|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
HRP20050089B1
(hr)
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
KR101078098B1
(ko)
|
2003-01-14 |
2011-10-28 |
아레나 파마슈티칼스, 인크. |
대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
JP2004313181A
(ja)
*
|
2003-04-02 |
2004-11-11 |
Canon Inc |
感染症起炎菌検出用プローブ及びプローブセット、ならびに担体及び遺伝子検査方法
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
JP4886511B2
(ja)
|
2003-07-30 |
2012-02-29 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
|
|
BR122019017579B8
(pt)
|
2003-08-15 |
2021-07-27 |
Novartis Ag |
2,4-pirimidinadiaminas, seus usos, combinação e composição farmacêutica
|
|
US8131475B2
(en)
|
2003-09-03 |
2012-03-06 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Methods for identifying, diagnosing, and predicting survival of lymphomas
|
|
EP2543376A1
(en)
|
2004-04-08 |
2013-01-09 |
Targegen, Inc. |
Benzotriazine inhibitors of kinases
|
|
EP1598343A1
(de)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
US7521457B2
(en)
*
|
2004-08-20 |
2009-04-21 |
Boehringer Ingelheim International Gmbh |
Pyrimidines as PLK inhibitors
|
|
AU2005276974B2
(en)
|
2004-08-25 |
2012-08-02 |
Targegen, Inc. |
Heterocyclic compounds and methods of use
|
|
GB0419161D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
CN101115761B
(zh)
|
2005-01-19 |
2012-07-18 |
里格尔药品股份有限公司 |
2,4-嘧啶二胺化合物的前药及其应用
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
AU2006254840B2
(en)
|
2005-06-08 |
2012-08-02 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
WO2007028445A1
(en)
*
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
|
AR054834A1
(es)
*
|
2005-07-15 |
2007-07-18 |
Glaxo Group Ltd |
Derivados de 1,1-dioxido-2,3-dihidro-1,2-benzoisotiazol-6-il-1h-indazol-4-il-2,4 pirimidina diamina
|
|
GB0517329D0
(en)
*
|
2005-08-25 |
2005-10-05 |
Merck Sharp & Dohme |
Stimulation of neurogenesis
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
NZ567851A
(en)
|
2005-11-01 |
2011-09-30 |
Targegen Inc |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2007085540A1
(en)
*
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
|
KR101411695B1
(ko)
|
2006-02-17 |
2014-07-03 |
리겔 파마슈티칼스, 인크. |
자가면역 질환의 치료 또는 예방을 위한 2,4-피리미딘디아민 화합물
|
|
ES2622493T3
(es)
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
EP3266867A1
(en)
|
2006-04-14 |
2018-01-10 |
Cell Signaling Technology, Inc. |
Gene defects and mutant alk kinase in human solid tumors
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
CA2598893C
(en)
|
2006-10-11 |
2012-04-10 |
Astellas Pharma Inc. |
Eml4-alk fusion gene
|
|
EP1914240B1
(en)
|
2006-10-11 |
2009-12-02 |
Astellas Pharma Inc. |
EML4-ALK fusion gene
|
|
EP2222647B1
(en)
|
2006-10-23 |
2015-08-05 |
Cephalon, Inc. |
Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors
|
|
ME00811B
(me)
*
|
2006-12-08 |
2012-03-20 |
Novartis Ag |
JEDINJENJA l KOMPOZICIJE KAO INHIBITORI PROTEIN KINAZE
|
|
KR101364277B1
(ko)
*
|
2006-12-08 |
2014-02-21 |
아이알엠 엘엘씨 |
단백질 키나제 억제제로서의 화합물
|
|
EP2099771A1
(en)
*
|
2006-12-19 |
2009-09-16 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
CL2008000197A1
(es)
|
2007-01-26 |
2008-08-01 |
Smithkline Beecham Corp |
Compuestos derivados de 2,4-diamino pirimidina, inhibidores de antranilamida de cinasa aurora; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer.
|
|
DK2146779T3
(en)
|
2007-04-18 |
2016-11-28 |
Pfizer Prod Inc |
Sulfonylamid derivatives to treat abnormal cell growth.
