JP2015516434A5 - - Google Patents
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- JP2015516434A5 JP2015516434A5 JP2015511713A JP2015511713A JP2015516434A5 JP 2015516434 A5 JP2015516434 A5 JP 2015516434A5 JP 2015511713 A JP2015511713 A JP 2015511713A JP 2015511713 A JP2015511713 A JP 2015511713A JP 2015516434 A5 JP2015516434 A5 JP 2015516434A5
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- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- alkylene
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261644802P | 2012-05-09 | 2012-05-09 | |
| US61/644,802 | 2012-05-09 | ||
| US201361798188P | 2013-03-15 | 2013-03-15 | |
| US61/798,188 | 2013-03-15 | ||
| PCT/US2013/040404 WO2013170068A2 (en) | 2012-05-09 | 2013-05-09 | Nuclear transport modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017160341A Division JP2018012715A (ja) | 2012-05-09 | 2017-08-23 | 核内輸送調節因子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516434A JP2015516434A (ja) | 2015-06-11 |
| JP2015516434A5 true JP2015516434A5 (enExample) | 2016-06-30 |
| JP6195909B2 JP6195909B2 (ja) | 2017-09-13 |
Family
ID=49448240
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511713A Active JP6195909B2 (ja) | 2012-05-09 | 2013-05-09 | 核内輸送調節因子およびその使用 |
| JP2017160341A Withdrawn JP2018012715A (ja) | 2012-05-09 | 2017-08-23 | 核内輸送調節因子およびその使用 |
| JP2018154275A Withdrawn JP2018172444A (ja) | 2012-05-09 | 2018-08-20 | 核内輸送調節因子およびその使用 |
| JP2019206852A Active JP6818849B2 (ja) | 2012-05-09 | 2019-11-15 | 核内輸送調節因子およびその使用 |
| JP2020218700A Withdrawn JP2021063104A (ja) | 2012-05-09 | 2020-12-28 | 核内輸送調節因子およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017160341A Withdrawn JP2018012715A (ja) | 2012-05-09 | 2017-08-23 | 核内輸送調節因子およびその使用 |
| JP2018154275A Withdrawn JP2018172444A (ja) | 2012-05-09 | 2018-08-20 | 核内輸送調節因子およびその使用 |
| JP2019206852A Active JP6818849B2 (ja) | 2012-05-09 | 2019-11-15 | 核内輸送調節因子およびその使用 |
| JP2020218700A Withdrawn JP2021063104A (ja) | 2012-05-09 | 2020-12-28 | 核内輸送調節因子およびその使用 |
Country Status (32)
Families Citing this family (40)
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|---|---|---|---|---|
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| JP6106605B2 (ja) | 2011-01-17 | 2017-04-05 | カリオファーム セラピューティクス，インコーポレイテッド | オレフィン含有核輸送調節剤およびその使用 |
| ES2954991T3 (es) | 2011-07-29 | 2023-11-28 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y usos de los mismos |
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| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
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| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
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| EP3341079A4 (en) * | 2015-08-25 | 2019-05-08 | President and Fellows of Harvard College | METHOD AND COMPOSITIONS RELATED TO DIAGNOSIS AND TREATMENT OF CANCER |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP3397633A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP3423468A4 (en) * | 2016-02-29 | 2019-10-23 | Ohio State Innovation Foundation | AZA PEPTIDE ALDEHYDE AND KETONE |
| US10961271B2 (en) | 2016-03-16 | 2021-03-30 | Ionis Pharmaceuticals, Inc. | Methods of modulating KEAP1 |
| WO2017190087A1 (en) | 2016-04-30 | 2017-11-02 | Envision Diagnostics, Inc. | Medical devices, systems, and methods for performing eye exams and eye tracking |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| JP7167168B2 (ja) | 2018-01-10 | 2022-11-08 | エックスダブリューファルマ リミテッド | ケタミンのプロドラッグ、組成物及びそれらの使用 |
| WO2019232724A1 (en) | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| WO2020092965A1 (en) | 2018-11-01 | 2020-05-07 | Karyopharm Therapeutics Inc. | E2f1 as a biomarker for treatments using xpo1 inhibitors |
