ID26876A - Derivat-derivat benzotiepin 1,1-dioksida, proses pembuatannya, bahan-bahan farmasi yang terdiri dari senyawa-senyawa ini dan penggunaannya - Google Patents

Derivat-derivat benzotiepin 1,1-dioksida, proses pembuatannya, bahan-bahan farmasi yang terdiri dari senyawa-senyawa ini dan penggunaannya

Info

Publication number
ID26876A
ID26876A IDW20002564A ID20002564A ID26876A ID 26876 A ID26876 A ID 26876A ID W20002564 A IDW20002564 A ID W20002564A ID 20002564 A ID20002564 A ID 20002564A ID 26876 A ID26876 A ID 26876A
Authority
ID
Indonesia
Prior art keywords
benzotiepin
derivates
dioxide
compounds
making
Prior art date
Application number
IDW20002564A
Other languages
English (en)
Inventor
Wendelin Dr Frick
Alfons Dr Enhsen
Heiner Dr Glombik
Hubert Dr Heuer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of ID26876A publication Critical patent/ID26876A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
IDW20002564A 1998-06-10 1999-05-29 Derivat-derivat benzotiepin 1,1-dioksida, proses pembuatannya, bahan-bahan farmasi yang terdiri dari senyawa-senyawa ini dan penggunaannya ID26876A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ID26876A true ID26876A (id) 2001-02-15

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
IDW20002562A ID28695A (id) 1998-06-10 1999-05-28 TURUNAN-TURUNAN BENZO (b) TIEPIN 1,1-DIOKSIDA, PROSES PENYIAPAN, SEDIAAN FARMASI YANG MENGANDUNG SENYAWA-SENYAWA INI, DAN PENGGUNAANNYA
IDW20002564A ID26876A (id) 1998-06-10 1999-05-29 Derivat-derivat benzotiepin 1,1-dioksida, proses pembuatannya, bahan-bahan farmasi yang terdiri dari senyawa-senyawa ini dan penggunaannya

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IDW20002562A ID28695A (id) 1998-06-10 1999-05-28 TURUNAN-TURUNAN BENZO (b) TIEPIN 1,1-DIOKSIDA, PROSES PENYIAPAN, SEDIAAN FARMASI YANG MENGANDUNG SENYAWA-SENYAWA INI, DAN PENGGUNAANNYA

Country Status (26)

