JP2015522037A5 - - Google Patents
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- Publication number
- JP2015522037A5 JP2015522037A5 JP2015520651A JP2015520651A JP2015522037A5 JP 2015522037 A5 JP2015522037 A5 JP 2015522037A5 JP 2015520651 A JP2015520651 A JP 2015520651A JP 2015520651 A JP2015520651 A JP 2015520651A JP 2015522037 A5 JP2015522037 A5 JP 2015522037A5
- Authority
- JP
- Japan
- Prior art keywords
- vemurafenib
- theta
- degrees
- choline salt
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960003862 vemurafenib Drugs 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 239000004381 Choline salt Substances 0.000 claims 13
- 235000019417 choline salt Nutrition 0.000 claims 13
- -1 Vemurafenib choline salt Chemical class 0.000 claims 12
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 12
- 238000001144 powder X-ray diffraction data Methods 0.000 claims 4
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 3
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 239000007790 solid phase Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000002441 X-ray diffraction Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 150000003248 quinolines Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667769P | 2012-07-03 | 2012-07-03 | |
| US61/667,769 | 2012-07-03 | ||
| PCT/US2013/049082 WO2014008270A1 (en) | 2012-07-03 | 2013-07-02 | Solid state form of vemurafenib choline salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015522037A JP2015522037A (ja) | 2015-08-03 |
| JP2015522037A5 true JP2015522037A5 (enExample) | 2016-08-18 |
Family
ID=48794226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520651A Withdrawn JP2015522037A (ja) | 2012-07-03 | 2013-07-02 | ベムラフェニブコリン塩の固体形態 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9221815B2 (enExample) |
| EP (1) | EP2870154A1 (enExample) |
| JP (1) | JP2015522037A (enExample) |
| CN (1) | CN104470920A (enExample) |
| EA (1) | EA201590041A1 (enExample) |
| WO (1) | WO2014008270A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016512518A (ja) | 2013-03-14 | 2016-04-28 | ラシオファルム ゲーエムベーハー | ベムラフェニブ塩酸塩の固体形態 |
| CZ2013943A3 (cs) * | 2013-11-27 | 2015-06-03 | Zentiva, K.S. | Krystalické formy vemurafenibu |
| WO2016083956A1 (en) | 2014-11-29 | 2016-06-02 | Shilpa Medicare Limited | Substantially pure vemurafenib and its salts |
| EP3072528B1 (en) | 2015-03-26 | 2017-07-05 | ratiopharm GmbH | Composition comprising vemurafenib and cationic copolymer based on methacrylates |
| WO2017098336A1 (en) * | 2015-12-11 | 2017-06-15 | Laurus Labs Private Limited | Novel polymorphs of vemurafenib, process for its preparation and pharmaceutical composition thereof |
| EP3478091B1 (en) * | 2016-06-29 | 2024-03-20 | Halo Life Science, LLC | Method of preparing a low odor dicholinium ellagate salt and other low odor organic salts of choline |
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| ES2920288T3 (es) * | 2017-05-25 | 2022-08-02 | Liquid Biopsy Res Llc | Procedimientos para la detección de melanoma |
| WO2020070390A1 (en) | 2018-10-03 | 2020-04-09 | Jyväskylän Yliopisto | Vemurafenib and salts thereof for use in the treatment of enteroviral infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2395004T3 (en) | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| KR20170058465A (ko) * | 2009-04-03 | 2017-05-26 | 에프. 호프만-라 로슈 아게 | 프로판-１-술폰산 ｛３-［５-（４-클로로-페닐）-１Ｈ-피롤로［２，３-ｂ］피리딘-３-카르보닐］-２，４-디플루오로-페닐｝-아미드 조성물 및 그의 용도 |
| TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
-
2013
- 2013-07-02 EA EA201590041A patent/EA201590041A1/ru unknown
- 2013-07-02 WO PCT/US2013/049082 patent/WO2014008270A1/en not_active Ceased
- 2013-07-02 EP EP13737761.0A patent/EP2870154A1/en not_active Withdrawn
- 2013-07-02 JP JP2015520651A patent/JP2015522037A/ja not_active Withdrawn
- 2013-07-02 US US14/412,039 patent/US9221815B2/en active Active
- 2013-07-02 CN CN201380035844.3A patent/CN104470920A/zh active Pending
-
2015
- 2015-11-18 US US14/944,806 patent/US20160068530A1/en not_active Abandoned
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