JP2008539267A5 - - Google Patents
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- Publication number
- JP2008539267A5 JP2008539267A5 JP2008509128A JP2008509128A JP2008539267A5 JP 2008539267 A5 JP2008539267 A5 JP 2008539267A5 JP 2008509128 A JP2008509128 A JP 2008509128A JP 2008509128 A JP2008509128 A JP 2008509128A JP 2008539267 A5 JP2008539267 A5 JP 2008539267A5
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- JP
- Japan
- Prior art keywords
- compound according
- och
- formula
- carbon
- attached form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 0 *C(*)(*)CN(CC1)CCC1c1n[o]c2c1c(*)c(*)c(*)c2* Chemical compound *C(*)(*)CN(CC1)CCC1c1n[o]c2c1c(*)c(*)c(*)c2* 0.000 description 2
- HCZRPIBEYGFTPF-UHFFFAOYSA-N CC(C)(CN(CC1)CCC1c1n[o]c2ccccc12)C(O)=O Chemical compound CC(C)(CN(CC1)CCC1c1n[o]c2ccccc12)C(O)=O HCZRPIBEYGFTPF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67520205P | 2005-04-26 | 2005-04-26 | |
| PCT/US2006/016057 WO2006116614A1 (en) | 2005-04-26 | 2006-04-26 | Benzisoxazole piperidine compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539267A JP2008539267A (ja) | 2008-11-13 |
| JP2008539267A5 true JP2008539267A5 (enExample) | 2012-12-06 |
Family
ID=36754209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509128A Pending JP2008539267A (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペリジン化合物及びその使用方法 |
| JP2008509129A Expired - Fee Related JP5049267B2 (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペラジン化合物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509129A Expired - Fee Related JP5049267B2 (ja) | 2005-04-26 | 2006-04-26 | ベンズイソオキサゾールピペラジン化合物およびその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7494998B2 (enExample) |
| EP (2) | EP1877405B1 (enExample) |
| JP (2) | JP2008539267A (enExample) |
| CN (1) | CN101208314B (enExample) |
| AT (2) | ATE461925T1 (enExample) |
| AU (1) | AU2006239302B2 (enExample) |
| CA (2) | CA2606471C (enExample) |
| CY (1) | CY1110026T1 (enExample) |
| DE (2) | DE602006013115D1 (enExample) |
| DK (1) | DK1877390T3 (enExample) |
| ES (2) | ES2340066T3 (enExample) |
| MX (1) | MX2007013352A (enExample) |
| PL (1) | PL1877390T3 (enExample) |
| PT (1) | PT1877390E (enExample) |
| WO (1) | WO2006116614A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ544331A (en) | 2003-07-22 | 2010-03-26 | Arena Pharm Inc | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| PE20061130A1 (es) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| ATE461925T1 (de) * | 2005-04-26 | 2010-04-15 | Hypnion Inc | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung |
| EP2027119A2 (en) | 2006-05-18 | 2009-02-25 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| US8148417B2 (en) | 2006-05-18 | 2012-04-03 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| NZ571829A (en) | 2006-05-18 | 2011-10-28 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor |
| US7762006B2 (en) * | 2006-06-14 | 2010-07-27 | Siestamed, Technologies | Medical equipment drying device |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| WO2008114220A2 (en) * | 2007-03-19 | 2008-09-25 | Insuline Medical Ltd. | Device for drug delivery and associated connections thereto |
| US9220837B2 (en) * | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
| US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
| EP2131900B1 (en) * | 2007-03-19 | 2018-05-30 | Insuline Medical Ltd. | Drug delivery device |
| WO2009081262A1 (en) | 2007-12-18 | 2009-07-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| ES2421237T7 (es) | 2007-08-15 | 2013-09-30 | Arena Pharmaceuticals, Inc. | Derivados de imidazo[1,2-a]piridin como moduladores del receptor serotoninérgico 5ht2a en el tratamiento de trastornos relacionados con el mismo |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2009126830A2 (en) * | 2008-04-09 | 2009-10-15 | Surmodics, Inc. | Delivery of nucleic acid complexes from materials including negatively charged groups |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| TR201805216T4 (en) | 2008-10-28 | 2018-06-21 | Arena Pharm Inc | COMPOSITIONS OF A USEFUL 5-HT2A SEROTONINE RECEPTOR MODULATOR FOR THE TREATMENT OF RELATED DISORDERS |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| RU2532893C2 (ru) | 2008-11-07 | 2014-11-10 | Инсьюлин Медикал Лтд. | Устройство и способ доставки лекарственных средств |
