JP2013522212A5 - - Google Patents
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- Publication number
- JP2013522212A5 JP2013522212A5 JP2012557185A JP2012557185A JP2013522212A5 JP 2013522212 A5 JP2013522212 A5 JP 2013522212A5 JP 2012557185 A JP2012557185 A JP 2012557185A JP 2012557185 A JP2012557185 A JP 2012557185A JP 2013522212 A5 JP2013522212 A5 JP 2013522212A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- mutation
- leukemia
- kit according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 230000035772 mutation Effects 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 5
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 201000002510 thyroid cancer Diseases 0.000 claims 4
- 206010000830 Acute leukaemia Diseases 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 238000010253 intravenous injection Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 206010064571 Gene mutation Diseases 0.000 claims 2
- 230000036457 multidrug resistance Effects 0.000 claims 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 1
- 102000003910 Cyclin D Human genes 0.000 claims 1
- 108090000259 Cyclin D Proteins 0.000 claims 1
- 102100039121 Histone-lysine N-methyltransferase MECOM Human genes 0.000 claims 1
- 101001033728 Homo sapiens Histone-lysine N-methyltransferase MECOM Proteins 0.000 claims 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 1
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 claims 1
- 206010069755 K-ras gene mutation Diseases 0.000 claims 1
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 206010038111 Recurrent cancer Diseases 0.000 claims 1
- 206010070308 Refractory cancer Diseases 0.000 claims 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 102100022748 Wilms tumor protein Human genes 0.000 claims 1
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 1
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000016914 ras Proteins Human genes 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31174110P | 2010-03-08 | 2010-03-08 | |
| US61/311,741 | 2010-03-08 | ||
| PCT/US2011/027619 WO2011112635A1 (en) | 2010-03-08 | 2011-03-08 | Cdc7 kinase inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522212A JP2013522212A (ja) | 2013-06-13 |
| JP2013522212A5 true JP2013522212A5 (enExample) | 2014-08-28 |
| JP5827962B2 JP5827962B2 (ja) | 2015-12-02 |
Family
ID=43903897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557185A Active JP5827962B2 (ja) | 2010-03-08 | 2011-03-08 | Ｃｄｃ７キナーゼ阻害剤およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US9180105B2 (enExample) |
| EP (3) | EP4201402A1 (enExample) |
| JP (1) | JP5827962B2 (enExample) |
| CN (1) | CN102844023B (enExample) |
| AU (1) | AU2011224457B2 (enExample) |
| CA (1) | CA2789484C (enExample) |
| DK (1) | DK2544674T3 (enExample) |
| EA (1) | EA025443B1 (enExample) |
| ES (1) | ES2661367T3 (enExample) |
| TR (1) | TR201800962T4 (enExample) |
| WO (1) | WO2011112635A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05007322A (es) | 2003-01-06 | 2006-02-17 | Angiochem Inc | Aprotinina y analogos como portadores a traves de la barrera sangre-cerebro. |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| MX355683B (es) | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
| MX2011004019A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de etoposido y doxorubicina para entrega de farmacos. |
| RU2011118056A (ru) | 2008-10-15 | 2012-11-27 | Ангиокем Инк. | Конъюгаты агонистов glp-1 и их применение |
| CN102307904A (zh) | 2008-12-05 | 2012-01-04 | 安吉奥开米公司 | 神经降压素或神经降压素类似物的缀合物及其用途 |
| CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
| US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
| CN102596993A (zh) | 2009-07-02 | 2012-07-18 | 安吉奥开米公司 | 多聚体肽结合物以及其应用 |
| CA2789484C (en) | 2010-03-08 | 2019-10-22 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
| KR102320190B1 (ko) * | 2014-01-24 | 2021-11-03 | 에이아이 테라퓨틱스, 인코포레이티드 | 아필리모드 조성물 및 이를 사용하기 위한 방법 |
| JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
| CN103980285B (zh) * | 2014-06-06 | 2016-03-16 | 中国医学科学院医药生物技术研究所 | 一种吡喃萘醌类抗生素及其制备和应用 |
| CN107249638B (zh) | 2014-11-07 | 2021-05-14 | 人工智能治疗公司 | 阿匹莫德用于治疗肾癌 |
| KR102554779B1 (ko) * | 2014-12-23 | 2023-07-11 | 슬로안-케테링인스티튜트퍼캔서리서치 | 그라나티신 b의 다형체 |
| DK3307326T3 (da) | 2015-06-15 | 2020-10-19 | Angiochem Inc | Fremgangsmåder til behandling af leptomeningeal karcinomatose |
| KR20170054190A (ko) * | 2015-11-09 | 2017-05-17 | (주)앰틱스바이오 | 진균 감염 치료 및 예방을 위한 신규한 키나아제 및 이들의 용도 |
