JP2016513696A5 - - Google Patents

Download PDF

Info

Publication number
JP2016513696A5
JP2016513696A5 JP2016502433A JP2016502433A JP2016513696A5 JP 2016513696 A5 JP2016513696 A5 JP 2016513696A5 JP 2016502433 A JP2016502433 A JP 2016502433A JP 2016502433 A JP2016502433 A JP 2016502433A JP 2016513696 A5 JP2016513696 A5 JP 2016513696A5
Authority
JP
Japan
Prior art keywords
optionally substituted
substituted
optionally
compound
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016502433A
Other languages
English (en)
Japanese (ja)
Other versions
JP6534650B2 (ja
JP2016513696A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/027428 external-priority patent/WO2014152518A2/en
Publication of JP2016513696A publication Critical patent/JP2016513696A/ja
Publication of JP2016513696A5 publication Critical patent/JP2016513696A5/ja
Application granted granted Critical
Publication of JP6534650B2 publication Critical patent/JP6534650B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016502433A 2013-03-14 2014-03-14 ロイコトリエンa4加水分解酵素の阻害剤 Expired - Fee Related JP6534650B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781193P 2013-03-14 2013-03-14
US61/781,193 2013-03-14
PCT/US2014/027428 WO2014152518A2 (en) 2013-03-14 2014-03-14 Inhibitors of leukotriene a4 hydrolase

Publications (3)

Publication Number Publication Date
JP2016513696A JP2016513696A (ja) 2016-05-16
JP2016513696A5 true JP2016513696A5 (enExample) 2017-04-13
JP6534650B2 JP6534650B2 (ja) 2019-06-26

Family

ID=51581716

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016502433A Expired - Fee Related JP6534650B2 (ja) 2013-03-14 2014-03-14 ロイコトリエンa4加水分解酵素の阻害剤

Country Status (10)

Country Link
US (2) US9777006B2 (enExample)
EP (1) EP2970309A4 (enExample)
JP (1) JP6534650B2 (enExample)
KR (1) KR20150127246A (enExample)
AU (1) AU2014239567B2 (enExample)
BR (1) BR112015022864A8 (enExample)
CA (1) CA2906084A1 (enExample)
MX (1) MX2015011678A (enExample)
RU (1) RU2678196C2 (enExample)
WO (1) WO2014152518A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3205644A1 (en) 2005-12-29 2017-08-16 Celtaxsys Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
EP2968265A4 (en) 2013-03-14 2016-12-28 Celtaxsys Inc INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
CN104530151A (zh) * 2015-01-15 2015-04-22 佛山市赛维斯医药科技有限公司 一种含硝基苯s-葡萄糖苷结构的化合物及其用途
CN104530152A (zh) * 2015-01-15 2015-04-22 佛山市赛维斯医药科技有限公司 一种含丙烯腈基和三氟甲氧苯基o-葡萄糖苷结构化合物及用途
CN104530153A (zh) * 2015-01-15 2015-04-22 佛山市赛维斯医药科技有限公司 一类苯基s-葡萄糖苷衍生物、其制备方法和在医药上的用途
WO2018107158A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
WO2019036024A1 (en) 2017-08-17 2019-02-21 Bristol-Myers Squibb Company 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
US11426399B2 (en) * 2018-05-15 2022-08-30 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase
EP3801559B1 (en) 2018-05-31 2025-01-01 Celltaxis, LLC Method of reducing pulmonary exacerbations in respiratory disease patients
KR20250174699A (ko) 2018-10-30 2025-12-12 크로노스 바이오, 인코포레이티드 Cdk9 활성을 조절하기 위한 화합물, 조성물 및 방법
UY39377A (es) 2020-08-14 2022-03-31 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
CA3221177A1 (en) 2021-11-01 2023-05-04 Meghan Kerrisk Campbell Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6815872A (enExample) 1967-11-22 1969-05-27
JPS5614663B2 (enExample) 1971-08-21 1981-04-06
US4582833A (en) 1984-04-16 1986-04-15 American Cyanamid Company 2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines
US4576943A (en) 1984-10-09 1986-03-18 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines
US5308852A (en) 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
AU1952597A (en) 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US5952349A (en) 1996-07-10 1999-09-14 Schering Corporation Muscarinic antagonists for treating memory loss
US6309561B1 (en) 1997-12-24 2001-10-30 3M Innovative Properties Company Liquid crystal compounds having a chiral fluorinated terminal portion
US6380203B1 (en) * 1998-01-14 2002-04-30 Merck & Co., Inc. Angiogenesis inhibitors
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
US6699873B1 (en) 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
AU2001234420A1 (en) 2000-02-03 2001-08-14 Eli Lilly And Company Potentiators of glutamate receptors
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
JP2001354657A (ja) 2000-06-09 2001-12-25 Sds Biotech:Kk 置換ピペラジン誘導体及び農園芸用殺菌剤
US6875483B2 (en) 2000-07-06 2005-04-05 Fuji Photo Film Co., Ltd. Liquid crystal composition comprising liquid crystal molecules and alignment promoter
WO2002064211A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
DE60229114D1 (en) 2001-03-02 2008-11-13 Axys Pharm Inc Cathepsincystein-proteasehemmer
AUPR362001A0 (en) 2001-03-08 2001-04-05 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2826011B1 (fr) 2001-06-14 2004-12-10 Oreal Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
IL160845A0 (en) 2001-09-14 2004-08-31 Tularik Inc Linked biaryl compounds
AU2002363236A1 (en) 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
AU2003290527A1 (en) 2002-10-17 2004-05-04 Decode Genetics Ehf. Susceptibility gene for myocardial infarction
US20040198777A1 (en) 2002-12-20 2004-10-07 Mitokor, Inc. Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto
JPWO2004089410A1 (ja) 2003-04-03 2006-07-06 協和醗酵工業株式会社 神経因性疼痛の予防及び/または治療剤
WO2004099164A1 (en) 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection
JP2005008581A (ja) * 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
WO2005012296A1 (en) 2003-07-28 2005-02-10 Janssen Pharmaceutica N.V. Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators
CA2539276A1 (en) 2003-09-17 2005-03-31 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
DE10356579A1 (de) * 2003-12-04 2005-07-07 Merck Patent Gmbh Aminderivate
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
ATE437880T1 (de) 2004-02-04 2009-08-15 Neurosearch As Dimere azacyclische verbindungen und deren verwendung
WO2006033795A2 (en) * 2004-09-17 2006-03-30 Wyeth Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
WO2006105304A2 (en) 2005-03-31 2006-10-05 Janssen Pharmaceutica N.V. Phenyl and pyridyl lta4h modulators
GB0514018D0 (en) 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
BRPI0616187A2 (pt) 2005-09-21 2011-06-14 Decode Genetics Ehf composto, composiÇço farmacÊutica, e, uso de uma quantidade terapeuticamente eficaz de um composto
CN1947717B (zh) 2005-10-14 2012-09-26 卓敏 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
DE102005049954A1 (de) 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
EP3205644A1 (en) 2005-12-29 2017-08-16 Celtaxsys Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
CN102633783A (zh) 2006-02-10 2012-08-15 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
EP2058309A4 (en) * 2006-08-04 2010-12-22 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUND
BRPI0718059A2 (pt) 2006-10-19 2013-11-05 Holffmann La Roche Ag F Aminometil-2-imidazóis com afinidade com os receptores amina-associado traço
ES2620818T3 (es) 2006-12-14 2017-06-29 Janssen Pharmaceutica N.V. Procedimiento para la preparación de derivados de piperazinil y diazepanil benzamida
FR2911138B1 (fr) 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911140B1 (fr) 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911139A1 (fr) 2007-01-05 2008-07-11 Sanofi Aventis Sa Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
RU2010103104A (ru) 2007-07-02 2011-08-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазола в качестве антагонистов рецептора ccr2
US7902181B2 (en) 2007-12-12 2011-03-08 Astrazeneca Ab Compounds 010
EA201001359A1 (ru) * 2008-02-26 2011-04-29 Новартис Аг Гетероциклические соединения в качестве ингибиторов cxcr2
US20100029657A1 (en) 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
EP2110374A1 (en) 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
WO2010011912A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Trpv4 antagonists
CN102030700B (zh) 2009-09-30 2016-06-01 中国医学科学院药物研究所 苯甲酰胺基羧酸类化合物及其制法和药物用途
EP2493852B1 (en) 2009-10-30 2014-04-09 Janssen Pharmaceutica NV 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
AU2010328419A1 (en) 2009-12-07 2012-06-21 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
HUE052110T2 (hu) 2010-07-29 2021-04-28 Rigel Pharmaceuticals Inc AMPK-t aktiváló heterociklusos vegyületek és alkalmazásuk
US8609669B2 (en) * 2010-11-16 2013-12-17 Abbvie Inc. Potassium channel modulators
WO2012125832A2 (en) 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
EP2714661B1 (en) 2011-05-23 2015-09-30 Janssen Pharmaceutica, N.V. Picolinamido - propanoic acid derivatives useful as glucagon receptor antagonists
CN103159742B (zh) 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
US9006235B2 (en) * 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
EP2968265A4 (en) 2013-03-14 2016-12-28 Celtaxsys Inc INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE

Similar Documents

Publication Publication Date Title
JP2016516043A5 (enExample)
JP2016513681A5 (enExample)
JP2016506962A5 (enExample)
JP2015522650A5 (enExample)
JP2017509586A5 (enExample)
JP2015537020A5 (enExample)
CY1118721T1 (el) Παραγωγα 2,3 διϋδρο-1η-ινδεν-1-υλ-2,7-διαζασπειρο[3.6]εννεανιου και η χρηση αυτων ως ανταγωνιστες ή αντιστροφοι αγωνιστες του υποδοχεα γκρελινης
JP2014503574A5 (enExample)
JP2016506961A5 (enExample)
JP2013542261A5 (enExample)
WO2015200481A8 (en) Mnk inhibitors and methods related thereto
EA201490418A1 (ru) Новые макроциклические соединения в качестве ингибиторов фактора xia
MX2017010477A (es) Compuestos triciclicos y usos de los mismos en medicina.
EA201390969A1 (ru) Модуляторы глюкагонового рецептора
EA201692095A1 (ru) Имидазо[4,5-c]хинолин-2-оновые соединения и их применение в лечении рака
EA201391486A1 (ru) Способы и композиции для лечения болезни паркинсона
TN2013000434A1 (en) Novel imidazole derivatives useful for the treatment of arthritis
EA201391263A1 (ru) Комбинированные терапии гематологических опухолей
RU2015147447A (ru) Производные доластатина 10 и ауристатинов
CY1124251T1 (el) Παραγωγα καρβοξαμιδιου
JP2015521195A5 (enExample)
JP2019535723A5 (enExample)
EA201791829A1 (ru) Амидные соединения в качестве агонистов рецептора 5-ht
MX341341B (es) Derivados de benzamida y su uso como inhibidores de proteina de choque termico 90 kda (hsp90).
RU2013136895A (ru) Новое бициклическое соединение или его соль