|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
*
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
IL166241A0
(en)
|
2002-07-29 |
2006-01-15 |
Rigel Pharmaceuticals Inc |
Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
|
|
RS20050532A
(sr)
|
2003-01-14 |
2007-12-31 |
Arena Pharmaceuticals Inc., |
Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
JP2004313181A
(ja)
*
|
2003-04-02 |
2004-11-11 |
Canon Inc |
感染症起炎菌検出用プローブ及びプローブセット、ならびに担体及び遺伝子検査方法
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
ES2421139T3
(es)
|
2003-07-30 |
2013-08-29 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
|
|
ATE542801T1
(de)
*
|
2003-08-15 |
2012-02-15 |
Novartis Ag |
Zur behandlung von neoplastischen krankheiten, entzündlichen erkrankungen und erkrankungen des immunsystems geeignete 2,4-pyrimidindiamine
|
|
US8131475B2
(en)
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
AU2005231507B2
(en)
|
2004-04-08 |
2012-03-01 |
Targegen, Inc. |
Benzotriazine inhibitors of kinases
|
|
EP1598343A1
(de)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
US7521457B2
(en)
*
|
2004-08-20 |
2009-04-21 |
Boehringer Ingelheim International Gmbh |
Pyrimidines as PLK inhibitors
|
|
NZ588896A
(en)
|
2004-08-25 |
2012-05-25 |
Targegen Inc |
Heterocyclic compounds and methods of use
|
|
GB0419161D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
US7449458B2
(en)
|
2005-01-19 |
2008-11-11 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
WO2006133426A2
(en)
|
2005-06-08 |
2006-12-14 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
WO2007009681A1
(en)
*
|
2005-07-15 |
2007-01-25 |
Glaxo Group Limited |
1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES
|
|
WO2007028445A1
(en)
*
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
|
GB0517329D0
(en)
*
|
2005-08-25 |
2005-10-05 |
Merck Sharp & Dohme |
Stimulation of neurogenesis
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
WO2007053452A1
(en)
|
2005-11-01 |
2007-05-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2007085540A1
(en)
*
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
|
KR101411695B1
(ko)
|
2006-02-17 |
2014-07-03 |
리겔 파마슈티칼스, 인크. |
자가면역 질환의 치료 또는 예방을 위한 2,4-피리미딘디아민 화합물
|
|
WO2007098507A2
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
PL2450437T3
(pl)
|
2006-04-14 |
2017-12-29 |
Cell Signaling Technology Inc |
Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych
|
|
CA2598893C
(en)
*
|
2006-10-11 |
2012-04-10 |
Astellas Pharma Inc. |
Eml4-alk fusion gene
|
|
EP1914240B1
(en)
|
2006-10-11 |
2009-12-02 |
Astellas Pharma Inc. |
EML4-ALK fusion gene
|
|
MX2009004426A
(es)
|
2006-10-23 |
2009-08-12 |
Cephalon Inc |
Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
|
|
EA019941B1
(ru)
*
|
2006-12-08 |
2014-07-30 |
АйАрЭм ЭлЭлСи |
Соединения и композиции в качестве ингибиторов протеинкиназы
|
|
JP5208123B2
(ja)
*
|
2006-12-08 |
2013-06-12 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
タンパク質キナーゼ阻害剤としての化合物および組成物
|
|
CA2670645A1
(en)
*
|
2006-12-19 |
2008-07-03 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
PE20081636A1
(es)
|
2007-01-26 |
2009-01-10 |
Smithkline Beecham Corp |
Inhibidores de antranilamida para aurora quinasa
|
|
DK2146779T3
(en)
|
2007-04-18 |
2016-11-28 |
Pfizer Prod Inc |
Sulfonylamid derivatives to treat abnormal cell growth.
