JP2002517491A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002517491A5 JP2002517491A5 JP2000553419A JP2000553419A JP2002517491A5 JP 2002517491 A5 JP2002517491 A5 JP 2002517491A5 JP 2000553419 A JP2000553419 A JP 2000553419A JP 2000553419 A JP2000553419 A JP 2000553419A JP 2002517491 A5 JP2002517491 A5 JP 2002517491A5
- Authority
- JP
- Japan
- Prior art keywords
- acid group
- alkyl
- butyl
- ethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 description 10
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825804A DE19825804C2 (de) | 1998-06-10 | 1998-06-10 | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19825804.6 | 1998-06-10 | ||
| PCT/EP1999/003701 WO1999064410A1 (de) | 1998-06-10 | 1999-05-28 | BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002517491A JP2002517491A (ja) | 2002-06-18 |
| JP2002517491A5 true JP2002517491A5 (enExample) | 2006-06-29 |
| JP4374426B2 JP4374426B2 (ja) | 2009-12-02 |
Family
ID=7870440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553419A Expired - Fee Related JP4374426B2 (ja) | 1998-06-10 | 1999-05-28 | ベンゾ（ｂ）チエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
| JP2000553418A Expired - Lifetime JP3374129B2 (ja) | 1998-06-10 | 1999-05-29 | ベンゾチエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553418A Expired - Lifetime JP3374129B2 (ja) | 1998-06-10 | 1999-05-29 | ベンゾチエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6387944B1 (enExample) |
| EP (2) | EP1086092B1 (enExample) |
| JP (2) | JP4374426B2 (enExample) |
| KR (2) | KR100681721B1 (enExample) |
| CN (2) | CN1127497C (enExample) |
| AR (2) | AR018633A1 (enExample) |
| AT (2) | ATE227715T1 (enExample) |
| AU (2) | AU753275B2 (enExample) |
| BR (2) | BR9912188B1 (enExample) |
| CA (2) | CA2334775C (enExample) |
| CZ (2) | CZ297989B6 (enExample) |
| DE (3) | DE19825804C2 (enExample) |
| DK (2) | DK1086092T3 (enExample) |
| ES (2) | ES2182535T3 (enExample) |
| HU (2) | HU229761B1 (enExample) |
| ID (2) | ID28695A (enExample) |
| IL (1) | IL140078A (enExample) |
| NO (1) | NO327075B1 (enExample) |
| NZ (1) | NZ508681A (enExample) |
| PL (2) | PL196074B1 (enExample) |
| PT (2) | PT1086092E (enExample) |
| RU (2) | RU2215001C2 (enExample) |
| TR (2) | TR200003634T2 (enExample) |
| WO (2) | WO1999064410A1 (enExample) |
| ZA (2) | ZA200007061B (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| ATE242007T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| CN1217927C (zh) * | 2000-12-21 | 2005-09-07 | 阿文蒂斯药物德国有限公司 | 新的1,2－二苯基氮杂环丁烷酮、其制备方法、含有所述化合物的药物及其在治疗脂质代谢病症中的应用 |
| DE10064402A1 (de) * | 2000-12-21 | 2002-06-27 | Aventis Pharma Gmbh | Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP1425018B1 (de) * | 2001-08-22 | 2008-10-22 | Sanofi-Aventis Deutschland GmbH | Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MXPA04002179A (es) | 2001-09-08 | 2004-06-29 | Astrazeneca Ab | Derivados de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte del acido ileal biliar (ibat) para tratar hiperlipidemia. |
| WO2003061604A2 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| FR2848452B1 (fr) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
| US20040138145A1 (en) * | 2002-12-12 | 2004-07-15 | Aventis Pharma S.A. | Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| DE102006053636B4 (de) * | 2006-11-14 | 2008-09-18 | Sanofi-Aventis Deutschland Gmbh | Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung |
| DE102006053635B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US20100221513A1 (en) * | 2008-09-05 | 2010-09-02 | Wisconsin Alumni Research Foundation | Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications |
| US20110294767A1 (en) | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| EP3400944B1 (en) | 2010-11-04 | 2020-07-15 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| AU2011326872C1 (en) | 2010-11-08 | 2015-02-19 | Albireo Ab | A pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder |
