JP2018534288A5 - - Google Patents
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- Publication number
- JP2018534288A5 JP2018534288A5 JP2018519487A JP2018519487A JP2018534288A5 JP 2018534288 A5 JP2018534288 A5 JP 2018534288A5 JP 2018519487 A JP2018519487 A JP 2018519487A JP 2018519487 A JP2018519487 A JP 2018519487A JP 2018534288 A5 JP2018534288 A5 JP 2018534288A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- amount
- cytarabine
- aml
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 43
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 42
- 229960000684 cytarabine Drugs 0.000 claims description 42
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 41
- 229940125904 compound 1 Drugs 0.000 claims description 23
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 19
- 229960000975 daunorubicin Drugs 0.000 claims description 19
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 19
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims description 18
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims description 18
- 229960000908 idarubicin Drugs 0.000 claims description 18
- 108700028369 Alleles Proteins 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- 238000009093 first-line therapy Methods 0.000 claims description 13
- 238000002560 therapeutic procedure Methods 0.000 claims description 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 13
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 12
- 229960005420 etoposide Drugs 0.000 claims description 12
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims description 12
- 229960001156 mitoxantrone Drugs 0.000 claims description 12
- 230000000155 isotopic effect Effects 0.000 claims description 10
- 239000002207 metabolite Substances 0.000 claims description 10
- 239000000651 prodrug Substances 0.000 claims description 10
- 229940002612 prodrug Drugs 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
- DYLUUSLLRIQKOE-UHFFFAOYSA-N enasidenib Chemical compound N=1C(C=2N=C(C=CC=2)C(F)(F)F)=NC(NCC(C)(O)C)=NC=1NC1=CC=NC(C(F)(F)F)=C1 DYLUUSLLRIQKOE-UHFFFAOYSA-N 0.000 claims description 8
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 7
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 6
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 231100000024 genotoxic Toxicity 0.000 claims description 3
- 230000001738 genotoxic effect Effects 0.000 claims description 3
- 208000014951 hematologic disease Diseases 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 208000019838 Blood disease Diseases 0.000 claims description 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 6
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 6
- 238000000034 method Methods 0.000 description 36
- 239000003112 inhibitor Substances 0.000 description 24
- 239000000126 substance Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 2
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BRQZOOWELDMGOE-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C[C]=N1 BRQZOOWELDMGOE-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021087311A JP2021130682A (ja) | 2015-10-15 | 2021-05-25 | 悪性腫瘍の治療のための併用療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562242256P | 2015-10-15 | 2015-10-15 | |
| US62/242,256 | 2015-10-15 | ||
| US201562255194P | 2015-11-13 | 2015-11-13 | |
| US62/255,194 | 2015-11-13 | ||
| PCT/US2016/057083 WO2017066599A1 (en) | 2015-10-15 | 2016-10-14 | Combination therapy for treating malignancies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021087311A Division JP2021130682A (ja) | 2015-10-15 | 2021-05-25 | 悪性腫瘍の治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018534288A JP2018534288A (ja) | 2018-11-22 |
| JP2018534288A5 true JP2018534288A5 (enExample) | 2019-11-28 |
Family
ID=57208385
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519487A Withdrawn JP2018534288A (ja) | 2015-10-15 | 2016-10-14 | 悪性腫瘍の治療のための併用療法 |
| JP2021087311A Pending JP2021130682A (ja) | 2015-10-15 | 2021-05-25 | 悪性腫瘍の治療のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021087311A Pending JP2021130682A (ja) | 2015-10-15 | 2021-05-25 | 悪性腫瘍の治療のための併用療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10905692B2 (enExample) |
| EP (2) | EP3362057A1 (enExample) |
| JP (2) | JP2018534288A (enExample) |
| KR (2) | KR20180063125A (enExample) |
| CN (1) | CN108366980A (enExample) |
| AU (1) | AU2016340087C1 (enExample) |
| BR (1) | BR112018007304A2 (enExample) |
| CA (1) | CA3001599A1 (enExample) |
| CL (1) | CL2018000927A1 (enExample) |
| EA (1) | EA201890968A1 (enExample) |
| IL (2) | IL311873A (enExample) |
| MX (2) | MX394796B (enExample) |
| SG (1) | SG10201912886XA (enExample) |
| WO (1) | WO2017066599A1 (enExample) |