Country Link
US (1) US6387944B1 (id)
EP (2) EP1086092B1 (id)
JP (2) JP4374426B2 (id)
KR (2) KR100681721B1 (id)
CN (2) CN1127497C (id)
AR (2) AR018633A1 (id)
AT (2) ATE227715T1 (id)
AU (2) AU753275B2 (id)
BR (2) BR9912188B1 (id)
CA (2) CA2334775C (id)
CZ (2) CZ297989B6 (id)
DE (3) DE19825804C2 (id)
DK (2) DK1086092T3 (id)
ES (2) ES2182535T3 (id)
HK (2) HK1036799A1 (id)
HU (2) HU229761B1 (id)
ID (2) ID28695A (id)
IL (1) IL140078A (id)
NO (1) NO327075B1 (id)
NZ (1) NZ508681A (id)
PL (2) PL196074B1 (id)
PT (2) PT1086092E (id)
RU (2) RU2215001C2 (id)
TR (2) TR200003634T2 (id)
WO (2) WO1999064410A1 (id)
ZA (2) ZA200007061B (id)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
HUP0401081A3 (en) * 2000-12-21 2010-06-28 Sanofi Aventis Deutschland Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and their use
OA12654A (en) * 2001-08-22 2006-06-15 Aventis Pharma Gmbh Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances,and the use thereof.
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
JP3616635B2 (ja) 2001-09-08 2005-02-02 アストラゼネカ アクチボラグ 高脂質血症の治療のための回腸胆汁酸運搬（ｉｂａｔ）阻害活性を持つベンゾチアゼピン及びベンゾチアジアゼピン誘導体
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
SE0201937D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
US20040138145A1 (en) * 2002-12-12 2004-07-15 Aventis Pharma S.A. Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
DE102006053636B4 (de) * 2006-11-14 2008-09-18 Sanofi-Aventis Deutschland Gmbh Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
DE102006053635B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US20100221513A1 (en) * 2008-09-05 2010-09-02 Wisconsin Alumni Research Foundation Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
SG190433A1 (en) 2010-11-08 2013-06-28 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
EP2637668B1 (en) 2010-11-08 2016-05-11 Albireo AB Ibat inhibitors for the treatment of liver diseases
EP2770990A4 (en) 2011-10-28 2015-03-11 Lumena Pharmaceuticals Inc Gallic acid refluxing agent for the treatment of hypertension and chronic liver disease
EP2771003B1 (en) 2011-10-28 2017-04-19 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
WO2014144485A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
JP6751020B2 (ja) 2014-06-25 2020-09-02 Ｅａファーマ株式会社 固形製剤及びその着色防止又は着色低減方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
RU2750937C2 (ru) 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
CA3011565C (en) 2016-02-09 2024-01-02 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
WO2019032026A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
WO2019032027A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CA3100113A1 (en) 2018-06-05 2019-12-12 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
KR20210024033A (ko) 2018-06-20 2021-03-04 알비레오 에이비 오데빅시바트의 약학 제제
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
LT3921028T (lt) 2019-02-06 2023-02-10 Albireo Ab Benzotiadiazepino junginiai ir jų naudojimas kaip tulžies rūgšties moduliatorių
TWI835997B (zh) 2019-02-06 2024-03-21 瑞典商艾爾比瑞歐公司 苯并噻氮呯化合物及其用作膽酸調節劑之用途
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
BR112021015815A2 (pt) 2019-02-12 2022-01-18 Mirum Pharmaceuticals Inc Métodos para tratar colestase
AR120674A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzotiazepina y su uso como ácido biliar
TW202134220A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
TW202134222A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途
WO2021110885A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158184A1 (en) 2019-12-04 2021-08-10 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
ES2973355T3 (es) 2019-12-04 2024-06-19 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
ES2973549T3 (es) 2019-12-04 2024-06-20 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares
JP2023504647A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
TW202134223A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CN116157389A (zh) 2020-08-03 2023-05-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
KR20230106651A (ko) 2020-11-12 2023-07-13 알비레오 에이비 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트
BR112023010799A2 (pt) 2020-12-04 2023-10-03 Albireo Ab Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2023237728A1 (en) 2022-06-09 2023-12-14 Albireo Ab Treating hepatitis
US20240067617A1 (en) 2022-07-05 2024-02-29 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US20240207286A1 (en) 2022-12-09 2024-06-27 Albireo Ab Asbt inhibitors in the treatment of renal diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0781278T3 (da) * 1994-09-13 2001-04-17 Monsanto Co Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
WO1997033882A1 (en) * 1996-03-11 1997-09-18 G.D. Searle And Co. Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
JP2000128842A (ja) * 1998-08-20 2000-05-09 Takeda Chem Ind Ltd ４級アンモニウム塩誘導体およびその用途

Also Published As

Publication number Publication date
EP1086092B1 (de) 2002-11-13
HUP0102554A3 (en) 2002-12-28
CA2334775C (en) 2009-10-13
HU228570B1 (en) 2013-04-29
BR9911123A (pt) 2006-01-03
CZ297989B6 (cs) 2007-05-16
EP1086113B1 (de) 2004-02-11
ID28695A (id) 2001-06-28
ZA200007061B (en) 2001-07-18
CA2334773A1 (en) 1999-12-16
NO20006251D0 (no) 2000-12-08
IL140078A0 (en) 2002-02-10
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
PL196074B1 (pl) 2007-12-31
KR100681721B1 (ko) 2007-02-15
IL140078A (en) 2004-08-31
KR20010052701A (ko) 2001-06-25
KR20010052682A (ko) 2001-06-25
ZA200007060B (en) 2001-07-18
CN1152039C (zh) 2004-06-02
CA2334775A1 (en) 1999-12-16
JP2002517490A (ja) 2002-06-18
AR018633A1 (es) 2001-11-28
WO1999064409A3 (de) 2000-03-02
NO20006251L (no) 2001-02-07
JP3374129B2 (ja) 2003-02-04
CA2334773C (en) 2009-05-26
PT1086113E (pt) 2004-06-30
BR9911123B1 (pt) 2010-12-14
DE59903411D1 (de) 2002-12-19
HK1036799A1 (en) 2002-01-18
DK1086113T3 (da) 2004-05-24
ES2215387T3 (es) 2004-10-01
HUP0102256A3 (en) 2002-04-29
EP1086113A2 (de) 2001-03-28
DE59908522D1 (de) 2004-03-18
CZ20004592A3 (cs) 2001-04-11
RU2215001C2 (ru) 2003-10-27
AU4501999A (en) 1999-12-30
JP2002517491A (ja) 2002-06-18
BR9912188B1 (pt) 2010-12-14
WO1999064409A2 (de) 1999-12-16
CN1127497C (zh) 2003-11-12
JP4374426B2 (ja) 2009-12-02
TR200003634T2 (tr) 2001-06-21
PT1086092E (pt) 2003-03-31
PL344827A1 (en) 2001-11-19
HU229761B1 (hu) 2014-06-30
TR200003632T2 (tr) 2001-04-20
DK1086092T3 (da) 2003-03-10
AR018634A1 (es) 2001-11-28
EP1086092A1 (de) 2001-03-28
HK1039490A1 (en) 2002-04-26
US6387944B1 (en) 2002-05-14
NZ508681A (en) 2002-06-28
CN1305487A (zh) 2001-07-25
CN1305469A (zh) 2001-07-25
HUP0102554A1 (hu) 2001-10-28
ATE227715T1 (de) 2002-11-15
ATE259372T1 (de) 2004-02-15
BR9912188A (pt) 2001-04-10
DE19825804A1 (de) 1999-12-16
NO327075B1 (no) 2009-04-20
PL196057B1 (pl) 2007-11-30
AU4503199A (en) 1999-12-30
WO1999064410A1 (de) 1999-12-16
CZ297925B6 (cs) 2007-05-02
AU753275B2 (en) 2002-10-10
RU2220141C2 (ru) 2003-12-27
AU752633B2 (en) 2002-09-26
DE19825804C2 (de) 2000-08-24
CZ20004591A3 (cs) 2001-04-11
ES2182535T3 (es) 2003-03-01
HUP0102256A1 (hu) 2001-12-28