| AU2012328453B2 (en) | 2011-10-28 | 2017-05-04 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| ES2633766T3 (es) * | 2011-10-28 | 2017-09-25 | Lumena Pharmaceuticals Llc | Inhibidores de reciclaje de ácido biliar para el tratamiento de enfermedades de hígado colestático pediátrico |
| KR20230152818A (ko) | 2013-03-15 | 2023-11-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
| JP2016514678A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | バレット食道と胃食道逆流性疾患を処置するための胆汁酸再利用阻害剤 |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Ｅａファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3011619C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| RU2750944C2 (ru) | 2016-02-09 | 2021-07-06 | Альбирео Аб | Пероральный состав холестирамина и его применение |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| JP7328207B2 (ja) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用 |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| SG11202012170PA (en) | 2018-06-20 | 2021-01-28 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| EP3921028B1 (en) | 2019-02-06 | 2022-11-09 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| EP3921027B1 (en) | 2019-02-06 | 2023-07-19 | Albireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| ES2982943T3 (es) | 2019-02-12 | 2024-10-21 | Mirum Pharmaceuticals Inc | Métodos para aumentar el crecimiento en sujetos pediátricos con hepatopatía colestásica |
| TWI865673B (zh) | 2019-12-04 | 2024-12-11 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| JP7696898B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AR120682A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
| EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| TWI871392B (zh) | 2019-12-04 | 2025-02-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| PE20230234A1 (es) | 2019-12-04 | 2023-02-07 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP7748451B2 (ja) | 2020-08-03 | 2025-10-02 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| EP4243831A1 (en) | 2020-11-12 | 2023-09-20 | Albireo AB | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| CA3259103A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia (di)azepine compounds and their use as bile acid modulators |
| EP4629997A1 (en) | 2022-12-09 | 2025-10-15 | Albireo AB | Asbt inhibitors in the treatment of renal diseases |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE199718T1 (de) * | 1994-09-13 | 2001-03-15 | Monsanto Co | Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate- aufnahme |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| RU2202549C2 (ru) * | 1996-03-11 | 2003-04-20 | Джи. Ди. Сирл Энд Ко. | Бензотиепины, фармацевтическая композиция на их основе, способ профилактики или лечения гиперлипидемического состояния |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| AU5301599A (en) * | 1998-08-20 | 2000-03-14 | Takeda Chemical Industries Ltd. | Quaternary ammonium salts and their use |
-
1998
- 1998-06-10 DE DE19825804A patent/DE19825804C2/de not_active Expired - Lifetime
-
1999
- 1999-05-28 AT AT99927784T patent/ATE227715T1/de active
- 1999-05-28 BR BRPI9912188-3A patent/BR9912188B1/pt not_active IP Right Cessation
- 1999-05-28 PT PT99927784T patent/PT1086092E/pt unknown
- 1999-05-28 DE DE59903411T patent/DE59903411D1/de not_active Expired - Lifetime
- 1999-05-28 CA CA002334775A patent/CA2334775C/en not_active Expired - Fee Related
- 1999-05-28 JP JP2000553419A patent/JP4374426B2/ja not_active Expired - Fee Related
- 1999-05-28 RU RU2001101491/04A patent/RU2215001C2/ru not_active IP Right Cessation
- 1999-05-28 EP EP99927784A patent/EP1086092B1/de not_active Expired - Lifetime
- 1999-05-28 ES ES99927784T patent/ES2182535T3/es not_active Expired - Lifetime
- 1999-05-28 ID IDW20002562A patent/ID28695A/id unknown
- 1999-05-28 PL PL344827A patent/PL196074B1/pl unknown
- 1999-05-28 AU AU45019/99A patent/AU753275B2/en not_active Ceased
- 1999-05-28 US US09/719,047 patent/US6387944B1/en not_active Expired - Lifetime
- 1999-05-28 KR KR1020007013964A patent/KR100681721B1/ko not_active Expired - Fee Related
