JP2014508752A5 - - Google Patents

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Publication number
JP2014508752A5
JP2014508752A5 JP2013553913A JP2013553913A JP2014508752A5 JP 2014508752 A5 JP2014508752 A5 JP 2014508752A5 JP 2013553913 A JP2013553913 A JP 2013553913A JP 2013553913 A JP2013553913 A JP 2013553913A JP 2014508752 A5 JP2014508752 A5 JP 2014508752A5
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Japan
Prior art keywords
prevention
salt
treatment
cancer
compound
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JP2013553913A
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English (en)
Japanese (ja)
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JP2014508752A (ja
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Priority claimed from DE102011080405A external-priority patent/DE102011080405A1/de
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Priority claimed from PCT/EP2012/052520 external-priority patent/WO2012110518A1/de
Publication of JP2014508752A publication Critical patent/JP2014508752A/ja
Publication of JP2014508752A5 publication Critical patent/JP2014508752A5/ja
Pending legal-status Critical Current

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JP2013553913A 2011-02-17 2012-02-14 治療用の置換３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デカ−３−エン−２−オン Pending JP2014508752A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161443852P 2011-02-17 2011-02-17
US61/443,852 2011-02-17
EP11154805.3 2011-02-17
EP11154805 2011-02-17
DE102011080405A DE102011080405A1 (de) 2011-08-04 2011-08-04 Substituierte 3-(Biphenyl-3-yl)-8,8-difluor-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one zur Therapie
DE102011080405.6 2011-08-04
PCT/EP2012/052520 WO2012110518A1 (de) 2011-02-17 2012-02-14 Substituierte 3-(biphenyl-3-yl)-8,8-difluor-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one zur therapie

Publications (2)

Publication Number Publication Date
JP2014508752A JP2014508752A (ja) 2014-04-10
JP2014508752A5 true JP2014508752A5 (enExample) 2015-04-02

Family

ID=46671961

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013553914A Active JP5905908B2 (ja) 2011-02-17 2012-02-14 治療のための置換された３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デク−３−エン−２−オン類およびハロゲン−置換されたスピロ環状ケトエノール類
JP2013553913A Pending JP2014508752A (ja) 2011-02-17 2012-02-14 治療用の置換３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デカ−３−エン−２−オン

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2013553914A Active JP5905908B2 (ja) 2011-02-17 2012-02-14 治療のための置換された３−（ビフェニル−３−イル）−８，８−ジフルオロ−４−ヒドロキシ−１−アザスピロ［４．５］デク−３−エン−２−オン類およびハロゲン−置換されたスピロ環状ケトエノール類

Country Status (7)

Country Link
US (2) US8946124B2 (enExample)
EP (2) EP2675788A1 (enExample)
JP (2) JP5905908B2 (enExample)
CN (2) CN103649049B (enExample)
BR (1) BR112013021021A2 (enExample)
CA (1) CA2827398A1 (enExample)
WO (2) WO2012110519A1 (enExample)

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SG10201913595YA (en) 2016-09-30 2020-02-27 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
MA49235B1 (fr) 2016-12-09 2021-02-26 Vertex Pharma Modulateur de régulateur de conductance transmembranaire de fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur
CN108721304B (zh) * 2017-04-17 2020-10-16 北京大学 用于治疗肿瘤的药物组合物及其用途
EP3634402B1 (en) 2017-06-08 2026-01-21 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
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IL273831B2 (en) 2017-10-19 2024-10-01 Vertex Pharma Crystalline forms and compositions of cftr modulators
CN111757874B (zh) 2017-12-08 2024-03-08 弗特克斯药品有限公司 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
US11414439B2 (en) 2018-04-13 2022-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
ES1313721Y (es) * 2018-04-13 2025-05-13 Bayer Ag Formulación sólida de mezclas insecticidas
CN112770742A (zh) 2018-07-27 2021-05-07 阿佩塔生物科学有限公司 用于治疗蠕形螨引起的眼部和面部疾病的多杀菌素制剂
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN118164897B (zh) * 2024-03-11 2024-11-15 南开大学 一种螺环特胺酸类化合物及其制备方法和应用
CN119842724B (zh) * 2025-03-24 2025-07-15 浙江农林大学 台湾乳白蚁Or-43884基因及其在防治白蚁中的应用

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