JP5827962B2 - Ｃｄｃ７キナーゼ阻害剤およびその使用 - Google Patents

Ｃｄｃ７キナーゼ阻害剤およびその使用 Download PDF

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JP5827962B2
JP5827962B2 JP2012557185A JP2012557185A JP5827962B2 JP 5827962 B2 JP5827962 B2 JP 5827962B2 JP 2012557185 A JP2012557185 A JP 2012557185A JP 2012557185 A JP2012557185 A JP 2012557185A JP 5827962 B2 JP5827962 B2 JP 5827962B2
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cancer
mutation
optionally substituted
certain embodiments
leukemia
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JP2013522212A5 (enExample
JP2013522212A (ja
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フラッティーニ，マーク，ジー．
ジャーバッラー，ハキム
ケリー，トーマス，ジェイ．
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スローン ケタリング インスティテュート フォア キャンサー リサーチ
スローン ケタリング インスティテュート フォア キャンサー リサーチ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P27/02—Ophthalmic agents
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    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
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    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pathology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
JP2012557185A 2010-03-08 2011-03-08 Ｃｄｃ７キナーゼ阻害剤およびその使用 Active JP5827962B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31174110P 2010-03-08 2010-03-08
US61/311,741 2010-03-08
PCT/US2011/027619 WO2011112635A1 (en) 2010-03-08 2011-03-08 Cdc7 kinase inhibitors and uses thereof

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JP2013522212A JP2013522212A (ja) 2013-06-13
JP2013522212A5 JP2013522212A5 (enExample) 2014-08-28
JP5827962B2 true JP5827962B2 (ja) 2015-12-02

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US (8) US9180105B2 (enExample)
EP (3) EP3338770B1 (enExample)
JP (1) JP5827962B2 (enExample)
CN (1) CN102844023B (enExample)
AU (1) AU2011224457B2 (enExample)
CA (1) CA2789484C (enExample)
DK (1) DK2544674T3 (enExample)
EA (1) EA025443B1 (enExample)
ES (1) ES2661367T3 (enExample)
TR (1) TR201800962T4 (enExample)
WO (1) WO2011112635A1 (enExample)

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