|
|
TWI389893B
(zh)
*
|
2007-07-06 |
2013-03-21 |
Astellas Pharma Inc |
二（芳胺基）芳基化合物
|
|
WO2009010789A2
(en)
*
|
2007-07-16 |
2009-01-22 |
Astrazeneca Ab |
Pyrimidine derivatives 934
|
|
ES2424977T3
(es)
*
|
2007-08-08 |
2013-10-10 |
Glaxosmithkline Intellectual Property Development Limited |
Derivados de 2-[(2-{fenilamino}-1H-pirrolo[2,3-D]pirimidin-4-il)amino]benzamida como inhibidores de IGF-1R para el tratamiento del cáncer
|
|
WO2009032694A1
(en)
*
|
2007-08-28 |
2009-03-12 |
Dana Farber Cancer Institute |
Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis
|
|
MX2010002336A
(es)
|
2007-08-28 |
2010-03-25 |
Irm Llc |
Derivados de 2-bifenil-amino-4-amino-pirimidina como inhibidores de cinasa.
|
|
EP2234986A2
(en)
|
2007-12-20 |
2010-10-06 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
US20100317663A1
(en)
*
|
2008-02-19 |
2010-12-16 |
Jerry Leroy Adams |
Anilinopyridines as inhibitors of fak
|
|
KR101238585B1
(ko)
*
|
2008-04-07 |
2013-02-28 |
노파르티스 아게 |
단백질 키나제 억제제로서의 화합물 및 조성물
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
CA2728893C
(en)
|
2008-04-16 |
2017-03-14 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk protein kinase
|
|
MX2010011463A
(es)
|
2008-04-16 |
2011-06-03 |
Portola Pharm Inc |
2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
|
|
JP2011518219A
(ja)
|
2008-04-22 |
2011-06-23 |
ポートラ ファーマシューティカルズ， インコーポレイテッド |
タンパク質キナーゼの阻害剤
|
|
MX2010012703A
(es)
|
2008-05-21 |
2010-12-21 |
Ariad Pharma Inc |
Derivados fosforosos como inhibidores de cinasa.
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
CN102124000B
(zh)
*
|
2008-06-17 |
2014-09-17 |
阿斯利康(瑞典)有限公司 |
吡啶化合物
|
|
US8445505B2
(en)
|
2008-06-25 |
2013-05-21 |
Irm Llc |
Pyrimidine derivatives as kinase inhibitors
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
SG10201510696RA
(en)
|
2008-06-27 |
2016-01-28 |
Celgene Avilomics Res Inc |
Heteroaryl compounds and uses thereof
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
JO3067B1
(ar)
*
|
2008-10-27 |
2017-03-15 |
Glaxosmithkline Llc |
بيرميدينات بيرازولو امينو كمثبطات ل fak
|
|
AR074209A1
(es)
|
2008-11-24 |
2010-12-29 |
Boehringer Ingelheim Int |
Derivados de pirimidina utiles para el tratamiento del cancer
|
|
TWI491605B
(zh)
|
2008-11-24 |
2015-07-11 |
Boehringer Ingelheim Int |
新穎化合物
|
|
WO2010071885A1
(en)
|
2008-12-19 |
2010-06-24 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
|
EP2565193B1
(en)
|
2009-01-23 |
2014-03-19 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
WO2010112210A1
(en)
|
2009-04-03 |
2010-10-07 |
Cellzome Ag |
Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
|
|
EP2419423A1
(en)
|
2009-04-14 |
2012-02-22 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
JP5918693B2
(ja)
|
2009-05-05 |
2016-05-18 |
ダナ ファーバー キャンサー インスティテュート インコーポレイテッド |
Ｅｇｆｒ阻害剤及び疾患の治療方法
|
|
TW201100441A
(en)
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
US20120142667A1
(en)
*
|
2009-06-10 |
2012-06-07 |
Nigel Ramsden |
Pyrimidine derivatives as zap-70 inhibitors
|
|
CA2764983A1
(en)
*
|
2009-06-10 |
2010-12-16 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
WO2010144909A1
(en)
|
2009-06-12 |
2010-12-16 |
Novartis Ag |
Fused heterocyclic compounds and their uses
|
|
EP2443095A1
(en)
*
|
2009-06-18 |
2012-04-25 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
US20120172384A1
(en)
*
|
2009-06-18 |
2012-07-05 |
Mihiro Sunose |
Heterocyclylaminopyrimidines as kinase inhibitors
|
|
CA2771675A1
(en)
*
|
2009-09-11 |
2011-03-17 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
|
US20130137709A1
(en)
*
|
2010-05-05 |
2013-05-30 |
Nathanael S. Gray |
Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith
|
|
CN103003264B
(zh)
|
2010-05-21 |
2014-08-06 |
切米利亚股份公司 |
嘧啶衍生物
|
|
WO2012019132A2
(en)
|
2010-08-06 |
2012-02-09 |
Cell Signaling Technology, Inc. |
Anaplastic lymphoma kinase in kidney cancer
|
|
MY160734A
(en)
|
2010-08-10 |
2017-03-15 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
SG188548A1
(en)
|
2010-09-22 |
2013-04-30 |
Arena Pharm Inc |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20130317029A1
(en)
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
NZ710636A
(en)
|
2010-11-01 |
2017-02-24 |
Celgene Avilomics Res Inc |
Heterocyclic compounds and uses thereof
|
|
WO2012061428A2
(en)
|
2010-11-01 |
2012-05-10 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
WO2012061303A1
(en)
|
2010-11-01 |
2012-05-10 |
Avila Therapeutics, Inc. |
Heteroaryl compounds and uses thereof
|
|
AU2011323484B2
(en)
|
2010-11-01 |
2016-10-06 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as Syk modulators
|
|
WO2012060847A1
(en)
|
2010-11-07 |
2012-05-10 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
WO2012064706A1
(en)
|
2010-11-10 |
2012-05-18 |
Avila Therapeutics, Inc. |
Mutant-selective egfr inhibitors and uses thereof
|
|
JP6000273B2
(ja)
|
2010-11-29 |
2016-09-28 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
大環状キナーゼ阻害剤
|
|
BR112013015000A2
(pt)
*
|
2010-12-17 |
2016-08-09 |
Novartis Ag |
formas cristalinas de 5-cloron2-(2-isopropóxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidina-2,4-diamina
|
|
US8546443B2
(en)
|
2010-12-21 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Benzylic oxindole pyrimidines
|
|
JP2012153674A
(ja)
|
2011-01-28 |
2012-08-16 |
Astellas Pharma Inc |
ジ（アリールアミノ）アリール化合物の製造方法及びその合成中間体
|
|
BR112013019643B1
(pt)
*
|
2011-02-02 |
2022-04-19 |
Novartis Ag |
Uso de inibidores de álcali
|
|
EP2675794B1
(en)
|
2011-02-17 |
2019-02-13 |
Cancer Therapeutics Crc Pty Limited |
Selective fak inhibitors
|
|
DK2675793T3
(en)
|
2011-02-17 |
2018-11-12 |
Cancer Therapeutics Crc Pty Ltd |
FAK INHIBITORS
|
|
CA2830129C
(en)
|
2011-03-24 |
2016-07-19 |
Chemilia Ab |
Novel pyrimidine derivatives
|
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
|
AU2012245387C1
(en)
|
2011-04-22 |
2016-05-05 |
Signal Pharmaceuticals, Llc |
Substituted Diaminocarboxamide and Diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
BR112013027734A2
(pt)
|
2011-05-04 |
2017-08-08 |
Ariad Pharma Inc |
compostos para a inibição de proliferação celular em cânceres impulsionados pelo egfr, método e composição farmacêutica
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
CA2853498A1
(en)
|
2011-10-28 |
2013-05-02 |
Celgene Avilomics Research, Inc. |
Methods of treating a bruton's tyrosine kinase disease or disorder
|
|
CA2856291C
(en)
|
2011-11-17 |
2020-08-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
SG11201402570QA
(en)
|
2011-11-23 |
2014-06-27 |
Portola Pharm Inc |
Pyrazine kinase inhibitors
|
|
PL2822939T3
(pl)
|
2012-03-06 |
2016-08-31 |
Cephalon Inc |
Skondensowane bicykliczne pochodne 2,4-diaminopirymidyny jako podwójne inhibitory ALK i FAK
|
|
SMT201800571T1
(it)
|
2012-03-15 |
2019-01-11 |
Celgene Car Llc |
Sali di un inibitore di chinasi del recettore del fattore di crescita dell’epidermide
|
|
BR112014022789B1
(pt)
|
2012-03-15 |
2022-04-19 |
Celgene Car Llc |
Formas sólidas de um inibidor de quinase de receptor do fator de crescimento epidérmico, composição farmacêutica e usos do mesmo
|
|
AU2013204563B2
(en)
|
2012-05-05 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
KR101582852B1
(ko)
|
2012-05-24 |
