|
JO3474B1
(ar)
|
2014-08-29 |
2020-07-05 |
Amgen Inc |
مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
|
|
US11306107B2
(en)
|
2016-02-25 |
2022-04-19 |
Amgen Inc. |
Compounds that inhibit MCL-1 protein
|
|
WO2017197046A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
C3-carbon linked glutarimide degronimers for target protein degradation
|
|
WO2017197051A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Amine-linked c3-glutarimide degronimers for target protein degradation
|
|
EP3454862B1
(en)
|
2016-05-10 |
2024-09-11 |
C4 Therapeutics, Inc. |
Spirocyclic degronimers for target protein degradation
|
|
EP4491236A3
(en)
|
2016-05-10 |
2025-04-02 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
|
UY37342A
(es)
|
2016-07-22 |
2018-01-31 |
Servier Lab |
Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1, usos y composiciones farmacéuticas de éstos
|
|
JP6453507B2
(ja)
*
|
2017-03-30 |
2019-01-16 |
アムジエン・インコーポレーテツド |
Ｍｃｌ−１タンパク質を阻害する化合物
|
|
CN118440096A
(zh)
|
2017-06-20 |
2024-08-06 |
C4医药公司 |
用于蛋白降解的n/o-连接的降解决定子和降解决定子体
|
|
US20200239494A1
(en)
*
|
2017-08-15 |
2020-07-30 |
Abbvie Inc. |
Macrocyclic mcl-1 inhibitors and methods of use
|
|
PE20200837A1
(es)
*
|
2017-08-15 |
2020-08-13 |
Abbvie Inc |
Compuestos macrociclicos derivados de diazaciclononadeca [1,2,3-c/d] indenos inhibidores de la proteina de diferenciacion celular de leucemia mieloide inducida (mcl-1) y composiciones farmaceuticas que los comprenden
|
|
WO2019036575A1
(en)
|
2017-08-18 |
2019-02-21 |
Amgen Inc. |
MCL-1 PROTEIN INHIBITING COMPOUNDS
|
|
WO2019046150A1
(en)
|
2017-08-29 |
2019-03-07 |
Amgen Inc. |
MACROCYCLIC COMPOUNDS FOR INHIBITING MCL-1 PROTEIN
|
|
US11274105B2
(en)
|
2018-03-05 |
2022-03-15 |
Amgen Inc. |
Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
|
|
DK3793565T3
(en)
*
|
2018-05-14 |
2022-03-07 |
Gilead Sciences Inc |
Mcl-1-inhibitorer
|
|
MX2021005463A
(es)
*
|
2018-11-09 |
2021-06-18 |
Prelude Therapeutics Inc |
Derivados de espiro-sulfonamida como inhibidores de la proteina de leucemia de celula mieloide 1 (mcl-1).
|
|
CN120698983A
(zh)
|
2018-12-20 |
2025-09-26 |
C4医药公司 |
靶向蛋白降解
|
|
US11498928B2
(en)
|
2019-01-18 |
2022-11-15 |
Ascentage Pharma (Suzhou) Co., Ltd. |
Macrocyclic spiroethers as Mcl-1 inhibitors
|
|
BR112021023229A2
(pt)
|
2019-05-20 |
2022-05-31 |
Servier Lab |
Conjugados anticorpo-fármaco inibidores de mcl-1 e métodos de uso
|
|
EP3972695A1
(en)
|
2019-05-23 |
2022-03-30 |
Gilead Sciences, Inc. |
Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
|
|
ES2975083T3
(es)
*
|
2019-06-21 |
2024-07-03 |
Janssen Pharmaceutica Nv |
Inhibidores macrocíclicos de MCL-1
|
|
BR112021026376A2
(pt)
|
2019-06-25 |
2022-05-10 |
Gilead Sciences Inc |
Proteínas de fusão flt3l-fc e métodos de uso
|
|
BR112022000251A2
(pt)
|
2019-07-09 |
2022-05-17 |
Janssen Pharmaceutica Nv |
Derivados macrocíclicos de espirociclo como inibidores de mcl-1
|
|
EP3771469A1
(en)
*
|
2019-07-30 |
2021-02-03 |
Amgen, Inc |
Formulations and dosages for administering a compound that inhibits mcl1 protein
|
|
CN112479876B
(zh)
*
|
2019-09-12 |
2023-07-21 |
苏州亚盛药业有限公司 |
氧氮杂环庚烷类螺环化合物、中间体及其制备方法
|
|
PL4045083T3
(pl)
|
2019-10-18 |
2024-05-13 |
Forty Seven, Inc. |
Terapie skojarzone do leczenia zespołów mielodysplastycznych i ostrej białaczki szpikowej
|
|
CN114599392A
(zh)
|
2019-10-31 |
2022-06-07 |
四十七公司 |
基于抗cd47和抗cd20的血癌治疗
|
|
KR20250175006A
(ko)
|
2019-11-04 |
2025-12-15 |
레볼루션 메디슨즈, 인크. |
Ras 억제제
|
|
CA3159559A1
(en)
*
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
