JP2011068653A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011068653A5 JP2011068653A5 JP2010237937A JP2010237937A JP2011068653A5 JP 2011068653 A5 JP2011068653 A5 JP 2011068653A5 JP 2010237937 A JP2010237937 A JP 2010237937A JP 2010237937 A JP2010237937 A JP 2010237937A JP 2011068653 A5 JP2011068653 A5 JP 2011068653A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- administered
- composition according
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 9
- 230000037396 body weight Effects 0.000 claims 8
- 239000002552 dosage form Substances 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 3
- 239000006187 pill Substances 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010062904 Hormone-refractory prostate cancer Diseases 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- VONIYVYPMHRCOX-UHFFFAOYSA-N CC(C)(C(N(C1=S)c(cc2C(F)(F)F)ccc2C#N)O)N1c(cc1)cc(F)c1C(NC)=O Chemical compound CC(C)(C(N(C1=S)c(cc2C(F)(F)F)ccc2C#N)O)N1c(cc1)cc(F)c1C(NC)=O VONIYVYPMHRCOX-UHFFFAOYSA-N 0.000 description 1
- NMWKXPOYFABJRA-UHFFFAOYSA-N CNC(c(c(F)c1)ccc1N(C1(CCCC1)C(N1c(cc2)cc(C(F)(F)F)c2C#N)=O)C1=S)=O Chemical compound CNC(c(c(F)c1)ccc1N(C1(CCCC1)C(N1c(cc2)cc(C(F)(F)F)c2C#N)=O)C1=S)=O NMWKXPOYFABJRA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68083505P | 2005-05-13 | 2005-05-13 | |
| US60/680,835 | 2005-05-13 | ||
| US75035105P | 2005-12-15 | 2005-12-15 | |
| US60/750,351 | 2005-12-15 | ||
| US75655206P | 2006-01-06 | 2006-01-06 | |
| US60/756,552 | 2006-01-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511114A Division JP4644737B2 (ja) | 2005-05-13 | 2006-03-29 | ジアリールヒダントイン化合物 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012168904A Division JP5150780B2 (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
| JP2012168905A Division JP2012211190A (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011068653A JP2011068653A (ja) | 2011-04-07 |
| JP2011068653A5 true JP2011068653A5 (enExample) | 2012-09-13 |
| JP5138753B2 JP5138753B2 (ja) | 2013-02-06 |
Family
ID=37431537
Family Applications (13)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511114A Expired - Lifetime JP4644737B2 (ja) | 2005-05-13 | 2006-03-29 | ジアリールヒダントイン化合物 |
| JP2010237937A Expired - Lifetime JP5138753B2 (ja) | 2005-05-13 | 2010-10-22 | ジアリールヒダントイン化合物 |
| JP2012168905A Withdrawn JP2012211190A (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
| JP2012168904A Expired - Lifetime JP5150780B2 (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
| JP2015039980A Expired - Lifetime JP6013535B2 (ja) | 2005-05-13 | 2015-03-02 | ジアリールヒダントイン化合物 |
| JP2016148183A Withdrawn JP2016183200A (ja) | 2005-05-13 | 2016-07-28 | ジアリールヒダントイン化合物 |
| JP2018039424A Withdrawn JP2018100292A (ja) | 2005-05-13 | 2018-03-06 | ジアリールヒダントイン化合物 |
| JP2019134558A Pending JP2019218352A (ja) | 2005-05-13 | 2019-07-22 | ジアリールヒダントイン化合物 |
| JP2020187901A Withdrawn JP2021035970A (ja) | 2005-05-13 | 2020-11-11 | ジアリールヒダントイン化合物 |
| JP2022071531A Pending JP2022101657A (ja) | 2005-05-13 | 2022-04-25 | ジアリールヒダントイン化合物 |
| JP2023043191A Pending JP2023075313A (ja) | 2005-05-13 | 2023-03-17 | ジアリールヒダントイン化合物 |
| JP2024115820A Withdrawn JP2024153705A (ja) | 2005-05-13 | 2024-07-19 | ジアリールヒダントイン化合物 |
| JP2025134786A Withdrawn JP2025166151A (ja) | 2005-05-13 | 2025-08-13 | ジアリールヒダントイン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511114A Expired - Lifetime JP4644737B2 (ja) | 2005-05-13 | 2006-03-29 | ジアリールヒダントイン化合物 |
Family Applications After (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012168905A Withdrawn JP2012211190A (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
| JP2012168904A Expired - Lifetime JP5150780B2 (ja) | 2005-05-13 | 2012-07-30 | ジアリールヒダントイン化合物 |
| JP2015039980A Expired - Lifetime JP6013535B2 (ja) | 2005-05-13 | 2015-03-02 | ジアリールヒダントイン化合物 |
| JP2016148183A Withdrawn JP2016183200A (ja) | 2005-05-13 | 2016-07-28 | ジアリールヒダントイン化合物 |
| JP2018039424A Withdrawn JP2018100292A (ja) | 2005-05-13 | 2018-03-06 | ジアリールヒダントイン化合物 |
| JP2019134558A Pending JP2019218352A (ja) | 2005-05-13 | 2019-07-22 | ジアリールヒダントイン化合物 |
| JP2020187901A Withdrawn JP2021035970A (ja) | 2005-05-13 | 2020-11-11 | ジアリールヒダントイン化合物 |
| JP2022071531A Pending JP2022101657A (ja) | 2005-05-13 | 2022-04-25 | ジアリールヒダントイン化合物 |
| JP2023043191A Pending JP2023075313A (ja) | 2005-05-13 | 2023-03-17 | ジアリールヒダントイン化合物 |
| JP2024115820A Withdrawn JP2024153705A (ja) | 2005-05-13 | 2024-07-19 | ジアリールヒダントイン化合物 |
| JP2025134786A Withdrawn JP2025166151A (ja) | 2005-05-13 | 2025-08-13 | ジアリールヒダントイン化合物 |
Country Status (30)
| Country | Link |
|---|---|
| EP (5) | EP3970721A1 (enExample) |
| JP (13) | JP4644737B2 (enExample) |
| KR (12) | KR101782236B1 (enExample) |
| CN (6) | CN105037273B (enExample) |
| AT (1) | ATE541571T1 (enExample) |
| AU (1) | AU2006248109B2 (enExample) |
| BE (1) | BE2013C074I2 (enExample) |
| BR (1) | BRPI0610359B8 (enExample) |
| CA (1) | CA2608436C (enExample) |
| CY (2) | CY1112798T1 (enExample) |
| DK (2) | DK1893196T4 (enExample) |
| ES (2) | ES2378778T5 (enExample) |
| FR (1) | FR13C0071I2 (enExample) |
| HK (1) | HK1217103A1 (enExample) |
| HR (2) | HRP20120323T4 (enExample) |
| HU (1) | HUS1300076I1 (enExample) |
| IL (4) | IL187328A (enExample) |
| LU (1) | LU92338I2 (enExample) |
| ME (1) | ME01992B (enExample) |
| MX (4) | MX346924B (enExample) |
| NO (4) | NO339997B1 (enExample) |
| NZ (3) | NZ564223A (enExample) |
| PL (2) | PL2444085T3 (enExample) |
| PT (2) | PT1893196E (enExample) |
| RS (2) | RS53967B1 (enExample) |
| RU (3) | RU2448096C3 (enExample) |
| SG (1) | SG10201703816SA (enExample) |
| SI (2) | SI1893196T2 (enExample) |
| WO (1) | WO2006124118A1 (enExample) |
| ZA (2) | ZA200710870B (enExample) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1709193B1 (en) | 2003-12-19 | 2011-03-16 | The Regents of The University of California | Methods and materials for assessing prostate cancer therapies |
| WO2005099693A2 (en) | 2004-02-24 | 2005-10-27 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| CA2608436C (en) * | 2005-05-13 | 2015-03-24 | The Regents Of The University Of California | Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| ES2689292T3 (es) | 2006-03-27 | 2018-11-13 | The Regents Of The University Of California | Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos |
| NZ572374A (en) * | 2006-03-29 | 2011-12-22 | Univ California | Diarylthiohydantoin compounds |
| WO2008093838A1 (ja) * | 2007-02-01 | 2008-08-07 | Chugai Seiyaku Kabushiki Kaisha | スルファモイル基を有するピリジルイミダゾリジン誘導体、およびその医薬としての使用 |
