EA201590041A1 - Твердая форма холиновой соли вемурафениба - Google Patents
Твердая форма холиновой соли вемурафенибаInfo
- Publication number
- EA201590041A1 EA201590041A1 EA201590041A EA201590041A EA201590041A1 EA 201590041 A1 EA201590041 A1 EA 201590041A1 EA 201590041 A EA201590041 A EA 201590041A EA 201590041 A EA201590041 A EA 201590041A EA 201590041 A1 EA201590041 A1 EA 201590041A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vemurafenib
- choline salt
- solid form
- solid forms
- preparation
- Prior art date
Links
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003862 vemurafenib Drugs 0.000 title abstract 6
- 239000007787 solid Substances 0.000 title abstract 4
- 239000004381 Choline salt Substances 0.000 title abstract 3
- 235000019417 choline salt Nutrition 0.000 title abstract 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical class C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 3
- 150000003248 quinolines Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667769P | 2012-07-03 | 2012-07-03 | |
| PCT/US2013/049082 WO2014008270A1 (en) | 2012-07-03 | 2013-07-02 | Solid state form of vemurafenib choline salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201590041A1 true EA201590041A1 (ru) | 2015-04-30 |
Family
ID=48794226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590041A EA201590041A1 (ru) | 2012-07-03 | 2013-07-02 | Твердая форма холиновой соли вемурафениба |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9221815B2 (enExample) |
| EP (1) | EP2870154A1 (enExample) |
| JP (1) | JP2015522037A (enExample) |
| CN (1) | CN104470920A (enExample) |
| EA (1) | EA201590041A1 (enExample) |
| WO (1) | WO2014008270A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016512518A (ja) | 2013-03-14 | 2016-04-28 | ラシオファルム ゲーエムベーハー | ベムラフェニブ塩酸塩の固体形態 |
| CZ2013943A3 (cs) * | 2013-11-27 | 2015-06-03 | Zentiva, K.S. | Krystalické formy vemurafenibu |
| WO2016083956A1 (en) | 2014-11-29 | 2016-06-02 | Shilpa Medicare Limited | Substantially pure vemurafenib and its salts |
| EP3072528B1 (en) | 2015-03-26 | 2017-07-05 | ratiopharm GmbH | Composition comprising vemurafenib and cationic copolymer based on methacrylates |
| WO2017098336A1 (en) * | 2015-12-11 | 2017-06-15 | Laurus Labs Private Limited | Novel polymorphs of vemurafenib, process for its preparation and pharmaceutical composition thereof |
| EP3478091B1 (en) * | 2016-06-29 | 2024-03-20 | Halo Life Science, LLC | Method of preparing a low odor dicholinium ellagate salt and other low odor organic salts of choline |
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| ES2920288T3 (es) * | 2017-05-25 | 2022-08-02 | Liquid Biopsy Res Llc | Procedimientos para la detección de melanoma |
| WO2020070390A1 (en) | 2018-10-03 | 2020-04-09 | Jyväskylän Yliopisto | Vemurafenib and salts thereof for use in the treatment of enteroviral infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2395004T3 (en) | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| KR20170058465A (ko) * | 2009-04-03 | 2017-05-26 | 에프. 호프만-라 로슈 아게 | 프로판-１-술폰산 ｛３-［５-（４-클로로-페닐）-１Ｈ-피롤로［２，３-ｂ］피리딘-３-카르보닐］-２，４-디플루오로-페닐｝-아미드 조성물 및 그의 용도 |
| TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
-
2013
- 2013-07-02 EA EA201590041A patent/EA201590041A1/ru unknown
- 2013-07-02 WO PCT/US2013/049082 patent/WO2014008270A1/en not_active Ceased
- 2013-07-02 EP EP13737761.0A patent/EP2870154A1/en not_active Withdrawn
- 2013-07-02 JP JP2015520651A patent/JP2015522037A/ja not_active Withdrawn
- 2013-07-02 US US14/412,039 patent/US9221815B2/en active Active
- 2013-07-02 CN CN201380035844.3A patent/CN104470920A/zh active Pending
-
2015
- 2015-11-18 US US14/944,806 patent/US20160068530A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015522037A (ja) | 2015-08-03 |
| WO2014008270A1 (en) | 2014-01-09 |
| US20160068530A1 (en) | 2016-03-10 |
| CN104470920A (zh) | 2015-03-25 |
| EP2870154A1 (en) | 2015-05-13 |
| US20150183779A1 (en) | 2015-07-02 |
| US9221815B2 (en) | 2015-12-29 |
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