CN101208314B - 苯并异*唑哌嗪化合物及其使用方法 - Google Patents

苯并异*唑哌嗪化合物及其使用方法 Download PDF

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Publication number
CN101208314B
CN101208314B CN2006800230473A CN200680023047A CN101208314B CN 101208314 B CN101208314 B CN 101208314B CN 2006800230473 A CN2006800230473 A CN 2006800230473A CN 200680023047 A CN200680023047 A CN 200680023047A CN 101208314 B CN101208314 B CN 101208314B
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CN
China
Prior art keywords
sleep
compounds
compound
conhs
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2006800230473A
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English (en)
Chinese (zh)
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CN101208314A (zh
Inventor
D·考夫林
J·F·怀特
K·施奥萨基
D·G·汉高尔
M·索洛蒙
D·M·埃加
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Hypnion Inc
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Hypnion Inc
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Priority claimed from PCT/US2006/016059 external-priority patent/WO2006116615A1/en
Publication of CN101208314A publication Critical patent/CN101208314A/zh
Application granted granted Critical
Publication of CN101208314B publication Critical patent/CN101208314B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2006800230473A 2005-04-26 2006-04-26 苯并异*唑哌嗪化合物及其使用方法 Expired - Fee Related CN101208314B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67520205P 2005-04-26 2005-04-26
US60/675,202 2005-04-26
PCT/US2006/016059 WO2006116615A1 (en) 2005-04-26 2006-04-26 Benzisoxazole piperazine compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
CN101208314A CN101208314A (zh) 2008-06-25
CN101208314B true CN101208314B (zh) 2010-12-08

Family

ID=36754209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800230473A Expired - Fee Related CN101208314B (zh) 2005-04-26 2006-04-26 苯并异*唑哌嗪化合物及其使用方法

Country Status (15)

Country Link
US (3) US7494998B2 (enExample)
EP (2) EP1877390B1 (enExample)
JP (2) JP2008539267A (enExample)
CN (1) CN101208314B (enExample)
AT (2) ATE459621T1 (enExample)
AU (1) AU2006239302B2 (enExample)
CA (2) CA2606473C (enExample)
CY (1) CY1110026T1 (enExample)
DE (2) DE602006012650D1 (enExample)
DK (1) DK1877390T3 (enExample)
ES (2) ES2340066T3 (enExample)
MX (1) MX2007013352A (enExample)
PL (1) PL1877390T3 (enExample)
PT (1) PT1877390E (enExample)
WO (1) WO2006116614A1 (enExample)

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AU2007254244C1 (en) 2006-05-18 2014-07-31 Arena Pharmaceuticals, Inc. 3-pyrazolyl-benzamide-4-ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
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US7762006B2 (en) * 2006-06-14 2010-07-27 Siestamed, Technologies Medical equipment drying device
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US8827979B2 (en) * 2007-03-19 2014-09-09 Insuline Medical Ltd. Drug delivery device
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US9567327B2 (en) 2007-08-15 2017-02-14 Arena Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
EP2231229A1 (en) 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US20090263449A1 (en) * 2008-04-09 2009-10-22 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
SG157299A1 (en) * 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
CN102264354B (zh) 2008-10-28 2015-03-25 艾尼纳制药公司 用于治疗5-ht2a5-羟色胺受体相关障碍的5-ht2a5-羟色胺受体调节剂组合物
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
CN102245137A (zh) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 用于药物递送的装置和方法
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
WO2011075596A1 (en) 2009-12-18 2011-06-23 Arena Pharmaceuticals, Inc. Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
US8565107B2 (en) 2010-09-24 2013-10-22 Hand Held Products, Inc. Terminal configurable for use within an unknown regulatory domain
WO2016201373A1 (en) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
HK1247555A1 (zh) 2015-07-15 2018-09-28 Axovant Sciences Gmbh 用於预防和治疗与神经变性疾病相关的幻觉的作为5-ht2a血清素受体的调节剂的二芳基脲和芳基杂芳基脲衍生物
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
EP3986890B9 (en) 2019-06-18 2025-04-16 Pfizer Inc. Benzisoxazole sulfonamide derivatives
CN114981264B (zh) * 2019-12-24 2024-07-26 住友制药株式会社 脂肪酸酰胺衍生物
JP7655885B2 (ja) * 2021-06-30 2025-04-02 住友ファーマ株式会社 脂肪族酸アミド誘導体を含有する医薬組成物

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CN1177297A (zh) * 1995-12-12 1998-03-25 埃斯蒂文博士实验室股份有限公司 治疗强迫症、睡眠呼吸暂停、性功能障碍、呕吐和运动症的药物

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Also Published As

Publication number Publication date
EP1877405A1 (en) 2008-01-16
US20080214539A1 (en) 2008-09-04
AU2006239302B2 (en) 2011-07-07
JP5049267B2 (ja) 2012-10-17
JP2008539267A (ja) 2008-11-13
ATE461925T1 (de) 2010-04-15
EP1877405B1 (en) 2010-03-03
US8088778B2 (en) 2012-01-03
MX2007013352A (es) 2008-03-26
CY1110026T1 (el) 2015-01-14
US7494998B2 (en) 2009-02-24
PT1877390E (pt) 2010-05-31
EP1877390B1 (en) 2010-03-24
US8129410B2 (en) 2012-03-06
EP1877390A1 (en) 2008-01-16
JP2008539268A (ja) 2008-11-13
ATE459621T1 (de) 2010-03-15
ES2340066T3 (es) 2010-05-28
CA2606473C (en) 2013-08-13
US20090163514A1 (en) 2009-06-25
DK1877390T3 (da) 2010-05-31
PL1877390T3 (pl) 2010-08-31
CN101208314A (zh) 2008-06-25
AU2006239302A1 (en) 2006-11-02
DE602006012650D1 (de) 2010-04-15
WO2006116614A1 (en) 2006-11-02
US20070004752A1 (en) 2007-01-04
CA2606471C (en) 2014-02-11
CA2606473A1 (en) 2006-11-02
CA2606471A1 (en) 2006-11-02
ES2341127T3 (es) 2010-06-15
DE602006013115D1 (de) 2010-05-06

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