- 1999-05-28 HU HU0102256 patent/HU229761B1/hu not_active IP Right Cessation
- 1999-05-28 DK DK99927784T patent/DK1086092T3/da active
- 1999-05-28 TR TR2000/03634T patent/TR200003634T2/xx unknown
- 1999-05-28 WO PCT/EP1999/003701 patent/WO1999064410A1/de not_active Ceased
- 1999-05-28 CN CN99807171A patent/CN1127497C/zh not_active Expired - Fee Related
- 1999-05-28 CZ CZ20004592A patent/CZ297989B6/cs not_active IP Right Cessation
- 1999-05-29 NZ NZ508681A patent/NZ508681A/en not_active IP Right Cessation
- 1999-05-29 EP EP99927802A patent/EP1086113B1/de not_active Expired - Lifetime
- 1999-05-29 KR KR1020007013931A patent/KR100562184B1/ko not_active Expired - Lifetime
- 1999-05-29 CN CNB998071722A patent/CN1152039C/zh not_active Expired - Lifetime
- 1999-05-29 ID IDW20002564A patent/ID26876A/id unknown
- 1999-05-29 HU HU0102554A patent/HU228570B1/hu unknown
- 1999-05-29 WO PCT/EP1999/003743 patent/WO1999064409A2/de not_active Ceased
- 1999-05-29 PL PL99345901A patent/PL196057B1/pl unknown
- 1999-05-29 CA CA002334773A patent/CA2334773C/en not_active Expired - Lifetime
- 1999-05-29 BR BRPI9911123-3A patent/BR9911123B1/pt not_active IP Right Cessation
- 1999-05-29 PT PT99927802T patent/PT1086113E/pt unknown
- 1999-05-29 DK DK99927802T patent/DK1086113T3/da active
- 1999-05-29 JP JP2000553418A patent/JP3374129B2/ja not_active Expired - Lifetime
- 1999-05-29 AU AU45031/99A patent/AU752633B2/en not_active Expired
- 1999-05-29 IL IL14007899A patent/IL140078A/en not_active IP Right Cessation
- 1999-05-29 TR TR2000/03632T patent/TR200003632T2/xx unknown
- 1999-05-29 AT AT99927802T patent/ATE259372T1/de active
- 1999-05-29 RU RU2001101499/04A patent/RU2220141C2/ru active
- 1999-05-29 ES ES99927802T patent/ES2215387T3/es not_active Expired - Lifetime
- 1999-05-29 DE DE59908522T patent/DE59908522D1/de not_active Expired - Lifetime
- 1999-05-29 CZ CZ20004591A patent/CZ297925B6/cs not_active IP Right Cessation
- 1999-06-08 AR ARP990102715A patent/AR018633A1/es active IP Right Grant
- 1999-06-08 AR ARP990102716A patent/AR018634A1/es active IP Right Grant
-
2000
- 2000-11-30 ZA ZA200007061A patent/ZA200007061B/en unknown
- 2000-11-30 ZA ZA200007060A patent/ZA200007060B/xx unknown
- 2000-12-08 NO NO20006251A patent/NO327075B1/no not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002517491A5 (enExample) | ||
| BR0008979A (pt) | Composto quìmico, uso de um composto, método de tratamento, processo de preparação de um composto, composição farmacêutica e método de fabricação da mesma | |
| JP2004533444A5 (enExample) | ||
| JP2002501049A5 (enExample) | ||
| JP2002525286A5 (enExample) | ||
| CA2284732A1 (en) | Analogs of cocaine | |
| GEP20094723B (en) | Tetraazabenzo [e] azulene derivatives and analogs thereof | |
| JP2003535094A5 (enExample) | ||
| ATE300941T1 (de) | Pharmazeutische formulierung enthaltend tolterodin sowie ihre verwendung | |
| CA2430692A1 (en) | Geldanamycin derivative and use of same to treat cancer | |
| AU2003225617A1 (en) | Thiadiazolylpiperazine derivatives useful for treating or preventing pain | |
| EP1862458A3 (en) | Therapeutic agents useful for treating pain | |
| JPH11193282A5 (enExample) | ||
| JP2002527414A5 (enExample) | ||
| EP1184034A3 (en) | Oral drug composition containing a verapamil derivative as a drug-absorption promotor | |
| CA2530308A1 (en) | 5ht2c receptor agonists for the treatment of diabetes and obesity | |
| JP2002521468A5 (enExample) | ||
| JP2002522501A5 (enExample) | ||
| JP2002506864A5 (enExample) | ||
| RU2003134629A (ru) | Соединения цефема | |
| WO1999033450A3 (en) | Pharmaceutical composition containing sibutramine and orlistat | |
| EP1857442A3 (en) | Novel antimycobacterial compounds | |
| JP2003520208A5 (enExample) | ||
| CA2438509A1 (en) | Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria | |
| RU96103685A (ru) | 1,2,5-тиадиазольные производные индолилалкил-пиридинил- и пиримидинил-пиперазинов, способ лечения или предотвращения развития сосудистой головной боли и фармацевтическая композиция |