MX354725B - Metodo de tratamiento de una enfermedad proliferativa. - Google Patents
Metodo de tratamiento de una enfermedad proliferativa.Info
- Publication number
- MX354725B MX354725B MX2014005726A MX2014005726A MX354725B MX 354725 B MX354725 B MX 354725B MX 2014005726 A MX2014005726 A MX 2014005726A MX 2014005726 A MX2014005726 A MX 2014005726A MX 354725 B MX354725 B MX 354725B
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- proliferative disease
- serine
- kinase inhibitor
- threonine kinase
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 229940121742 Serine/threonine kinase inhibitor Drugs 0.000 abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558619P | 2011-11-11 | 2011-11-11 | |
| PCT/US2012/064269 WO2013070996A1 (en) | 2011-11-11 | 2012-11-09 | Method of treating a proliferative disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014005726A MX2014005726A (es) | 2014-05-28 |
| MX354725B true MX354725B (es) | 2018-03-16 |
Family
ID=47279036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014005726A MX354725B (es) | 2011-11-11 | 2012-11-09 | Metodo de tratamiento de una enfermedad proliferativa. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11007194B2 (enExample) |
| EP (1) | EP2776037B1 (enExample) |
| JP (1) | JP6150813B2 (enExample) |
| CN (2) | CN108542906A (enExample) |
| AU (1) | AU2012335663B2 (enExample) |
| BR (1) | BR112014011223A8 (enExample) |
| CA (1) | CA2855243C (enExample) |
| MX (1) | MX354725B (enExample) |
| RU (1) | RU2622015C2 (enExample) |
| WO (1) | WO2013070996A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| JP6342396B2 (ja) * | 2012-08-07 | 2018-06-13 | ノバルティス アーゲー | B−Raf阻害薬、EGFR阻害薬及び場合によってはPI3K−α阻害薬を含む組合せ医薬 |
| BR112018074941A2 (pt) * | 2016-06-03 | 2019-03-12 | Caponigro Giordano | combinações farmacêuticas |
| US11590133B2 (en) * | 2016-12-11 | 2023-02-28 | Memorial Sloan Kettering Cancer Center | Methods and compositions for treatment of BRAF mutant cancers |
| CN110256408B (zh) * | 2018-07-12 | 2022-03-22 | 深圳市塔吉瑞生物医药有限公司 | 一种二芳基吡唑化合物及包含该化合物的组合物及其用途 |
| TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
| CA3163703A1 (en) * | 2020-01-07 | 2021-07-15 | Steve Kelsey | Shp2 inhibitor dosing and methods of treating cancer |
| AU2021289163B2 (en) | 2020-06-09 | 2024-05-02 | Array Biopharma Inc. | 4-oxo-3,4-dihydroquinazolinon compounds for the treatment of BRAF-associated diseases and disorders |
| CA3257280A1 (en) | 2022-05-25 | 2023-11-30 | Msd International Gmbh | COMBINATION OF A BRAF INHIBITOR, AN EGFR INHIBITOR AND A PD-1 ANTAGONIST FOR THE TREATMENT OF COLORECTAL CANCER MSI-H/DMMR, WITH BRAF V600E MUTATION |
| AU2024204522B1 (en) | 2023-03-09 | 2024-08-22 | Minneamrita Therapeutics Llc | Drug combination for treatment of gastric cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| US20080085902A1 (en) | 2003-09-23 | 2008-04-10 | Guido Bold | Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent |
| DK1692113T3 (en) | 2003-11-14 | 2018-01-08 | Lorus Therapeutics Inc | ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES |
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| US20070099856A1 (en) * | 2005-05-13 | 2007-05-03 | Gumerlock Paul H | Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen |
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| EP1919460A2 (en) | 2005-08-22 | 2008-05-14 | Novartis AG | Pharmaceutical compositions comprising a ph-dependent drug, a ph modifier and a retarding agent |
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| MX2009003456A (es) | 2006-10-02 | 2009-04-14 | Irm Llc | Compuestos y composiciones como inhibidores de proteina cinasa. |
