JP2011523412A5 - - Google Patents

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JP2011523412A5
JP2011523412A5 JP2011509488A JP2011509488A JP2011523412A5 JP 2011523412 A5 JP2011523412 A5 JP 2011523412A5 JP 2011509488 A JP2011509488 A JP 2011509488A JP 2011509488 A JP2011509488 A JP 2011509488A JP 2011523412 A5 JP2011523412 A5 JP 2011523412A5
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substituted
heteroaryl
compound
alkyl
bond
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JP2011523412A (ja
JP5837417B2 (ja
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Priority claimed from PCT/US2009/003014 external-priority patent/WO2009151529A1/en
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JP2011509488A 2008-05-14 2009-05-14 スフィンゴシンリン酸受容体の新規なモジュレーター Active JP5837417B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12760308P 2008-05-14 2008-05-14
US61/127,603 2008-05-14
US12/465,767 2009-05-14
PCT/US2009/003014 WO2009151529A1 (en) 2008-05-14 2009-05-14 Novel modulators of sphingosine phosphate receptors
US12/465,767 US8796318B2 (en) 2008-05-14 2009-05-14 Modulators of sphingosine phosphate receptors

Related Child Applications (1)

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JP2015217236A Division JP2016041736A (ja) 2008-05-14 2015-11-05 スフィンゴシンリン酸受容体の新規なモジュレーター

Publications (3)

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JP2011523412A JP2011523412A (ja) 2011-08-11
JP2011523412A5 true JP2011523412A5 (enExample) 2012-07-05
JP5837417B2 JP5837417B2 (ja) 2015-12-24

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JP2011509488A Active JP5837417B2 (ja) 2008-05-14 2009-05-14 スフィンゴシンリン酸受容体の新規なモジュレーター
JP2015217236A Pending JP2016041736A (ja) 2008-05-14 2015-11-05 スフィンゴシンリン酸受容体の新規なモジュレーター

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JP2015217236A Pending JP2016041736A (ja) 2008-05-14 2015-11-05 スフィンゴシンリン酸受容体の新規なモジュレーター

Country Status (20)