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| EP2220050A2 (en) * | 2007-10-26 | 2010-08-25 | The Regents Of The University Of California | Diarylhydantoin compounds as androgen receptor modulators |
| US8524755B2 (en) * | 2009-02-24 | 2013-09-03 | Medivation Prostate Therapeutics, Inc. | Specific diarylhydantoin and diarylthiohydantoin compounds |
| CN101817787B (zh) * | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
| KR20120036842A (ko) * | 2009-05-12 | 2012-04-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 악성의 호르몬 민감성 전립선 암에 대한 마커로서의 포스포디에스테라제 4ｄ7 |
| KR101456994B1 (ko) * | 2009-09-10 | 2014-11-04 | 통유지 | 안드로겐 수용체 길항제 및 그의 용도 |
| TW201111378A (en) * | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| JP2013504531A (ja) | 2009-09-11 | 2013-02-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | 抗癌薬としての置換（ヘテロアリールメチル）チオヒダントイン |
| AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
| PL2509961T3 (pl) | 2009-12-11 | 2016-09-30 | Pochodne imidazolidynodionu | |
| SG10201907588XA (en) * | 2010-02-16 | 2019-09-27 | Aragon Pharmaceuticals Inc | Androgen Receptor Modulators And Uses Thereof |
| HUE038637T2 (hu) * | 2010-02-24 | 2018-12-28 | Medivation Prostate Therapeutics Llc | Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására |
| RU2434851C1 (ru) | 2010-07-22 | 2011-11-27 | Александр Васильевич Иващенко | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
| ES2560304T3 (es) | 2010-12-06 | 2016-02-18 | Autifony Therapeutics Limited | Derivados de hidantoína útiles como inhibidores de Kv3 |
| CN103608333B (zh) * | 2011-03-10 | 2016-01-06 | 苏州开拓药业有限公司 | 雄激素受体拮抗剂及其用途 |
| KR101958177B1 (ko) | 2011-04-21 | 2019-03-15 | 오리온 코포레이션 | 안드로겐 수용체 조절성 카복스아미드 |
| EP2718285B1 (en) | 2011-06-07 | 2016-03-16 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| JP6158180B2 (ja) * | 2011-07-29 | 2017-07-05 | メディベイション プロステイト セラピューティクス， インコーポレイテッド | 乳がんの処置 |
| PT2785349T (pt) | 2011-11-30 | 2019-12-11 | Astrazeneca Ab | Tratamento combinado de cancro |
| CN103159680A (zh) | 2011-12-14 | 2013-06-19 | 爱美尼迪药物有限公司 | 咪唑二酮类化合物及其用途 |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2013175215A1 (en) | 2012-05-22 | 2013-11-28 | Autifony Therapeutics Limited | Triazoles as kv3 inhibitors |
| EP2852588B8 (en) | 2012-05-22 | 2018-01-10 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| KR102189940B1 (ko) * | 2012-09-04 | 2020-12-14 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 이미다졸린 유도체, 이의 제조 방법, 및 이들의 의약에서의 용도 |
| TWI673051B (zh) * | 2012-09-11 | 2019-10-01 | 美商梅維森前列腺療法有限責任公司 | 恩雜魯它脈（ｅｎｚａｌｕｔａｍｉｄｅ）之調和物 |
| EP2895464A4 (en) * | 2012-09-11 | 2016-06-15 | Reddys Lab Ltd Dr | POLYMORPHIC ENZALUTAMIDE FORMS AND THEIR PREPARATION |
| CN115737643A (zh) | 2012-09-26 | 2023-03-07 | 阿拉贡药品公司 | 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素 |
| US9944607B2 (en) | 2012-10-16 | 2018-04-17 | Whitehead Institute For Biomedical Research | Thiohydantoin derivatives and uses thereof |
| CA2889756C (en) * | 2012-10-26 | 2023-03-14 | Memorial Sloan-Kettering Cancer Center | Thiohydantoin compounds as androgen receptor modulators |
| DK2945628T3 (da) | 2013-01-15 | 2020-05-04 | Aragon Pharmaceuticals Inc | Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer |
| RU2520134C1 (ru) * | 2013-02-27 | 2014-06-20 | Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") | Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения |
| WO2014167428A2 (en) * | 2013-04-10 | 2014-10-16 | Shilpa Medicare Limited | Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide |
| EP3010889B1 (de) | 2013-06-20 | 2018-10-03 | Bayer CropScience Aktiengesellschaft | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| WO2015018356A1 (zh) * | 2013-08-08 | 2015-02-12 | 上海医药集团股份有限公司 | 二芳基乙内酰脲衍生物、其制备方法、药物组合物和应用 |
| WO2015042170A1 (en) | 2013-09-17 | 2015-03-26 | Wayne State University | Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds |
| RU2016110546A (ru) * | 2013-09-19 | 2017-10-24 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Комбинированная лекарственная терапия |
| CN105188699B (zh) * | 2013-10-14 | 2017-04-26 | 杭州普晒医药科技有限公司 | 恩杂鲁胺的固态形式及其制备方法和用途 |
| EP3063135A1 (en) | 2013-10-31 | 2016-09-07 | Sun Pharmaceutical Industries Ltd | Process for the preparation of enzalutamide |
| WO2015092617A1 (en) | 2013-12-16 | 2015-06-25 | Ranbaxy Laboratories Limited | Processes and intermediates for the preparation of enzalutamide |
| US9682960B2 (en) * | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| CN104803919A (zh) * | 2014-01-26 | 2015-07-29 | 上海医药工业研究院 | 用于制备恩杂鲁胺中间体的方法 |
| WO2015121768A1 (en) | 2014-02-13 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of enzalutamide |
| CZ2014232A3 (cs) | 2014-04-07 | 2015-10-14 | Zentiva, K.S. | Způsob výroby enzalutamidu |
| CN103896847B (zh) * | 2014-04-09 | 2016-01-20 | 沈江 | 一种非甾体类抗雄激素化合物及其制备方法和应用 |
| CN103910679B (zh) * | 2014-04-23 | 2016-05-25 | 杭州新博思生物医药有限公司 | 一种恩杂鲁胺的制备方法 |
| CN104003939B (zh) * | 2014-06-06 | 2017-07-07 | 山东大学 | 二芳基取代乙内酰硫脲类化合物及其制备方法与应用 |
| CN104016924B (zh) * | 2014-06-16 | 2016-04-13 | 上海鼎雅药物化学科技有限公司 | 一种“一锅法”合成恩杂鲁胺的方法 |
| WO2015196144A2 (en) | 2014-06-20 | 2015-12-23 | England Pamela M | Androgen receptor antagonists |
| RU2557235C1 (ru) * | 2014-07-08 | 2015-07-20 | Александр Васильевич Иващенко | Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты |
| US20170190670A1 (en) * | 2014-07-11 | 2017-07-06 | Shilpa Medicare Limited | Improved process for the preparation of enzalutamide |
| EA201791222A1 (ru) | 2014-12-05 | 2017-09-29 | Арагон Фармасьютикалз, Инк. | Противораковые композиции |
| RU2017120330A (ru) | 2014-12-12 | 2019-01-14 | Медивэйшн Простейт Терапьютикс, Ллс | Способ прогнозирования ответа на терапевтические агенты для лечения рака молочной железы и способ лечения рака молочной железы |
| CN104610111A (zh) * | 2014-12-26 | 2015-05-13 | 杭州和泽医药科技有限公司 | 一种4-异硫代氰酰基-2-(三氟甲基)苯甲腈的制备方法 |
| CN105523958B (zh) * | 2015-01-13 | 2017-11-03 | 北京海步医药科技股份有限公司 | 一种制备二芳基硫代乙内酰脲衍生物关键中间体的方法 |
| HK1245791A1 (zh) * | 2015-01-20 | 2018-08-31 | 阿尔维纳斯运营股份有限公司 | 用於雄激素受体的靶向降解的化合物和方法 |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CN106187905B (zh) * | 2015-05-05 | 2020-02-21 | 北京海步医药科技股份有限公司 | 丁鲁他胺的结晶形式及其制备方法 |
| ITUB20151204A1 (it) | 2015-05-28 | 2016-11-28 | Olon Spa | Procedimento per la preparazione di enzalutamide |
| ITUB20151311A1 (it) * | 2015-05-28 | 2016-11-28 | Olon Spa | Procedimento per la preparazione di enzalutamide |
