JP2014518266A5 - - Google Patents
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- JP2014518266A5 JP2014518266A5 JP2014518879A JP2014518879A JP2014518266A5 JP 2014518266 A5 JP2014518266 A5 JP 2014518266A5 JP 2014518879 A JP2014518879 A JP 2014518879A JP 2014518879 A JP2014518879 A JP 2014518879A JP 2014518266 A5 JP2014518266 A5 JP 2014518266A5
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- JP
- Japan
- Prior art keywords
- further characterized
- curve
- powder
- ray diffraction
- diffraction pattern
- Prior art date
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502497P | 2011-06-29 | 2011-06-29 | |
| US61/502,497 | 2011-06-29 | ||
| PCT/US2012/043922 WO2013003249A1 (en) | 2011-06-29 | 2012-06-25 | Novel crystalline forms of a dipeptidyl peptidase-iv inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198829A Division JP2017039752A (ja) | 2011-06-29 | 2016-10-07 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014518266A JP2014518266A (ja) | 2014-07-28 |
| JP2014518266A5 true JP2014518266A5 (enExample) | 2015-05-21 |
Family
ID=47424494
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518880A Active JP5873554B2 (ja) | 2011-06-29 | 2012-06-25 | キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の調製プロセス |
| JP2014518879A Pending JP2014518266A (ja) | 2011-06-29 | 2012-06-25 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
| JP2016198829A Pending JP2017039752A (ja) | 2011-06-29 | 2016-10-07 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
| JP2018055962A Withdrawn JP2018115191A (ja) | 2011-06-29 | 2018-03-23 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518880A Active JP5873554B2 (ja) | 2011-06-29 | 2012-06-25 | キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の調製プロセス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198829A Pending JP2017039752A (ja) | 2011-06-29 | 2016-10-07 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
| JP2018055962A Withdrawn JP2018115191A (ja) | 2011-06-29 | 2018-03-23 | ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8895603B2 (enExample) |
| EP (2) | EP2726075A4 (enExample) |
| JP (4) | JP5873554B2 (enExample) |
| KR (2) | KR20140034862A (enExample) |
| CN (3) | CN106946886A (enExample) |
| AR (1) | AR089554A1 (enExample) |
| AU (2) | AU2012275637B2 (enExample) |
| CA (2) | CA2838738A1 (enExample) |
| MX (2) | MX2013014892A (enExample) |
| RU (2) | RU2598072C2 (enExample) |
| TW (1) | TWI574965B (enExample) |
| WO (2) | WO2013003249A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2598072C2 (ru) | 2011-06-29 | 2016-09-20 | Мерк Шарп И Доум Корп. | Новые кристаллические формы ингибиторов дипептидилпептидазы-iv |
| EP2814485A4 (en) | 2012-02-17 | 2015-08-26 | Merck Sharp & Dohme | DIPEPTIDYLPEPTIDASE IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES |
| EP2874626A4 (en) | 2012-07-23 | 2016-03-23 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
| EP2874622A4 (en) | 2012-07-23 | 2015-12-30 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
| TWI500613B (zh) | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
| US9937153B2 (en) | 2013-08-30 | 2018-04-10 | Merck Sharp & Dohme Ltd. | Oral pharmaceutical formulation of omarigliptin |
| CN105392772B (zh) * | 2014-03-20 | 2017-09-15 | 意大利合成制造有限公司 | 奥格列汀的关键中间体的制备方法 |
| CN105037367A (zh) * | 2014-04-18 | 2015-11-11 | 四川海思科制药有限公司 | 氨基六元环类衍生物及其在医药上的应用 |
| CN105085528A (zh) * | 2014-05-15 | 2015-11-25 | 成都贝斯凯瑞生物科技有限公司 | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 |
