JP2014502641A5 - - Google Patents
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- Publication number
- JP2014502641A5 JP2014502641A5 JP2013549602A JP2013549602A JP2014502641A5 JP 2014502641 A5 JP2014502641 A5 JP 2014502641A5 JP 2013549602 A JP2013549602 A JP 2013549602A JP 2013549602 A JP2013549602 A JP 2013549602A JP 2014502641 A5 JP2014502641 A5 JP 2014502641A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- crm1
- alkyl
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101100004408 Arabidopsis thaliana BIG gene Proteins 0.000 claims description 10
- 101100485279 Drosophila melanogaster emb gene Proteins 0.000 claims description 10
- 102100029095 Exportin-1 Human genes 0.000 claims description 10
- 101100485284 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CRM1 gene Proteins 0.000 claims description 10
- 101150094313 XPO1 gene Proteins 0.000 claims description 10
- 108700002148 exportin 1 Proteins 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 230000001404 mediated effect Effects 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161433501P | 2011-01-17 | 2011-01-17 | |
| US61/433,501 | 2011-01-17 | ||
| PCT/US2012/021406 WO2012099807A1 (en) | 2011-01-17 | 2012-01-16 | Olefin containing nuclear transport modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249440A Division JP2017110008A (ja) | 2011-01-17 | 2016-12-22 | オレフィン含有核輸送調節剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502641A JP2014502641A (ja) | 2014-02-03 |
| JP2014502641A5 true JP2014502641A5 (enExample) | 2017-03-02 |
| JP6106605B2 JP6106605B2 (ja) | 2017-04-05 |
Family
ID=46516027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549602A Expired - Fee Related JP6106605B2 (ja) | 2011-01-17 | 2012-01-16 | オレフィン含有核輸送調節剤およびその使用 |
| JP2016249440A Withdrawn JP2017110008A (ja) | 2011-01-17 | 2016-12-22 | オレフィン含有核輸送調節剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249440A Withdrawn JP2017110008A (ja) | 2011-01-17 | 2016-12-22 | オレフィン含有核輸送調節剤およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9303000B2 (enExample) |
| EP (1) | EP2665362B1 (enExample) |
| JP (2) | JP6106605B2 (enExample) |
| CN (1) | CN103402359B (enExample) |
| AU (1) | AU2012207565B2 (enExample) |
| CA (1) | CA2824808A1 (enExample) |
| WO (1) | WO2012099807A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011109799A1 (en) | 2010-03-05 | 2011-09-09 | Karyopharm Therapeutics, Inc. | Nuclear transport modulatiors and uses thereof |
| WO2012099807A1 (en) * | 2011-01-17 | 2012-07-26 | Karyopharm Therapeutics, Inc. | Olefin containing nuclear transport modulators and uses thereof |
| AR087342A1 (es) | 2011-07-29 | 2014-03-19 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y sus usos |
| EA201490406A1 (ru) | 2011-07-29 | 2014-07-30 | Кариофарм Терапевтикс, Инк. | Модуляторы ядерного транспорта и их применение |
| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| CN103937872A (zh) * | 2013-01-23 | 2014-07-23 | 上海市东方医院 | Crm1在胃癌诊断与治疗中的应用 |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| US11571455B2 (en) | 2013-04-11 | 2023-02-07 | Vanderbilt University | Methods and compositions for treating alcoholic liver disease |
| KR102322794B1 (ko) * | 2013-06-21 | 2021-11-05 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 핵수송 조절인자 및 이의 용도 |
| WO2014205393A1 (en) * | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US9861615B2 (en) | 2013-11-28 | 2018-01-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of beta-thalassemias |
| SG11201700789SA (en) | 2014-08-15 | 2017-02-27 | Karyopharm Therapeutics Inc | Polymorphs of selinexor |
| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| SG11201809559UA (en) | 2016-06-13 | 2018-12-28 | Glaxosmithkline Ip Dev Ltd | Substituted pyridines as inhibitors of dnmt1 |