|
|
TWI389893B
(zh)
*
|
2007-07-06 |
2013-03-21 |
Astellas Pharma Inc |
二（芳胺基）芳基化合物
|
|
CN101796046A
(zh)
|
2007-07-16 |
2010-08-04 |
阿斯利康(瑞典)有限公司 |
嘧啶衍生物934
|
|
EP2188292B1
(en)
*
|
2007-08-08 |
2013-05-29 |
GlaxoSmithKline Intellectual Property Development Limited |
2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d]pyrimidin-4-yl) amino]benzamide derivatives as igf-1r inhibitors for the treatment of cancer
|
|
BRPI0815979A2
(pt)
*
|
2007-08-28 |
2017-06-13 |
Irm Llc |
compostos e composições com inibidores de quinase, bem como uso dos mesmos
|
|
WO2009032703A1
(en)
*
|
2007-08-28 |
2009-03-12 |
Irm Llc |
2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
|
|
CA2710118A1
(en)
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
WO2009105498A1
(en)
*
|
2008-02-19 |
2009-08-27 |
Smithkline Beecham Corporation |
Anilinopyridines as inhibitors of fak
|
|
AU2009233964B2
(en)
*
|
2008-04-07 |
2012-06-07 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
US8063058B2
(en)
|
2008-04-16 |
2011-11-22 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk and JAK protein kinases
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
KR20100132550A
(ko)
|
2008-04-16 |
2010-12-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드
|
|
BRPI0910668A2
(pt)
|
2008-04-22 |
2019-09-24 |
Portola Pharmaceutiacals Inc |
inibidores de proteína quinases
|
|
JP2011523646A
(ja)
|
2008-05-21 |
2011-08-18 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
キナーゼ阻害剤としてのリン誘導体
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
CN102124000B
(zh)
*
|
2008-06-17 |
2014-09-17 |
阿斯利康(瑞典)有限公司 |
吡啶化合物
|
|
US8445505B2
(en)
|
2008-06-25 |
2013-05-21 |
Irm Llc |
Pyrimidine derivatives as kinase inhibitors
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
AU2009262068C1
(en)
*
|
2008-06-27 |
2015-07-02 |
Celgene Car Llc |
Heteroaryl compounds and uses thereof
|
|
JO3067B1
(ar)
*
|
2008-10-27 |
2017-03-15 |
Glaxosmithkline Llc |
بيرميدينات بيرازولو امينو كمثبطات ل fak
|
|
TW201024281A
(en)
|
2008-11-24 |
2010-07-01 |
Boehringer Ingelheim Int |
New compounds
|
|
AR074210A1
(es)
|
2008-11-24 |
2010-12-29 |
Boehringer Ingelheim Int |
Derivados de pirimidina como inhibidores de ptk2-quinasa
|
|
WO2010071885A1
(en)
|
2008-12-19 |
2010-06-24 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
|
PL2389372T3
(pl)
|
2009-01-23 |
2016-02-29 |
Rigel Pharmaceuticals Inc |
Kompozycje i sposoby hamowania szlaku JAK
|
|
US20120270237A9
(en)
|
2009-04-03 |
2012-10-25 |
Cellzone AG |
Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
|
|
WO2010118986A1
(en)
|
2009-04-14 |
2010-10-21 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
KR101705158B1
(ko)
|
2009-05-05 |
2017-02-09 |
다나-파버 캔서 인스티튜트 인크. |
Ｅｇｆｒ 억제제 및 질환 치료방법
|
|
TW201100441A
(en)
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
EP2440534A2
(en)
*
|
2009-06-10 |
