And Technology Méthode de préparation et utilisation de composés présentant une action biocide
DE102006015470A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006015467A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006015468A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006018828A1 (de) 2006-04-22 2007-10-25 Bayer Cropscience Ag Alkoxyalkyl-substituierte cyclische Ketoenole
DE102006025874A1 (de) 2006-06-02 2007-12-06 Bayer Cropscience Ag Alkoxyalkyl-substituierte cyclische Ketoenole
TWI381811B (zh) 2006-06-23 2013-01-11 Dow Agrosciences Llc 用以防治可抵抗一般殺蟲劑之昆蟲的方法
DE102006033154A1 (de) * 2006-07-18 2008-01-24 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
DE102006033572A1 (de) 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
DE102006039912A1 (de) 2006-08-25 2008-03-20 Bayer Healthcare Ag Substituierte Spirotetronsäuren und ihre Verwendung
DE102006050148A1 (de) 2006-10-25 2008-04-30 Bayer Cropscience Ag Trifluormethoxy-phenylsubstituierte Tetramsäure-Derivate
JP5047588B2 (ja) 2006-10-31 2012-10-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 キノリン誘導体およびそれを含んでなる農園芸用殺虫剤
US8202890B2 (en) 2006-11-30 2012-06-19 Meiji Seika Pharma Co., Ltd. Pest control agent
DE102006057036A1 (de) * 2006-12-04 2008-06-05 Bayer Cropscience Ag Biphenylsubstituierte spirocyclische Ketoenole
DE102006057037A1 (de) 2006-12-04 2008-06-05 Bayer Cropscience Ag cis-Alkoxyspirocyclische biphenylsubstituierte Tetramsäure-Derivate
DE102007001866A1 (de) 2007-01-12 2008-07-17 Bayer Cropscience Ag Spirocyclische Tetronsäure-Derivate
BRPI0807371A2 (pt) 2007-03-01 2014-05-06 Basf Se Misturas pesticidas, composto, métodos para proteger plantas do ataque ou de infestação por insetos, acarídeos ou nematódeos, para controlar insertos, aracnídeos ou nematódeos, para proteger sementes, para proteger animais contra infestação ou infecção por parasitas, e para tratar animais infestados ou infectados por parasitas, semente, uso de uma mistura, e, composição pesticida ou parasitica
EP1987717A1 (de) 2007-04-30 2008-11-05 Bayer CropScience AG Pyridoncarboxamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung
EP1987718A1 (de) 2007-04-30 2008-11-05 Bayer CropScience AG Verwendung von Pyridin-2-oxy-3-carbonamiden als Safener
EP1992614A1 (de) 2007-05-16 2008-11-19 Bayer CropScience Aktiengesellschaft 3-(2-Alkoxy-phenyl)-substituierte Tetramate
EP2020413A1 (de) 2007-08-02 2009-02-04 Bayer CropScience AG Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate
EP2045240A1 (de) 2007-09-25 2009-04-08 Bayer CropScience AG Halogenalkoxyspirocyclische Tetram- und Tetronsäure-Derivate
GB0720126D0 (en) 2007-10-15 2007-11-28 Syngenta Participations Ag Chemical compounds
EP2103615A1 (de) 2008-03-19 2009-09-23 Bayer CropScience AG 4'4'-Dioxaspiro-spirocyclisch substituierte Tetramate
WO2010005692A2 (en) 2008-06-16 2010-01-14 E. I. Du Pont De Nemours And Company Insecticidal cyclic carbonyl amidines
CA2730493A1 (en) * 2008-07-14 2010-01-21 Cropsolution, Inc. Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CA2730844A1 (en) 2008-07-17 2010-01-21 Thomas Bretschneider Heterocyclic compounds used as pesticides
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US8389443B2 (en) 2008-12-02 2013-03-05 Bayer Cropscience Ag Geminal alkoxy/alkylspirocyclic substituted tetramate derivatives
EP2352376B1 (en) 2008-12-02 2014-01-01 Syngenta Participations AG Spiroheterocyclic n-oxyamides as pesticides
TWI396627B (zh) 2008-12-05 2013-05-21 Bobst Sa 在用於處理平板元件之機器中的校準方法
EP2369934B1 (en) 2008-12-12 2014-04-09 Syngenta Participations AG Spiroheterocyclic n-oxypiperidines as pesticides
WO2010069502A2 (de) 2008-12-18 2010-06-24 Bayer Cropscience Ag Tetrazolsubstituierte anthranilsäureamide als pestizide
ES2589007T3 (es) 2008-12-26 2016-11-08 Dow Agrosciences, Llc Composiciones estables de insecticida de tipo sulfoximina
NZ593168A (en) 2008-12-26 2013-12-20 Dow Agrosciences Llc Stable insecticide compositions and methods for producing same
KR101703633B1 (ko) 2009-03-11 2017-02-07 바이엘 인텔렉쳐 프로퍼티 게엠베하 할로겐알킬메틸렌옥시페닐-치환된 케토에놀
CN102378750A (zh) 2009-03-31 2012-03-14 东丽株式会社 发光元件材料前体和其制造方法
WO2010133337A1 (de) 2009-05-19 2010-11-25 Bayer Cropscience Ag Herbizide spiroheterocyclische tetronsäurederivate
CN102448964A (zh) 2009-05-26 2012-05-09 先正达参股股份有限公司 新型螺杂环呋喃和噻吩衍生物
GB0921344D0 (en) 2009-12-04 2010-01-20 Syngenta Participations Ag Chemical compounds
GB0921343D0 (en) 2009-12-04 2010-01-20 Syngenta Participations Ag Chemical compounds
GB0921346D0 (en) 2009-12-04 2010-01-20 Syngenta Participations Ag Chemical compounds
BR112012020084B1 (pt) 2010-02-10 2017-12-19 Bayer Intellectual Property Gmbh A process for the preparation of pesticides and / or herbicides and / or fungi and / or fungi and / or fungicides and / or fungicides and / or fungicides and / or fungicides. METHOD FOR INCREASING THE ACTION OF PESTICIDES AND / OR HERBICIDES AND / OR FUNGICIDES COMPREHENDING SUCH COMPOUNDS
WO2011098443A1 (de) 2010-02-10 2011-08-18 Bayer Cropscience Ag Spiroheterocyclisch-substituierte tetramsäure-derivate
DE102010008642A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
DE102010008644A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
DE102010008643A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie

Similar Documents

Publication Publication Date Title
JP2014508752A5 (enExample)
JP2012255026A5 (enExample)
JP2013522326A5 (enExample)
JP2014521735A5 (enExample)
JP2013525444A5 (enExample)
CA2925624C (en) Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
JP2017524735A5 (enExample)
JP2016536286A5 (enExample)
JP2011006480A5 (enExample)
JP2013509429A5 (enExample)
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
JP2016517888A5 (enExample)
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
EA201291220A1 (ru) Производные аминопиримидина в качестве модуляторов lrrk2
JP2016501221A5 (enExample)
JP2017537066A5 (enExample)
JP2013542261A5 (enExample)
EP2702994A3 (en) Methods of administering pirfenidone therapy
JP2011518833A5 (enExample)
JP2013014622A5 (enExample)
EP2853543A8 (en) Anti-blys antibody
JP2015512943A5 (enExample)
JP2016523907A5 (enExample)
JP2014509653A5 (enExample)
ME02841B (me) Supstituirani piperidil-etil-pirimidin kao inhibitor grelin-o-acil-transferaze