| US11065230B2 (en) | 2016-09-16 | 2021-07-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of systemic mastocytosis |
| WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
| US11771739B2 (en) | 2017-06-16 | 2023-10-03 | Vanderbilt University | Methods and compositions for treating microbial inflammation |
| WO2019152731A1 (en) * | 2018-01-31 | 2019-08-08 | Alpine Androsciences, Inc. | Androgen receptor antagonists |
| WO2019232724A1 (en) | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| CN111606890A (zh) | 2019-02-26 | 2020-09-01 | 微境生物医药科技(上海)有限公司 | 含丙烯酰基的核转运调节剂及其用途 |
| EP3962898A1 (en) | 2019-05-01 | 2022-03-09 | Karyopharm Therapeutics, Inc. | Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97249A (en) | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| US20030018025A1 (en) | 1995-06-07 | 2003-01-23 | Neurogen Corporation, Corporation Of The State Of Delaware | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands |
| JP4054992B2 (ja) * | 1996-04-25 | 2008-03-05 | 日産化学工業株式会社 | エチレン誘導体および有害生物防除剤 |
| DE69723267T2 (de) * | 1996-04-25 | 2004-04-22 | Nissan Chemical Industries, Ltd. | Ethylenderivate und pestizide |
| CN1964718A (zh) * | 2004-06-03 | 2007-05-16 | 高山生物科学股份有限公司 | 来普霉素化合物 |
| WO2006019020A1 (ja) * | 2004-08-16 | 2006-02-23 | Sankyo Company, Limited | 置換されたウレア化合物 |
| TWI330639B (en) | 2005-11-15 | 2010-09-21 | Otsuka Pharma Co Ltd | Oxazole compound and pharmaceutical composition |
| JP2007210929A (ja) * | 2006-02-09 | 2007-08-23 | Sankyo Co Ltd | ウレア化合物を含有する医薬 |
| GEP20115139B (en) * | 2006-03-09 | 2011-01-10 | Eisai R&D Man Co Ltd | Polycyclic cinnamide derivative |
| EP2014652B1 (en) | 2006-04-18 | 2014-08-06 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor |
| PL2018435T3 (pl) * | 2006-05-17 | 2012-11-30 | Pioneer Hi Bred Int | Sztuczne minichromosomy roślinne |
| KR101130380B1 (ko) | 2006-06-13 | 2012-04-23 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도 |
| CA2662112A1 (en) | 2006-09-05 | 2008-03-13 | Kyowa Hakko Kirin Co., Ltd. | Imidazole derivatives and their use as cannabinoid type 2 (cb2) receptor modulators |
| EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| WO2011109799A1 (en) | 2010-03-05 | 2011-09-09 | Karyopharm Therapeutics, Inc. | Nuclear transport modulatiors and uses thereof |
| WO2012099807A1 (en) | 2011-01-17 | 2012-07-26 | Karyopharm Therapeutics, Inc. | Olefin containing nuclear transport modulators and uses thereof |
| EA201490406A1 (ru) | 2011-07-29 | 2014-07-30 | Кариофарм Терапевтикс, Инк. | Модуляторы ядерного транспорта и их применение |
| AR087342A1 (es) | 2011-07-29 | 2014-03-19 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y sus usos |
| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| WO2014152263A1 (en) | 2013-03-15 | 2014-09-25 | Karyopharm Therapeutics Inc. | Exo olefin-containing nuclear transport modulators and uses thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| KR102322794B1 (ko) | 2013-06-21 | 2021-11-05 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 핵수송 조절인자 및 이의 용도 |
| WO2014205393A1 (en) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
-
2012
- 2012-01-16 WO PCT/US2012/021406 patent/WO2012099807A1/en not_active Ceased
- 2012-01-16 JP JP2013549602A patent/JP6106605B2/ja not_active Expired - Fee Related
- 2012-01-16 US US13/350,864 patent/US9303000B2/en not_active Expired - Fee Related
- 2012-01-16 EP EP12736172.3A patent/EP2665362B1/en not_active Ceased
- 2012-01-16 CA CA2824808A patent/CA2824808A1/en not_active Abandoned
- 2012-01-16 AU AU2012207565A patent/AU2012207565B2/en not_active Ceased
- 2012-01-16 CN CN201280010891.8A patent/CN103402359B/zh not_active Expired - Fee Related
-
2016
- 2016-12-22 JP JP2016249440A patent/JP2017110008A/ja not_active Withdrawn
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