JP2016523907A5 - - Google Patents
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- Publication number
- JP2016523907A5 JP2016523907A5 JP2016523869A JP2016523869A JP2016523907A5 JP 2016523907 A5 JP2016523907 A5 JP 2016523907A5 JP 2016523869 A JP2016523869 A JP 2016523869A JP 2016523869 A JP2016523869 A JP 2016523869A JP 2016523907 A5 JP2016523907 A5 JP 2016523907A5
- Authority
- JP
- Japan
- Prior art keywords
- dioxo
- carbazole
- carboxamide
- fluoro
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- -1 2-hydroxypropan-2-yl Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- ZRYMMWAJAFUANM-INIZCTEOSA-N (7s)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5h-carbazole-1-carboxamide Chemical compound C1[C@@H](C(C)(C)O)CCC2=C1NC1=C2C(C2=C(C(=CC=C2)N2C(C3=CC=CC(F)=C3N(C)C2=O)=O)C)=C(F)C=C1C(N)=O ZRYMMWAJAFUANM-INIZCTEOSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WQLRVJLVBJTPDC-INIZCTEOSA-N CC(C)([C@@H](CC1)Cc2c1c1c(-c3cccc(N(C(C=C4N5C=CC=C4Cl)=O)C5=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O Chemical compound CC(C)([C@@H](CC1)Cc2c1c1c(-c3cccc(N(C(C=C4N5C=CC=C4Cl)=O)C5=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O WQLRVJLVBJTPDC-INIZCTEOSA-N 0.000 description 2
- UGOUGTGKDWPLNV-UCFFOFKASA-N CC(C)([C@@H](CC1)Cc2c1c(C(c1cccc(N(C(C=C3N4C=CC=C3F)=O)C4=O)c1C)=C(CC1C(N)=O)F)c1[nH]2)O Chemical compound CC(C)([C@@H](CC1)Cc2c1c(C(c1cccc(N(C(C=C3N4C=CC=C3F)=O)C4=O)c1C)=C(CC1C(N)=O)F)c1[nH]2)O UGOUGTGKDWPLNV-UCFFOFKASA-N 0.000 description 1
- OILCFDXBRQHLMC-INIZCTEOSA-N CC(C)([C@@H](CC1)Cc2c1c1c(-c3cccc(N(C(C=C4N5C=CC=C4F)=O)C5=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O Chemical compound CC(C)([C@@H](CC1)Cc2c1c1c(-c3cccc(N(C(C=C4N5C=CC=C4F)=O)C5=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O OILCFDXBRQHLMC-INIZCTEOSA-N 0.000 description 1
- FPEKPVWYNZREQW-OAHLLOKOSA-N CC(C)([C@H](CC1)Cc2c1c1c(-c3cccc(N(C(c4cccc(F)c4N4)=O)C4=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O Chemical compound CC(C)([C@H](CC1)Cc2c1c1c(-c3cccc(N(C(c4cccc(F)c4N4)=O)C4=O)c3C)c(F)cc(C(N)=O)c1[nH]2)O FPEKPVWYNZREQW-OAHLLOKOSA-N 0.000 description 1
- CJKYBOFIPNUNMH-NRFANRHFSA-N CC(C)(c(cc1)cc2c1c(C(c1cccc(N(C(C=C3N4C=CC=C3Cl)=O)C4=O)c1C)=C(C)C[C@@H]1C(N)=O)c1[nH]2)O Chemical compound CC(C)(c(cc1)cc2c1c(C(c1cccc(N(C(C=C3N4C=CC=C3Cl)=O)C4=O)c1C)=C(C)C[C@@H]1C(N)=O)c1[nH]2)O CJKYBOFIPNUNMH-NRFANRHFSA-N 0.000 description 1
- RPQWRQVJFPCCAW-NRFANRHFSA-N CC(C)(c1ccc2c(C(c3cccc(N(C(c4cccc(F)c4N4)=O)C4=O)c3C)=C(C)C[C@@H]3C(N)=O)c3[nH]c2c1)O Chemical compound CC(C)(c1ccc2c(C(c3cccc(N(C(c4cccc(F)c4N4)=O)C4=O)c3C)=C(C)C[C@@H]3C(N)=O)c3[nH]c2c1)O RPQWRQVJFPCCAW-NRFANRHFSA-N 0.000 description 1
- CJSGAKAHWDXMND-IBGZPJMESA-N Cc(c(C(c1c([C@H](C2)C(N)=O)[nH]c3cc(CCO)ccc13)=C2F)ccc1)c1N(C(C=C1N2C=CC=C1F)=O)C2=O Chemical compound Cc(c(C(c1c([C@H](C2)C(N)=O)[nH]c3cc(CCO)ccc13)=C2F)ccc1)c1N(C(C=C1N2C=CC=C1F)=O)C2=O CJSGAKAHWDXMND-IBGZPJMESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361839141P | 2013-06-25 | 2013-06-25 | |
