JP6150813B2 - 増殖性疾患の治療方法 - Google Patents

増殖性疾患の治療方法 Download PDF

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JP6150813B2
JP6150813B2 JP2014541283A JP2014541283A JP6150813B2 JP 6150813 B2 JP6150813 B2 JP 6150813B2 JP 2014541283 A JP2014541283 A JP 2014541283A JP 2014541283 A JP2014541283 A JP 2014541283A JP 6150813 B2 JP6150813 B2 JP 6150813B2
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braf
treatment
inhibitor
mutation
formula
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JP2014533272A5 (enExample
JP2014533272A (ja
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スチュアート，ダリン
ダス サカー，メグナ
ダス サカー，メグナ
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ノバルティス アーゲー
ノバルティス アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014541283A 2011-11-11 2012-11-09 増殖性疾患の治療方法 Expired - Fee Related JP6150813B2 (ja)

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US201161558619P 2011-11-11 2011-11-11
US61/558,619 2011-11-11
PCT/US2012/064269 WO2013070996A1 (en) 2011-11-11 2012-11-09 Method of treating a proliferative disease

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JP2014533272A JP2014533272A (ja) 2014-12-11
JP2014533272A5 JP2014533272A5 (enExample) 2015-12-24
JP6150813B2 true JP6150813B2 (ja) 2017-06-21

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JP2014541283A Expired - Fee Related JP6150813B2 (ja) 2011-11-11 2012-11-09 増殖性疾患の治療方法

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US (1) US11007194B2 (enExample)
EP (1) EP2776037B1 (enExample)
JP (1) JP6150813B2 (enExample)
CN (2) CN108542906A (enExample)
AU (1) AU2012335663B2 (enExample)
BR (1) BR112014011223A8 (enExample)
CA (1) CA2855243C (enExample)
MX (1) MX354725B (enExample)
RU (1) RU2622015C2 (enExample)
WO (1) WO2013070996A1 (enExample)

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US11590133B2 (en) * 2016-12-11 2023-02-28 Memorial Sloan Kettering Cancer Center Methods and compositions for treatment of BRAF mutant cancers
CN110256408B (zh) * 2018-07-12 2022-03-22 深圳市塔吉瑞生物医药有限公司 一种二芳基吡唑化合物及包含该化合物的组合物及其用途
TWI817018B (zh) 2019-06-28 2023-10-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和失調症之化合物
CA3163703A1 (en) * 2020-01-07 2021-07-15 Steve Kelsey Shp2 inhibitor dosing and methods of treating cancer
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Publication number Publication date
CN108542906A (zh) 2018-09-18
US11007194B2 (en) 2021-05-18
MX354725B (es) 2018-03-16
RU2014117707A (ru) 2015-12-20
AU2012335663B2 (en) 2015-12-24
BR112014011223A2 (pt) 2017-05-09
CA2855243A1 (en) 2013-05-16
EP2776037B1 (en) 2019-01-09
MX2014005726A (es) 2014-05-28
CA2855243C (en) 2020-04-14
HK1198920A1 (en) 2015-06-19
BR112014011223A8 (pt) 2023-01-31
RU2622015C2 (ru) 2017-06-08
CN103917236A (zh) 2014-07-09
EP2776037A1 (en) 2014-09-17
AU2012335663A1 (en) 2014-05-29
US20140275136A1 (en) 2014-09-18
WO2013070996A1 (en) 2013-05-16
JP2014533272A (ja) 2014-12-11

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