MX2015011678A - Inhibidores de leucotrieno a4 hidrolasa. - Google Patents
Inhibidores de leucotrieno a4 hidrolasa.Info
- Publication number
- MX2015011678A MX2015011678A MX2015011678A MX2015011678A MX2015011678A MX 2015011678 A MX2015011678 A MX 2015011678A MX 2015011678 A MX2015011678 A MX 2015011678A MX 2015011678 A MX2015011678 A MX 2015011678A MX 2015011678 A MX2015011678 A MX 2015011678A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- solar
- solar panel
- exemplary embodiments
- accordance
- Prior art date
Links
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 title abstract 3
- 108010072713 leukotriene A4 hydrolase Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781193P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/027428 WO2014152518A2 (en) | 2013-03-14 | 2014-03-14 | Inhibitors of leukotriene a4 hydrolase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015011678A true MX2015011678A (es) | 2016-07-08 |
Family
ID=51581716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015011678A MX2015011678A (es) | 2013-03-14 | 2014-03-14 | Inhibidores de leucotrieno a4 hidrolasa. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9777006B2 (enExample) |
| EP (1) | EP2970309A4 (enExample) |
| JP (1) | JP6534650B2 (enExample) |
| KR (1) | KR20150127246A (enExample) |
| AU (1) | AU2014239567B2 (enExample) |
| BR (1) | BR112015022864A8 (enExample) |
| CA (1) | CA2906084A1 (enExample) |
| MX (1) | MX2015011678A (enExample) |
| RU (1) | RU2678196C2 (enExample) |
| WO (1) | WO2014152518A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3205644A1 (en) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
| EP2968265A4 (en) | 2013-03-14 | 2016-12-28 | Celtaxsys Inc | INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| CN104530151A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一种含硝基苯s-葡萄糖苷结构的化合物及其用途 |
| CN104530152A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一种含丙烯腈基和三氟甲氧苯基o-葡萄糖苷结构化合物及用途 |
| CN104530153A (zh) * | 2015-01-15 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类苯基s-葡萄糖苷衍生物、其制备方法和在医药上的用途 |
| WO2018107158A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
| WO2019036024A1 (en) | 2017-08-17 | 2019-02-21 | Bristol-Myers Squibb Company | 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
| US11426399B2 (en) * | 2018-05-15 | 2022-08-30 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
| EP3801559B1 (en) | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
| KR20250174699A (ko) | 2018-10-30 | 2025-12-12 | 크로노스 바이오, 인코포레이티드 | Cdk9 활성을 조절하기 위한 화합물, 조성물 및 방법 |
| UY39377A (es) | 2020-08-14 | 2022-03-31 | Novartis Ag | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos |
| CA3221177A1 (en) | 2021-11-01 | 2023-05-04 | Meghan Kerrisk Campbell | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
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| NL6815872A (enExample) | 1967-11-22 | 1969-05-27 | ||
| JPS5614663B2 (enExample) | 1971-08-21 | 1981-04-06 | ||
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| US4576943A (en) | 1984-10-09 | 1986-03-18 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines |
| US5308852A (en) | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
| US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| AU1952597A (en) | 1996-02-13 | 1997-09-02 | G.D. Searle & Co. | Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor |
| US5952349A (en) | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| US6309561B1 (en) | 1997-12-24 | 2001-10-30 | 3M Innovative Properties Company | Liquid crystal compounds having a chiral fluorinated terminal portion |
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| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
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| AU2001234420A1 (en) | 2000-02-03 | 2001-08-14 | Eli Lilly And Company | Potentiators of glutamate receptors |
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| US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