| US61/839,141 | 2013-06-25 | ||
| PCT/US2014/043978 WO2014210085A1 (en) | 2013-06-25 | 2014-06-25 | Substituted tetrahydrocarbazole and carbazole carboxamide compounds useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523907A JP2016523907A (ja) | 2016-08-12 |
| JP2016523907A5 true JP2016523907A5 (enExample) | 2017-07-06 |
| JP6353529B2 JP6353529B2 (ja) | 2018-07-04 |
Family
ID=51210830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016523869A Expired - Fee Related JP6353529B2 (ja) | 2013-06-25 | 2014-06-25 | 置換されたテトラヒドロカルバゾールおよびカルバゾールカルボキサミド化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US9334290B2 (enExample) |
| EP (1) | EP3013814B1 (enExample) |
| JP (1) | JP6353529B2 (enExample) |
| KR (1) | KR102346508B1 (enExample) |
| CN (1) | CN105358546B (enExample) |
| AR (1) | AR096721A1 (enExample) |
| AU (1) | AU2014302548B2 (enExample) |
| BR (1) | BR112015030723A8 (enExample) |
| CA (1) | CA2916500A1 (enExample) |
| CL (1) | CL2015003635A1 (enExample) |
| CY (1) | CY1119371T1 (enExample) |
| DK (1) | DK3013814T3 (enExample) |
| EA (1) | EA026729B1 (enExample) |
| ES (1) | ES2636652T3 (enExample) |
| HR (1) | HRP20171031T1 (enExample) |
| HU (1) | HUE034460T2 (enExample) |
| IL (1) | IL243296B (enExample) |
| LT (1) | LT3013814T (enExample) |
| MA (1) | MA38648B1 (enExample) |
| MY (1) | MY176631A (enExample) |
| PE (1) | PE20160519A1 (enExample) |
| PH (1) | PH12015502630A1 (enExample) |
| PL (1) | PL3013814T3 (enExample) |
| PT (1) | PT3013814T (enExample) |
| RS (1) | RS56371B1 (enExample) |
| SI (1) | SI3013814T1 (enExample) |
| SM (1) | SMT201700422T1 (enExample) |
| TN (1) | TN2015000529A1 (enExample) |
| TW (1) | TWI648272B (enExample) |
| UY (1) | UY35625A (enExample) |
| WO (1) | WO2014210085A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014302550A1 (en) | 2013-06-25 | 2016-02-11 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
| LT3209651T (lt) * | 2014-10-24 | 2020-01-10 | Bristol-Myers Squibb Company | Karbazolo dariniai |
| AU2015335783B2 (en) | 2014-10-24 | 2019-10-03 | Bristol-Myers Squibb Company | Tricyclic atropisomer compounds |
| LT3461821T (lt) | 2014-10-24 | 2020-08-10 | Bristol-Myers Squibb Company | Indolo karboksamido junginiai, naudotini kaip kinazės inhibitoriai |
| AU2017290142A1 (en) | 2016-07-01 | 2019-01-17 | Brio Device Llc | Intubation stylet with video feed |
| CN108101905A (zh) * | 2016-11-24 | 2018-06-01 | 中国科学院上海药物研究所 | 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途 |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| WO2018118830A1 (en) | 2016-12-20 | 2018-06-28 | Bristol-Myers Squibb Company | Process for preparing tetrahydrocarbazole carboxamide compound |
| JP7331843B2 (ja) | 2018-04-27 | 2023-08-23 | 小野薬品工業株式会社 | Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤 |
