CN104520274B - Pfkfb3抑制剂和用作抗癌治疗剂的方法 - Google Patents

Pfkfb3抑制剂和用作抗癌治疗剂的方法 Download PDF

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Publication number
CN104520274B
CN104520274B CN201380024610.9A CN201380024610A CN104520274B CN 104520274 B CN104520274 B CN 104520274B CN 201380024610 A CN201380024610 A CN 201380024610A CN 104520274 B CN104520274 B CN 104520274B
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cancer
pfk
carcinoma
purposes
trifluoromethyl
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Chinese (zh)
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CN104520274A (zh
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P·钱德
G·H·塔博斯基
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Advanced Cancer Therapeutics LLC
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Advanced Cancer Therapeutics LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380024610.9A 2012-03-29 2013-03-14 Pfkfb3抑制剂和用作抗癌治疗剂的方法 Expired - Fee Related CN104520274B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610578370.2A CN106074368B (zh) 2012-03-29 2013-03-14 Pfkfb3抑制剂和用作抗癌治疗剂的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261617073P 2012-03-29 2012-03-29
US61/617,073 2012-03-29
PCT/US2013/031159 WO2013148228A1 (en) 2012-03-29 2013-03-14 Pfkfb3 inhibitor and methods of use as an anti-cancer therapeutic

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CN201610578370.2A Division CN106074368B (zh) 2012-03-29 2013-03-14 Pfkfb3抑制剂和用作抗癌治疗剂的方法

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CN104520274A CN104520274A (zh) 2015-04-15
CN104520274B true CN104520274B (zh) 2016-08-24

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US (2) US9649305B2 (enExample)
EP (1) EP2831047B1 (enExample)
JP (1) JP6075903B2 (enExample)
CN (2) CN104520274B (enExample)
AU (1) AU2013240340B2 (enExample)
CA (1) CA2868787A1 (enExample)
ES (1) ES2629932T3 (enExample)
IN (1) IN2014DN08886A (enExample)
WO (1) WO2013148228A1 (enExample)

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MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
SG11201702401RA (en) 2014-10-14 2017-04-27 Novartis Ag Antibody molecules to pd-l1 and uses thereof
US20180148429A1 (en) * 2015-05-13 2018-05-31 Selvita S.A. Substituted quinoxaline derivatives
WO2016191660A1 (en) * 2015-05-28 2016-12-01 University Of Louisville Research Foundation, Inc. Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer
US20180207273A1 (en) 2015-07-29 2018-07-26 Novartis Ag Combination therapies comprising antibody molecules to tim-3
US20180340025A1 (en) 2015-07-29 2018-11-29 Novartis Ag Combination therapies comprising antibody molecules to lag-3
EP3328418A1 (en) 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
CN108495651A (zh) 2015-12-17 2018-09-04 诺华股份有限公司 抗pd-1的抗体分子及其用途
EP3538518A1 (en) * 2016-11-08 2019-09-18 Merck Patent GmbH Substituted quinoxaline derivatives as inhibitors of pfkfb
CN109136206B (zh) * 2017-06-15 2021-07-23 厦门大学 Pfkfb3蛋白的第194位酪氨酸的磷酸化及其应用
CN109134434B (zh) * 2017-11-06 2021-02-19 北京大学深圳研究生院 喹啉或喹唑啉类化合物及其制备方法和应用
CN121045142A (zh) * 2019-08-06 2025-12-02 北卡罗来纳查佩尔山大学 Rna靶向配体、其组合物以及其制备和使用方法
CN111228265A (zh) * 2020-02-10 2020-06-05 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） p38γ抑制剂在制备治疗胰腺癌药物中的应用
KR102344676B1 (ko) 2020-02-12 2021-12-30 한국과학기술연구원 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법
CN111996247B (zh) * 2020-08-27 2021-09-10 北京大学人民医院 糖酵解抑制剂及其在修复内皮细胞损伤中的应用
CN114617884B (zh) * 2020-12-10 2023-06-02 中国科学院大连化学物理研究所 Pfk-158在制备抗冠状病毒药物中的应用及药物
EP4340897A4 (en) * 2021-05-16 2025-04-09 Metanoia Bio Inc. Methods and compositions for treating pancreatic and hepatic disease
WO2023147161A2 (en) * 2022-01-31 2023-08-03 New Frontier Bio, Inc. Nicotinate and nicotinamide riboside-based compounds and derivatives thereof
CN120695195A (zh) * 2025-06-20 2025-09-26 华中科技大学同济医学院附属协和医院 靶向cdc20和糖酵解通路双靶点抑制剂在治疗子宫内膜癌中的应用

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Also Published As

Publication number Publication date
EP2831047A4 (en) 2015-09-02
US20170258783A1 (en) 2017-09-14
JP2015512398A (ja) 2015-04-27
CN106074368A (zh) 2016-11-09
JP6075903B2 (ja) 2017-02-08
CN106074368B (zh) 2019-01-22
US20150064175A1 (en) 2015-03-05
IN2014DN08886A (enExample) 2015-05-22
EP2831047A1 (en) 2015-02-04
CA2868787A1 (en) 2013-10-03
US9649305B2 (en) 2017-05-16
ES2629932T3 (es) 2017-08-16
CN104520274A (zh) 2015-04-15
EP2831047B1 (en) 2017-05-03
WO2013148228A1 (en) 2013-10-03
AU2013240340B2 (en) 2016-11-10
AU2013240340A1 (en) 2014-10-23
US10010542B2 (en) 2018-07-03

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