2012-04-18 |
Cellzome Limited |
Pyrimidine derivatives as zap-70 inhibitors
|
|
MX2011013325A
(es)
*
|
2009-06-10 |
2012-04-30 |
Abbott Lab |
2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
|
|
US8765747B2
(en)
|
2009-06-12 |
2014-07-01 |
Dana-Farber Cancer Institute, Inc. |
Fused 2-aminothiazole compounds
|
|
WO2010146133A1
(en)
*
|
2009-06-18 |
2010-12-23 |
Cellzome Limited |
Heterocyclylaminopyrimidines as kinase inhibitors
|
|
WO2010146132A1
(en)
*
|
2009-06-18 |
2010-12-23 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
CA2771675A1
(en)
*
|
2009-09-11 |
2011-03-17 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
|
WO2011140338A1
(en)
*
|
2010-05-05 |
2011-11-10 |
Gatekeeper Pharmaceuticals, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
BR112012029647A2
(pt)
|
2010-05-21 |
2016-08-02 |
Chemilia Ab |
novos derivados de pirimidinas
|
|
US20120101108A1
(en)
|
2010-08-06 |
2012-04-26 |
Cell Signaling Technology, Inc. |
Anaplastic Lymphoma Kinase In Kidney Cancer
|
|
PH12013500246A1
(en)
|
2010-08-10 |
2019-10-11 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
CN103221410B
(zh)
|
2010-09-22 |
2017-09-15 |
艾尼纳制药公司 |
Gpr119受体调节剂和对与其相关的障碍的治疗
|
|
BR112013010564B1
(pt)
|
2010-11-01 |
2021-09-21 |
Celgene Car Llc |
Compostos heterocíclicos e composições compreendendo os mesmos
|
|
JP5956999B2
(ja)
|
2010-11-01 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ， インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
|
AU2011323484B2
(en)
|
2010-11-01 |
2016-10-06 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as Syk modulators
|
|
EP2975027A1
(en)
|
2010-11-01 |
2016-01-20 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
WO2012061415A1
(en)
|
2010-11-01 |
2012-05-10 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
AU2010363329A1
(en)
|
2010-11-07 |
2013-05-09 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
|
WO2012074951A1
(en)
|
2010-11-29 |
2012-06-07 |
OSI Pharmaceuticals, LLC |
Macrocyclic kinase inhibitors
|
|
PL2651918T3
(pl)
*
|
2010-12-17 |
2017-12-29 |
Novartis Ag |
Krystaliczne formy 5-chloro-N2-(2-izopropoksy-5-metylo-4-piperydyn-4-ylofenylo)-N4-[2-(propano-2-sulfonylo)-fenylo]-pirymidyno-2,4-diaminy
|
|
US8546443B2
(en)
|
2010-12-21 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Benzylic oxindole pyrimidines
|
|
JP2012153674A
(ja)
|
2011-01-28 |
2012-08-16 |
Astellas Pharma Inc |
ジ（アリールアミノ）アリール化合物の製造方法及びその合成中間体
|
|
PT2670401E
(pt)
*
|
2011-02-02 |
2015-10-12 |
Novartis Ag |
Métodos de utilização de inibidores de alk
|
|
WO2012110773A1
(en)
|
2011-02-17 |
2012-08-23 |
Cancer Therapeutics Crc Pty Limited |
Fak inhibitors
|
|
DK2675794T3
(da)
|
2011-02-17 |
2019-05-06 |
Cancer Therapeutics Crc Pty Ltd |
Selektive fak-inhibitorer
|
|
MX2013010898A
(es)
|
2011-03-24 |
2013-12-06 |
Chemilia Ab |
Novedoso derivados de la pirimidina.