| ITUB20151256A1 (it) | 2015-05-28 | 2016-11-28 | Olon Spa | Processo industriale per la preparazione di enzalutamide |
| US10118899B2 (en) | 2015-05-29 | 2018-11-06 | Astellas Pharma, Inc. | Production method of enzalutamide crystal form |
| SMT202000258T1 (it) * | 2015-09-10 | 2020-07-08 | Jiangsu Hengrui Medicine Co | Forma cristallina di inibitore del recettore degli androgeni e procedimento di preparazione dello stesso |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| CN110167556A (zh) * | 2016-07-08 | 2019-08-23 | 詹森药业有限公司 | 用于治疗癌症的硫代乙内酰脲雄性激素受体拮抗剂 |
| US10933059B2 (en) | 2016-12-16 | 2021-03-02 | Kangpu Biopharmaceuticals. Ltd. | Combination, application thereof and treatment method |
| JP7172997B2 (ja) | 2017-04-28 | 2022-11-16 | アステラス製薬株式会社 | エンザルタミドを含有する経口投与用医薬組成物 |
| MX2020003845A (es) | 2017-10-16 | 2020-11-06 | Aragon Pharmaceuticals Inc | Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración. |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| CZ2018234A3 (cs) | 2018-05-21 | 2019-12-04 | Zentiva Ks | Zvýšení rozpustnosti a biodostupnosti enzalutamidu |
| CN108976171B (zh) * | 2018-08-27 | 2020-06-16 | 长沙泽达医药科技有限公司 | 化合物、组合物及其在药物制备中的用途 |
| JP2022509917A (ja) | 2018-11-05 | 2022-01-25 | ファイザー・インク | がんを処置するための組合せ |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| AU2019387367A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| CN109796437B (zh) * | 2019-02-26 | 2021-08-24 | 上海健康医学院 | 具有ar和hdac双重抑制作用的乙内酰脲类和乙内酰硫脲类化合物及用途 |
| US20220242829A1 (en) | 2019-06-27 | 2022-08-04 | Synthon B.V. | Process for preparation of enzalutamide |
| CN110452166A (zh) * | 2019-09-06 | 2019-11-15 | 浙江朗华制药有限公司 | 一种5-异硫氰酰基-3-三氟甲基-2-氰基吡啶的制备方法 |
| US20220347102A1 (en) | 2019-10-03 | 2022-11-03 | Synthon B.V. | Pharmaceutical composition comprising enzalutamide |
| WO2021240206A1 (en) | 2020-05-24 | 2021-12-02 | Lotus International Pte. Ltd. | Enzalutamide formulation |
| BR112023002295A2 (pt) | 2020-08-13 | 2023-03-14 | Pfizer | Terapia de combinação |
| TW202237615A (zh) | 2020-12-11 | 2022-10-01 | 南韓商日東製藥股份有限公司 | 作為雄激素受體及磷酸二酯酶雙重抑制劑的新穎化合物 |
| KR20230159510A (ko) | 2021-03-24 | 2023-11-21 | 화이자 인코포레이티드 | Ddr 유전자 돌연변이된 전이성 거세-감수성 전립선암의 치료를 위한 탈라조파립과 항안드로겐의 조합 |
| EP4112603A1 (en) | 2021-06-29 | 2023-01-04 | Química Sintética, S.A. | Processes for the preparation of non-steroidal antiandrogens |
| KR102861133B1 (ko) | 2021-10-13 | 2025-09-16 | 주식회사 엘지에너지솔루션 | 배터리 충방전 프로파일 분석 방법 및 배터리 충방전 프로파일 분석 장치 |
| CN114181155A (zh) * | 2021-12-21 | 2022-03-15 | 上海朝晖药业有限公司 | 碘-恩杂鲁胺及其制备方法及其应用 |
| CN117164520B (zh) * | 2022-01-28 | 2025-04-25 | 南京思聚生物医药有限公司 | 一种局部作用的雄激素受体拮抗剂及其应用 |
| KR20230170859A (ko) | 2022-06-11 | 2023-12-19 | 이태영 | 패스트칫솔 |
| CN117327019A (zh) * | 2022-06-23 | 2024-01-02 | 南京思聚生物医药有限公司 | 一种局部作用的雄激素受体拮抗剂的应用 |
| TWI883565B (zh) | 2022-10-02 | 2025-05-11 | 美商輝瑞大藥廠 | 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合 |
| EP4374853A1 (en) | 2022-11-22 | 2024-05-29 | Lotus Pharmaceutical Co., Ltd. | Solid formulation of enzalutamide |
| TW202425976A (zh) | 2022-12-17 | 2024-07-01 | 美商輝瑞大藥廠 | 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合 |
| CN115850186B (zh) * | 2023-02-07 | 2024-04-09 | 长沙泽达医药科技有限公司 | 一种乙撑硫脲衍生物的晶型及用途 |
| WO2025125565A1 (en) | 2023-12-13 | 2025-06-19 | Krka, D.D., Novo Mesto | Tablet comprising enzalutamide |