| US9862725B2 (en) | 2014-07-21 | 2018-01-09 | Merck Sharp & Dohme Corp. | Process for preparing chiral dipeptidyl peptidase-IV inhibitors |
| WO2016015596A1 (en) * | 2014-07-29 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Process for preparing 2, 3-disubstituted-5-oxopyran compound |
| CN106316888B (zh) * | 2015-06-29 | 2018-05-18 | 深圳翰宇药业股份有限公司 | 一种手性氨基吡喃酮类化合物的合成方法 |
| WO2017032705A1 (en) | 2015-08-25 | 2017-03-02 | Sandoz Ag | Crystalline form of omarigliptin |
| CN105130995B (zh) * | 2015-09-09 | 2017-08-11 | 杭州成邦医药科技有限公司 | 吡咯酮类化合物及其制备方法和应用 |
| WO2017081590A1 (en) * | 2015-11-09 | 2017-05-18 | Sun Pharmaceutical Industries Limited | Process for the preparation of omarigliptin |
| CN105348286B (zh) * | 2015-11-25 | 2018-12-18 | 中山奕安泰医药科技有限公司 | 一种2-甲基磺酰基-2,4,5,6-四氢吡咯[3，4-c]吡唑苯磺酸盐的制备方法 |
| WO2017093209A1 (en) | 2015-12-03 | 2017-06-08 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for preparing aminotetrahydropyrans |
| CN105399744B (zh) * | 2015-12-17 | 2017-07-18 | 黄燕鸽 | 一种奥格列汀的合成方法 |
| EP3181565A1 (en) | 2015-12-18 | 2017-06-21 | Sandoz Ag | Crystalline omarigliptin salts |
| CN106916157A (zh) * | 2015-12-25 | 2017-07-04 | 四川海思科制药有限公司 | 取代的氨基吡喃衍生物的晶型 |
| CN106928228B (zh) * | 2015-12-29 | 2019-08-30 | 杭州普晒医药科技有限公司 | 奥格列汀盐及其晶型、它们的制备方法和药物组合物 |
| CN107652291B (zh) * | 2016-07-26 | 2020-07-14 | 中国科学院上海药物研究所 | 一种制备手性四氢吡喃衍生物的方法 |
| WO2018028666A1 (zh) * | 2016-08-12 | 2018-02-15 | 正大天晴药业集团股份有限公司 | Dpp-iv长效抑制剂的结晶及其盐 |
| CN107793389B (zh) * | 2016-09-05 | 2021-06-29 | 中国科学院上海药物研究所 | 手性四氢吡喃衍生物及其制备与用途 |
| KR102599958B1 (ko) * | 2016-09-28 | 2023-11-09 | (주)아모레퍼시픽 | (r)-n-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 제조방법 |
| CN106674227B (zh) * | 2016-12-06 | 2019-03-19 | 上海博志研新药物技术有限公司 | 一种奥格列汀及其中间体的制备方法 |
| EP3335704A1 (en) | 2016-12-16 | 2018-06-20 | Hexal AG | Pharmaceutical composition comprising omarigliptin |
| EP3335701A1 (en) | 2016-12-16 | 2018-06-20 | Hexal AG | Pharmaceutical composition comprising omarigliptin |
| EP3335703A1 (en) | 2016-12-16 | 2018-06-20 | Hexal AG | Pharmaceutical composition comprising omarigliptin |
| MD3448859T2 (ro) | 2017-03-20 | 2020-03-31 | Forma Therapeutics Inc | Compoziții de pirolopirol în calitate de activatori ai piruvatkinazei (PKR) |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CN113831266B (zh) * | 2019-01-22 | 2024-04-05 | 河南医学高等专科学校 | 1-(2,5-二氟苯基)-1-氧代戊-4-炔-2-基氨基甲酸烷基酯的合成 |
| CN110453177A (zh) * | 2019-08-06 | 2019-11-15 | 太仓碧奇新材料研发有限公司 | 一种柔性有机整流器的制备方法 |
| AU2020350763A1 (en) | 2019-09-19 | 2022-04-07 | Novo Nordisk Health Care Ag | Pyruvate kinase R (PKR) activating compositions |
| CN111793071B (zh) * | 2020-07-06 | 2021-06-04 | 四川凯科医药科技有限公司 | 奥格列汀的合成工艺 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (55)
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| US5041442A (en) | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
| NZ337164A (en) * | 1997-03-21 | 2001-05-25 | Du Pont Pharm Co | Method of preparing 4-arylamino-1-alkyl-[1,2,3]-triazolo][4,5-c]pyridine derivatives |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| CN1243707C (zh) | 2000-09-14 | 2006-03-01 | 国家海洋局第一海洋研究所 | 共轭亚油酸的制造方法 |
| US7026316B2 (en) | 2001-03-27 | 2006-04-11 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2003000181A2 (en) | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| EP1406872B1 (en) | 2001-06-20 | 2007-12-19 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| CN1212303C (zh) | 2001-12-31 | 2005-07-27 | 中国科学院新疆理化技术研究所 | 使用混合溶剂合成共轭亚油酸的方法 |