Similar Documents

Publication Publication Date Title
ID26876A (id) Derivat-derivat benzotiepin 1,1-dioksida, proses pembuatannya, bahan-bahan farmasi yang terdiri dari senyawa-senyawa ini dan penggunaannya
ID18613A (id) Oksadiazol baru, proses pembuatannya serta penggunaannya sebagai komposisi farmasi
NO20006630D0 (no) Farmasöytisk sammensetning for behandlingen av diabetes
ID23600A (id) Turunan tiazolidin dan oksazolidin, pembuatan dan penggunaannya untuk pengobatan (pecahan dari p-950453)
EE200000468A (et) Ühendid, nende kasutamine ja farmatseutiline kompositsioon
ATE309206T1 (de) Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen
ID26420A (id) Indolinon-indolinon tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi-komposisi farmasi
ID24620A (id) Proses pembuatan turunan-turunan dari keluarga taksoid
DK1052974T3 (da) Farmaceutisk sammensætning indeholdende epothilon
ID30299A (id) Turunan oksazolidinon, proses pembuatannya dan komposisi farmasi yang mengandungnya
ID30393A (id) Senyawa tienopirimidina, pembuatan dan penggunaannya
NO952130D0 (no) Anvendelse av tieno(1,5)benzodiazepin for behandling av tilstander i mave/tarmkanalen
DE69940166D1 (de) Feinteilige acrylpolymere und diese enthaltende plastisole
DE69723398T2 (de) Polyalkylphenoxyaminoalkane und diese enthaltende freibstoffzusammensetzungen
ID20137A (id) Turunan propanolamina, proses pembuatannya, sediaan farmasi yang mengandung senyawa ini, dan penggunannya
ID25469A (id) Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya
ID25516A (id) Senyawa-senyawa yang mengandung cincin-cincin beranggotakan enam, proses pembuatannya, dan penggunaannya sebagai obat
ID26102A (id) Proses pembuatan senyawa-senyawa stilbena
ID23436A (id) Senyawa-senyawa akrilonitril, proses untuk produksinya dan pestisida-pestisida yang mengandungnya
ID17810A (id) Turunan-turunan 2,4-tiazolidindion tersubstitusi baru, proses untuk pembuatannya dan komposisi farmasi yang mengandungnya
ID26137A (id) Komposisi farmasi baru dari uridin trifosfat
ID24173A (id) 1,2,3,4,5,6 heksahidro-2-6-metano-3-benzazosin-10-ol, proses pembuatan dan penggunannya untuk obat-obatan
HRP20040171A2 (en) Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
DE69706146D1 (de) Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
ID20967A (id) Kroman tersubstitusi sulfonamida, proses pembuatannya, penggunaannya sebagai obat, dan sediaan farmasi yang mengandung bahan tersebut