| WO2025210510A1 (en) | 2024-04-04 | 2025-10-09 | Pfizer Inc. | Tmprss2-erg and rb1 as predictive biomarkers for treatment with a parp inhibitor |
| WO2026078615A1 (en) | 2024-10-09 | 2026-04-16 | Pfizer Inc. | Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer |
| WO2026078619A1 (en) | 2024-10-09 | 2026-04-16 | Pfizer Inc. | Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2329276A1 (fr) | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
| SU1380610A3 (ru) * | 1982-12-06 | 1988-03-07 | Пфайзер Инк. (Фирма) | Способ получени спирогетероазолидиндионов или их фармацевтически приемлемых солей |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| FR2671348B1 (fr) | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
| US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
| FR2693461B1 (fr) | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| FR2715402B1 (fr) * | 1994-01-05 | 1996-10-04 | Roussel Uclaf | Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| WO1995019770A1 (en) † | 1994-01-21 | 1995-07-27 | Sepracor, Inc. | Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex |
| FR2725206B1 (fr) | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US5656651A (en) | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
| FR2741342B1 (fr) * | 1995-11-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
| PL346795A1 (en) | 1998-09-22 | 2002-02-25 | Yamanouchi Pharma Co Ltd | Cyanophenyl derivatives |
| FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
| US6861432B2 (en) | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
| AU2003279442A1 (en) | 2002-10-04 | 2004-04-23 | Laboratoires Fournier S.A. | 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
| FR2850652B1 (fr) | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| US20050005529A1 (en) | 2003-07-10 | 2005-01-13 | David Brault | Lighting system for a greenhouse |
| WO2005099693A2 (en) * | 2004-02-24 | 2005-10-27 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| KR20070106969A (ko) * | 2004-09-09 | 2007-11-06 | 추가이 세이야쿠 가부시키가이샤 | 신규 이미다졸리딘 유도체 및 그 용도 |
| CA2608436C (en) * | 2005-05-13 | 2015-03-24 | The Regents Of The University Of California | Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
-
2006
- 2006-03-29 CA CA2608436A patent/CA2608436C/en not_active Expired - Lifetime
- 2006-03-29 RU RU2007146462A patent/RU2448096C3/ru active
- 2006-03-29 NZ NZ564223A patent/NZ564223A/en unknown
- 2006-03-29 KR KR1020157019319A patent/KR101782236B1/ko not_active Expired - Lifetime
- 2006-03-29 KR KR1020217035915A patent/KR102481886B1/ko not_active Expired - Lifetime
- 2006-03-29 WO PCT/US2006/011417 patent/WO2006124118A1/en not_active Ceased
- 2006-03-29 DK DK06748863.5T patent/DK1893196T4/en active
- 2006-03-29 KR KR1020227045048A patent/KR102713358B1/ko not_active Expired - Lifetime
- 2006-03-29 MX MX2015003843A patent/MX346924B/es unknown
- 2006-03-29 ME MEP-2012-154A patent/ME01992B/me unknown
- 2006-03-29 EP EP21193326.2A patent/EP3970721A1/en active Pending
- 2006-03-29 KR KR1020127019589A patent/KR101332924B1/ko not_active Expired - Lifetime
- 2006-03-29 MX MX2019015200A patent/MX394667B/es unknown
- 2006-03-29 EP EP06748863.5A patent/EP1893196B2/en not_active Expired - Lifetime
