JP2015096544A5 - - Google Patents
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- Publication number
- JP2015096544A5 JP2015096544A5 JP2015000566A JP2015000566A JP2015096544A5 JP 2015096544 A5 JP2015096544 A5 JP 2015096544A5 JP 2015000566 A JP2015000566 A JP 2015000566A JP 2015000566 A JP2015000566 A JP 2015000566A JP 2015096544 A5 JP2015096544 A5 JP 2015096544A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- group
- medicament
- compound
- ratios
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 210000003739 neck Anatomy 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 claims 1
- 206010024305 Leukaemia monocytic Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 108020002496 Lysophospholipase Proteins 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 239000002834 estrogen receptor modulator Substances 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000006894 monocytic leukemia Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229940075993 receptor modulator Drugs 0.000 claims 1
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007047738.6 | 2007-10-05 | ||
| DE102007047738A DE102007047738A1 (de) | 2007-10-05 | 2007-10-05 | Imidazolderivate |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527344A Division JP5725860B2 (ja) | 2007-10-05 | 2008-09-09 | イミダゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015096544A JP2015096544A (ja) | 2015-05-21 |
| JP2015096544A5 true JP2015096544A5 (enExample) | 2015-07-30 |
| JP5997782B2 JP5997782B2 (ja) | 2016-09-28 |
Family
ID=40151186
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527344A Expired - Fee Related JP5725860B2 (ja) | 2007-10-05 | 2008-09-09 | イミダゾール誘導体 |
| JP2015000566A Expired - Fee Related JP5997782B2 (ja) | 2007-10-05 | 2015-01-05 | イミダゾール誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527344A Expired - Fee Related JP5725860B2 (ja) | 2007-10-05 | 2008-09-09 | イミダゾール誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100249132A1 (enExample) |
| EP (1) | EP2193122B1 (enExample) |
| JP (2) | JP5725860B2 (enExample) |
| KR (1) | KR20100075602A (enExample) |
| CN (1) | CN101809001B (enExample) |
| AR (1) | AR068659A1 (enExample) |
| AU (1) | AU2008310117B2 (enExample) |
| BR (1) | BRPI0817609A2 (enExample) |
| CA (1) | CA2701568C (enExample) |
| DE (1) | DE102007047738A1 (enExample) |
| EA (1) | EA201000558A1 (enExample) |
| ES (1) | ES2601139T3 (enExample) |
| IL (1) | IL204683A (enExample) |
| MX (1) | MX2010003368A (enExample) |
| WO (1) | WO2009046804A1 (enExample) |
| ZA (1) | ZA201003125B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009049211A1 (de) * | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| CA2825599C (en) | 2011-02-01 | 2021-07-13 | The Board Of Trustees Of The University Of Illinois | 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors |
| ES2587856T3 (es) | 2011-03-18 | 2016-10-27 | Ono Pharmaceutical Co., Ltd. | Derivado de tetrahidrocarbolina |
| ES2648901T3 (es) * | 2011-10-28 | 2018-01-08 | Inhibitaxin Limited | Derivados de piridazina útiles en terapia |
| US9630945B2 (en) | 2012-12-19 | 2017-04-25 | Novartis Ag | Autotaxin inhibitors |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| BR112016000779A8 (pt) | 2013-07-18 | 2020-01-07 | Novartis Ag | inibidores de autotaxina que compreendem núcleo do ciclo de benzilamida de anel heteroaromático, seus usos, composição e combinação farmacêuticas |
| EP3022201A1 (en) * | 2013-07-18 | 2016-05-25 | Novartis AG | Autotaxin inhibitors |
| ES2875899T3 (es) | 2013-11-22 | 2021-11-11 | Sabre Therapeutics Llc | Compuestos inhibidores de autotaxina |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| JP6500092B2 (ja) * | 2014-09-15 | 2019-04-10 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｔ型カルシウムチャンネルブロッカーとしてのトリアゾール化合物 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| JP6873919B2 (ja) | 2015-05-27 | 2021-05-19 | セイバー セラピューティクス エルエルシー | オートタキシン阻害剤とその使用 |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| US20230277490A1 (en) * | 2020-07-31 | 2023-09-07 | Cedars-Sinai Medical Center | Glutamine as an anticancer therapy in solid tumors |
| EP4197596A1 (en) | 2021-12-15 | 2023-06-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Imidazole derivatives for the treatment and prophylaxis of infectious diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| TWI288136B (en) * | 2000-02-18 | 2007-10-11 | Kirin Brewery | Novel isoxazole and thiazole compounds and use thereof as drugs |
| FR2889190A1 (fr) * | 2005-08-01 | 2007-02-02 | Merck Sante Soc Par Actions Si | Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant |
-
2007
- 2007-10-05 DE DE102007047738A patent/DE102007047738A1/de not_active Withdrawn
-
2008
- 2008-09-09 EA EA201000558A patent/EA201000558A1/ru unknown
- 2008-09-09 BR BRPI0817609 patent/BRPI0817609A2/pt not_active IP Right Cessation
- 2008-09-09 CN CN2008801089528A patent/CN101809001B/zh not_active Expired - Fee Related
- 2008-09-09 MX MX2010003368A patent/MX2010003368A/es not_active Application Discontinuation
- 2008-09-09 CA CA2701568A patent/CA2701568C/en not_active Expired - Fee Related
- 2008-09-09 AU AU2008310117A patent/AU2008310117B2/en not_active Ceased
- 2008-09-09 ES ES08801940.1T patent/ES2601139T3/es active Active
- 2008-09-09 US US12/681,380 patent/US20100249132A1/en not_active Abandoned
- 2008-09-09 EP EP08801940.1A patent/EP2193122B1/de not_active Not-in-force
- 2008-09-09 KR KR1020107009777A patent/KR20100075602A/ko not_active Withdrawn
- 2008-09-09 WO PCT/EP2008/007367 patent/WO2009046804A1/de not_active Ceased
- 2008-09-09 JP JP2010527344A patent/JP5725860B2/ja not_active Expired - Fee Related
- 2008-10-03 AR ARP080104330A patent/AR068659A1/es unknown
-
2010
- 2010-03-23 IL IL204683A patent/IL204683A/en not_active IP Right Cessation
- 2010-05-04 ZA ZA2010/03125A patent/ZA201003125B/en unknown
-
2015
- 2015-01-05 JP JP2015000566A patent/JP5997782B2/ja not_active Expired - Fee Related