JP2015512398A5 - - Google Patents
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- Publication number
- JP2015512398A5 JP2015512398A5 JP2015503286A JP2015503286A JP2015512398A5 JP 2015512398 A5 JP2015512398 A5 JP 2015512398A5 JP 2015503286 A JP2015503286 A JP 2015503286A JP 2015503286 A JP2015503286 A JP 2015503286A JP 2015512398 A5 JP2015512398 A5 JP 2015512398A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- composition according
- quinolin
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- IAJOMYABKVAZCN-AATRIKPKSA-N (e)-1-pyridin-4-yl-3-[7-(trifluoromethyl)quinolin-2-yl]prop-2-en-1-one Chemical compound N=1C2=CC(C(F)(F)F)=CC=C2C=CC=1\C=C\C(=O)C1=CC=NC=C1 IAJOMYABKVAZCN-AATRIKPKSA-N 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 210000004392 genitalia Anatomy 0.000 claims 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
- 229960002411 imatinib Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 102100022629 Fructose-2,6-bisphosphatase Human genes 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 101000823463 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000016624 Retinal neoplasm Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 201000010918 connective tissue cancer Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 1
- 235000008191 folinic acid Nutrition 0.000 claims 1
- 239000011672 folinic acid Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000002414 glycolytic effect Effects 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229960001691 leucovorin Drugs 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000008933 retinal cancer Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617073P | 2012-03-29 | 2012-03-29 | |
| US61/617,073 | 2012-03-29 | ||
| PCT/US2013/031159 WO2013148228A1 (en) | 2012-03-29 | 2013-03-14 | Pfkfb3 inhibitor and methods of use as an anti-cancer therapeutic |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512398A JP2015512398A (ja) | 2015-04-27 |
| JP2015512398A5 true JP2015512398A5 (enExample) | 2016-03-10 |
| JP6075903B2 JP6075903B2 (ja) | 2017-02-08 |
Family
ID=49261041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503286A Expired - Fee Related JP6075903B2 (ja) | 2012-03-29 | 2013-03-14 | Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9649305B2 (enExample) |
| EP (1) | EP2831047B1 (enExample) |
| JP (1) | JP6075903B2 (enExample) |
| CN (2) | CN106074368B (enExample) |
| AU (1) | AU2013240340B2 (enExample) |
| CA (1) | CA2868787A1 (enExample) |
| ES (1) | ES2629932T3 (enExample) |
| IN (1) | IN2014DN08886A (enExample) |
| WO (1) | WO2013148228A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| CN114920840A (zh) | 2014-10-14 | 2022-08-19 | 诺华股份有限公司 | 针对pd-l1的抗体分子及其用途 |
| CA2979302A1 (en) * | 2015-05-13 | 2016-11-17 | Selvita S.A. | Substituted quinoxaline derivatives |
| US20180147198A1 (en) * | 2015-05-28 | 2018-05-31 | University Of Louisville Research Foundation, Inc. | Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| CN114272371A (zh) | 2015-07-29 | 2022-04-05 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| PL3317301T3 (pl) | 2015-07-29 | 2021-11-15 | Novartis Ag | Terapie skojarzone zawierające cząsteczki przeciwciał przeciw lag-3 |
| KR102833068B1 (ko) | 2015-12-17 | 2025-07-14 | 노파르티스 아게 | Pd-1에 대한 항체 분자 및 그의 용도 |
| AU2017357488A1 (en) * | 2016-11-08 | 2019-06-20 | Merck Patent Gmbh | Substituted quinoxaline derivatives as inhibitors of PFKFB |
| CN109136206B (zh) * | 2017-06-15 | 2021-07-23 | 厦门大学 | Pfkfb3蛋白的第194位酪氨酸的磷酸化及其应用 |
| CN109134434B (zh) * | 2017-11-06 | 2021-02-19 | 北京大学深圳研究生院 | 喹啉或喹唑啉类化合物及其制备方法和应用 |
| KR20220059472A (ko) * | 2019-08-06 | 2022-05-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Rna-표적화 리간드, 이의 조성물, 및 이의 제조 및 사용 방법 |
| CN111228265A (zh) * | 2020-02-10 | 2020-06-05 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | p38γ抑制剂在制备治疗胰腺癌药物中的应用 |
| KR102344676B1 (ko) | 2020-02-12 | 2021-12-30 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법 |
| CN111996247B (zh) * | 2020-08-27 | 2021-09-10 | 北京大学人民医院 | 糖酵解抑制剂及其在修复内皮细胞损伤中的应用 |
| CN114617884B (zh) * | 2020-12-10 | 2023-06-02 | 中国科学院大连化学物理研究所 | Pfk-158在制备抗冠状病毒药物中的应用及药物 |
| EP4340897A4 (en) * | 2021-05-16 | 2025-04-09 | Metanoia Bio Inc. | Methods and compositions for treating pancreatic and hepatic disease |
| WO2023147161A2 (en) * | 2022-01-31 | 2023-08-03 | New Frontier Bio, Inc. | Nicotinate and nicotinamide riboside-based compounds and derivatives thereof |
| CN120695195A (zh) * | 2025-06-20 | 2025-09-26 | 华中科技大学同济医学院附属协和医院 | 靶向cdc20和糖酵解通路双靶点抑制剂在治疗子宫内膜癌中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| CN1182846C (zh) * | 2003-03-14 | 2005-01-05 | 南开大学 | 水溶性抗癌药紫杉醇复合物及其制备方法 |
| CN1554336A (zh) * | 2003-12-23 | 2004-12-15 | 广州国桥医药研究有限公司 | 水溶性青蒿素制剂的制备方法 |
| MXPA06011770A (es) * | 2004-04-12 | 2007-04-13 | Torrent Pharmaceuticals Ltd | 2-propen-1-onas como inductores de hsp 70. |
| CN101020060A (zh) * | 2007-03-10 | 2007-08-22 | 杨喜鸿 | 恩替卡韦的环糊精包合物及其制备方法和药物应用 |
| JP2010531304A (ja) * | 2007-06-18 | 2010-09-24 | ユニバーシティ オブ ルイビル リサーチ ファウンデーション、インコーポレイテッド | 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー |
| EP2488533B1 (en) * | 2009-10-13 | 2014-07-23 | Council of Scientific & Industrial Research | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof |
| CN102000080A (zh) * | 2010-09-21 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种喜树碱类化合物的增溶方法 |
-
2013
- 2013-03-14 US US14/388,983 patent/US9649305B2/en not_active Expired - Fee Related
- 2013-03-14 CN CN201610578370.2A patent/CN106074368B/zh not_active Expired - Fee Related
- 2013-03-14 WO PCT/US2013/031159 patent/WO2013148228A1/en not_active Ceased
- 2013-03-14 EP EP13770319.5A patent/EP2831047B1/en not_active Not-in-force
- 2013-03-14 ES ES13770319.5T patent/ES2629932T3/es active Active
- 2013-03-14 IN IN8886DEN2014 patent/IN2014DN08886A/en unknown
- 2013-03-14 CN CN201380024610.9A patent/CN104520274B/zh not_active Expired - Fee Related
- 2013-03-14 CA CA2868787A patent/CA2868787A1/en not_active Abandoned
- 2013-03-14 AU AU2013240340A patent/AU2013240340B2/en not_active Ceased
- 2013-03-14 JP JP2015503286A patent/JP6075903B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-09 US US15/482,956 patent/US10010542B2/en not_active Expired - Fee Related