| CN117281803A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2022212893A1 (en) | 2021-04-02 | 2022-10-06 | Biogen Ma Inc. | Combination treatment methods of multiple sclerosis |
| KR20240148839A (ko) * | 2022-02-15 | 2024-10-11 | 에프. 호프만-라 로슈 아게 | 1,2,3,5,6,7-헥사히드로-s-인다센 유도체 제조를 위한 공정 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
| CA2140722A1 (en) | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| US7405295B2 (en) | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005047290A2 (en) | 2003-11-11 | 2005-05-26 | Cellular Genomics Inc. | Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors |
| WO2006044687A2 (en) | 2004-10-15 | 2006-04-27 | Takeda San Diego, Inc. | Kinase inhibitors |
| SG159549A1 (en) | 2004-11-10 | 2010-03-30 | Cgi Pharmaceuticals Inc | Imidazo[1,2-a] pyrazin-8-ylamines useful as modulators of kinase activity |
| PL1831227T3 (pl) | 2004-12-17 | 2013-10-31 | Glenmark Pharmaceuticals Sa | Nowe związki heterocykliczne użyteczne w leczeniu stanów zapalnych i dolegliwości alergicznych |
| AU2006223409B2 (en) | 2005-03-10 | 2011-07-21 | Gilead Connecticut, Inc. | Certain substituted amides, method of making, and method of use thereof |
| US20070185184A1 (en) | 2005-09-16 | 2007-08-09 | Serenex, Inc. | Carbazole derivatives |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| ES2390135T3 (es) | 2005-11-22 | 2012-11-06 | Merck Sharp & Dohme Corp. | Compuestos tricíclicos útiles como inhibidores de quinasas |
| JP2010502751A (ja) | 2006-09-11 | 2010-01-28 | シージーアイ ファーマシューティカルズ，インコーポレイティド | キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 |
| CA2663178C (en) | 2006-09-11 | 2016-01-12 | Matrix Laboratories Ltd. | Dibenzofuran derivatives as inhibitors of pde-4 and pde-10 |
| US20090062251A1 (en) | 2007-08-17 | 2009-03-05 | Astrazeneca Ab | Novel Compounds 002 |
| US8431569B2 (en) | 2007-12-13 | 2013-04-30 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| US20110046378A1 (en) | 2008-02-14 | 2011-02-24 | Siemens Medical Solutions Usa, Inc. | Novel Imaging Agents for Detecting Neurological Dysfunction |
| GB0809360D0 (en) | 2008-05-22 | 2008-07-02 | Isis Innovation | Calcium modulation |
| EP2151441A1 (en) | 2008-08-06 | 2010-02-10 | Julius-Maximilians-Universität Würzburg | Beta-carbolin-derivates as substrates for an enzyme |
| PE20110819A1 (es) * | 2008-12-19 | 2011-11-02 | Bristol Myers Squibb Co | Compuestos de carbazol carboxamida utiles como inhibidores de cinasa |
| CN101475571B (zh) | 2009-01-21 | 2011-06-22 | 中国药科大学 | β-咔啉类细胞周期蛋白依赖性激酶2抑制剂及其用途 |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| EP2552914B1 (de) | 2010-03-26 | 2015-11-11 | Merck Patent GmbH | Benzonaphthyridinamine als autotaxin-inhibitoren |
| US8685969B2 (en) * | 2010-06-16 | 2014-04-01 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
| EP2455378A1 (en) | 2010-11-03 | 2012-05-23 | Philip Morris Products S.A. | Carbazole and carboline derivatives, and preparation and therapeutic applications thereof |