|
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
|
TWI548621B
(zh)
|
2011-04-22 |
2016-09-11 |
標誌製藥公司 |
經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
|
|
AU2012250517B2
(en)
|
2011-05-04 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
JP2014532658A
(ja)
|
2011-10-28 |
2014-12-08 |
セルジーン アヴィロミクス リサーチ， インコーポレイテッド |
ブルトン型チロシンキナーゼ疾患または障害を治療する方法
|
|
JP6106685B2
(ja)
|
2011-11-17 |
2017-04-05 |
ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド |
Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤
|
|
EP2782579B1
(en)
|
2011-11-23 |
2019-01-02 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
|
KR102068374B1
(ko)
|
2012-03-06 |
2020-01-20 |
세파론, 인코포레이티드 |
이중 alk 및 fak 억제제로서의 융합된 비시클릭 2,4-디아미노피리미딘 유도체
|
|
ES2880109T3
(es)
|
2012-03-15 |
2021-11-23 |
Celgene Car Llc |
Formas sólidas de un inhibidor de la cinasa del receptor del factor de crecimiento epidérmico
|
|
JP6317320B2
(ja)
|
2012-03-15 |
2018-04-25 |
セルジーン シーエーアール エルエルシー |
上皮成長因子受容体キナーゼ阻害剤の塩
|
|
JP6469567B2
(ja)
|
2012-05-05 |
2019-02-13 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
|
|
KR101582852B1
(ko)
|
2012-05-24 |
2016-01-07 |
서울대학교 산학협력단 |
타우 단백질 매개 신경 퇴행성 질환 치료제
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
WO2014058921A2
(en)
|
2012-10-08 |
2014-04-17 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
EP4223770A3
(en)
|
2012-11-05 |
2023-10-18 |
Foundation Medicine, Inc. |
Novel fusion molecules and uses thereof
|
|
CN104854101B
(zh)
*
|
2012-11-06 |
2018-05-01 |
上海复尚慧创医药研究有限公司 |
Alk激酶抑制剂
|
|
CN103804299A
(zh)
*
|
2012-11-14 |
2014-05-21 |
韩冰 |
一类具有神经保护作用的化合物及其用途
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
CA2898326C
(en)
|
2013-01-18 |
2022-05-17 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
CN105188371A
(zh)
|
2013-02-08 |
2015-12-23 |
西建阿维拉米斯研究公司 |
Erk抑制剂及其用途
|
|
WO2014128235A1
(en)
|
2013-02-22 |
2014-08-28 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer and preventing drug resistance
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
EP3004111A1
(en)
|
2013-05-29 |
2016-04-13 |
Cephalon, Inc. |
Pyrrolotriazines as alk inhibitors
|
|
JP2016522247A
(ja)
|
2013-06-18 |
2016-07-28 |
ノバルティス アーゲー |
組合せ医薬
|
|
JP6510510B2
(ja)
*
|
2013-07-11 |
2019-05-08 |
ベータ ファーマシューティカルズ カンパニー リミテッド |
プロテインチロシンキナーゼモジュレーター及び使用方法
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
WO2015038868A1
(en)
*
|
2013-09-13 |
2015-03-19 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivatives
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
AU2014337044A1
(en)
|
2013-10-18 |
2016-05-05 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
WO2015058126A1
(en)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
|
ES2738289T3
(es)
|
2013-11-06 |
2020-01-21 |
Hospital Clinic Barcelona |
Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
WO2015164614A1
(en)
*
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
WO2016025561A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Forms and compositions of an erk inhibitor
|
|
WO2016029002A2
(en)
*
|
2014-08-22 |
2016-02-25 |
Clovis Oncology, Inc. |
Growth factor receptor inhibitors
|
|
PT3209647T
(pt)
|
2014-10-21 |
2020-09-10 |
Ariad Pharma Inc |
Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidino-2,4-diamina
|
|
EP3712134B1
(en)
|
2014-12-16 |
