JP2016185995A5 - - Google Patents

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Publication number
JP2016185995A5
JP2016185995A5 JP2016153074A JP2016153074A JP2016185995A5 JP 2016185995 A5 JP2016185995 A5 JP 2016185995A5 JP 2016153074 A JP2016153074 A JP 2016153074A JP 2016153074 A JP2016153074 A JP 2016153074A JP 2016185995 A5 JP2016185995 A5 JP 2016185995A5
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JP
Japan
Prior art keywords
day
disease
compound
use according
week
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Application number
JP2016153074A
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English (en)
Japanese (ja)
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JP2016185995A (ja
JP6362644B2 (ja
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Publication of JP2016185995A publication Critical patent/JP2016185995A/ja
Publication of JP2016185995A5 publication Critical patent/JP2016185995A5/ja
Application granted granted Critical
Publication of JP6362644B2 publication Critical patent/JP6362644B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016153074A 2009-03-19 2016-08-03 高い経口バイオアベイラビリティを有するモルフィナン誘導体 Expired - Fee Related JP6362644B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16170209P 2009-03-19 2009-03-19
US61/161,702 2009-03-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014046328A Division JP2014101388A (ja) 2009-03-19 2014-03-10 高い経口バイオアベイラビリティを有するモルフィナン誘導体

Publications (3)

Publication Number Publication Date
JP2016185995A JP2016185995A (ja) 2016-10-27
JP2016185995A5 true JP2016185995A5 (enExample) 2016-12-28
JP6362644B2 JP6362644B2 (ja) 2018-07-25

Family

ID=42738186

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012500776A Expired - Fee Related JP5555890B2 (ja) 2009-03-19 2009-12-04 高い経口バイオアベイラビリティを有するモルフィナン誘導体
JP2014046328A Pending JP2014101388A (ja) 2009-03-19 2014-03-10 高い経口バイオアベイラビリティを有するモルフィナン誘導体
JP2014097613A Withdrawn JP2014139257A (ja) 2009-03-19 2014-05-09 高い経口バイオアベイラビリティを有するモルフィナン誘導体
JP2016153074A Expired - Fee Related JP6362644B2 (ja) 2009-03-19 2016-08-03 高い経口バイオアベイラビリティを有するモルフィナン誘導体

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2012500776A Expired - Fee Related JP5555890B2 (ja) 2009-03-19 2009-12-04 高い経口バイオアベイラビリティを有するモルフィナン誘導体
JP2014046328A Pending JP2014101388A (ja) 2009-03-19 2014-03-10 高い経口バイオアベイラビリティを有するモルフィナン誘導体
JP2014097613A Withdrawn JP2014139257A (ja) 2009-03-19 2014-05-09 高い経口バイオアベイラビリティを有するモルフィナン誘導体

Country Status (6)

Country Link
US (4) US20100240691A1 (enExample)
EP (2) EP2408303A4 (enExample)
JP (4) JP5555890B2 (enExample)
AU (1) AU2009342654B2 (enExample)
CA (1) CA2754984C (enExample)
WO (1) WO2010107457A1 (enExample)

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WO2010107457A1 (en) * 2009-03-19 2010-09-23 Alkermes, Inc. Morphinan derivatives with high oral bioavailability
LT2506712T (lt) * 2009-12-04 2019-06-25 Alkermes Pharma Ireland Limited Morfinano dariniai, skirti narkotinių medžiagų perdozavimo gydymui
SMT202400030T1 (it) 2010-08-23 2024-03-13 Alkermes Pharma Ireland Ltd Metodi per trattare l'aumento di peso indotto da antipsicotici
US10195191B2 (en) 2011-12-15 2019-02-05 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
HUE044957T2 (hu) * 2011-12-15 2019-11-28 Alkermes Pharma Ireland Ltd Samidorphan (ALKS 33) opioid agonistákkal alkotott kombinációja
ES2692771T3 (es) 2011-12-15 2018-12-05 Alkermes Pharma Ireland Limited Samidorfano (ALKS 33) en combinación con buprenorfina para el tratamiento de trastornos depresivos
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
AU2014268361B2 (en) * 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US20200022974A1 (en) 2018-07-23 2020-01-23 Trevi Therapeutics, Inc. Treatment of chronic cough, breathlessness and dyspnea
KR20220127849A (ko) 2020-01-10 2022-09-20 트레비 테라퓨틱스, 인코포레이티드 날부핀의 투여 방법
WO2021178405A1 (en) * 2020-03-02 2021-09-10 University Of Southern California Opioid receptor antagonists
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
WO2025038406A1 (en) * 2023-08-11 2025-02-20 Virginia Commonwealth University Design, synthesis, and biological evaluation of nitrogen-walk derivatives of nan as mu opioid receptor selective modulators

Family Cites Families (24)

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US3856795A (en) * 1972-04-25 1974-12-24 American Home Prod Process for preparation of secondary amines from tertiary amines
US4032529A (en) * 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates
US3957793A (en) * 1974-09-20 1976-05-18 Sterling Drug Inc. Hydroxyiminobenzazocines
US4127577A (en) * 1975-11-24 1978-11-28 Sterling Drug Inc. Aminomethanobenzazocine process
US4205171A (en) * 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
US5028612A (en) * 1990-03-22 1991-07-02 Hillel Glover Method for treating emotional numbness
US5258386A (en) * 1991-06-05 1993-11-02 The United States Of America As Represented By The Secretary Of The Army (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
US5512593A (en) * 1993-03-02 1996-04-30 John S. Nagle Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor
KR19990077125A (ko) * 1996-01-10 1999-10-25 파올로 비지, 엔리꼬 카쭐라니 헤테로고리-축합 모르핀 유도체 (ⅱ)
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
ES2304477T3 (es) * 2000-10-31 2008-10-16 Rensselaer Polytechnic Institute Procedimiento de preparacion de compuestos con afinidad a receptores opioides.
EP1748978B1 (en) * 2004-05-14 2014-06-04 Janssen Pharmaceutica NV Carboxamido opioid compounds
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
ATE557006T1 (de) * 2004-11-05 2012-05-15 Rensselaer Polytech Inst 4-hydroxybenzomorphane
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
US20090214650A1 (en) * 2006-02-01 2009-08-27 Alkermes, Inc. Methods of Treating alcoholism and alcohol related disorders using combination drug therapy and swellable polymers
JP5581211B2 (ja) * 2007-08-09 2014-08-27 レンセラール ポリテクニック インスティチュート 第四級オピオイドカルボキサミド
WO2010107457A1 (en) * 2009-03-19 2010-09-23 Alkermes, Inc. Morphinan derivatives with high oral bioavailability
WO2010141666A2 (en) * 2009-06-04 2010-12-09 The General Hospital Corporation Modulating endogenous beta-endorphin levels
US9211293B2 (en) * 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
JP5929635B2 (ja) * 2012-08-30 2016-06-08 株式会社デンソー 多段式横型鍛造装置

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