2016-01-07 |
서울대학교 산학협력단 |
타우 단백질 매개 신경 퇴행성 질환 치료제
|
|
KR101446742B1
(ko)
*
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
WO2014058921A2
(en)
|
2012-10-08 |
2014-04-17 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
WO2014063054A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
|
|
HK1214831A1
(zh)
|
2012-11-05 |
2016-08-05 |
Foundation Medicine, Inc. |
新型融合分子及其应用
|
|
CN104854101B
(zh)
*
|
2012-11-06 |
2018-05-01 |
上海复尚慧创医药研究有限公司 |
Alk激酶抑制剂
|
|
CN103804299A
(zh)
*
|
2012-11-14 |
2014-05-21 |
韩冰 |
一类具有神经保护作用的化合物及其用途
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
US10980804B2
(en)
|
2013-01-18 |
2021-04-20 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
US9561228B2
(en)
|
2013-02-08 |
2017-02-07 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
EP2958592A1
(en)
|
2013-02-22 |
2015-12-30 |
F. Hoffmann-La Roche AG |
Methods of treating cancer and preventing drug resistance
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
HK1222848A1
(zh)
|
2013-05-29 |
2017-07-14 |
Cephalon, Inc. |
用作alk抑制剂的吡咯并三嗪
|
|
US20160129003A1
(en)
|
2013-06-18 |
2016-05-12 |
Novartis Ag |
Pharmaceutical Combinations
|
|
EP3019489A4
(en)
*
|
2013-07-11 |
2016-12-28 |
Betta Pharmaceuticals Co Ltd |
MODULATORS OF TYROSINE KINASE PROTEIN AND METHODS OF USE
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
WO2015038868A1
(en)
*
|
2013-09-13 |
2015-03-19 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivatives
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
AU2014337122B2
(en)
|
2013-10-18 |
2019-01-03 |
Dana-Farber Cancer Institute, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
|
US10047070B2
(en)
|
2013-10-18 |
2018-08-14 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
CN106232831B
(zh)
|
2013-11-06 |
2021-02-26 |
美国卫生和人力服务部 |
通过表达谱分析对淋巴瘤类型进行亚型分类的方法
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
WO2015164614A1
(en)
*
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
US10005760B2
(en)
|
2014-08-13 |
2018-06-26 |
Celgene Car Llc |
Forms and compositions of an ERK inhibitor
|
|
WO2016029002A2
(en)
*
|
2014-08-22 |
2016-02-25 |
Clovis Oncology, Inc. |
Growth factor receptor inhibitors
|
|
RS60737B1
(sr)
|
2014-10-21 |
2020-09-30 |
Ariad Pharma Inc |
Kristalni oblici 5-hloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina
|
|
WO2016100308A1
(en)
|
2014-12-16 |
2016-06-23 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-jun n-terminal kinase in skin
|
|
ES2877642T3
(es)
|
2014-12-16 |
2021-11-17 |
Signal Pharm Llc |
Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida
|
|
EP3236959B1
(en)
|
2014-12-23 |
2025-09-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
PL3242666T3
(pl)
|
2015-01-06 |
2025-02-17 |
Arena Pharmaceuticals, Inc. |
Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
|
|
US20180022710A1
(en)
|
2015-01-29 |
2018-01-25 |
Signal Pharmaceuticals, Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
AU2016243529B2
(en)
|
2015-03-27 |
2021-03-25 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
WO2016167511A2
(ko)
*
|
2015-04-14 |
2016-10-20 |
한국화학연구원 |
N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
HUE060476T2
(hu)
|
2015-06-22 |
2023-03-28 |
Arena Pharm Inc |
(R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
|
|
EP3795553B1
(en)
|
2015-07-24 |
2024-05-15 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|
|
EP4019515A1
(en)
|
2015-09-09 |
2022-06-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
CN106699743B
(zh)
*
|
2015-11-05 |
2020-06-12 |
湖北生物医药产业技术研究院有限公司 |
嘧啶类衍生物及其用途
|
|
CN106883213B
(zh)
*
|
2015-12-15 |
2021-04-20 |
合肥中科普瑞昇生物医药科技有限公司 |