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| FR2826011B1 (fr) | 2001-06-14 | 2004-12-10 | Oreal | Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique |
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| DE10356579A1 (de) * | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| SE0303480D0 (sv) | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
| ATE437880T1 (de) | 2004-02-04 | 2009-08-15 | Neurosearch As | Dimere azacyclische verbindungen und deren verwendung |
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| GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| BRPI0616187A2 (pt) | 2005-09-21 | 2011-06-14 | Decode Genetics Ehf | composto, composiÇço farmacÊutica, e, uso de uma quantidade terapeuticamente eficaz de um composto |
| CN1947717B (zh) | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
| DE102005049954A1 (de) | 2005-10-19 | 2007-05-31 | Sanofi-Aventis Deutschland Gmbh | Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen |
| EP3205644A1 (en) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| CN102633783A (zh) | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| EP2058309A4 (en) * | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
| BRPI0718059A2 (pt) | 2006-10-19 | 2013-11-05 | Holffmann La Roche Ag F | Aminometil-2-imidazóis com afinidade com os receptores amina-associado traço |
| ES2620818T3 (es) | 2006-12-14 | 2017-06-29 | Janssen Pharmaceutica N.V. | Procedimiento para la preparación de derivados de piperazinil y diazepanil benzamida |
| FR2911138B1 (fr) | 2007-01-05 | 2009-02-20 | Sanofi Aventis Sa | Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| FR2911140B1 (fr) | 2007-01-05 | 2009-02-20 | Sanofi Aventis Sa | Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| RU2010103104A (ru) | 2007-07-02 | 2011-08-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные имидазола в качестве антагонистов рецептора ccr2 |
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| EA201001359A1 (ru) * | 2008-02-26 | 2011-04-29 | Новартис Аг | Гетероциклические соединения в качестве ингибиторов cxcr2 |
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| EP2110374A1 (en) | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
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| US9006235B2 (en) * | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| EP2968265A4 (en) | 2013-03-14 | 2016-12-28 | Celtaxsys Inc | INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE |
-
2014
- 2014-03-14 MX MX2015011678A patent/MX2015011678A/es unknown
- 2014-03-14 EP EP14769747.8A patent/EP2970309A4/en not_active Withdrawn
- 2014-03-14 WO PCT/US2014/027428 patent/WO2014152518A2/en not_active Ceased
- 2014-03-14 CA CA2906084A patent/CA2906084A1/en not_active Abandoned
- 2014-03-14 AU AU2014239567A patent/AU2014239567B2/en not_active Ceased
- 2014-03-14 RU RU2015137975A patent/RU2678196C2/ru not_active IP Right Cessation
- 2014-03-14 KR KR1020157028772A patent/KR20150127246A/ko not_active Ceased
- 2014-03-14 BR BR112015022864A patent/BR112015022864A8/pt not_active Application Discontinuation
- 2014-03-14 JP JP2016502433A patent/JP6534650B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-10 US US14/849,825 patent/US9777006B2/en not_active Expired - Fee Related
-
2017
- 2017-09-14 US US15/704,199 patent/US10399986B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014239567A1 (en) | 2015-10-01 |
| EP2970309A4 (en) | 2016-11-09 |
| RU2678196C2 (ru) | 2019-01-24 |
| AU2014239567B2 (en) | 2017-12-14 |
| RU2015137975A (ru) | 2017-04-28 |
| KR20150127246A (ko) | 2015-11-16 |
| RU2015137975A3 (enExample) | 2018-03-26 |
| US20180127424A1 (en) | 2018-05-10 |
| WO2014152518A3 (en) | 2014-11-13 |
| US9777006B2 (en) | 2017-10-03 |
| US10399986B2 (en) | 2019-09-03 |
| US20160068534A1 (en) | 2016-03-10 |
| BR112015022864A8 (pt) | 2019-11-26 |
| BR112015022864A2 (pt) | 2017-07-18 |
| JP6534650B2 (ja) | 2019-06-26 |
| CA2906084A1 (en) | 2014-09-25 |
| EP2970309A2 (en) | 2016-01-20 |
| WO2014152518A2 (en) | 2014-09-25 |
| JP2016513696A (ja) | 2016-05-16 |
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