| MA54383A (fr) | 2018-12-06 | 2021-10-13 | Biogen Ma Inc | Protéine neurofilamenteuse pour guider une intervention thérapeutique dans la sclérose laterale amyotrophique |
| CN111606890A (zh) | 2019-02-26 | 2020-09-01 | 微境生物医药科技(上海)有限公司 | 含丙烯酰基的核转运调节剂及其用途 |
| CN109928939A (zh) * | 2019-02-27 | 2019-06-25 | 上海卡洛化学有限公司 | 一种2,2,6,6-四甲基吗啉的制备方法 |
| CA3135712A1 (en) * | 2019-05-01 | 2020-11-05 | Brian Clinton AUSTAD | Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors |
| CN111145135B (zh) * | 2019-12-30 | 2021-08-10 | 腾讯科技（深圳）有限公司 | 一种图像去扰处理方法、装置、设备及存储介质 |
| WO2022209477A1 (ja) | 2021-04-01 | 2022-10-06 | アルプスアルパイン株式会社 | 操作検出装置 |
| US20240199637A1 (en) * | 2021-04-21 | 2024-06-20 | Natco Pharma Limited | Improved process for the preparation of 7-(morpholinyl)-2-(n-piperazinyl)methylthieno[2, 3-c]pyridine derivatives |
| AU2022326513B9 (en) | 2021-08-13 | 2025-10-23 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| TWI857509B (zh) * | 2022-03-07 | 2024-10-01 | 高雄醫學大學 | 用於治療 ｂ 型肝炎病毒感染的方法 |
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2013
- 2013-05-09 SM SM20200347T patent/SMT202000347T1/it unknown
- 2013-05-09 HU HUE18164757A patent/HUE050452T2/hu unknown
- 2013-05-09 SI SI201331239T patent/SI2858991T1/sl unknown
- 2013-05-09 EP EP18164757.9A patent/EP3404027B1/en active Active
- 2013-05-09 ES ES20153455T patent/ES3016982T3/es active Active
- 2013-05-09 RS RS20200639A patent/RS60424B1/sr unknown
- 2013-05-09 IN IN9434DEN2014 patent/IN2014DN09434A/en unknown
- 2013-05-09 CA CA2872190A patent/CA2872190C/en active Active
- 2013-05-09 PL PL13779943T patent/PL2858991T3/pl unknown
- 2013-05-09 JP JP2015511713A patent/JP6195909B2/ja active Active
- 2013-05-09 ME MEP-2020-110A patent/ME03795B/me unknown
- 2013-05-09 HR HRP20181838TT patent/HRP20181838T1/hr unknown
- 2013-05-09 EP EP20153455.9A patent/EP3663291B1/en active Active
- 2013-05-09 GE GEAP202213653A patent/GEAP202213653A/en unknown
- 2013-05-09 RS RS20181360A patent/RS58058B1/sr unknown
- 2013-05-09 LT LTEP18164757.9T patent/LT3404027T/lt unknown
- 2013-05-09 MX MX2014013551A patent/MX364992B/es active IP Right Grant
- 2013-05-09 WO PCT/US2013/040404 patent/WO2013170068A2/en not_active Ceased
- 2013-05-09 HU HUE13779943A patent/HUE040427T2/hu unknown
- 2013-05-09 ES ES18164757T patent/ES2794866T3/es active Active
- 2013-05-09 AU AU2013259384A patent/AU2013259384B2/en active Active
- 2013-05-09 UA UAA201413015A patent/UA118085C2/uk unknown
- 2013-05-09 ES ES13779943T patent/ES2702279T3/es active Active
- 2013-05-09 UA UAA201710733A patent/UA124922C2/uk unknown
- 2013-05-09 DK DK18164757.9T patent/DK3404027T3/da active
- 2013-05-09 EA EA201492050A patent/EA036639B1/ru unknown
- 2013-05-09 GE GEAP201313653A patent/GEP20237477B/en unknown
- 2013-05-09 SI SI201331730T patent/SI3404027T1/sl unknown
- 2013-05-09 NZ NZ702663A patent/NZ702663A/en unknown
- 2013-05-09 EP EP13779943.3A patent/EP2858991B1/en active Active
- 2013-05-09 SG SG11201407268SA patent/SG11201407268SA/en unknown
- 2013-05-09 US US13/891,044 patent/US9096543B2/en active Active
- 2013-05-09 SM SM20180686T patent/SMT201800686T1/it unknown
- 2013-05-09 US US14/399,868 patent/US9266843B2/en active Active
- 2013-05-09 CN CN201380036570.XA patent/CN104428295B/zh active Active
- 2013-05-09 PL PL18164757T patent/PL3404027T3/pl unknown
- 2013-05-09 BR BR112014027860A patent/BR112014027860B8/pt active IP Right Grant
- 2013-05-09 KR KR1020147034556A patent/KR102095429B1/ko active Active
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