一种egfr和alk激酶的双重抑制剂
|
|
US10710993B2
(en)
*
|
2016-06-27 |
2020-07-14 |
Hangzhou REX Pharmaceutical Co., LTD. |
Benzofuran pyrazole amine kinase inhibitor
|
|
NZ751713A
(en)
|
2016-08-29 |
2022-07-01 |
Univ Michigan Regents |
Aminopyrimidines as alk inhibitors
|
|
KR101876514B1
(ko)
*
|
2016-11-08 |
2018-07-10 |
한국화학연구원 |
신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물
|
|
WO2018151873A1
(en)
|
2017-02-16 |
2018-08-23 |
Arena Pharmaceuticals, Inc. |
Compounds and methods for treatment of primary biliary cholangitis
|
|
KR101923852B1
(ko)
|
2017-02-24 |
2018-11-29 |
재단법인 대구경북첨단의료산업진흥재단 |
혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
|
|
JOP20190281A1
(ar)
*
|
2017-06-13 |
2019-12-02 |
Korea Res Inst Chemical Tech |
مشتق n2، n4 ثنائي فينيل بيريميدين -2، 4- ثنائي أمين، وطريقة لتحضيره، وتركيبة صيدلانية تحتوي على المشتق بوصفه مكون فعال للوقاية من السرطان أو علاجه
|
|
WO2019051084A1
(en)
|
2017-09-07 |
2019-03-14 |
Revolution Medicines, Inc. |
SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER
|
|
KR101992621B1
(ko)
|
2017-12-07 |
2019-09-27 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
WO2019120094A1
(zh)
*
|
2017-12-21 |
2019-06-27 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制激酶活性的芳基磷氧化物
|
|
WO2019117813A1
(en)
*
|
2017-12-15 |
2019-06-20 |
National University Of Singapore |
Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
|
|
EP3773591A4
(en)
|
2018-04-05 |
2021-12-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
AXL KINASE INHIBITORS AND THEIR USE
|
|
US12156866B2
(en)
|
2018-06-06 |
2024-12-03 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
JP7590185B2
(ja)
|
2018-06-25 |
2024-11-26 |
ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド |
Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用
|
|
WO2020076723A1
(en)
|
2018-10-08 |
2020-04-16 |
Revolution Medicines, Inc. |
Shp2 inhibitor compositions for use in treating cancer
|
|
CN112771032B
(zh)
*
|
2018-10-29 |
2023-01-03 |
江苏先声药业有限公司 |
作为第四代egfr抑制剂的嘧啶吡唑类化合物
|
|
WO2020097400A1
(en)
|
2018-11-07 |
2020-05-14 |
Dana-Farber Cancer Institute, Inc. |
Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
|
|
US12415816B2
(en)
|
2018-11-07 |
2025-09-16 |
Dana-Farber Cancer Institute, Inc. |
Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
US12522583B2
(en)
|
2018-11-07 |
2026-01-13 |
Dana-Farber Cancer Institute, Inc. |
Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof
|
|
AU2019413694B2
(en)
|
2018-12-28 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
WO2020147702A1
(en)
*
|
2019-01-17 |
2020-07-23 |
Betta Pharmaceuticals Co., Ltd |
Egfr inhibitors, compositions and methods thereof
|
|
CN113727758A
(zh)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
双环杂环基化合物及其用途
|
|
US12187722B2
(en)
*
|
2019-03-15 |
2025-01-07 |
The General Hospital Corporation |
Small molecule inhibitors of TEAD transcription factors
|
|
BR112021018168B1
(pt)
|
2019-03-21 |
2023-11-28 |
Onxeo |
Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
|
|
CN114302878A
(zh)
|
2019-07-03 |
2022-04-08 |
大日本住友制药肿瘤公司 |
酪氨酸激酶非受体1(tnk1)抑制剂及其用途
|
|
KR102168179B1
(ko)
*
|
2019-10-31 |
2020-10-20 |
주식회사 온코빅스 |
암세포 성장 억제 효과를 나타내는 신규한 헤테로 고리 치환 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
|
|
KR20220109407A
(ko)
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
Ras 억제제
|
|
EP4054719B1
(en)
|
2019-11-04 |
2026-02-11 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
JP7823816B2
(ja)
|
2019-11-04 |
2026-03-04 |
レヴォリューション・メディスンズ，インコーポレイテッド |
Ｒａｓ阻害剤
|
|
CA3159348A1
(en)
|
2019-11-08 |
2021-05-14 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
