CN101208314B - 苯并异*唑哌嗪化合物及其使用方法 - Google Patents

苯并异*唑哌嗪化合物及其使用方法 Download PDF

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Publication number
CN101208314B
CN101208314B CN2006800230473A CN200680023047A CN101208314B CN 101208314 B CN101208314 B CN 101208314B CN 2006800230473 A CN2006800230473 A CN 2006800230473A CN 200680023047 A CN200680023047 A CN 200680023047A CN 101208314 B CN101208314 B CN 101208314B
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CN
China
Prior art keywords
sleep
compounds
compound
conhs
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2006800230473A
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English (en)
Chinese (zh)
Other versions
CN101208314A (zh
Inventor
D·考夫林
J·F·怀特
K·施奥萨基
D·G·汉高尔
M·索洛蒙
D·M·埃加
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Hypnion Inc
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Hypnion Inc
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Filing date
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Priority claimed from PCT/US2006/016059 external-priority patent/WO2006116615A1/en
Publication of CN101208314A publication Critical patent/CN101208314A/zh
Application granted granted Critical
Publication of CN101208314B publication Critical patent/CN101208314B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2006800230473A 2005-04-26 2006-04-26 苯并异*唑哌嗪化合物及其使用方法 Expired - Fee Related CN101208314B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67520205P 2005-04-26 2005-04-26
US60/675,202 2005-04-26
PCT/US2006/016059 WO2006116615A1 (en) 2005-04-26 2006-04-26 Benzisoxazole piperazine compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
CN101208314A CN101208314A (zh) 2008-06-25
CN101208314B true CN101208314B (zh) 2010-12-08

Family

ID=36754209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800230473A Expired - Fee Related CN101208314B (zh) 2005-04-26 2006-04-26 苯并异*唑哌嗪化合物及其使用方法

Country Status (15)

Country Link
US (3) US7494998B2 (enExample)
EP (2) EP1877405B1 (enExample)
JP (2) JP2008539267A (enExample)
CN (1) CN101208314B (enExample)
AT (2) ATE461925T1 (enExample)
AU (1) AU2006239302B2 (enExample)
CA (2) CA2606471C (enExample)
CY (1) CY1110026T1 (enExample)
DE (2) DE602006013115D1 (enExample)
DK (1) DK1877390T3 (enExample)
ES (2) ES2340066T3 (enExample)
MX (1) MX2007013352A (enExample)
PL (1) PL1877390T3 (enExample)
PT (1) PT1877390E (enExample)
WO (1) WO2006116614A1 (enExample)

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US7762006B2 (en) * 2006-06-14 2010-07-27 Siestamed, Technologies Medical equipment drying device
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
WO2008114220A2 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Device for drug delivery and associated connections thereto
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
EP2131900B1 (en) * 2007-03-19 2018-05-30 Insuline Medical Ltd. Drug delivery device
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
ES2421237T7 (es) 2007-08-15 2013-09-30 Arena Pharmaceuticals, Inc. Derivados de imidazo[1,2-a]piridin como moduladores del receptor serotoninérgico 5ht2a en el tratamiento de trastornos relacionados con el mismo
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2009126830A2 (en) * 2008-04-09 2009-10-15 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
SG157299A1 (en) 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
TR201805216T4 (en) 2008-10-28 2018-06-21 Arena Pharm Inc COMPOSITIONS OF A USEFUL 5-HT2A SEROTONINE RECEPTOR MODULATOR FOR THE TREATMENT OF RELATED DISORDERS
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
RU2532893C2 (ru) 2008-11-07 2014-11-10 Инсьюлин Медикал Лтд. Устройство и способ доставки лекарственных средств
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8980891B2 (en) 2009-12-18 2015-03-17 Arena Pharmaceuticals, Inc. Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US8565107B2 (en) 2010-09-24 2013-10-22 Hand Held Products, Inc. Terminal configurable for use within an unknown regulatory domain
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
CN108472285A (zh) 2015-07-15 2018-08-31 阿速万科学有限责任公司 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
SI4299135T1 (sl) 2019-06-18 2025-12-31 Pfizer Inc. Benzizoksazolni sulfonamidni derivati
TWI917344B (zh) 2019-12-24 2026-03-11 日商住友製藥股份有限公司 脂肪族酸醯胺衍生物
JP7655885B2 (ja) * 2021-06-30 2025-04-02 住友ファーマ株式会社 脂肪族酸アミド誘導体を含有する医薬組成物

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CN1177297A (zh) * 1995-12-12 1998-03-25 埃斯蒂文博士实验室股份有限公司 治疗强迫症、睡眠呼吸暂停、性功能障碍、呕吐和运动症的药物

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Marcello Leopoldo, et al.Structure-affinity relationship study ou N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides,aNewClass of 5-Hydroxytryptamine7Receptor Agents.Journal of Medicinal Chemistry47 26.2004,47(26),6616-6624. *

Also Published As

Publication number Publication date
CN101208314A (zh) 2008-06-25
ATE461925T1 (de) 2010-04-15
DE602006013115D1 (de) 2010-05-06
PL1877390T3 (pl) 2010-08-31
DK1877390T3 (da) 2010-05-31
CA2606471A1 (en) 2006-11-02
EP1877405A1 (en) 2008-01-16
ES2340066T3 (es) 2010-05-28
AU2006239302B2 (en) 2011-07-07
US8129410B2 (en) 2012-03-06
JP2008539268A (ja) 2008-11-13
PT1877390E (pt) 2010-05-31
JP2008539267A (ja) 2008-11-13
DE602006012650D1 (de) 2010-04-15
EP1877390A1 (en) 2008-01-16
AU2006239302A1 (en) 2006-11-02
CA2606473C (en) 2013-08-13
ATE459621T1 (de) 2010-03-15
ES2341127T3 (es) 2010-06-15
US20080214539A1 (en) 2008-09-04
CA2606473A1 (en) 2006-11-02
CY1110026T1 (el) 2015-01-14
US8088778B2 (en) 2012-01-03
WO2006116614A1 (en) 2006-11-02
JP5049267B2 (ja) 2012-10-17
US20070004752A1 (en) 2007-01-04
US20090163514A1 (en) 2009-06-25
CA2606471C (en) 2014-02-11
US7494998B2 (en) 2009-02-24
EP1877405B1 (en) 2010-03-03
MX2007013352A (es) 2008-03-26
EP1877390B1 (en) 2010-03-24

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