TWI778443B
(zh)
|
2019-11-12 |
2022-09-21 |
美商基利科學股份有限公司 |
Mcl1抑制劑
|
|
JP7441947B2
(ja)
*
|
2019-11-26 |
2024-03-01 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｍｃｌ１阻害剤を調製するためのプロセス及び中間体
|
|
US11845723B2
(en)
|
2019-12-24 |
2023-12-19 |
Gilead Sciences, Inc. |
Diacylglycerol kinase modulating compounds
|
|
CR20220396A
(es)
|
2020-02-14 |
2022-11-14 |
Jounce Therapeutics Inc |
Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos
|
|
AU2021222332A1
(en)
*
|
2020-02-21 |
2022-10-20 |
Janssen Pharmaceutica Nv |
Macrocyclic indole derivatives as inhibitors of MCL-1
|
|
JP2021161114A
(ja)
*
|
2020-03-31 |
2021-10-11 |
アムジエン・インコーポレーテツド |
Ｍｃｌ−１化合物のメチル化
|
|
WO2021211922A1
(en)
*
|
2020-04-16 |
2021-10-21 |
Prelude Therapeutics, Incorporated |
Spiro-sulfonimidamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein
|
|
EP4143194A1
(en)
|
2020-05-01 |
2023-03-08 |
Gilead Sciences, Inc. |
Cd73 inhibiting 2,4-dioxopyrimidine compounds
|
|
JP7785692B2
(ja)
*
|
2020-05-06 |
2025-12-15 |
アムジエン・インコーポレーテツド |
ビニル保護アルコール中間体の合成
|
|
US12441681B2
(en)
|
2020-05-06 |
2025-10-14 |
Amgen Inc. |
Synthesis of sulfonamide intermediates
|
|
TWI827924B
(zh)
*
|
2020-05-06 |
2024-01-01 |
美商安進公司 |
大環Mcl-1抑制劑中間體的閉環合成
|
|
WO2021225835A1
(en)
*
|
2020-05-06 |
2021-11-11 |
Amgen Inc. |
Synthesis of vinylic alcohol intermediates
|
|
TWI867217B
(zh)
|
2020-05-06 |
2024-12-21 |
美商安進公司 |
乙烯基環丁基中間體之合成
|
|
MX2022015813A
(es)
*
|
2020-06-10 |
2023-01-24 |
Janssen Pharmaceutica Nv |
2-amino-3-fluoro-but-3-enamidas macrociclicas como inhibidores de mcl-1.
|
|
CA3193132A1
(en)
|
2020-09-03 |
2022-03-10 |
Amgen Inc. |
Diol desymmetrization by nucleophilic aromatic substitution
|
|
IL301298A
(en)
|
2020-09-15 |
2023-05-01 |
Revolution Medicines Inc |
Indole derivatives as RAS inhibitors in cancer therapy
|
|
CN116457334A
(zh)
*
|
2020-11-19 |
2023-07-18 |
吉利德科学公司 |
用于制备大环mcl1抑制剂的方法和中间体
|
|
WO2022115451A1
(en)
|
2020-11-24 |
2022-06-02 |
Novartis Ag |
Mcl-1 inhibitor antibody-drug conjugates and methods of use
|
|
AU2021385537A1
(en)
*
|
2020-11-25 |
2023-06-22 |
Amgen Inc. |
Enantioselective alkenylation of aldehydes
|
|
WO2022122667A1
(en)
|
2020-12-07 |
2022-06-16 |
Cellestia Biotech Ag |
Pharmaceutical combinations for treating cancer
|
|
EP4008324A1
(en)
|
2020-12-07 |
2022-06-08 |
Cellestia Biotech AG |
Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
|
|
JP2023554070A
(ja)
|
2020-12-17 |
2023-12-26 |
ヤンセン ファーマシューティカ エヌ．ベー． |
Ｍｃｌ－１の阻害剤としての分岐３－フルオロ－ブタ－３－エナミド
|
|
TW202302145A
(zh)
|
2021-04-14 |
2023-01-16 |
美商基利科學股份有限公司 |
ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
|
|
WO2022229102A1
(en)
|
2021-04-26 |
2022-11-03 |
Janssen Pharmaceutica Nv |
Macrocyclic 2-allyltetrahydrofurans as inhibitors of mcl-1
|
|
CN117616031A
(zh)
|
2021-05-05 |
2024-02-27 |
锐新医药公司 |
用于治疗癌症的ras抑制剂
|
|
WO2022245671A1
(en)
|
2021-05-18 |
2022-11-24 |
Gilead Sciences, Inc. |
Methods of using flt3l-fc fusion proteins
|
|
WO2022261301A1
(en)
|
2021-06-11 |
2022-12-15 |
Gilead Sciences, Inc. |
Combination mcl-1 inhibitors with anti-cancer agents
|
|
JP7673255B2
(ja)
|
2021-06-11 |
2025-05-08 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｍｃｌ－１阻害剤と抗体薬物コンジュゲートとの組み合わせ
|
|
AU2022297367B2
(en)
|
2021-06-23 |
2025-04-10 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CA3222277A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CN117377671A
(zh)
|
2021-06-23 |
2024-01-09 |
吉利德科学公司 |
二酰基甘油激酶调节化合物
|
|
IL309378A
(en)
|
2021-06-23 |
2024-02-01 |
Gilead Sciences Inc |