| CN101522026A (zh) | 2006-10-06 | 2009-09-02 | Irm责任有限公司 | 蛋白激酶抑制剂及其应用方法 |
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| KR20100038119A (ko) | 2007-08-01 | 2010-04-12 | 화이자 인코포레이티드 | 피라졸 화합물 및 raf 억제제로서 이의 용도 |
| UA100865C2 (ru) | 2007-10-19 | 2013-02-11 | Эбботт Гмбх Унд Ко. Кг | Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины |
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| PL2324008T3 (pl) | 2008-07-24 | 2012-09-28 | Nerviano Medical Sciences Srl | 3,4-diarylopirazole jako inhibitory kinazy białkowej |
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| BR122021018683B1 (pt) | 2008-10-07 | 2022-11-16 | Kudos Pharmaceuticals Limited | Formulação farmacêutica de 4-[3-(4-ciclopropanocarbonil- piperazina-1-carbonil)-4-flúor- benzil]-2h-ftalazin-1-ona, uso de um polímero de matriz, forma de dosagem e método para produzir uma dispersão amorfa sólida |
| WO2010056662A1 (en) | 2008-11-11 | 2010-05-20 | University Of Washington | Activated wnt-beta-catenin signaling in melanoma |
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| KR101256018B1 (ko) | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물 |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| CN104958294A (zh) | 2010-01-27 | 2015-10-07 | 内尔维安诺医学科学有限公司 | 作为蛋白激酶抑制剂的3,4-二芳基吡唑的亚磺酰氨基衍生物 |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| JP5938038B2 (ja) | 2010-08-03 | 2016-06-22 | ネルヴィアーノ・メディカル・サイエンシズ・ソチエタ・ア・レスポンサビリタ・リミタータ | ピラゾロフェニル−ベンゼンスルホンアミド化合物の誘導体及びその抗腫瘍薬としての使用 |
| DK2688572T3 (en) | 2011-03-21 | 2017-06-12 | Valcuria Ab | PHARMACEUTICAL COMPOSITION WITH AN HDAC INHIBITOR AND A STEROID AND USE THEREOF |
| CA2844407A1 (en) | 2011-06-14 | 2012-12-20 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
| WO2013078264A1 (en) | 2011-11-23 | 2013-05-30 | Novartis Ag | Pharmaceutical formulations |
| RU2015121367A (ru) | 2012-11-08 | 2017-01-10 | Новартис Аг | Фармацевтическая комбинация, содержащая ингибитор b-raf и ингибитор деацетилазы гистонов, и ее применение при лечении пролиферативных заболеваний |
-
2012
- 2012-11-09 US US14/355,903 patent/US11007194B2/en active Active
- 2012-11-09 CA CA2855243A patent/CA2855243C/en active Active
- 2012-11-09 JP JP2014541283A patent/JP6150813B2/ja not_active Expired - Fee Related
- 2012-11-09 AU AU2012335663A patent/AU2012335663B2/en active Active
- 2012-11-09 CN CN201810135736.8A patent/CN108542906A/zh active Pending
- 2012-11-09 BR BR112014011223A patent/BR112014011223A8/pt not_active IP Right Cessation
- 2012-11-09 RU RU2014117707A patent/RU2622015C2/ru active
- 2012-11-09 EP EP12795175.4A patent/EP2776037B1/en active Active
- 2012-11-09 WO PCT/US2012/064269 patent/WO2013070996A1/en not_active Ceased
- 2012-11-09 MX MX2014005726A patent/MX354725B/es active IP Right Grant
- 2012-11-09 CN CN201280054663.0A patent/CN103917236A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN108542906A (zh) | 2018-09-18 |
| US11007194B2 (en) | 2021-05-18 |
| RU2014117707A (ru) | 2015-12-20 |
| AU2012335663B2 (en) | 2015-12-24 |
| BR112014011223A2 (pt) | 2017-05-09 |
| CA2855243A1 (en) | 2013-05-16 |
| EP2776037B1 (en) | 2019-01-09 |
| MX2014005726A (es) | 2014-05-28 |
| CA2855243C (en) | 2020-04-14 |
| HK1198920A1 (en) | 2015-06-19 |
| BR112014011223A8 (pt) | 2023-01-31 |
| RU2622015C2 (ru) | 2017-06-08 |
| CN103917236A (zh) | 2014-07-09 |
| EP2776037A1 (en) | 2014-09-17 |
| JP6150813B2 (ja) | 2017-06-21 |
| AU2012335663A1 (en) | 2014-05-29 |
| US20140275136A1 (en) | 2014-09-18 |
| WO2013070996A1 (en) | 2013-05-16 |
| JP2014533272A (ja) | 2014-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |