JP2014513123A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513123A5 JP2014513123A5 JP2014509345A JP2014509345A JP2014513123A5 JP 2014513123 A5 JP2014513123 A5 JP 2014513123A5 JP 2014509345 A JP2014509345 A JP 2014509345A JP 2014509345 A JP2014509345 A JP 2014509345A JP 2014513123 A5 JP2014513123 A5 JP 2014513123A5
- Authority
- JP
- Japan
- Prior art keywords
- amorphous solid
- compound
- formula
- solid according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007787 solid Substances 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 14
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- 208000031886 HIV Infections Diseases 0.000 claims description 6
- 208000037357 HIV infectious disease Diseases 0.000 claims description 6
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims description 4
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229960000366 emtricitabine Drugs 0.000 claims description 4
- 230000009477 glass transition Effects 0.000 claims description 4
- 239000002777 nucleoside Substances 0.000 claims description 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000002002 slurry Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
- 229960004693 tenofovir disoproxil fumarate Drugs 0.000 claims description 4
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 claims description 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims description 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 2
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 102100034343 Integrase Human genes 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 229940072107 ascorbate Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims description 2
- 229940120124 dichloroacetate Drugs 0.000 claims description 2
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 229960003586 elvitegravir Drugs 0.000 claims description 2
- JUZYLCPPVHEVSV-LJQANCHMSA-N elvitegravir Chemical compound COC1=CC=2N([C@H](CO)C(C)C)C=C(C(O)=O)C(=O)C=2C=C1CC1=CC=CC(Cl)=C1F JUZYLCPPVHEVSV-LJQANCHMSA-N 0.000 claims description 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 229910021485 fumed silica Inorganic materials 0.000 claims description 2
- 239000003084 hiv integrase inhibitor Substances 0.000 claims description 2
- 229940049920 malate Drugs 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims description 2
- 235000001968 nicotinic acid Nutrition 0.000 claims description 2
- 239000011664 nicotinic acid Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000001384 succinic acid Substances 0.000 claims description 2
- 229940095064 tartrate Drugs 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 2
- 229950000339 xinafoate Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
- AWGBKZRMLNVLAF-UHFFFAOYSA-N 3,5-dibromo-n,2-dihydroxybenzamide Chemical compound ONC(=O)C1=CC(Br)=CC(Br)=C1O AWGBKZRMLNVLAF-UHFFFAOYSA-N 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 0 CC(C)c1nc(CN(C)C(NC(CCN2CCOCC2)C(NC(CCC(Cc2ccccc2)NC(OCc2cnc[s]2)=*)Cc2ccccc2)=O)=*)c[s]1 Chemical compound CC(C)c1nc(CN(C)C(NC(CCN2CCOCC2)C(NC(CCC(Cc2ccccc2)NC(OCc2cnc[s]2)=*)Cc2ccccc2)=O)=*)c[s]1 0.000 description 1
- 229940122440 HIV protease inhibitor Drugs 0.000 description 1
- 239000004030 hiv protease inhibitor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161481509P | 2011-05-02 | 2011-05-02 | |
| US61/481,509 | 2011-05-02 | ||
| PCT/US2012/035871 WO2012151165A1 (en) | 2011-05-02 | 2012-04-30 | Amorphous solid salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513123A JP2014513123A (ja) | 2014-05-29 |
| JP2014513123A5 true JP2014513123A5 (enExample) | 2015-06-25 |
Family
ID=46086061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509345A Pending JP2014513123A (ja) | 2011-05-02 | 2012-04-30 | 無定形固体の塩 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140187771A1 (enExample) |
| EP (1) | EP2705027B1 (enExample) |
| JP (1) | JP2014513123A (enExample) |
| AU (1) | AU2012250890B2 (enExample) |
| CA (1) | CA2836768A1 (enExample) |
| ES (1) | ES2543923T3 (enExample) |
