JP2008539267A5 - - Google Patents
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- JP2008539267A5 JP2008539267A5 JP2008509128A JP2008509128A JP2008539267A5 JP 2008539267 A5 JP2008539267 A5 JP 2008539267A5 JP 2008509128 A JP2008509128 A JP 2008509128A JP 2008509128 A JP2008509128 A JP 2008509128A JP 2008539267 A5 JP2008539267 A5 JP 2008539267A5
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- JP
- Japan
- Prior art keywords
- compound according
- och
- formula
- carbon
- attached form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 0 *C(*)(*)CN(CC1)CCC1c1n[o]c2c1c(*)c(*)c(*)c2* Chemical compound *C(*)(*)CN(CC1)CCC1c1n[o]c2c1c(*)c(*)c(*)c2* 0.000 description 2
- HCZRPIBEYGFTPF-UHFFFAOYSA-N CC(C)(CN(CC1)CCC1c1n[o]c2ccccc12)C(O)=O Chemical compound CC(C)(CN(CC1)CCC1c1n[o]c2ccccc12)C(O)=O HCZRPIBEYGFTPF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67520205P | 2005-04-26 | 2005-04-26 | |
| PCT/US2006/016057 WO2006116614A1 (en) | 2005-04-26 | 2006-04-26 | Benzisoxazole piperidine compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539267A JP2008539267A (ja) | 2008-11-13 |
| JP2008539267A5 true JP2008539267A5 (enExample) | 2012-12-06 |
Family
ID=36754209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509129A Expired - Fee Related JP5049267B2 (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペラジン化合物およびその使用方法 |
| JP2008509128A Pending JP2008539267A (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペリジン化合物及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509129A Expired - Fee Related JP5049267B2 (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペラジン化合物およびその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7494998B2 (enExample) |
| EP (2) | EP1877405B1 (enExample) |
| JP (2) | JP5049267B2 (enExample) |
| CN (1) | CN101208314B (enExample) |
| AT (2) | ATE461925T1 (enExample) |
| AU (1) | AU2006239302B2 (enExample) |
| CA (2) | CA2606473C (enExample) |
| CY (1) | CY1110026T1 (enExample) |
| DE (2) | DE602006013115D1 (enExample) |
| DK (1) | DK1877390T3 (enExample) |
| ES (2) | ES2341127T3 (enExample) |
| MX (1) | MX2007013352A (enExample) |
| PL (1) | PL1877390T3 (enExample) |
| PT (1) | PT1877390E (enExample) |
| WO (1) | WO2006116614A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8754238B2 (en) | 2003-07-22 | 2014-06-17 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| PE20061130A1 (es) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| CN101208314B (zh) * | 2005-04-26 | 2010-12-08 | 海普尼昂公司 | 苯并异*唑哌嗪化合物及其使用方法 |
| USRE45336E1 (en) | 2006-05-18 | 2015-01-13 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| NZ594353A (en) | 2006-05-18 | 2013-02-22 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor |
| US8148418B2 (en) | 2006-05-18 | 2012-04-03 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| US7762006B2 (en) * | 2006-06-14 | 2010-07-27 | Siestamed, Technologies | Medical equipment drying device |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| CN104069567A (zh) * | 2007-03-19 | 2014-10-01 | 茵苏莱恩医药有限公司 | 药物输送设备 |
| US9220837B2 (en) * | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
| US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
| EP2136863A2 (en) * | 2007-03-19 | 2009-12-30 | Insuline Medical Ltd. | Device for drug delivery and associated connections thereto |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| EP2231229A1 (en) | 2007-12-18 | 2010-09-29 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US20090263449A1 (en) * | 2008-04-09 | 2009-10-22 | Surmodics, Inc. | Delivery of nucleic acid complexes from materials including negatively charged groups |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| HRP20180589T1 (hr) | 2008-10-28 | 2018-05-18 | Arena Pharmaceuticals, Inc. | Pripravci modulatora serotoninskog receptora 5-ht2a koji su korisni za liječenje s njim povezanih poremećaja |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| KR20110086132A (ko) | 2008-11-07 | 2011-07-27 | 인슐린 메디컬 엘티디 | 약물 전달 장치 및 방법 |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| US8565107B2 (en) | 2010-09-24 | 2013-10-22 | Hand Held Products, Inc. | Terminal configurable for use within an unknown regulatory domain |