Country Link
US (8) US8796318B2 (enExample)
EP (3) EP2291080B1 (enExample)
JP (2) JP5837417B2 (enExample)
AU (2) AU2009258242B2 (enExample)
CY (2) CY1123338T1 (enExample)
DK (1) DK2291080T3 (enExample)
EA (1) EA021672B1 (enExample)
ES (2) ES2549761T3 (enExample)
FI (2) FI2291080T5 (enExample)
HR (1) HRP20150982T1 (enExample)
HU (2) HUE025984T2 (enExample)
LT (1) LTC2291080I2 (enExample)
MY (2) MY172105A (enExample)
NL (1) NL301065I2 (enExample)
NO (1) NO2020034I1 (enExample)
NZ (1) NZ589617A (enExample)
PL (2) PL2913326T3 (enExample)
PT (2) PT2913326T (enExample)
SI (1) SI2291080T1 (enExample)
WO (1) WO2009151529A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007292993B2 (en) 2006-09-07 2013-01-24 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
NZ580454A (en) 2007-03-16 2011-05-27 Actelion Pharmaceuticals Ltd Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
PT2195311E (pt) 2007-08-17 2011-05-25 Actelion Pharmaceuticals Ltd Derivados de piridina como moduladores do receptor s1p1/edg1
CA2700917A1 (en) 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
KR20100095593A (ko) 2007-12-10 2010-08-31 액테리온 파마슈티칼 리미티드 S1p1/edg1의 작동약으로서 티오펜 유도체
JP5481395B2 (ja) 2008-03-07 2014-04-23 アクテリオン ファーマシューティカルズ リミテッド 新規なアミノメチルベンゼン誘導体
AU2009258242B2 (en) 2008-05-14 2015-07-16 The Scripps Research Institute Novel modulators of sphingosine phosphate receptors
HUE043090T2 (hu) 2008-06-09 2019-08-28 Univ Muenchen Ludwig Maximilians Gyógyszerek fehérjék aggregálódásának gátlására olyan betegségeknél, amelyek fehérje-aggregálódással és/vagy neurodegeneratív megbetegedésekkel függnek össze
US20100010053A1 (en) * 2008-06-20 2010-01-14 Jose Luis Castro Pineiro Compounds
KR20190004843A (ko) 2008-07-23 2019-01-14 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체
JP5726737B2 (ja) 2008-08-27 2015-06-03 アリーナ ファーマシューティカルズ, インコーポレイテッド 自己免疫障害および免疫性障害の治療において有用なs1p1受容体のアゴニストとしての置換三環式酸誘導体
WO2010085582A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
WO2010085584A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Pyrazole-i, 2, 4 -oxad iazole derivatives as s.phing0sine-1-ph0sphate agonists
JP2012515787A (ja) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および炎症性疾患の処置におけるs1pアゴニストとしての置換オキサジアゾール誘導体
SI2454255T1 (sl) 2009-07-16 2014-01-31 Actelion Pharmaceuticals Ltd. Derivati piridin-4-ila kot agonisti s1p1/edg1
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
RS61829B1 (sr) * 2009-11-13 2021-06-30 Receptos Llc Selektivni modulatori receptora sfingozin 1 fosfata i metode hiralne sinteze
RS57070B1 (sr) * 2009-11-13 2018-06-29 Celgene Int Ii Sarl Modulatori sfingozin 1 fosfatnog receptora i postupci asimetričnih sinteza
AU2015202660B2 (en) * 2009-11-13 2016-10-27 Receptos Llc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
AU2010319982B2 (en) * 2009-11-13 2016-02-04 Receptos Llc Selective heterocyclic sphingosine 1 phosphate receptor modulators
CN108558740B (zh) 2010-01-27 2021-10-19 艾尼纳制药公司 S1p1受体调节剂及其盐的制备方法
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
EP2390252A1 (en) * 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
WO2012040532A1 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
KR101869120B1 (ko) 2011-01-19 2018-06-19 이도르시아 파마슈티컬스 리미티드 2-메톡시-피리딘-4-일 유도체
US8865754B2 (en) 2011-03-03 2014-10-21 Proteotech Inc. Compounds for the treatment of neurodegenerative diseases
CN102718726A (zh) * 2011-03-31 2012-10-10 上海铂力生物科技有限公司 作为免疫调节剂的(z)-5-苯亚甲基噻唑啉-4-酮衍生物
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
CA2894281C (en) 2012-12-20 2021-04-20 Inception 2, Inc. Triazolone compounds and uses thereof
PT2958913T (pt) 2013-02-20 2018-12-03 Lg Chemical Ltd Agonistas de recetores de esfingosina-1-fosfato, métodos para a sua preparação e composições farmacêuticas que os contêm como agente ativo
MX363545B (es) * 2013-03-15 2019-03-27 Idorsia Pharmaceuticals Ltd Derivados piridin-4-ilo.
EP3041826A4 (en) 2013-09-06 2017-02-15 Inception 2, Inc. Triazolone compounds and uses thereof
EP2853532B1 (en) * 2013-09-28 2020-12-09 Instytut Farmakologii Polskiej Akademii Nauk 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
WO2015066515A1 (en) * 2013-11-01 2015-05-07 Receptos, Inc. Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith
AU2015281799B2 (en) * 2014-06-26 2019-11-28 Central Adelaide Local Health Network Incorporated Enzyme interacting agents
PL3242666T3 (pl) 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
AU2016246398A1 (en) 2015-04-06 2017-10-26 Auspex Pharmaceuticals, Inc. Deuterium-substituted oxadiazoles
ES2770348T3 (es) 2015-05-20 2020-07-01 Idorsia Pharmaceuticals Ltd Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol
HUE060476T2 (hu) 2015-06-22 2023-03-28 Arena Pharm Inc (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
ES3022204T3 (en) 2016-06-14 2025-05-28 Receptos Llc Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof
WO2018033149A1 (zh) 2016-08-19 2018-02-22 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
CN109640982A (zh) 2016-09-14 2019-04-16 苏州科睿思制药有限公司 奥扎莫德盐酸盐的晶型及其制备方法
EP3518922B1 (en) 2016-09-29 2026-02-11 Receptos LLC Compounds and methods for treating lupus
WO2018136893A1 (en) 2017-01-23 2018-07-26 Naqi Logics, Llc Apparatus, methods, and systems for using imagined direction to define actions, functions, or execution