| EP3515903B1 (en) * | 2016-09-22 | 2020-10-21 | Cancer Research Technology Limited | Preparation and uses of pyrimidinone derivatives |
| EP3589747B1 (en) * | 2017-03-01 | 2021-05-19 | Takeda Pharmaceutical Company Limited | Method of predicting effects of cdc7 inhibitor |
| DK3391907T3 (da) | 2017-04-20 | 2020-03-09 | Iomx Therapeutics Ag | Intracellulær kinase sik3, der er associeret med resistens over for antitumorimmunresponser, og anvendelser deraf |
| CN107349199A (zh) * | 2017-07-18 | 2017-11-17 | 华北制药集团新药研究开发有限责任公司 | 榴菌素类化合物的医药用途 |
| CN107903277B (zh) * | 2017-10-18 | 2019-09-20 | 浙江大学 | 一种n-甲基-美达霉素类化合物及其制备方法和应用 |
| WO2019202160A2 (en) | 2018-04-20 | 2019-10-24 | Iomx Therapeutics Ag | A 5-thiazolecarboxamide kinase inhibitor and uses thereof |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| NL2021185B1 (en) * | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| EP4294513A1 (en) | 2021-02-19 | 2023-12-27 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| WO2025122699A1 (en) * | 2023-12-05 | 2025-06-12 | Lin Bioscience, Inc. | Cdc7 inhibitor combinational therapy |
Family Cites Families (37)
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|---|---|---|---|---|
| GB1184422A (en) * | 1966-02-22 | 1970-03-18 | Ciba Ltd | Antibiotic Granaticin B and Process for its Manufacture |
| CH476102A (de) | 1966-02-22 | 1969-07-31 | Ciba Geigy | Verfahren zur Herstellung eines neuen Antibiotikums |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5593970A (en) | 1990-06-11 | 1997-01-14 | Biochem Pharma Inc. | Heterocyclic anthracycline analogs |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| DE4121468A1 (de) * | 1991-06-28 | 1993-01-14 | Deutsches Primatenzentrum Gmbh | Antivirale substanzen und diese enthaltende arzneimittel |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
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| EP0932427A1 (en) | 1997-07-22 | 1999-08-04 | Emed Corporation | Needle for iontophoretic delivery of agent |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| ATE318818T1 (de) * | 1998-06-16 | 2006-03-15 | Us Gov Health & Human Serv | Annellierte azepinone als inhibitoren cyclin- abhängiger kinasen |
| US20010047032A1 (en) | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
| JP4457211B2 (ja) * | 2004-02-03 | 2010-04-28 | 学校法人慶應義塾 | ナフトキノン誘導体化合物又はその薬理学的に許容される塩、並びに、それらを有効成分として含有するＣｄｃ２５ホスファターゼ阻害剤及び抗腫瘍剤 |
| CA2789484C (en) * | 2010-03-08 | 2019-10-22 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
| KR102554779B1 (ko) | 2014-12-23 | 2023-07-11 | 슬로안-케테링인스티튜트퍼캔서리서치 | 그라나티신 b의 다형체 |
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2011
- 2011-03-08 CA CA2789484A patent/CA2789484C/en active Active
- 2011-03-08 TR TR2018/00962T patent/TR201800962T4/en unknown
- 2011-03-08 EP EP23150649.4A patent/EP4201402A1/en active Pending
- 2011-03-08 AU AU2011224457A patent/AU2011224457B2/en active Active
- 2011-03-08 CN CN201180012863.5A patent/CN102844023B/zh active Active
- 2011-03-08 DK DK11709276.7T patent/DK2544674T3/da active
- 2011-03-08 ES ES11709276.7T patent/ES2661367T3/es active Active
- 2011-03-08 EA EA201270730A patent/EA025443B1/ru not_active IP Right Cessation
- 2011-03-08 EP EP17198166.5A patent/EP3338770B1/en active Active
- 2011-03-08 WO PCT/US2011/027619 patent/WO2011112635A1/en not_active Ceased
- 2011-03-08 JP JP2012557185A patent/JP5827962B2/ja active Active
- 2011-03-08 US US13/583,170 patent/US9180105B2/en active Active
- 2011-03-08 EP EP11709276.7A patent/EP2544674B1/en active Active
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2015
- 2015-11-09 US US14/936,472 patent/US9492427B2/en active Active
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2016
- 2016-11-11 US US15/349,905 patent/US9782386B2/en active Active
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2017
- 2017-10-10 US US15/728,609 patent/US10123992B2/en active Active
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2018
- 2018-11-13 US US16/189,780 patent/US11045446B2/en active Active
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2021
- 2021-05-26 US US17/330,957 patent/US11666550B2/en active Active
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2023
- 2023-04-24 US US18/138,351 patent/US12109189B2/en active Active
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2024
- 2024-09-04 US US18/824,504 patent/US20240423951A1/en active Pending