|
BR112022008858A2
(pt)
|
2019-11-08 |
2022-09-06 |
Revolution Medicines Inc |
Composto, composição farmacêutica e métodos para inibir sos1 em um sujeito, para inibir a interação de sos1 e uma proteína, para tratar ou prevenir uma doença e para tratar ou prevenir câncer
|
|
JP7390487B2
(ja)
*
|
2019-12-03 |
2023-12-01 |
サムジン ファーマシューティカル カンパニー，リミテッド |
焦点接着キナーゼ阻害剤としての新規なアダマンタン誘導体
|
|
CN114929279A
(zh)
|
2020-01-07 |
2022-08-19 |
锐新医药公司 |
Shp2抑制剂给药和治疗癌症的方法
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
CA3169286A1
(en)
*
|
2020-02-25 |
2021-09-02 |
Dana-Farber Cancer Institute, Inc. |
Potent and selective degraders of alk
|
|
CA3183032A1
(en)
|
2020-06-18 |
2021-12-23 |
Mallika Singh |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
|
MX2023002248A
(es)
|
2020-09-03 |
2023-05-16 |
Revolution Medicines Inc |
Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
|
|
CR20230165A
(es)
|
2020-09-15 |
2023-06-02 |
Revolution Medicines Inc |
Derivados indólicos como inhibidores de ras en el tratamiento del cáncer
|
|
CN117396472A
(zh)
|
2020-12-22 |
2024-01-12 |
上海齐鲁锐格医药研发有限公司 |
Sos1抑制剂及其用途
|
|
JP2024502175A
(ja)
*
|
2021-01-07 |
2024-01-17 |
オンタリオ・インスティテュート・フォー・キャンサー・リサーチ（オーアイシーアール） |
Ｎｕａｋキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用
|
|
JP7737117B2
(ja)
*
|
2021-04-01 |
2025-09-10 |
セラペックス カンパニー リミテッド |
タンパク質キナーゼに対する阻害活性を有するピリミジン誘導体及びそれを含む治療用医薬組成物
|
|
WO2022208454A1
(en)
*
|
2021-04-02 |
2022-10-06 |
Bridge Biotherapeutics, Inc. |
N2-phenylpyrimidine-2,4-diamine compounds, and preparation methods and methods of use thereof
|
|
WO2022214681A1
(en)
|
2021-04-09 |
2022-10-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
|
CR20230558A
(es)
|
2021-05-05 |
2024-01-24 |
Revolution Medicines Inc |
Inhibidores de ras para el tratamiento del cáncer
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
IL308193A
(en)
|
2021-05-05 |
2024-01-01 |
Revolution Medicines Inc |
RAS inhibitors
|
|
WO2022272309A1
(en)
|
2021-06-25 |
2022-12-29 |
Foundation Medicine, Inc. |
Methods of using somatic hla-i loh to predict response of immune checkpoint inhibitor-treated patients with lung cancer
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023107705A1
(en)
|
2021-12-10 |
2023-06-15 |
Incyte Corporation |
Bicyclic amines as cdk12 inhibitors
|
|
JP2025500878A
(ja)
|
2021-12-17 |
2025-01-15 |
ジェンザイム・コーポレーション |
Ｓｈｐ２阻害剤としてのピラゾロピラジン化合物
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
CN119136806A
(zh)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
用于治疗免疫难治性肺癌的方法
|
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
KR102929746B1
(ko)
|
2023-03-23 |
2026-02-26 |
청주대학교 산학협력단 |
콘크리트 양생용 광발열 단열시트 및 콘크리트 구조물의 조기 시공 방법
|
|
AU2024241633A1
(en)
|
2023-03-30 |
2025-11-06 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
|
CN121100123A
(zh)
|
2023-04-14 |
2025-12-09 |
锐新医药公司 |
Ras抑制剂的结晶形式
|
|
TW202448897A
(zh)
|
2023-04-14 |
2024-12-16 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑之結晶形式、含有其之組合物及其使用方法
|
|
WO2024229406A1
(en)
|
2023-05-04 |
2024-11-07 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
CN121335887A
(zh)
*
|
2023-06-08 |
2026-01-13 |
希格生科（深圳）有限公司 |
含氮芳环化合物及其医药用途
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
TW202530228A
(zh)
|
2023-10-12 |
2025-08-01 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
TW202542151A
(zh)
|
2023-12-22 |
2025-11-01 |
美商銳格醫藥有限公司 |
Ｓｏｓ１抑制劑及其用途
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
TW202547461A
(zh)
|
2024-05-17 |
2025-12-16 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
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