JP2014533272A5

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Publication number: JP2014533272A5
Authority: JP; Japan
Prior art keywords: mutation; formula; braf; treatment; agent
Prior art date: 2012-11-09
Legal status : Granted

Application number

JP2014541283A

Other languages

English (en)

Japanese (ja)

Other versions

JP6150813B2 (ja

JP2014533272A (ja

Filing date

2012-11-09

Publication date

2015-12-24

2012-11-09 Application filed filed Critical

2012-11-09 Priority claimed from PCT/US2012/064269 external-priority patent/WO2013070996A1/en

2014-12-11 Publication of JP2014533272A publication Critical patent/JP2014533272A/ja

2015-12-24 Publication of JP2014533272A5 publication Critical patent/JP2014533272A5/ja

2017-06-21 Application granted granted Critical

2017-06-21 Publication of JP6150813B2 publication Critical patent/JP6150813B2/ja

Status Active legal-status Critical Current

2032-11-09 Anticipated expiration legal-status Critical

Links

230000035772 mutation Effects 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
230000002062 proliferating effect Effects 0.000 claims description 8
229940125431 BRAF inhibitor Drugs 0.000 claims description 7
201000010099 disease Diseases 0.000 claims description 6
206010009944 Colon cancer Diseases 0.000 claims description 4
208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
201000001441 melanoma Diseases 0.000 claims description 4
239000003814 drug Substances 0.000 claims description 3
101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 2
108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims description 2
102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims description 2
102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims 4
229940079593 drug Drugs 0.000 claims 1
238000000034 method Methods 0.000 description 4
241000699670 Mus sp. Species 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1

JP2014541283A 2011-11-11 2012-11-09 増殖性疾患の治療方法 Active JP6150813B2 (ja)