| RU2017145976A (ru) | 2015-06-12 | 2019-07-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна |
| TW201720439A (zh) | 2015-07-15 | 2017-06-16 | Axovant Sciences Gmbh | 用於預防及治療與神經退化性疾病相關的幻覺之作為５－ｈｔ２ａ血清素受體的二芳基及芳基雜芳基脲衍生物 |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| LT4299135T (lt) | 2019-06-18 | 2025-09-10 | Pfizer Inc. | Benzizoksazolo sulfonamido dariniai |
| PT4082616T (pt) * | 2019-12-24 | 2025-12-02 | Sumitomo Pharma Co Ltd | Derivado de amida ácida alifática |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331541A (en) * | 1965-06-07 | 1967-07-18 | Bell & Howell Co | Sprocketless projector |
| US5364866A (en) | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
| FR2742052B1 (fr) | 1995-12-12 | 1998-04-10 | Esteve Labor Dr | Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports |
| ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| AU3261097A (en) | 1996-06-21 | 1998-01-14 | Glaxo Group Limited | Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders |
| DE69829317T2 (de) * | 1997-12-25 | 2006-04-06 | Meiji Seika Kaisha Ltd. | Tetrahydrobenzindol-derivate |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| ES2317116T3 (es) | 2001-02-16 | 2009-04-16 | Aventis Pharmaceuticals Inc. | Derivados de carbonilos sustituidos heterociclicos y su uso como ligandos del receptor de dopamina d3. |
| US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| CN101208314B (zh) * | 2005-04-26 | 2010-12-08 | 海普尼昂公司 | 苯并异*唑哌嗪化合物及其使用方法 |
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2006
- 2006-04-26 CN CN2006800230473A patent/CN101208314B/zh not_active Expired - Fee Related
- 2006-04-26 CA CA2606473A patent/CA2606473C/en active Active
- 2006-04-26 JP JP2008509129A patent/JP5049267B2/ja not_active Expired - Fee Related
- 2006-04-26 AT AT06751667T patent/ATE461925T1/de active
- 2006-04-26 WO PCT/US2006/016057 patent/WO2006116614A1/en not_active Ceased
- 2006-04-26 DE DE602006013115T patent/DE602006013115D1/de active Active
- 2006-04-26 DK DK06751667.4T patent/DK1877390T3/da active
- 2006-04-26 ES ES06751667T patent/ES2341127T3/es active Active
- 2006-04-26 PT PT06751667T patent/PT1877390E/pt unknown
- 2006-04-26 AT AT06751665T patent/ATE459621T1/de not_active IP Right Cessation
- 2006-04-26 ES ES06751665T patent/ES2340066T3/es active Active
- 2006-04-26 CA CA2606471A patent/CA2606471C/en active Active
- 2006-04-26 US US11/412,856 patent/US7494998B2/en not_active Expired - Fee Related
- 2006-04-26 JP JP2008509128A patent/JP2008539267A/ja active Pending
- 2006-04-26 US US11/912,741 patent/US8129410B2/en not_active Expired - Fee Related
- 2006-04-26 PL PL06751667T patent/PL1877390T3/pl unknown
- 2006-04-26 EP EP06751665A patent/EP1877405B1/en not_active Not-in-force
- 2006-04-26 DE DE602006012650T patent/DE602006012650D1/de active Active
- 2006-04-26 AU AU2006239302A patent/AU2006239302B2/en not_active Ceased
- 2006-04-26 EP EP06751667A patent/EP1877390B1/en not_active Not-in-force
- 2006-04-26 MX MX2007013352A patent/MX2007013352A/es active IP Right Grant
-
2009
- 2009-02-11 US US12/369,477 patent/US8088778B2/en not_active Expired - Fee Related
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2010
- 2010-05-07 CY CY20101100403T patent/CY1110026T1/el unknown