| US8555875B2 (en) * | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| US8565107B2 (en) | 2010-09-24 | 2013-10-22 | Hand Held Products, Inc. | Terminal configurable for use within an unknown regulatory domain |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| CN108472285A (zh) | 2015-07-15 | 2018-08-31 | 阿速万科学有限责任公司 | 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物 |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| SI4299135T1 (sl) | 2019-06-18 | 2025-12-31 | Pfizer Inc. | Benzizoksazolni sulfonamidni derivati |
| TWI917344B (zh) | 2019-12-24 | 2026-03-11 | 日商住友製藥股份有限公司 | 脂肪族酸醯胺衍生物 |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331541A (en) * | 1965-06-07 | 1967-07-18 | Bell & Howell Co | Sprocketless projector |
| US5364866A (en) | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
| FR2742052B1 (fr) | 1995-12-12 | 1998-04-10 | Esteve Labor Dr | Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports |
| ZA9610738B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| WO1997049698A1 (en) | 1996-06-21 | 1997-12-31 | Glaxo Group Limited | Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders |
| WO1999033804A1 (en) * | 1997-12-25 | 1999-07-08 | Meiji Seika Kaisha, Ltd. | Tetrahydrobenzindole derivatives |
| US6605623B1 (en) * | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6331541B1 (en) * | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| ATE455108T1 (de) | 2001-02-16 | 2010-01-15 | Aventis Pharma Inc | Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| ATE461925T1 (de) | 2005-04-26 | 2010-04-15 | Hypnion Inc | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung |
-
2006
- 2006-04-26 AT AT06751667T patent/ATE461925T1/de active
- 2006-04-26 CA CA2606471A patent/CA2606471C/en not_active Expired - Lifetime
- 2006-04-26 US US11/412,856 patent/US7494998B2/en not_active Expired - Fee Related
- 2006-04-26 ES ES06751665T patent/ES2340066T3/es not_active Expired - Lifetime
- 2006-04-26 CN CN2006800230473A patent/CN101208314B/zh not_active Expired - Fee Related
- 2006-04-26 EP EP06751665A patent/EP1877405B1/en not_active Expired - Lifetime
- 2006-04-26 WO PCT/US2006/016057 patent/WO2006116614A1/en not_active Ceased
- 2006-04-26 JP JP2008509128A patent/JP2008539267A/ja active Pending
- 2006-04-26 PT PT06751667T patent/PT1877390E/pt unknown
- 2006-04-26 AU AU2006239302A patent/AU2006239302B2/en not_active Ceased
- 2006-04-26 DE DE602006013115T patent/DE602006013115D1/de not_active Expired - Lifetime
- 2006-04-26 CA CA2606473A patent/CA2606473C/en not_active Expired - Lifetime
- 2006-04-26 PL PL06751667T patent/PL1877390T3/pl unknown
- 2006-04-26 MX MX2007013352A patent/MX2007013352A/es active IP Right Grant
- 2006-04-26 DK DK06751667.4T patent/DK1877390T3/da active
- 2006-04-26 JP JP2008509129A patent/JP5049267B2/ja not_active Expired - Fee Related
- 2006-04-26 AT AT06751665T patent/ATE459621T1/de not_active IP Right Cessation
- 2006-04-26 EP EP06751667A patent/EP1877390B1/en not_active Expired - Lifetime
- 2006-04-26 ES ES06751667T patent/ES2341127T3/es not_active Expired - Lifetime
- 2006-04-26 US US11/912,741 patent/US8129410B2/en not_active Expired - Fee Related
- 2006-04-26 DE DE602006012650T patent/DE602006012650D1/de not_active Expired - Lifetime
-
2009
- 2009-02-11 US US12/369,477 patent/US8088778B2/en not_active Expired - Fee Related
-
2010
- 2010-05-07 CY CY20101100403T patent/CY1110026T1/el unknown