2023-11-29 |
Signal Pharmaceuticals, LLC |
Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide
|
|
US9513297B2
(en)
|
2014-12-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
|
|
US10870651B2
(en)
|
2014-12-23 |
2020-12-22 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
CA3002540C
(en)
|
2015-01-06 |
2023-11-07 |
Arena Pharmaceuticals, Inc. |
Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
|
|
EP3250557B1
(en)
|
2015-01-29 |
2024-11-20 |
Signal Pharmaceuticals, LLC |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CN107427521B
(zh)
|
2015-03-27 |
2021-08-03 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
WO2016167511A2
(ko)
*
|
2015-04-14 |
2016-10-20 |
한국화학연구원 |
N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
CA2986441A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
JP6838744B2
(ja)
|
2015-06-22 |
2021-03-03 |
アリーナ ファーマシューティカルズ， インコーポレイテッド |
Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
|
|
EP3325432B1
(en)
|
2015-07-24 |
2020-09-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|
|
WO2017044858A2
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
CN106699743B
(zh)
*
|
2015-11-05 |
2020-06-12 |
湖北生物医药产业技术研究院有限公司 |
嘧啶类衍生物及其用途
|
|
CN106883213B
(zh)
*
|
2015-12-15 |
2021-04-20 |
合肥中科普瑞昇生物医药科技有限公司 |
一种egfr和alk激酶的双重抑制剂
|
|
WO2018001251A1
(zh)
*
|
2016-06-27 |
2018-01-04 |
杭州雷索药业有限公司 |
苯并呋喃吡唑胺类蛋白激酶抑制剂
|
|
SG11201901251SA
(en)
|
2016-08-29 |
2019-03-28 |
Univ Michigan Regents |
Aminopyrimidines as alk inhibitors
|
|
KR101876514B1
(ko)
|
2016-11-08 |
2018-07-10 |
한국화학연구원 |
신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물
|
|
CN110520124A
(zh)
|
2017-02-16 |
2019-11-29 |
艾尼纳制药公司 |
用于治疗原发性胆汁性胆管炎的化合物和方法
|
|
SG11201908234WA
(en)
|
2017-02-24 |
2019-10-30 |
Daegu Gyeongbuk Medical Innovation Found |
Pharmaceutical composition comprising compound capable of penetrating blood-brain barrier as effective ingredient for preventing or treating brain cancer
|
|
JOP20190281A1
(ar)
*
|
2017-06-13 |
2019-12-02 |
Korea Res Inst Chemical Tech |
مشتق n2، n4 ثنائي فينيل بيريميدين -2، 4- ثنائي أمين، وطريقة لتحضيره، وتركيبة صيدلانية تحتوي على المشتق بوصفه مكون فعال للوقاية من السرطان أو علاجه
|
|
TWI852912B
(zh)
|
2017-09-07 |
2024-08-21 |
美商銳新醫藥公司 |
Shp2抑制劑組合物以及治療癌症的方法
|
|
KR101992621B1
(ko)
|
2017-12-07 |
2019-09-27 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
US20210009613A1
(en)
*
|
2017-12-12 |
2021-01-14 |
Shenzhen Targetrx, Inc. |
Arylphosphine oxides for inhibiting kinase activity
|
|
WO2019117813A1
(en)
*
|
2017-12-15 |
2019-06-20 |
National University Of Singapore |
Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
|
|
BR112020020246A8
(pt)
|
2018-04-05 |
2022-10-18 |
Sumitomo Dainippon Pharma Oncology Inc |
Inibidores de cinase axl e uso dos mesmos
|
|
JP7397011B2
(ja)
|
2018-06-06 |
2023-12-12 |
アリーナ ファーマシューティカルズ， インコーポレイテッド |
Ｓ１ｐ１受容体に関連する状態を治療する方法
|
|
EP3810132A4
(en)
|
2018-06-25 |
2022-06-22 |
Dana-Farber Cancer Institute, Inc. |
TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
|
|
JP2022508651A
(ja)
|
2018-10-08 |
2022-01-19 |
レヴォリューション・メディスンズ，インコーポレイテッド |
癌を処置するためのｓｈｐ２阻害剤組成物および方法
|
|
WO2020088390A1
(zh)
*
|
2018-10-29 |
2020-05-07 |
江苏先声药业有限公司 |
作为第四代egfr抑制剂的嘧啶吡唑类化合物
|
|
WO2020097396A1
(en)
|
2018-11-07 |
2020-05-14 |
Dana-Farber Cancer Institute, Inc. |
Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
EP3876939A4
(en)
|
2018-11-07 |
2022-08-10 |
Dana-Farber Cancer Institute, Inc. |
Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
US12509455B2
(en)
|
2018-11-07 |
2025-12-30 |
Dana-Farber Cancer Institute, Inc. |
Imidazopyridine derivatives and aza-imidazopyridine derivatives as Janus kinase 2 inhibitors and uses thereof
|
|
CN113164477A
(zh)
|
2018-12-14 |
2021-07-23 |
达纳-法伯癌症研究所股份有限公司 |
C-jun-n-末端激酶的吡唑并吡啶抑制剂及其用途
|
|
EP3902542A4
(en)
|
2018-12-28 |
2022-09-07 |
Dana-Farber Cancer Institute, Inc. |
CYCLIN DEPENDENT KINASE 7 INHIBITORS AND USES THEREOF
|
|
WO2020147702A1
(en)
*
|
2019-01-17 |
2020-07-23 |
Betta Pharmaceuticals Co., Ltd |
Egfr inhibitors, compositions and methods thereof
|
|
US20230096028A1
(en)
|
2019-03-01 |
2023-03-30 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
|
JP2022525186A
(ja)
|
2019-03-15 |
2022-05-11 |
ザ ジェネラル ホスピタル コーポレイション |
Ｔｅａｄ転写因子新規小分子阻害剤
|
|
CA3129665A1
(en)
|
2019-03-21 |
2020-09-24 |
Onxeo |
A dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
|
WO2020243021A2
(en)
|
2019-05-24 |
2020-12-03 |
Foundation Medicine, Inc. |
Ntrk fusion molecules and uses thereof
|
|
AU2020300619A1
(en)
|
2019-07-03 |
2022-01-27 |
Sumitomo Pharma Oncology, Inc. |
Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
|
|
CA3156828A1
(en)
|
2019-10-03 |
2021-04-08 |
Dana-Farber Cancer Institute, Inc. |
Tricyclic kinase inhibitors and uses thereof
|
|
KR102168179B1
(ko)
*
|
2019-10-31 |
2020-10-20 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 헤테로 고리 치환 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
WO2021091956A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
MX2022005359A
(es)
|
2019-11-04 |
2022-06-02 |
Revolution Medicines Inc |
Inhibidores de ras.
|
|
CN121471132A
(zh)
|
2019-11-04 |
2026-02-06 |
锐新医药公司 |
Ras抑制剂
|
|
PH12022551102A1
(en)
|
2019-11-08 |
2023-11-20 |
Revolution Medicines Inc |
Bicyclic heteroaryl compounds and uses thereof
|
|
KR20220098759A
(ko)
|
2019-11-08 |
2022-07-12 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
키나제 억제제에 대해 내성을 획득한 암의 치료 방법
|
|
US12590070B2
(en)
|
2019-12-03 |
2026-03-31 |
Samjin Pharmaceutical Co., Ltd. |
Adamantane derivatives as inhibitors of focal adhesion kinase
|
|
CA3163703A1
(en)
|
2020-01-07 |
2021-07-15 |
Steve Kelsey |
Shp2 inhibitor dosing and methods of treating cancer
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
WO2021173677A1
(en)
*
|
2020-02-25 |
2021-09-02 |
Dana-Farber Cancer Institute, Inc. |
Potent and selective degraders of alk
|
|
EP4114979A4
(en)
|
2020-03-04 |
2025-08-27 |
Found Medicine Inc |
BCOR REDESIGNS AND THEIR USES
|
|
CN115916194A
(zh)
|
2020-06-18 |
2023-04-04 |
锐新医药公司 |
用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
|
|
EP4208261A1
(en)
|
2020-09-03 |
2023-07-12 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
IL301298A
(en)
|
2020-09-15 |
2023-05-01 |
Revolution Medicines Inc |
Indole derivatives as RAS inhibitors in cancer therapy
|
|
AU2021409816A1
(en)
|
2020-12-22 |
2023-07-06 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
|
US12643886B2
(en)
*
|
2021-01-07 |
2026-06-02 |
Ontario Institute for Cancer Research (OICR), The Governing Council of the University of Toronto, Sinai Health System |
Isoindolinone aminopyrimidine compounds as inhibitors of NUAK kinases, compositions and uses thereof
|
|
CA3207015A1
(en)
*
|
2021-04-01 |
2022-10-06 |
Tae Bo Sim |
Pyrimidine derivative with inhibitory activity against protein kinases and therapeutic pharmaceutical composition including the same
|
|
WO2022208454A1
(en)
|
2021-04-02 |
2022-10-06 |
Bridge Biotherapeutics, Inc. |
N2-phenylpyrimidine-2,4-diamine compounds, and preparation methods and methods of use thereof
|
|
EP4320153A1
(en)
|
2021-04-09 |
2024-02-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
|
PE20240088A1
(es)
|
2021-05-05 |
2024-01-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
IL308195A
(en)
|
2021-05-05 |
2024-01-01 |
Revolution Medicines Inc |
RAS inhibitors for cancer treatment
|
|
US20250084482A1
(en)
|
2021-06-25 |
2025-03-13 |
Foundation Medicine, Inc. |
Methods of using somatic hla-i loh to predict response of immune checkpoint inhibitor-treated patients with lung cancer
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
TW202329937A
(zh)
|
2021-12-03 |
2023-08-01 |
美商英塞特公司 |
雙環胺ｃｋ１２抑制劑
|
|
US12084453B2
(en)
|
2021-12-10 |
2024-09-10 |
Incyte Corporation |
Bicyclic amines as CDK12 inhibitors
|
|
TW202340214A
(zh)
|
2021-12-17 |
2023-10-16 |
美商健臻公司 |
做為shp2抑制劑之吡唑并吡𠯤化合物
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
|
EP4536364A1
(en)
|
2022-06-10 |
2025-04-16 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
KR102929746B1
(ko)
|
2023-03-23 |
2026-02-26 |
청주대학교 산학협력단 |
콘크리트 양생용 광발열 단열시트 및 콘크리트 구조물의 조기 시공 방법
|
|
CN121487738A
(zh)
|
2023-03-30 |
2026-02-06 |
锐新医药公司 |
诱导ras gtp水解的组合物和其用途
|
|
CN121487951A
(zh)
|
2023-04-07 |
2026-02-06 |
锐新医药公司 |
大环ras抑制剂
|
|
EP4695261A1
(en)
|
2023-04-14 |
2026-02-18 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
|
AU2024251341A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
KR20260019479A
(ko)
|
2023-05-04 |
2026-02-10 |
레볼루션 메디슨즈, 인크. |
Ras 관련 질환 또는 장애를 위한 병용 요법
|
|
CN121335887A
(zh)
*
|
2023-06-08 |
2026-01-13 |
希格生科（深圳）有限公司 |
含氮芳环化合物及其医药用途
|
|
CN121889155A
(zh)
|
2023-08-07 |
2026-04-17 |
锐新医药公司 |
用于治疗ras蛋白相关疾病或病症的rmc-6291
|
|
AU2024360465A1
(en)
|
2023-10-12 |
2026-04-09 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
AU2024404879A1
(en)
|
2023-12-22 |
2026-06-25 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20250375445A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026072904A2
(en)
|
2024-09-26 |
2026-04-02 |
Revolution Medicines, Inc. |
Compositions and methods for treating lung cancer
|
|
WO2026090116A2
(en)
|
2024-10-21 |
2026-04-30 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20260108528A1
(en)
|
2024-10-22 |
2026-04-23 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2026090245A1
(en)
|
2024-10-22 |
2026-04-30 |
Revolution Medicines, Inc. |
Use of ras inhibitors for treating cancer
|
|
WO2026106912A1
(en)
|
2024-11-12 |
2026-05-21 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026112260A1
(en)
|
2024-11-21 |
2026-05-28 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026122764A2
(en)
|
2024-12-06 |
2026-06-11 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026128688A2
(en)
|
2024-12-13 |
2026-06-18 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026161839A1
(en)
|
2025-01-27 |
2026-07-30 |
Revolution Medicines, Inc. |
Ras inhibitors
|