- 2006-03-29 CN CN201510296329.1A patent/CN105037273B/zh not_active Expired - Lifetime
- 2006-03-29 KR KR1020077029188A patent/KR101169832B1/ko not_active Expired - Lifetime
- 2006-03-29 KR KR1020177025842A patent/KR102020721B1/ko not_active Expired - Lifetime
- 2006-03-29 ES ES06748863.5T patent/ES2378778T5/es not_active Expired - Lifetime
- 2006-03-29 SI SI200631309T patent/SI1893196T2/sl unknown
- 2006-03-29 EP EP16171151.0A patent/EP3106162A1/en not_active Withdrawn
- 2006-03-29 AT AT06748863T patent/ATE541571T1/de active
- 2006-03-29 KR KR1020137012351A patent/KR101431407B1/ko not_active Expired - Lifetime
- 2006-03-29 CN CN202211664795.7A patent/CN116003328A/zh active Pending
- 2006-03-29 KR KR1020117007291A patent/KR101332889B1/ko not_active Expired - Lifetime
- 2006-03-29 PT PT06748863T patent/PT1893196E/pt unknown
- 2006-03-29 JP JP2008511114A patent/JP4644737B2/ja not_active Expired - Lifetime
- 2006-03-29 PL PL11184401T patent/PL2444085T3/pl unknown
- 2006-03-29 CN CN2012100273781A patent/CN102584712A/zh active Pending
- 2006-03-29 NZ NZ710355A patent/NZ710355A/en unknown
- 2006-03-29 SG SG10201703816SA patent/SG10201703816SA/en unknown
- 2006-03-29 PL PL06748863T patent/PL1893196T5/pl unknown
- 2006-03-29 KR KR1020147029832A patent/KR101579701B1/ko not_active Expired - Lifetime
- 2006-03-29 PT PT111844015T patent/PT2444085E/pt unknown
- 2006-03-29 CN CN202510689609.2A patent/CN120682155A/zh active Pending
- 2006-03-29 MX MX2007014132A patent/MX2007014132A/es active IP Right Grant
- 2006-03-29 EP EP12193684A patent/EP2561871A1/en not_active Withdrawn
- 2006-03-29 DK DK11184401T patent/DK2444085T3/en active
- 2006-03-29 RS RS20150269A patent/RS53967B1/sr unknown
- 2006-03-29 RS RS20120154A patent/RS52274B2/sr unknown
- 2006-03-29 EP EP11184401.5A patent/EP2444085B1/en not_active Revoked
- 2006-03-29 KR KR1020147003529A patent/KR101515335B1/ko not_active Expired - Lifetime
- 2006-03-29 NZ NZ591119A patent/NZ591119A/xx unknown
- 2006-03-29 BR BRPI0610359A patent/BRPI0610359B8/pt not_active IP Right Cessation
- 2006-03-29 HR HRP20120323TT patent/HRP20120323T4/hr unknown
- 2006-03-29 SI SI200631926T patent/SI2444085T1/sl unknown
- 2006-03-29 ES ES11184401.5T patent/ES2535179T3/es not_active Expired - Lifetime
- 2006-03-29 KR KR1020247032344A patent/KR20240148945A/ko active Pending
- 2006-03-29 KR KR1020197025316A patent/KR102324567B1/ko not_active Expired - Lifetime
- 2006-03-29 CN CN201910163070.1A patent/CN110003114B/zh not_active Expired - Lifetime
- 2006-03-29 AU AU2006248109A patent/AU2006248109B2/en active Active
- 2006-03-29 CN CN2006800255451A patent/CN101222922B/zh not_active Expired - Lifetime
-
2007
- 2007-11-12 IL IL187328A patent/IL187328A/en active Protection Beyond IP Right Term
- 2007-11-12 MX MX2022009759A patent/MX2022009759A/es unknown
- 2007-12-12 NO NO20076401A patent/NO339997B1/no active Protection Beyond IP Right Term
- 2007-12-13 ZA ZA2007/10870A patent/ZA200710870B/en unknown
-
2010
- 2010-10-22 JP JP2010237937A patent/JP5138753B2/ja not_active Expired - Lifetime
-
2011
- 2011-12-23 RU RU2011152891A patent/RU2638833C2/ru active
-
2012
- 2012-03-12 ZA ZA2012/01793A patent/ZA201201793B/en unknown