| AU2011330850B2 (en) | 2010-11-15 | 2016-01-28 | Viiv Healthcare Uk Limited | Inhibitors of HIV replication |
| WO2012156334A1 (en) | 2011-05-17 | 2012-11-22 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| WO2013054185A1 (en) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
-
2014
- 2014-06-24 AR ARP140102388A patent/AR096721A1/es unknown
- 2014-06-24 TW TW103121681A patent/TWI648272B/zh not_active IP Right Cessation
- 2014-06-24 UY UY0001035625A patent/UY35625A/es unknown
- 2014-06-25 WO PCT/US2014/043978 patent/WO2014210085A1/en not_active Ceased
- 2014-06-25 CA CA2916500A patent/CA2916500A1/en not_active Abandoned
- 2014-06-25 SI SI201430268T patent/SI3013814T1/sl unknown
- 2014-06-25 RS RS20170904A patent/RS56371B1/sr unknown
- 2014-06-25 US US14/314,602 patent/US9334290B2/en active Active
- 2014-06-25 PL PL14740094T patent/PL3013814T3/pl unknown
- 2014-06-25 PE PE2015002665A patent/PE20160519A1/es active IP Right Grant
- 2014-06-25 BR BR112015030723A patent/BR112015030723A8/pt not_active Application Discontinuation
- 2014-06-25 MA MA38648A patent/MA38648B1/fr unknown
- 2014-06-25 EA EA201592287A patent/EA026729B1/ru not_active IP Right Cessation
- 2014-06-25 CN CN201480035611.8A patent/CN105358546B/zh not_active Expired - Fee Related
- 2014-06-25 SM SM20170422T patent/SMT201700422T1/it unknown
- 2014-06-25 AU AU2014302548A patent/AU2014302548B2/en not_active Ceased
- 2014-06-25 TN TN2015000529A patent/TN2015000529A1/en unknown
- 2014-06-25 ES ES14740094.9T patent/ES2636652T3/es active Active
- 2014-06-25 JP JP2016523869A patent/JP6353529B2/ja not_active Expired - Fee Related
- 2014-06-25 KR KR1020167001632A patent/KR102346508B1/ko not_active Expired - Fee Related
- 2014-06-25 LT LTEP14740094.9T patent/LT3013814T/lt unknown
- 2014-06-25 HR HRP20171031TT patent/HRP20171031T1/hr unknown
- 2014-06-25 EP EP14740094.9A patent/EP3013814B1/en active Active
- 2014-06-25 PT PT147400949T patent/PT3013814T/pt unknown
- 2014-06-25 DK DK14740094.9T patent/DK3013814T3/en active
- 2014-06-25 MY MYPI2015704738A patent/MY176631A/en unknown
- 2014-06-25 HU HUE14740094A patent/HUE034460T2/en unknown
-
2015
- 2015-11-26 PH PH12015502630A patent/PH12015502630A1/en unknown
- 2015-12-15 CL CL2015003635A patent/CL2015003635A1/es unknown
- 2015-12-22 IL IL243296A patent/IL243296B/en active IP Right Grant
-
2016
- 2016-03-11 US US15/067,915 patent/US20160194338A1/en not_active Abandoned
-
2017
- 2017-06-16 US US15/625,417 patent/US9850258B2/en active Active
- 2017-09-06 CY CY20171100943T patent/CY1119371T1/el unknown
- 2017-11-10 US US15/809,437 patent/US10106559B2/en active Active
-
2018
- 2018-09-25 US US16/140,750 patent/US10435415B2/en active Active
-
2019
- 2019-08-22 US US16/547,675 patent/US20190382416A1/en not_active Abandoned
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