UY35625A - Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa - Google Patents

Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa

Info

Publication number
UY35625A
UY35625A UY0001035625A UY35625A UY35625A UY 35625 A UY35625 A UY 35625A UY 0001035625 A UY0001035625 A UY 0001035625A UY 35625 A UY35625 A UY 35625A UY 35625 A UY35625 A UY 35625A
Authority
UY
Uruguay
Prior art keywords
compounds
carboxamida
tetrahydrocarbazol
carbazol
compounds replaced
Prior art date
Application number
UY0001035625A
Other languages
English (en)
Spanish (es)
Inventor
Joseph A Tino
Anurag S Srivastava
Soo Sung Ko
Michael A Galella
Charles M Langevine
Delucca George
Liu Qingjie
Douglas A Batt
Scott Hunter Watterson
Shi Qing
Myra Beaudoin Bertrand
Original Assignee
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Company Una Corporación Del Estado De Delaware filed Critical Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Publication of UY35625A publication Critical patent/UY35625A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
UY0001035625A 2013-06-25 2014-06-24 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa UY35625A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361839141P 2013-06-25 2013-06-25

Publications (1)

Publication Number Publication Date
UY35625A true UY35625A (es) 2014-12-31

Family

ID=51210830

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035625A UY35625A (es) 2013-06-25 2014-06-24 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa

Country Status (31)

Country Link
US (6) US9334290B2 (enExample)
EP (1) EP3013814B1 (enExample)
JP (1) JP6353529B2 (enExample)
KR (1) KR102346508B1 (enExample)
CN (1) CN105358546B (enExample)
AR (1) AR096721A1 (enExample)
AU (1) AU2014302548B2 (enExample)
BR (1) BR112015030723A8 (enExample)
CA (1) CA2916500A1 (enExample)
CL (1) CL2015003635A1 (enExample)
CY (1) CY1119371T1 (enExample)
DK (1) DK3013814T3 (enExample)
EA (1) EA026729B1 (enExample)
ES (1) ES2636652T3 (enExample)
HR (1) HRP20171031T1 (enExample)
HU (1) HUE034460T2 (enExample)
IL (1) IL243296B (enExample)
LT (1) LT3013814T (enExample)
MA (1) MA38648B1 (enExample)
MY (1) MY176631A (enExample)
PE (1) PE20160519A1 (enExample)
PH (1) PH12015502630A1 (enExample)
PL (1) PL3013814T3 (enExample)
PT (1) PT3013814T (enExample)
RS (1) RS56371B1 (enExample)
SI (1) SI3013814T1 (enExample)
SM (1) SMT201700422T1 (enExample)
TN (1) TN2015000529A1 (enExample)
TW (1) TWI648272B (enExample)
UY (1) UY35625A (enExample)
WO (1) WO2014210085A1 (enExample)

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LT3209651T (lt) * 2014-10-24 2020-01-10 Bristol-Myers Squibb Company Karbazolo dariniai
AU2015335783B2 (en) 2014-10-24 2019-10-03 Bristol-Myers Squibb Company Tricyclic atropisomer compounds
LT3461821T (lt) 2014-10-24 2020-08-10 Bristol-Myers Squibb Company Indolo karboksamido junginiai, naudotini kaip kinazės inhibitoriai
AU2017290142A1 (en) 2016-07-01 2019-01-17 Brio Device Llc Intubation stylet with video feed
CN108101905A (zh) * 2016-11-24 2018-06-01 中国科学院上海药物研究所 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
US11590167B2 (en) 2016-12-03 2023-02-28 Juno Therapeutic, Inc. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
WO2018118830A1 (en) 2016-12-20 2018-06-28 Bristol-Myers Squibb Company Process for preparing tetrahydrocarbazole carboxamide compound
JP7331843B2 (ja) 2018-04-27 2023-08-23 小野薬品工業株式会社 Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤
CN117281803A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
KR20240148839A (ko) * 2022-02-15 2024-10-11 에프. 호프만-라 로슈 아게 1,2,3,5,6,7-헥사히드로-s-인다센 유도체 제조를 위한 공정

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Also Published As

Publication number Publication date
LT3013814T (lt) 2017-08-10
WO2014210085A1 (en) 2014-12-31
US10435415B2 (en) 2019-10-08
SMT201700422T1 (it) 2017-11-15
ES2636652T3 (es) 2017-10-06
EA201592287A1 (ru) 2016-06-30
EP3013814B1 (en) 2017-06-14
US20190382416A1 (en) 2019-12-19
MY176631A (en) 2020-08-19
US20140378475A1 (en) 2014-12-25
HK1223359A1 (en) 2017-07-28
BR112015030723A2 (pt) 2017-07-25
BR112015030723A8 (pt) 2020-01-07
TN2015000529A1 (en) 2017-04-06
PE20160519A1 (es) 2016-05-21
CY1119371T1 (el) 2018-02-14
US9334290B2 (en) 2016-05-10
US20160194338A1 (en) 2016-07-07
US9850258B2 (en) 2017-12-26
MA38648B1 (fr) 2018-06-29
IL243296B (en) 2018-05-31
KR20160022889A (ko) 2016-03-02
MA38648A1 (fr) 2017-09-29
KR102346508B1 (ko) 2022-01-03
HRP20171031T1 (hr) 2017-10-06
RS56371B1 (sr) 2017-12-29
US10106559B2 (en) 2018-10-23
PL3013814T3 (pl) 2017-11-30
CN105358546A (zh) 2016-02-24
AU2014302548A1 (en) 2016-02-11
PH12015502630A1 (en) 2016-03-07
AU2014302548B2 (en) 2018-05-10
WO2014210085A9 (en) 2015-12-23
DK3013814T3 (en) 2017-09-25
CN105358546B (zh) 2017-10-31
JP2016523907A (ja) 2016-08-12
TWI648272B (zh) 2019-01-21
HUE034460T2 (en) 2018-02-28
EP3013814A1 (en) 2016-05-04
SI3013814T1 (sl) 2017-08-31
JP6353529B2 (ja) 2018-07-04
EA026729B1 (ru) 2017-05-31
US20170283438A1 (en) 2017-10-05
US20180079758A1 (en) 2018-03-22
CA2916500A1 (en) 2014-12-31
TW201536774A (zh) 2015-10-01
AR096721A1 (es) 2016-01-27
US20190023719A1 (en) 2019-01-24
CL2015003635A1 (es) 2016-07-29
PT3013814T (pt) 2017-08-10

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