| AU2003225916A1 (en) | 2002-03-25 | 2003-10-13 | Merck & Co., Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| ATE451369T1 (de) | 2002-07-15 | 2009-12-15 | Merck & Co Inc | Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes |
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| US7101871B2 (en) | 2002-10-18 | 2006-09-05 | Merck & Co., Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004043940A1 (en) | 2002-11-07 | 2004-05-27 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| US7309714B2 (en) | 2002-12-04 | 2007-12-18 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| US20060052382A1 (en) | 2002-12-20 | 2006-03-09 | Duffy Joseph L | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CA2512546A1 (en) | 2003-01-17 | 2004-08-05 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
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| JO2625B1 (en) * | 2003-06-24 | 2011-11-01 | ميرك شارب اند دوم كوربوريشن | Phosphoric acid salts of dipeptidyl betidase inhibitor 4 |
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| CN1870990A (zh) | 2003-11-04 | 2006-11-29 | 默克公司 | 作为糖尿病治疗或预防用二肽基肽酶iv抑制剂的稠合苯基丙氨酸衍生物 |
| WO2005108382A1 (en) | 2004-05-04 | 2005-11-17 | Merck & Co., Inc. | 1,2,4-oxadiazole derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
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| WO2006009886A1 (en) | 2004-06-21 | 2006-01-26 | Merck & Co., Inc. | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| JP2008510810A (ja) | 2004-08-23 | 2008-04-10 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療または予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合トリアゾール誘導体 |
| US7884104B2 (en) | 2004-10-01 | 2011-02-08 | Merck Sharp & Dohme Corp. | Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
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| WO2006065826A2 (en) | 2004-12-15 | 2006-06-22 | Merck & Co., Inc. | Process to chiral beta amino acid derivatives by asymmetric hydrogenation |
| JP5094412B2 (ja) | 2005-01-19 | 2012-12-12 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病治療用又は予防用のジペプチジルペプチダーゼ−ｉｖ阻害剤としての二環系ピリミジン |
| WO2006104997A2 (en) | 2005-03-29 | 2006-10-05 | Merck & Co., Inc. | Tartaric acid salts of a dipeptidyl peptidase-iv inhibitor |
| US20090306037A1 (en) | 2005-05-02 | 2009-12-10 | Merck & Co., Inc. | Combination of a Dipeptidyl Peptidase-IV Inhibitor and a Cannabinoid CB1 Receptor Antagonist for the Treatment of Diabetes and Obesity |
| CA2607441C (en) | 2005-05-25 | 2013-02-12 | Merck & Co., Inc. | Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US20090221592A1 (en) | 2005-07-25 | 2009-09-03 | Ellison Martha E | Dodecylsulfate Salt Of A Dipeptidyl Peptidase-Iv Inhibitor |
| EP1962601B1 (en) | 2005-12-14 | 2014-10-15 | Merck Sharp & Dohme Corp. | Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes |
| CN101365432B (zh) | 2005-12-16 | 2011-06-22 | 默沙东公司 | 二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物 |
| JP5111398B2 (ja) | 2006-01-25 | 2013-01-09 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖ阻害剤としてのアミノシクロヘキサン類 |
| CA2640924C (en) | 2006-02-15 | 2013-10-08 | Merck & Co., Inc. | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| TW200806669A (en) | 2006-03-28 | 2008-02-01 | Merck & Co Inc | Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