- 2012-04-18 CY CY20121100367T patent/CY1112798T1/el unknown
- 2012-07-30 JP JP2012168905A patent/JP2012211190A/ja not_active Withdrawn
- 2012-07-30 JP JP2012168904A patent/JP5150780B2/ja not_active Expired - Lifetime
-
2013
- 2013-12-16 CY CY2013047C patent/CY2013047I1/el unknown
- 2013-12-17 HU HUS1300076C patent/HUS1300076I1/hu unknown
- 2013-12-17 LU LU92338C patent/LU92338I2/xx unknown
- 2013-12-18 BE BE2013C074C patent/BE2013C074I2/fr unknown
- 2013-12-18 FR FR13C0071C patent/FR13C0071I2/fr active Active
-
2015
- 2015-03-02 JP JP2015039980A patent/JP6013535B2/ja not_active Expired - Lifetime
- 2015-04-21 HR HRP20150437TT patent/HRP20150437T1/hr unknown
-
2016
- 2016-01-28 IL IL243812A patent/IL243812A0/en unknown
- 2016-05-05 HK HK16105142.8A patent/HK1217103A1/zh unknown
- 2016-07-28 JP JP2016148183A patent/JP2016183200A/ja not_active Withdrawn
- 2016-12-15 NO NO20161996A patent/NO342490B1/no unknown
-
2017
- 2017-05-04 NO NO2017019C patent/NO2017019I1/no unknown
- 2017-12-05 RU RU2017142159A patent/RU2017142159A/ru unknown
-
2018
- 2018-02-13 NO NO20180225A patent/NO20180225A1/no unknown
- 2018-03-06 JP JP2018039424A patent/JP2018100292A/ja not_active Withdrawn
- 2018-04-23 IL IL258880A patent/IL258880A/en unknown
-
2019
- 2019-07-22 JP JP2019134558A patent/JP2019218352A/ja active Pending
-
2020
- 2020-11-11 JP JP2020187901A patent/JP2021035970A/ja not_active Withdrawn
-
2022
- 2022-04-25 JP JP2022071531A patent/JP2022101657A/ja active Pending
-
2023
- 2023-03-17 JP JP2023043191A patent/JP2023075313A/ja active Pending
-
2024
- 2024-07-19 JP JP2024115820A patent/JP2024153705A/ja not_active Withdrawn
-
2025
- 2025-08-13 JP JP2025134786A patent/JP2025166151A/ja not_active Withdrawn
- 2025-09-21 IL IL323480A patent/IL323480A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012255026A5 (enExample) | ||
| JP2012092149A5 (enExample) | ||
| HRP20120323T4 (hr) | Spoj diaril-hidantoina | |
| JP2014516942A5 (enExample) | ||
| JP2010501575A5 (enExample) | ||
| JP2009102342A5 (enExample) | ||
| IL314360B1 (en) | Method for the synthesis of thyroid hormone analogs and their polymorphs | |
| JP2013511507A5 (enExample) | ||
| IL295418B1 (en) | Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus | |
| JP2015078230A5 (enExample) | ||
| JP2016185995A5 (enExample) | ||
| JP2012082215A5 (enExample) | ||
| PH12015502134A1 (en) | Mosapride sustained-release preparation for providing pharmacological and clinical effects with once-a-day administration | |
| FI3435996T3 (fi) | Elafibranori käytettäväksi primaarisen biliaarisen kolangiitin hoidossa | |
| JP2013518107A5 (enExample) | ||
| JP2020505423A5 (enExample) | ||
| JP2006515883A5 (enExample) | ||
| HRP20201316T1 (hr) | Novi modulatori receptora sfingozin-fosfata | |
| JP2015529234A5 (enExample) | ||
| ME02474B (me) | Terapijski režimi | |
| TW201513864A (zh) | 含低用量伊立替康鹽酸鹽水合物之抗腫瘤劑 | |
| JP2011500805A5 (enExample) | ||
| RU2015113031A (ru) | Использование 3-n-бутил изоиндолин кетонов при приготовлении лекарственных средств для профилактики и лечения церебрального инфаркта | |
| RU2012108144A (ru) | Противораковая терапия, направленная против раковых стволовых клеток и форм рака, устойчивых к лечению лекарственными препаратами | |
| JP2014058509A5 (enExample) |