| ZA (1) | ZA201802088B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2962943A1 (en) | 2014-09-29 | 2016-04-07 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3253746A1 (en) | 2015-02-04 | 2017-12-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| ES2862730T3 (es) | 2015-10-15 | 2021-10-07 | Celgene Corp | Combinación de un inhibidor de isocitrato deshidrogenasa 2 mutante con azacitidina y su uso para el tratamiento de la leucemia mielógena aguda |
| US12064445B2 (en) | 2015-12-03 | 2024-08-20 | Biosight Ltd. | Cytarabine conjugates for cancer therapy |
| BR112019004356A2 (pt) | 2016-09-07 | 2019-05-28 | Celgene Corporation | composições de comprimido |
| EP3618828B1 (en) | 2017-05-05 | 2023-11-01 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| BR112020000492A2 (pt) * | 2017-07-09 | 2020-07-14 | Biosight Ltd. | terapia de câncer de combinação |
| US10980788B2 (en) * | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| US20220017490A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| WO2020092915A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid dispersions for treatment of cancer |
| WO2021097160A1 (en) | 2019-11-14 | 2021-05-20 | Celgene Corporation | Pediatric formulations for treatment of cancer |
| CN111087408B (zh) * | 2020-01-03 | 2021-04-02 | 浙江大学 | 一种大环结构的idh2突变体抑制剂及其医药用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| CA2290624C (en) | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| PT1251832E (pt) | 2000-02-04 | 2007-01-31 | Depomed Inc | Forma de dosagem constituída por invólucro-e-núcleo que conduz a uma libertação do fármaco de ordem zero |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| CA2755394C (en) | 2009-03-13 | 2021-10-19 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011050211A2 (en) * | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| HUE038403T2 (hu) | 2012-01-06 | 2018-10-29 | Agios Pharmaceuticals Inc | Terápiásan alkalmazható vegyületek és alkalmazási módszereik |
| BR112016000489A8 (pt) | 2013-07-11 | 2020-01-07 | Agios Pharmaceuticals Inc | composto, composição farmacêutica que o compreende, uso da composição e métodos para fabricar compostos |
| TWI701242B (zh) | 2013-08-02 | 2020-08-11 | 美商阿吉斯藥品股份有限公司 | 治療活性化合物及其使用方法(三) |
| WO2015018060A1 (en) | 2013-08-09 | 2015-02-12 | Agios Pharmaceuticals, Inc. | Crystalline forms of therapeutically active compounds and use thereof |
| CA2962943A1 (en) | 2014-09-29 | 2016-04-07 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3253746A1 (en) | 2015-02-04 | 2017-12-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| MX365590B (es) | 2015-08-05 | 2019-06-07 | Agios Pharmaceuticals Inc | Metodos para preparar 6-(aril o heteroaril)-1,3,5-triazin-2,4-diol es y 6-(aril o heteroaril)-1,3,5-triazin-2,4-diaminas. |
| ES2862730T3 (es) | 2015-10-15 | 2021-10-07 | Celgene Corp | Combinación de un inhibidor de isocitrato deshidrogenasa 2 mutante con azacitidina y su uso para el tratamiento de la leucemia mielógena aguda |
| MA43374A (fr) | 2015-12-04 | 2018-10-10 | Agios Pharmaceuticals Inc | Méthodes de traitement de tumeurs malignes |
| JP6930991B2 (ja) | 2016-02-26 | 2021-09-01 | セルジーン コーポレイション | 血液学的悪性腫瘍及び固形腫瘍の治療のためのｉｄｈ２阻害剤 |
-
2016
- 2016-10-14 WO PCT/US2016/057083 patent/WO2017066599A1/en not_active Ceased
- 2016-10-14 BR BR112018007304A patent/BR112018007304A2/pt not_active Application Discontinuation
- 2016-10-14 AU AU2016340087A patent/AU2016340087C1/en active Active
- 2016-10-14 KR KR1020187010260A patent/KR20180063125A/ko not_active Ceased
- 2016-10-14 IL IL311873A patent/IL311873A/en unknown
- 2016-10-14 MX MX2018004595A patent/MX394796B/es unknown
- 2016-10-14 EP EP16787982.4A patent/EP3362057A1/en not_active Withdrawn
- 2016-10-14 EP EP22196348.1A patent/EP4147692A1/en active Pending
- 2016-10-14 CN CN201680060067.1A patent/CN108366980A/zh active Pending
- 2016-10-14 CA CA3001599A patent/CA3001599A1/en not_active Abandoned
- 2016-10-14 US US15/768,480 patent/US10905692B2/en active Active
- 2016-10-14 EA EA201890968A patent/EA201890968A1/ru unknown
- 2016-10-14 SG SG10201912886XA patent/SG10201912886XA/en unknown
- 2016-10-14 JP JP2018519487A patent/JP2018534288A/ja not_active Withdrawn
- 2016-10-14 KR KR1020257014978A patent/KR20250065944A/ko active Pending
-
2018
- 2018-03-21 IL IL258269A patent/IL258269A/en unknown
- 2018-03-28 ZA ZA2018/02088A patent/ZA201802088B/en unknown
- 2018-04-11 CL CL2018000927A patent/CL2018000927A1/es unknown
- 2018-04-13 MX MX2022006701A patent/MX2022006701A/es unknown
-
2020
- 2020-12-24 US US17/133,994 patent/US20210386749A1/en not_active Abandoned
-
2021
- 2021-05-25 JP JP2021087311A patent/JP2021130682A/ja active Pending
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