Diacylglyercol kinase modulating compounds
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023076983A1
(en)
|
2021-10-28 |
2023-05-04 |
Gilead Sciences, Inc. |
Pyridizin-3(2h)-one derivatives
|
|
PE20241186A1
(es)
|
2021-10-29 |
2024-06-03 |
Gilead Sciences Inc |
Compuestos de cd73
|
|
AU2022391938A1
(en)
|
2021-11-16 |
2024-07-04 |
Janssen Pharmaceutica Nv |
Macrocyclic 2-amino-but-3-enamides as inhibitors of mcl-1
|
|
US20230220106A1
(en)
|
2021-12-08 |
2023-07-13 |
Dragonfly Therapeutics, Inc. |
Antibodies targeting 5t4 and uses thereof
|
|
US20230203202A1
(en)
|
2021-12-08 |
2023-06-29 |
Dragonfly Therapeutics, Inc. |
Proteins binding nkg2d, cd16 and 5t4
|
|
AU2022419982A1
(en)
|
2021-12-22 |
2024-06-06 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
JP2024545193A
(ja)
|
2021-12-22 |
2024-12-05 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用
|
|
TW202340168A
(zh)
|
2022-01-28 |
2023-10-16 |
美商基利科學股份有限公司 |
Ｐａｒｐ７抑制劑
|
|
EP4493554A1
(en)
|
2022-03-17 |
2025-01-22 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
EP4499146A1
(en)
|
2022-03-24 |
2025-02-05 |
Gilead Sciences, Inc. |
Combination therapy for treating trop-2 expressing cancers
|
|
US12351588B2
(en)
|
2022-04-05 |
2025-07-08 |
Amgen Inc. |
Salt forms and solvates of Mcl-1 antagonists
|
|
AU2023250874A1
(en)
|
2022-04-05 |
2024-10-10 |
Amgen Inc. |
Amorphous and crystalline forms of mci-1 antagonists
|
|
TWI876305B
(zh)
|
2022-04-05 |
2025-03-11 |
美商基利科學股份有限公司 |
用於治療結腸直腸癌之組合療法
|
|
AU2023256670A1
(en)
|
2022-04-21 |
2024-10-17 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
KR20250027285A
(ko)
|
2022-05-20 |
2025-02-25 |
노파르티스 아게 |
항신생물 화합물의 항체-약물 접합체 및 그의 사용 방법
|
|
WO2024006929A1
(en)
|
2022-07-01 |
2024-01-04 |
Gilead Sciences, Inc. |
Cd73 compounds
|
|
US20240091351A1
(en)
|
2022-09-21 |
2024-03-21 |
Gilead Sciences, Inc. |
FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
|
|
AU2023409398A1
(en)
|
2022-12-22 |
2025-06-05 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2024215754A1
(en)
|
2023-04-11 |
2024-10-17 |
Gilead Sciences, Inc. |
Kras modulating compounds
|
|
AU2024259556A1
(en)
|
2023-04-21 |
2025-10-23 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
US20250042922A1
(en)
|
2023-06-30 |
2025-02-06 |
Gilead Sciences, Inc. |
Kras modulating compounds
|
|
WO2025024663A1
(en)
|
2023-07-26 |
2025-01-30 |
Gilead Sciences, Inc. |
Parp7 inhibitors
|
|
TW202519517A
(zh)
|
2023-07-26 |
2025-05-16 |
美商基利科學股份有限公司 |
Ｐａｒｐ７抑制劑
|
|
EP4516807A1
(en)
|
2023-08-28 |
2025-03-05 |
Consorcio Centro de Investigación Biomédica en Red |
Compositions for use in a method of providing improved hematopoietic stem cell engraftment
|
|
US20250109147A1
(en)
|
2023-09-08 |
2025-04-03 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
WO2025054347A1
(en)
|
2023-09-08 |
2025-03-13 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
WO2025096589A1
(en)
|
2023-11-03 |
2025-05-08 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
TW202540186A
(zh)
|
2023-11-22 |
2025-10-16 |
瑞士商諾華公司 |
抗ｃｄ７抗體藥物結合物及其使用方法
|
|
WO2025111450A1
(en)
|
2023-11-22 |
2025-05-30 |
Les Laboratoires Servier |
Anti-cd74 antibody-drug conjugates and methods of use thereof
|
|
WO2025126157A1
(en)
|
2023-12-15 |
2025-06-19 |
Advesya |
Anti-il-1rap binding domains and antibody-drug conjugates thereof
|
|
WO2025137640A1
(en)
|
2023-12-22 |
2025-06-26 |
Gilead Sciences, Inc. |
Azaspiro wrn inhibitors
|
|
US20250376484A1
(en)
|
2024-05-21 |
2025-12-11 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|