CN110545848A (zh) 2017-02-16 2019-12-06 艾尼纳制药公司 用于治疗具有肠外表现的炎症性肠病的化合物和方法
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
US10981900B2 (en) * 2017-02-28 2021-04-20 Medshine Discovery Inc. Spiro compound and use thereof
WO2018211323A1 (en) * 2017-05-17 2018-11-22 Oppilan Pharma Ltd. Hetercyclic compounds for the treatment of disease
US11117876B2 (en) 2017-08-31 2021-09-14 Receptos Llc Crystalline form of ozanimod hydrochloride, and processes for preparation thereof
WO2019094409A1 (en) 2017-11-07 2019-05-16 Teva Pharmaceuticals International Gmbh Salts and solid state forms of ozanimod
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
EP3847158A1 (en) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
AR116479A1 (es) 2018-09-25 2021-05-12 Quim Sintetica S A Intermediarios para la síntesis de ozanimod y procedimiento para la preparación del mencionado agonista del receptor de esfingosina-1-fosfato y de dichos intermediarios
WO2020152718A1 (en) 2019-01-25 2020-07-30 Mylan Laboratories Limited Polymorphic forms 5-[3-[(1s)-2,3-dihydro-1-[(2-hydroxyethyl) amino]-1h-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
CN114008034A (zh) * 2019-04-26 2022-02-01 瑞塞普托斯公司 1-磷酸鞘氨醇受体调节剂
CN112062785B (zh) * 2019-06-11 2023-06-27 广东东阳光药业有限公司 奥扎莫德及其中间体的制备方法
WO2021026479A1 (en) * 2019-08-07 2021-02-11 Stamford, Andrew Small molecule inhibitors of s1p2 receptor and uses thereof
EP4076448A4 (en) 2019-12-20 2024-03-27 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
KR20220158743A (ko) * 2020-03-27 2022-12-01 리셉토스 엘엘씨 스핑고신 1 포스페이트 수용체 조절제
EP4126828A1 (en) * 2020-03-27 2023-02-08 Receptos Llc Sphingosine 1 phosphate receptor modulators
WO2021195396A1 (en) * 2020-03-27 2021-09-30 Receptos Llc Sphingosine 1 phosphate receptor modulators
WO2021207051A1 (en) * 2020-04-06 2021-10-14 Bristol-Myers Squibb Company Methods of treating acute respiratory disorders
US20230233532A1 (en) * 2020-06-26 2023-07-27 The Penn State Research Foundation Sphingosine-1-phosphate receptor 1 agonist and liposomal formulations thereof
CA3191164A1 (en) * 2020-08-10 2022-02-17 Dana-Farber Cancer Institute, Inc. Substituted 1,2,4-oxadiazoles as small molecule inhibitors of ubiquitin-specific protease 28
EP4333841A1 (en) 2021-05-04 2024-03-13 Tenaya Therapeutics, Inc. 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef
WO2023152767A1 (en) 2022-02-11 2023-08-17 Mylan Laboratories Limited Polymorphic forms of ozanimod hydrochloride
WO2024117172A1 (ja) 2022-11-30 2024-06-06 花王株式会社 痒みの予防又は改善剤
WO2024246174A1 (en) 2023-05-31 2024-12-05 Química Sintética, S.A. Amorphous and crystalline form of ozanimod hydrochloride
CN119320366B (zh) * 2023-07-17 2025-11-18 中国医学科学院药物研究所 取代萘甲基噁二唑-苯胺类化合物及其用途
US11905265B1 (en) * 2023-10-13 2024-02-20 King Faisal University 3,4-dimethoxy-n′-(2-(5-phenyl-1,3,4-oxadiazol-2ylthio)acetoxy)benzimidamide as an antimicrobial compound
WO2025083549A1 (en) 2023-10-16 2025-04-24 Sun Pharma Advanced Research Company Limited Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31990A (en) * 1968-04-26 1974-05-16 Chinoin Gyogyszer Es Vegyeszet Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same
ATE249455T1 (de) 1998-01-23 2003-09-15 Sankyo Co Spiropiperidin-derivate
DE10240818A1 (de) 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
CA2509218C (en) 2002-12-20 2010-09-07 Merck & Co., Inc. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists
CN100441185C (zh) 2003-04-30 2008-12-10 麦克弗罗斯特加拿大有限公司 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂
WO2004110351A2 (en) * 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
AU2004277947A1 (en) 2003-10-01 2005-04-14 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists
CN1894225A (zh) 2003-12-17 2007-01-10 默克公司 作为鞘氨醇1-磷酸(内皮分化基因)受体激动剂的(3,4-二取代)丙酸酯
WO2005058845A2 (en) * 2003-12-19 2005-06-30 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
DK1650186T3 (da) 2004-10-22 2008-10-13 Sun Pharmaceutical Ind Ltd Nye dicarboxylsyrederivater
JP2008531546A (ja) 2005-02-22 2008-08-14 テバ ファーマシューティカル インダストリーズ リミティド エナンチオマー性インダニルアミン誘導体の合成のための改良されたプロセス
EP1893591A1 (en) 2005-06-08 2008-03-05 Novartis AG POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
CN101346372B (zh) 2005-12-23 2011-09-28 弗·哈夫曼-拉罗切有限公司 芳基-异*唑-4-基-*二唑衍生物
TWI382984B (zh) * 2006-04-03 2013-01-21 Astellas Pharma Inc 雜環化合物
US20080015193A1 (en) * 2006-06-20 2008-01-17 Mendoza Jose S Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof
US20080009534A1 (en) 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
MX2009003129A (es) 2006-09-29 2009-04-06 Novartis Ag Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.
JP2010510250A (ja) * 2006-11-21 2010-04-02 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン=1−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ
CN101562977A (zh) 2006-12-15 2009-10-21 艾博特公司 新的二唑化合物
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
US20090188269A1 (en) 2008-01-25 2009-07-30 Henkel Corporation High pressure connection systems and methods for their manufacture
DK2913326T3 (da) 2008-05-14 2020-08-17 Scripps Research Inst Hidtil ukendte modulatorer af sphingosinphosphatreceptorer
AU2009258242B2 (en) 2008-05-14 2015-07-16 The Scripps Research Institute Novel modulators of sphingosine phosphate receptors

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