MX354725B - Metodo de tratamiento de una enfermedad proliferativa. - Google Patents
Metodo de tratamiento de una enfermedad proliferativa.Info
- Publication number
- MX354725B MX354725B MX2014005726A MX2014005726A MX354725B MX 354725 B MX354725 B MX 354725B MX 2014005726 A MX2014005726 A MX 2014005726A MX 2014005726 A MX2014005726 A MX 2014005726A MX 354725 B MX354725 B MX 354725B
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- proliferative disease
- serine
- kinase inhibitor
- threonine kinase
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 229940121742 Serine/threonine kinase inhibitor Drugs 0.000 abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558619P | 2011-11-11 | 2011-11-11 | |
| PCT/US2012/064269 WO2013070996A1 (en) | 2011-11-11 | 2012-11-09 | Method of treating a proliferative disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014005726A MX2014005726A (es) | 2014-05-28 |
| MX354725B true MX354725B (es) | 2018-03-16 |
Family
ID=47279036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014005726A MX354725B (es) | 2011-11-11 | 2012-11-09 | Metodo de tratamiento de una enfermedad proliferativa. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11007194B2 (enExample) |
| EP (1) | EP2776037B1 (enExample) |
| JP (1) | JP6150813B2 (enExample) |
| CN (2) | CN103917236A (enExample) |
| AU (1) | AU2012335663B2 (enExample) |
| BR (1) | BR112014011223A8 (enExample) |
| CA (1) | CA2855243C (enExample) |
| MX (1) | MX354725B (enExample) |
| RU (1) | RU2622015C2 (enExample) |
| WO (1) | WO2013070996A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| EP3574904A1 (en) * | 2012-08-07 | 2019-12-04 | Array Biopharma, Inc. | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
| CN109890386B (zh) | 2016-06-03 | 2022-05-24 | 阵列生物制药公司 | 药物组合 |
| WO2018107146A1 (en) * | 2016-12-11 | 2018-06-14 | Memorial Sloan Kettering Cancer Center | Methods and compositions for treatment of braf mutant cancers |
| WO2020011141A1 (zh) * | 2018-07-12 | 2020-01-16 | 深圳市塔吉瑞生物医药有限公司 | 一种二芳基吡唑化合物及包含该化合物的组合物及其用途 |
| TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
| IL294484A (en) * | 2020-01-07 | 2022-09-01 | Revolution Medicines Inc | Shp2 inhibitor dosing and methods of treating cancer |
| PE20231651A1 (es) | 2020-06-09 | 2023-10-17 | Array Biopharma Inc | Compuestos para el tratamiento de enfermedades y trastornos asociados a braf |
| CA3257280A1 (en) | 2022-05-25 | 2023-11-30 | Msd International Gmbh | COMBINATION OF A BRAF INHIBITOR, AN EGFR INHIBITOR AND A PD-1 ANTAGONIST FOR THE TREATMENT OF COLORECTAL CANCER MSI-H/DMMR, WITH BRAF V600E MUTATION |
| ES3035530T3 (en) | 2023-03-09 | 2025-09-04 | Minneamrita Therapeutics Llc | Drug combination for the treatment of stomach cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| IL132991A (en) | 1997-05-22 | 2005-11-20 | Searle & Co | Substituted pyrazoles, pharmaceutical compositionscomprising them and their use as p38 inase inhibi tors |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
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| KR20070113295A (ko) | 2005-03-17 | 2007-11-28 | 노파르티스 아게 | 티로신/트레오닌 키나제 억제제, 특히 b-raf 키나제억제제로서의n-[3-(1-아미노-5,6,7,8-테트라히드로-2,4,4b-트리아자플루오렌-9-일)-페닐]벤즈아미드 |
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| US20080242667A1 (en) | 2005-08-26 | 2008-10-02 | Smithkline Beecham Corporation | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases |
| TWI387592B (zh) | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
| JP2009530261A (ja) | 2006-03-16 | 2009-08-27 | ファイザー・プロダクツ・インク | ピラゾール化合物 |
| JP2009532497A (ja) | 2006-04-05 | 2009-09-10 | ノバルティス アクチエンゲゼルシャフト | 癌を処置するための治療剤の組合せ |
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| CA2663366C (en) | 2006-10-02 | 2012-02-07 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2007308045A1 (en) | 2006-10-06 | 2008-04-17 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