| PT (1) | PT2705027E (enExample) |
| WO (1) | WO2012151165A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013130766A1 (en) * | 2012-03-01 | 2013-09-06 | Gilead Sciences, Inc. | Spray dried formulations |
| NZ706223A (en) | 2012-10-23 | 2018-11-30 | Cipla Ltd | Pharmaceutical antiretroviral composition |
| US20160200716A1 (en) | 2012-12-26 | 2016-07-14 | Assia Chemical Industries Ltd. | Cobicistat dichlohydrate salt |
| WO2015079415A1 (en) * | 2013-11-29 | 2015-06-04 | Mylan Laboratories Ltd. | Amorphous cobicistat solid dispersion |
| CN105732538B (zh) * | 2014-12-09 | 2018-04-13 | 杭州普晒医药科技有限公司 | 可比司他帕莫酸盐及其制备方法、药物组合物和用途 |
| WO2016094011A1 (en) * | 2014-12-11 | 2016-06-16 | Merck Sharp & Dohme Corp. | Crystal forms of a ccr5 antagonist |
| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| WO2016132378A2 (en) * | 2015-02-18 | 2016-08-25 | Msn Laboratories Private Limited | Novel process for the preparation of 1,3-thiazol-5-ylmethyl [(2r,5r)-5-{[(2s)-2- [(methyl{[2-(propan-2-yl)- 1,3-thiazol-4-yl] methyl} carbamoyl) amino] -4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate |
| TW201728582A (zh) * | 2016-01-28 | 2017-08-16 | 基利科學股份有限公司 | 結晶型 |
| ES2944958T3 (es) | 2016-06-29 | 2023-06-27 | Kezar Life Sciences | Sales cristalinas de inhibidor del inmunoproteasoma de epoxicetona peptídico |
| TWI751177B (zh) | 2016-06-29 | 2022-01-01 | 美商基澤生命科學公司 | 製備肽環氧酮免疫蛋白酶體抑制劑及其前驅體之方法 |
| RS66222B1 (sr) | 2017-12-07 | 2024-12-31 | Univ Emory | N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim |
| CN110368370B (zh) * | 2018-04-12 | 2022-08-12 | 湖南千金湘江药业股份有限公司 | 一种无定形半富马酸替诺福韦二吡呋酯片及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2049506T5 (pl) * | 2006-07-07 | 2024-09-09 | Gilead Sciences, Inc. | Modulatory farmakokinetycznych właściwości leków |
| EP3150586B1 (en) * | 2007-02-23 | 2020-01-08 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| EP2296633B1 (en) * | 2008-05-02 | 2015-09-30 | Gilead Sciences, Inc. | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
| UA108738C2 (uk) * | 2009-04-03 | 2015-06-10 | Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки |
-
2012
- 2012-04-30 PT PT127216455T patent/PT2705027E/pt unknown
- 2012-04-30 US US14/115,079 patent/US20140187771A1/en not_active Abandoned
- 2012-04-30 CA CA2836768A patent/CA2836768A1/en not_active Abandoned
- 2012-04-30 WO PCT/US2012/035871 patent/WO2012151165A1/en not_active Ceased
- 2012-04-30 JP JP2014509345A patent/JP2014513123A/ja active Pending
- 2012-04-30 AU AU2012250890A patent/AU2012250890B2/en not_active Ceased
- 2012-04-30 EP EP12721645.5A patent/EP2705027B1/en active Active
- 2012-04-30 ES ES12721645.5T patent/ES2543923T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513123A5 (enExample) | ||
| TWI814350B (zh) | 用於治療hiv之蛋白殼抑制劑 | |
| ES2977959T3 (es) | Formas de sal de colina de un inhibidor de la cápside del VIH | |
| JP6356919B2 (ja) | Ｈｉｖの処置のためのイソキノリン化合物 | |
| JP2022058398A (ja) | Ｂｒａｆ－ｖ６００関連疾患の治療に使用するためのｐｌｘ－８３９４またはｐｌｘ－７９０４ | |
| JP2015512406A5 (enExample) | ||
| RU2011108026A (ru) | Комбинированная терапия туберкулеза | |
| JP2013542247A5 (enExample) | ||
| RU2013121788A (ru) | Ингибиторы репликации вич | |
| JP2014518266A5 (enExample) | ||
| JP2014500295A5 (enExample) | ||
| JP2015038149A5 (enExample) | ||
| JP2010532373A5 (enExample) | ||
| JP2013542261A5 (enExample) | ||
| RU2016141569A (ru) | Комбинации | |
| WO2009082818A8 (en) | Novel c-21-keto lupane derivatives preparation and use thereof | |
| CA2826080A1 (en) | Administration regime for nitrocatechols | |
| JP2015509075A5 (enExample) | ||
| WO2011151722A3 (en) | Methods and compositions for oral pharmaceutical therapy | |
| KR20160043117A (ko) | 가속화된 경화반 퇴행을 위한 조성물 및 치료방법 | |
| JP2011527687A5 (enExample) | ||
| AU2015323321A1 (en) | Long acting pharmaceutical compositions | |
| EA201270651A1 (ru) | Карбоксамиды пиридинон гидроксициклопентила: ингибиторы вич интегразы и области терапевтического применения | |
| TN2014000031A1 (en) | Use of organic compound for the treatment of noonan syndrome | |
| JP2012523458A5 (enExample) |