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| EP2094081B1 (en) | 2006-11-14 | 2012-07-11 | Merck Sharp & Dohme Corp. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| CA2696211C (en) | 2007-08-21 | 2015-05-26 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| JO2870B1 (en) * | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
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| CA2771352A1 (en) * | 2009-09-02 | 2011-03-10 | Merck Sharp & Dohme Corp. | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| WO2011037793A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2011146358A1 (en) | 2010-05-21 | 2011-11-24 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2012078448A1 (en) | 2010-12-06 | 2012-06-14 | Schering Corporation | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| WO2012118945A2 (en) | 2011-03-03 | 2012-09-07 | Merck Sharp & Dohme Corp. | Fused bicyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| RU2598072C2 (ru) * | 2011-06-29 | 2016-09-20 | Мерк Шарп И Доум Корп. | Новые кристаллические формы ингибиторов дипептидилпептидазы-iv |
| EP2729468A4 (en) | 2011-07-05 | 2015-03-18 | Merck Sharp & Dohme | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| JP6480788B2 (ja) * | 2015-04-07 | 2019-03-13 | 株式会社マキタ | 打撃工具 |
-
2012
- 2012-06-25 RU RU2014102773/04A patent/RU2598072C2/ru not_active IP Right Cessation
- 2012-06-25 CA CA2838738A patent/CA2838738A1/en not_active Abandoned
- 2012-06-25 CA CA2838748A patent/CA2838748A1/en not_active Abandoned
- 2012-06-25 US US14/118,998 patent/US8895603B2/en active Active
- 2012-06-25 TW TW101122687A patent/TWI574965B/zh not_active IP Right Cessation
- 2012-06-25 MX MX2013014892A patent/MX2013014892A/es not_active Application Discontinuation
- 2012-06-25 KR KR1020137034363A patent/KR20140034862A/ko not_active Withdrawn
- 2012-06-25 AU AU2012275637A patent/AU2012275637B2/en not_active Ceased
- 2012-06-25 MX MX2013014891A patent/MX341299B/es active IP Right Grant
- 2012-06-25 EP EP12803996.3A patent/EP2726075A4/en not_active Withdrawn
- 2012-06-25 RU RU2014102764/04A patent/RU2014102764A/ru not_active Application Discontinuation
- 2012-06-25 CN CN201610882581.5A patent/CN106946886A/zh active Pending
- 2012-06-25 CN CN201280032077.6A patent/CN103987388A/zh active Pending
- 2012-06-25 JP JP2014518880A patent/JP5873554B2/ja active Active
- 2012-06-25 US US14/119,063 patent/US9187488B2/en active Active
- 2012-06-25 CN CN201280032105.4A patent/CN103702562A/zh active Pending
- 2012-06-25 WO PCT/US2012/043922 patent/WO2013003249A1/en not_active Ceased
- 2012-06-25 EP EP12804259.5A patent/EP2725905A4/en not_active Withdrawn
- 2012-06-25 AU AU2012275638A patent/AU2012275638A1/en not_active Abandoned
- 2012-06-25 KR KR1020137034362A patent/KR20140034861A/ko not_active Withdrawn
- 2012-06-25 JP JP2014518879A patent/JP2014518266A/ja active Pending
- 2012-06-25 WO PCT/US2012/043924 patent/WO2013003250A1/en not_active Ceased
- 2012-06-28 AR ARP120102322A patent/AR089554A1/es unknown
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2014
- 2014-10-06 US US14/507,001 patent/US9181262B2/en active Active
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2015
- 2015-10-02 US US14/873,641 patent/US9527855B2/en active Active
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2016
- 2016-10-07 JP JP2016198829A patent/JP2017039752A/ja active Pending
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2018
- 2018-03-23 JP JP2018055962A patent/JP2018115191A/ja not_active Withdrawn