CA2606471C - Benzisoxazole piperidine compounds and methods of use thereof - Google Patents

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Publication number

CA2606471C

CA2606471C CA2606471A CA2606471A CA2606471C CA 2606471 C CA2606471 C CA 2606471C CA 2606471 A CA2606471 A CA 2606471A CA 2606471 A CA2606471 A CA 2606471A CA 2606471 C CA2606471 C CA 2606471C

Authority

CA

Canada

Prior art keywords

sleep

compound

alkyl

conhs

another embodiment

Prior art date

2005-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 238000000034 method Methods 0.000 title abstract description 23
• RRNFVWZCXHFAEE-UHFFFAOYSA-N 1,2-benzoxazole;piperidine Chemical class C1CCNCC1.C1=CC=C2C=NOC2=C1 RRNFVWZCXHFAEE-UHFFFAOYSA-N 0.000 title abstract description 4
• 239000000203 mixture Substances 0.000 claims abstract description 49
• 150000001875 compounds Chemical class 0.000 claims description 269
• 125000000217 alkyl group Chemical group 0.000 claims description 106
• 238000011282 treatment Methods 0.000 claims description 76
• 150000003839 salts Chemical class 0.000 claims description 75
• 208000019116 sleep disease Diseases 0.000 claims description 66
• 229910052799 carbon Inorganic materials 0.000 claims description 63
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 61
• 239000003814 drug Substances 0.000 claims description 57
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 51
• 208000020685 sleep-wake disease Diseases 0.000 claims description 50
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 48
• 229910052739 hydrogen Inorganic materials 0.000 claims description 45
• 206010022437 insomnia Diseases 0.000 claims description 34
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 34
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 33
• 239000012453 solvate Substances 0.000 claims description 33
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 31
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• 229910052731 fluorine Inorganic materials 0.000 claims description 28
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 27
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 27
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