| WO2008100985A2 (en) | 2007-02-15 | 2008-08-21 | Novartis Ag | Combination of lbh589 with other therapeutic agents for treating cancer |
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| EA201000113A1 (ru) | 2007-08-01 | 2010-08-30 | Пфайзер Инк. | Пиразольные соединения |
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| AU2008323287B2 (en) | 2007-11-14 | 2011-07-14 | Addex Pharma S.A. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| US8129394B2 (en) | 2008-03-21 | 2012-03-06 | Novartis Ag | Heteroaryl-substituted imidazole compounds and uses thereof |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| BRPI0916356B1 (pt) | 2008-07-24 | 2022-08-23 | Nerviano Medical Sciences S.R.L | 3,4-diaril pirazois como inibidores da proteína quinase |
| MX2011001090A (es) | 2008-07-28 | 2011-03-15 | Gilead Sciences Inc | Compuestos de inhibidor de desacetilasa de histona de cicloalquilideno y heterocicloalquilideno. |
| US8778929B2 (en) | 2008-09-29 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Substituted heteroaryl inhibitors of B-RAF |
| MY160340A (en) | 2008-10-07 | 2017-02-28 | Astrazeneca Uk Ltd | Pharmaceutical formulation 514 |
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| AR075180A1 (es) | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| RU2402602C1 (ru) | 2009-02-12 | 2010-10-27 | Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН | КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Rac, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН |
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| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| EA023942B1 (ru) | 2010-01-27 | 2016-07-29 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Сульфонамидные производные 3,4-диарилпиразолов в качестве ингибиторов протеинкиназы |
| RU2639876C2 (ru) | 2010-03-30 | 2017-12-25 | Версеон Корпорейшн | Мультизамещенные ароматические соединения в качестве ингибиторов тромбина |
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| EP2688572B1 (en) | 2011-03-21 | 2017-05-03 | Valcuria AB | A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof. |
| CA2844407A1 (en) | 2011-06-14 | 2012-12-20 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
| KR102091295B1 (ko) | 2011-11-23 | 2020-03-19 | 어레이 바이오파마 인크. | 제약 제제 |
| CA2890663A1 (en) | 2012-11-08 | 2014-05-15 | Novartis Ag | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
-
2012
- 2012-11-09 BR BR112014011223A patent/BR112014011223A8/pt not_active Application Discontinuation
- 2012-11-09 AU AU2012335663A patent/AU2012335663B2/en active Active
- 2012-11-09 WO PCT/US2012/064269 patent/WO2013070996A1/en not_active Ceased
- 2012-11-09 CA CA2855243A patent/CA2855243C/en active Active
- 2012-11-09 US US14/355,903 patent/US11007194B2/en active Active
- 2012-11-09 RU RU2014117707A patent/RU2622015C2/ru active
- 2012-11-09 JP JP2014541283A patent/JP6150813B2/ja active Active
- 2012-11-09 MX MX2014005726A patent/MX354725B/es active IP Right Grant
- 2012-11-09 CN CN201280054663.0A patent/CN103917236A/zh active Pending
- 2012-11-09 CN CN201810135736.8A patent/CN108542906A/zh active Pending
- 2012-11-09 EP EP12795175.4A patent/EP2776037B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012335663A1 (en) | 2014-05-29 |
| US20140275136A1 (en) | 2014-09-18 |
| JP2014533272A (ja) | 2014-12-11 |
| CA2855243A1 (en) | 2013-05-16 |
| CN103917236A (zh) | 2014-07-09 |
| US11007194B2 (en) | 2021-05-18 |
| CN108542906A (zh) | 2018-09-18 |
| RU2014117707A (ru) | 2015-12-20 |
| RU2622015C2 (ru) | 2017-06-08 |
| JP6150813B2 (ja) | 2017-06-21 |
| WO2013070996A1 (en) | 2013-05-16 |
| EP2776037B1 (en) | 2019-01-09 |
| EP2776037A1 (en) | 2014-09-17 |
| AU2012335663B2 (en) | 2015-12-24 |
| CA2855243C (en) | 2020-04-14 |
| HK1198920A1 (en) | 2015-06-19 |
| BR112014011223A2 (pt) | 2017-05-09 |
| MX2014005726A (es) | 2014-05-28 |
| BR112014011223A8 (pt) | 2023-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |